-
公开(公告)号：US08460672B1
公开(公告)日：2013-06-11
申请号：US12893731
申请日：2010-09-29
CPC分类号： A61K39/29 , A61K39/12 , C12N2770/24234
摘要： The invention relates to immunogenic compositions useful as HCV vaccines. Provided are HCV mosaic polypeptide and nucleic acid compositions which provide higher levels of T-cell epitope coverage while minimizing the occurrence of unnatural and rare epitopes compared to natural HCV polypeptides and consensus HCV sequences.
摘要翻译： 本发明涉及可用作HCV疫苗的免疫原性组合物。 提供了与天然HCV多肽和共有HCV序列相比，提供更高水平的T细胞表位覆盖同时最小化非天然和罕见表位的发生的HCV嵌合多肽和核酸组合物。
-
2.发明申请AUTOMATED SYSTEMS FOR REMOVING TISSUE SAMPLES FROM SEEDS, AND RELATED METHODS 有权用于从种子中去除组织样品的自动化系统及相关方法公开(公告)号：US20120117865A1
公开(公告)日：2012-05-17
申请号：US13186126
申请日：2011-07-19
申请人： Kevin L. Deppermann , Michael W. Petersen , Allen N. Ondes , David W. Finley , William M. Fischer , John M. Jensen , David Butruille , Stanton Dotson , Sam Eathington , Heather M. Forbes , Bruce Schnicker , John Tamulonis
发明人： Kevin L. Deppermann , Michael W. Petersen , Allen N. Ondes , David W. Finley , William M. Fischer , John M. Jensen , David Butruille , Stanton Dotson , Sam Eathington , Heather M. Forbes , Bruce Schnicker , John Tamulonis
IPC分类号： A01C1/00
CPC分类号： G01N35/00584 , A01C1/00 , A01C1/025 , G01N1/04 , G01N1/20 , G01N1/286 , G01N33/0098 , G01N33/5097 , G01N2001/002
摘要： A seed sampling system is provided having an automated seed loading assembly including a seed bin and being operable to singulate seeds from a plurality of seeds within the seed bin. The system also includes an automated seed sampling assembly operable to remove tissue samples from the singulated seeds, and an automated seed transport assembly operable to transfer the singulated seeds from the seed loading assembly to the seed sampling assembly. The seed transport assembly includes multiple retention members. Each of the retention members is movable relative to the seed loading assembly and to the seed sampling assembly. The seed transport assembly is operable to position one of the multiple retention members adjacent to the seed loading assembly for engaging one of the singulated seeds, while positioning another of the retention members adjacent to the seed sampling assembly for presenting another of the singulated seeds to the seed sampling assembly.
摘要翻译： 提供种子采样系统，其具有包括种子仓的自动种子加载组件，并且可操作以从种子仓内的多个种子中分离种子。 该系统还包括可操作以从单个种子中去除组织样本的自动种子取样组件，以及可操作以将单种化种子从种子装载组件转移到种子采样组件的自动种子运输组件。 种子运输组件包括多个保持构件。 每个保持构件可相对于种子装载组件和种子取样组件移动。 种子运输组件可操作以将多个保持构件中的一个定位成与种子装载组件相邻以接合单个种子之一，同时将另一个保持构件定位成与种子取样组件相邻，以将另一个单个种子呈现到 种子采样总成。
-
公开(公告)号：US20110150915A1
公开(公告)日：2011-06-23
申请号：US12960287
申请日：2010-12-03
申请人： Bette T. Korber , Simon Perkins , Tanmoy Bhattacharya , William M. Fischer , James Theiler , Norman Letvin , Barton F. Haynes , Beatrice H. Hahn , Karina Yusim , Carla Kuiken
发明人： Bette T. Korber , Simon Perkins , Tanmoy Bhattacharya , William M. Fischer , James Theiler , Norman Letvin , Barton F. Haynes , Beatrice H. Hahn , Karina Yusim , Carla Kuiken
CPC分类号： A61K39/21 , A61K39/00 , A61K39/12 , C12N2740/16034
摘要： The present invention relates, in general, to an immunogenic composition (e.g., a vaccine) and, in particular, to a polyvalent immunogenic composition, such as a polyvalent HIV vaccine, and to methods of using same. The invention further relates to methods that use a genetic algorithm to create sets of polyvalent antigens suitable for use, for example, in vaccination strategies.
