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1.发明授权公开(公告)号：US06229001B1
公开(公告)日：2001-05-08
申请号：US08990791
申请日：1997-12-15
IPC分类号： C07H2102
CPC分类号： C12N9/003 , C07K14/35 , C12Q1/04 , C12Q1/689 , Y10S435/863 , Y10S435/864 , Y10S435/865 , Y10S435/866
摘要： The invention relates to the nucleic acid sequence and amino acid sequence of dihydrofolate reductase (DHFR) from mycobacteria and to expression of recombinant DHFR protein. Utilizing the recombinant protein, novel therapies and diagnostic strategies can be developed and selective antimycobacterial compositions can be designed and utilized to treat mycobacterial infections in patients. This invention includes all or portions of novel recombinant nucleic acids encoding DHFR for mycobacteria such as M. avium, to novel recombinant DHFR peptides produced by such sequences, and to vaccines, diagnostic kits, cells and therapies utilizing these peptides and nucleic acid sequences. The present invention relates to methods for using the sequences of the present invention to develop drugs specific to M. avium and other mycobacteria, to identify and sequence corresponding sequences in species other than M. avium, as well as diagnostic and treatment methods incorporating the disclosed sequences and peptides.
摘要翻译： 本发明涉及来自分枝杆菌的二氢叶酸还原酶（DHFR）和重组DHFR蛋白的表达的核酸序列和氨基酸序列。 利用重组蛋白，可以开发出新的疗法和诊断策略，并且可以设计和利用选择性抗分支杆菌组合物来治疗患者的分枝杆菌感染。 本发明包括编码用于分枝杆菌如鸟分枝杆菌的DHFR的新型重组核酸的全部或部分，以及由这些序列产生的新型重组DHFR肽以及利用这些肽和核酸序列的疫苗，诊断试剂盒，细胞和疗法。 本发明涉及使用本发明的序列开发针对鸟分枝杆菌和其他分枝杆菌特异性的药物的方法，以鉴定和序列除了鸟分枝杆菌以外的物种中的相应序列，以及结合所公开的诊断和治疗方法 序列和肽。
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2.发明授权Mycobacterium fol A gene that encodes for the enzyme dihydrofolate reductase 有权分枝杆菌分枝杆菌编码二氢叶酸还原酶的基因公开(公告)号：US06559295B1
公开(公告)日：2003-05-06
申请号：US09372591
申请日：1999-08-12
IPC分类号： C07H2102
CPC分类号： C12N9/003 , C07K14/35 , C12Q1/04 , C12Q1/689 , Y10S435/863 , Y10S435/864 , Y10S435/865 , Y10S435/866
摘要： The invention relates to the nucleic acid sequence and amino acid sequence of dihydrofolate reductase (DHFR) from mycobacteria and to expression of recombinant DHFR protein. Utilizing the recombinant protein, novel therapies and diagnostic strategies can be developed and selective antimycobacterial compositions can be designed and utilized to treat mycobacterial infections in patients. This invention includes all or portions of novel recombinant nucleic acids encoding DHFR for mycobacteria such as M. avium, to novel recombinant DHFR peptides produced by such sequences, and to vaccines, diagnostic kits, cells and therapies utilizing these peptides and nucleic acid sequences. The present invention relates to methods for using the sequences of the present invention to develop drugs specific to M. avium and other mycobacteria, to identify and sequence corresponding sequences in species other than M. avium, as well as diagnostic and treatment methods incorporating the disclosed sequences and peptides.
摘要翻译： 本发明涉及来自分枝杆菌的二氢叶酸还原酶（DHFR）和重组DHFR蛋白的表达的核酸序列和氨基酸序列。 利用重组蛋白，可以开发出新的疗法和诊断策略，并且可以设计和利用选择性抗分支杆菌组合物来治疗患者的分枝杆菌感染。 本发明包括编码用于分枝杆菌如鸟分枝杆菌的DHFR的新型重组核酸的全部或部分，以及由这些序列产生的新型重组DHFR肽以及利用这些肽和核酸序列的疫苗，诊断试剂盒，细胞和疗法。 本发明涉及使用本发明的序列开发针对鸟分枝杆菌和其他分枝杆菌特异性的药物的方法，以鉴定和序列除了鸟分枝杆菌以外的物种中的相应序列，以及结合所公开的诊断和治疗方法 序列和肽。
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公开(公告)号：US06264991B1
公开(公告)日：2001-07-24
申请号：US09135708
申请日：1998-08-18
IPC分类号： A61K950
CPC分类号： A61K45/06 , A61K9/1647 , A61K31/438 , A61K31/496 , A61K31/498 , A61K31/7036 , Y02A50/402 , Y02A50/478
摘要： A method of treating or preventing an intracellular infection in an animal comprising administering a first effective amount of a suitable drug contained in first biocompatible microspheres that have a diameter of less than or equal to about 10 microns, wherein the first microspheres release the suitable drug upon administration at a first effective rate. A second set of microspheres greater than 10 microns in diameter may also be administered to provide continuing systemic release of the drug.
摘要翻译： 一种治疗或预防动物细胞内感染的方法，其包括施用第一有效量的包含在直径小于或等于约10微米的第一生物相容性微球中的合适药物，其中所述第一微球释放适合的药物 以第一个有效率进行管理。 还可以施用直径大于10微米的第二组微球以提供药物的持续全身释放。
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