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    Salivary biomarkers for monitoring of type 2 diabetes treatment
    1.
    发明授权
    Salivary biomarkers for monitoring of type 2 diabetes treatment 有权

    公开(公告)号：US10317415B2

    公开(公告)日：2019-06-11

    申请号：US15066941

    申请日：2016-03-10

    申请人： Xinbin Gu ,  Grace Robinson

    发明人： Xinbin Gu ,  Grace Robinson

    IPC分类号： G01N33/68

    摘要： The disclosure relates to the identification of salivary biomarkers for diagnosis and monitoring of type 2 diabetes in a subject. Also provided are methods for noninvasively diagnosing and monitoring type 2 diabetes in a subject. More particularly, the expression of salivary biomarkers, including MUC-1, MUC-2, MUC-4, and MUC-5B, are highly associated with A1C level in African American patients with type 2 diabetes.

    Salivary Biomarkers For Diagnosis And Monitoring Of Type 2 Diabetes And Uses Thereof
    4.
    发明申请
    Salivary Biomarkers For Diagnosis And Monitoring Of Type 2 Diabetes And Uses Thereof 审中-公开
    唾液生物标志物用于诊断和监测2型糖尿病及其用途

    公开(公告)号：US20160266148A1

    公开(公告)日：2016-09-15

    申请号：US15066941

    申请日：2016-03-10

    申请人： Xinbin Gu ,  Grace Robinson

    发明人： Xinbin Gu ,  Grace Robinson

    IPC分类号： G01N33/68

    CPC分类号： G01N33/6893 ,  G01N2333/4725 ,  G01N2333/525 ,  G01N2800/042 ,  G01N2800/52

    摘要： The disclosure relates to the identification of salivary biomarkers for diagnosis and monitoring of type 2 diabetes in a subject. Also provided are methods for noninvasively diagnosing and monitoring type 2 diabetes in a subject. More particularly, the expression of salivary biomarkers, including MUC-1, MUC-2, MUC-4, and MUC-5B, are highly associated with A1C level in African American patients with type 2 diabetes.

    摘要翻译： 该公开内容涉及用于诊断和监测受试者的2型糖尿病的唾液生物标志物。 还提供了用于在受试者中非侵入性诊断和监测2型糖尿病的方法。 更具体地说，包括MUC-1，MUC-2，MUC-4和MUC-5B在内的唾液生物标志物的表达与非裔美国II型糖尿病患者的A1C水平高度相关。

    Mammal-specific Growth-defective Arbovirus
    6.
    发明申请
    Mammal-specific Growth-defective Arbovirus 有权

    公开(公告)号：US20210222132A1

    公开(公告)日：2021-07-22

    申请号：US16645788

    申请日：2018-09-11

    申请人： Xiaowu Pang ,  Xinbin Gu

    发明人： Xiaowu Pang ,  Xinbin Gu

    IPC分类号： C12N7/00

    摘要： Arbovirus carries an altered furin cleavage site that results in enhanced cleavage of a precursor polyprotein, such as, prE2 or prM. Dengue virus particles can have an amino acid alteration within amino acids 80-130 of prM. Zika virus particles can have alterations at amino residues at and/or about the furin cleavage site. The virus can be produced in insect cells. The virus does not form progeny virus in mammal cells.

    METHODS FOR TREATING TRIPLE NEGATIVE BREAST CANCER USING SALVIANOLIC ACID B
    7.
    发明申请
    METHODS FOR TREATING TRIPLE NEGATIVE BREAST CANCER USING SALVIANOLIC ACID B 有权

    公开(公告)号：US20210106552A1

    公开(公告)日：2021-04-15

    申请号：US17046577

    申请日：2019-04-11

    申请人： Xinbin GU

    发明人： Xinbin GU

    IPC分类号： A61K31/343 ,  A61P35/00 ,  A61K31/704

    摘要： The present disclosure provides methods related to treating triple-negative breast cancer (TNBC) in a mammal by administering salvianolic acid B (or a salt or solvate thereof) to promote ceramide-mediated apoptosis. In one form, the ceramide-mediated apoptosis of TNBC cells occurs by decreasing the level of one or more of glucosylceramide synthase and GM3 synthase in the subject through the use of an effective amount of salvianolic acid B. In another aspect, salvianolic acid B or its pharmaceutically acceptable salt or solvate is used as a medicament or in the manufacture of a medicament for treating TNBC.