-
4.发明授权公开(公告)号：US09011875B2
公开(公告)日：2015-04-21
申请号：US13399963
申请日：2012-02-17
申请人： Bette T. Korber , Simon Perkins , Tanmoy Bhattacharya , William M. Fischer , James Theiler , Norman Letvin , Barton F. Haynes , Beatrice H. Hahn , Karina Yusim , Carla Kuiken
发明人： Bette T. Korber , Simon Perkins , Tanmoy Bhattacharya , William M. Fischer , James Theiler , Norman Letvin , Barton F. Haynes , Beatrice H. Hahn , Karina Yusim , Carla Kuiken
CPC分类号： A61K39/21 , A61K39/00 , A61K39/12 , C12N2740/16034
摘要： The present invention relates to mosaic HIV-1 group M Gag sequences and to a composition comprising same.
摘要翻译： 本发明涉及镶嵌HIV-1组M Gag序列和涉及包含其的组合物。
-
5.发明授权Automated systems for removing tissue samples from seeds, and related methods 有权用于从种子中去除组织样品的自动化系统及相关方法公开(公告)号：US09003696B2
公开(公告)日：2015-04-14
申请号：US13186126
申请日：2011-07-19
申请人： Kevin L. Deppermann , Michael W. Petersen , Allen N. Ondes , David W. Finley , William M. Fischer , John M. Jensen , David Butruille , Stanton Dotson , Sam Eathington , Heather M. Forbes , Bruce Schnicker , John Tamulonis
发明人： Kevin L. Deppermann , Michael W. Petersen , Allen N. Ondes , David W. Finley , William M. Fischer , John M. Jensen , David Butruille , Stanton Dotson , Sam Eathington , Heather M. Forbes , Bruce Schnicker , John Tamulonis
CPC分类号： G01N35/00584 , A01C1/00 , A01C1/025 , G01N1/04 , G01N1/20 , G01N1/286 , G01N33/0098 , G01N33/5097 , G01N2001/002
摘要： A seed sampling system is provided having an automated seed loading assembly including a seed bin and being operable to singulate seeds from a plurality of seeds within the seed bin. The system also includes an automated seed sampling assembly operable to remove tissue samples from the singulated seeds, and an automated seed transport assembly operable to transfer the singulated seeds from the seed loading assembly to the seed sampling assembly. The seed transport assembly includes multiple retention members. Each of the retention members is movable relative to the seed loading assembly and to the seed sampling assembly. The seed transport assembly is operable to position one of the multiple retention members adjacent to the seed loading assembly for engaging one of the singulated seeds, while positioning another of the retention members adjacent to the seed sampling assembly for presenting another of the singulated seeds to the seed sampling assembly.
摘要翻译： 提供种子采样系统，其具有包括种子仓的自动种子加载组件，并且可操作以从种子仓内的多个种子中分离种子。 该系统还包括可操作以从单个种子中去除组织样本的自动种子取样组件，以及可操作以将单种化种子从种子装载组件转移到种子采样组件的自动种子运输组件。 种子运输组件包括多个保持构件。 每个保持构件可相对于种子装载组件和种子取样组件移动。 种子运输组件可操作以将多个保持构件中的一个定位成邻近种子装载组件以接合单个种子中的一个，同时将另一个保持构件定位成与种子取样组件相邻，以将另一个单个种子呈现到 种子采样总成。
-
6.发明授权Immunogenic compositions comprising human immunodeficiency virus (HIV) mosaic Nef proteins 有权包含人免疫缺陷病毒（HIV）镶嵌Nef蛋白的免疫原性组合物公开(公告)号：US08119140B2
公开(公告)日：2012-02-21
申请号：US11990222
申请日：2006-08-23
申请人： Bette T. Korber , Simon Perkins , Tanmoy Bhattacharya , William M. Fischer , James Theiler , Norman Letvin , Barton F. Haynes , Beatrice H. Hahn , Karina Yusim , Carla Kuiken
发明人： Bette T. Korber , Simon Perkins , Tanmoy Bhattacharya , William M. Fischer , James Theiler , Norman Letvin , Barton F. Haynes , Beatrice H. Hahn , Karina Yusim , Carla Kuiken
IPC分类号： A61K39/21
CPC分类号： A61K39/21 , A61K39/00 , A61K39/12 , C12N2740/16034
摘要： The present invention relates to mosaic clade M HIV-1 Nef polypeptides and to compositions comprising same. The polypeptides of the invention are suitable for use in inducing an immune response to HIV-1 in a human.
