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    Crystal structure of chorismate synthase and uses thereof
    2.
    发明申请
    Crystal structure of chorismate synthase and uses thereof 审中-公开
    chorismate合酶的晶体结构及其用途

    公开(公告)号：US20060211040A1

    公开(公告)日：2006-09-21

    申请号：US10529196

    申请日：2003-09-26

    Applicant: William Primrose ,  John Maclean ,  Sohai Ali

    Inventor： William Primrose ,  John Maclean ,  Sohai Ali

    IPC: G06F19/00

    CPC classification number: C12N9/88 ,  C07K2299/00 ,  C12Q1/34 ,  G16B15/00

    Abstract: The invention describes the identification of the structure coordinates for the enzyme Chorismate Synthase. There is a computer programmed to produce a three-dimensional representation of a molecule or molecular complex, wherein the molecule or molecular complex comprises a binding domain defined by the structure coordinates of (a) Arg 39, His 110, Ser 132, Thr 136, Lys 254, Gly 297, Lys 311, Thr 315, Arg 337 and Asp 339; or (b) Ser 9, His 10, Arg 39, Asp 54, Arg 107, His 110, Ser 132, Ala 133, Arg 134, Thr 136, Arg 337 and Asp 339. 1, or where the molecular complex or binding domain has a root mean square deviation of conserved residue backbone atoms of less than 2 A when superimposed on the relevant backbone atoms described by the structure coordinates of said amino acids.

    Abstract translation: 本发明描述了酶Chorismate Synthase的结构坐标的鉴定。 计算机被编程以产生分子或分子复合物的三维表示，其中分子或分子复合物包含由（a）Arg 39，His 110，Ser 132，Thr 136， Lys 254，Gly 297，Lys 311，Thr 315，Arg 337和Asp 339; 或（b）Ser 9，His 10，Arg 39，Asp 54，Arg 107，His 110，Ser 132，Ala 133，Arg 134，Thr 136，Arg 337和Asp 339. 1，或其中分子复合物或结合结构域 当由所述氨基酸的结构坐标描述的相关骨架原子上叠加时，具有小于2A的保守残基骨架原子的均方根偏差。

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