摘要翻译： 本发明涉及马赛克进化枝M HIV-1 Nef多肽及其组合物。 本发明的多肽适用于诱导人体对HIV-1的免疫应答。
-
公开(公告)号：US09017691B2
公开(公告)日：2015-04-28
申请号：US13130018
申请日：2009-11-18
IPC分类号： A61K39/21 , A61K39/00 , C07K14/005
CPC分类号： A61K39/21 , A61K39/12 , A61K39/235 , A61K39/275 , A61K2039/53 , C07K14/005 , C12N7/00 , C12N2710/10043 , C12N2710/10343 , C12N2710/24043 , C12N2740/16122 , C12N2740/16134 , C12N2740/16171 , C12N2740/16222 , C12N2740/16234 , C12N2740/16271 , C12N2740/16322 , C12N2740/16334 , Y02A50/467
摘要： The invention provides compositions, methods, and kits for the treatment or prevention of viral infections. The polyvalent (e.g., 2-valent) vaccines described herein incorporate computationally-optimized viral polypeptides that can increase the diversity or breadth and depth of cellular immune response in vaccinated subjects.
摘要翻译： 本发明提供用于治疗或预防病毒感染的组合物，方法和试剂盒。 本文所述的多价（例如2价）疫苗引入计算优化的病毒多肽，其可以增加接种受试者的细胞免疫应答的多样性或广度和深度。
-
公开(公告)号：US20120076812A1
公开(公告)日：2012-03-29
申请号：US13130018
申请日：2009-11-18
CPC分类号： A61K39/21 , A61K39/12 , A61K39/235 , A61K39/275 , A61K2039/53 , C07K14/005 , C12N7/00 , C12N2710/10043 , C12N2710/10343 , C12N2710/24043 , C12N2740/16122 , C12N2740/16134 , C12N2740/16171 , C12N2740/16222 , C12N2740/16234 , C12N2740/16271 , C12N2740/16322 , C12N2740/16334 , Y02A50/467
摘要： The invention provides compositions, methods, and kits for the treatment or prevention of viral infections. The polyvalent (e.g., 2-valent) vaccines described herein incorporate computationally-optimized viral polypeptides that can increase the diversity or breadth and depth of cellular immune response in vaccinated subjects.
摘要翻译： 本发明提供用于治疗或预防病毒感染的组合物，方法和试剂盒。 本文所述的多价（例如2价）疫苗引入计算优化的病毒多肽，其可以增加接种受试者的细胞免疫应答的多样性或广度和深度。
-
公开(公告)号：US20120231028A1
公开(公告)日：2012-09-13
申请号：US13399963
申请日：2012-02-17
申请人： Bette T. KORBER , Simon PERKINS , Tanmoy BHATTACHARYA , William M. FISCHER , James THEILER , Norman LETVIN , Barton F. HAYNES , Beatrice H. HAHN , Karina YUSIM , Carla KUIKEN
发明人： Bette T. KORBER , Simon PERKINS , Tanmoy BHATTACHARYA , William M. FISCHER , James THEILER , Norman LETVIN , Barton F. HAYNES , Beatrice H. HAHN , Karina YUSIM , Carla KUIKEN
IPC分类号： A61K39/21 , A61P37/04 , C12N15/867 , C07K14/155 , C07H21/04
CPC分类号： A61K39/21 , A61K39/00 , A61K39/12 , C12N2740/16034
摘要： The present invention relates, in general, to an immunogenic composition (e.g., a vaccine) and, in particular, to a polyvalent immunogenic composition, such as a polyvalent HIV vaccine, and to methods of using same. The invention further relates to methods that use a genetic algorithm to create sets of polyvalent antigens suitable for use, for example, in vaccination strategies.
-
公开(公告)号：US20090324631A1
公开(公告)日：2009-12-31
申请号：US11990222
申请日：2006-08-23
申请人： Bette T. Korber , Simon Perkins , Tanmoy Bhattacharya , William M. Fischer , James Theiler , Norman Letvin , Barton F. Haynes , Beatrice H. Hahn , Karina Yusim , Carla Kuiken
发明人： Bette T. Korber , Simon Perkins , Tanmoy Bhattacharya , William M. Fischer , James Theiler , Norman Letvin , Barton F. Haynes , Beatrice H. Hahn , Karina Yusim , Carla Kuiken
CPC分类号： A61K39/21 , A61K39/00 , A61K39/12 , C12N2740/16034
摘要： The present invention relates, in general, to an immunogenic composition (e.g., a vaccine) and, in particular, to a polyvalent immunogenic composition, such as a polyvalent HIV vaccine, and to methods of using same. The invention further relates to methods that use a genetic algorithm to create sets of polyvalent antigens suitable for use, for example, in vaccination strategies.
摘要翻译： 本发明一般涉及免疫原性组合物（例如疫苗），特别涉及多价免疫原性组合物，例如多价HIV疫苗，以及使用它们的方法。 本发明还涉及使用遗传算法来产生适合于例如疫苗接种策略中使用的多价抗原组的方法。
-
-
-
-
-
-
-
-
-
搜索结果
11 条记录 (耗时 0.021 秒)
