公开(公告)号：US06755886B2

公开(公告)日：2004-06-29

申请号：US10126039

申请日：2002-04-18

申请人： Jonathan Phillips ,  William L. Perry ,  William J. Kroenke

发明人： Jonathan Phillips ,  William L. Perry ,  William J. Kroenke

IPC分类号： B22F914

CPC分类号： B22F1/0096 ,  B22F9/04 ,  B22F2999/00 ,  B22F2202/13

摘要： Method for producing metallic particles. The method converts metallic nanoparticles into larger, spherical metallic particles. An aerosol of solid metallic nanoparticles and a non-oxidizing plasma having a portion sufficiently hot to melt the nanoparticles are generated. The aerosol is directed into the plasma where the metallic nanoparticles melt, collide, join, and spheroidize. The molten spherical metallic particles are directed away from the plasma and enter the afterglow where they cool and solidify.

摘要翻译： 金属粒子的制造方法 该方法将金属纳米粒子转化为较大的球形金属颗粒。 产生固体金属纳米颗粒和具有足够热以熔化纳米颗粒的部分的非氧化性等离子体的气溶胶。 气溶胶被引导到等离子体中，其中金属纳米粒子熔化，碰撞，接合和球化。 熔融的球形金属颗粒被引导离开等离子体并进入其中它们冷却和固化的余辉。

公开(公告)号：US06998103B1

公开(公告)日：2006-02-14

申请号：US10295129

申请日：2002-11-15

申请人： Jonathan Phillips ,  William L. Perry ,  Chun-Ku Chen

发明人： Jonathan Phillips ,  William L. Perry ,  Chun-Ku Chen

IPC分类号： D01F9/12

CPC分类号： D01F9/12 ,  B82Y30/00 ,  D01F9/127 ,  Y10S977/842 ,  Y10S977/844

摘要： Method for producing carbon nanotubes. Carbon nanotubes were prepared using a low power, atmospheric pressure, microwave-generated plasma torch system. After generating carbon monoxide microwave plasma, a flow of carbon monoxide was directed first through a bed of metal particles/glass beads and then along the outer surface of a ceramic tube located in the plasma. As a flow of argon was introduced into the plasma through the ceramic tube, ropes of entangled carbon nanotubes, attached to the surface of the tube, were produced. Of these, longer ropes formed on the surface portion of the tube located in the center of the plasma. Transmission electron micrographs of individual nanotubes revealed that many were single-walled.

摘要翻译： 碳纳米管的制造方法。 使用低功率，大气压，微波产生的等离子体焰炬系统制备碳纳米管。 在产生一氧化碳微波等离子体之后，一氧化碳流首先通过金属颗粒/玻璃珠床，然后沿着位于等离子体中的陶瓷管的外表面。 当通过陶瓷管将氩气流引入等离子体中时，产生附着在管表面的缠结碳纳米管的绳索。 其中，在位于等离子体中心的管的表面部分上形成更长的绳索。 单个纳米管的透射电子显微镜显示许多是单壁的。

公开(公告)号：US06689192B1

公开(公告)日：2004-02-10

申请号：US10017289

申请日：2001-12-13

申请人： Jonathan Phillips ,  William L. Perry ,  William J. Kroenke

发明人： Jonathan Phillips ,  William L. Perry ,  William J. Kroenke

IPC分类号： B22F900

CPC分类号： B22F9/12 ,  B22F2999/00 ,  B22F1/0018 ,  B22F2202/13 ,  B22F1/0048

摘要： Method for producing metallic nanoparticles. The method includes generating an aerosol of solid metallic microparticles, generating non-oxidizing plasma with a plasma hot zone at a temperature sufficiently high to vaporize the microparticles into metal vapor, and directing the aerosol into the hot zone of the plasma. The microparticles vaporize in the hot zone to metal vapor. The metal vapor is directed away from the hot zone and to the plasma afterglow where it cools and condenses to form solid metallic nanoparticles.

摘要翻译： 金属纳米粒子的制造方法。 该方法包括产生固体金属微粒的气溶胶，在足够高的温度下用等离子体热区产生非氧化性等离子体，以将微粒蒸发成金属蒸气，并引导气溶胶进入等离子体的热区。 微粒在热区中蒸发成金属蒸汽。 金属蒸气被引导离开热区和等离子体余辉，其中它冷却并冷凝以形成固体金属纳米颗粒。

公开(公告)号：US5158458A

公开(公告)日：1992-10-27

申请号：US720948

申请日：1991-06-25

申请人： William L. Perry

发明人： William L. Perry

IPC分类号： A61C1/18 ,  A61C8/00

CPC分类号： A61C8/0089 ,  A61C1/186

摘要： A system for driving and tightening components in a dental prosthodontic restoration. The system comprises at least a first driver having a body portion and a shank portion depending from the body portion, the body portion including a socket and a bore axially disposed through the body portion and opening through to the socket, the shank portion having a predetermined driver structure at one end. The system includes at least a first torque element comprising an outer member and an inner member, the inner member aligned with respect to the outer member and attached thereto by one or more spokes, the outer member having a predetermined geometry to enable the outer member to be received in the socket of the driver. A mandrel is also provided and includes a first portion received in the inner member of the torque element and a second portion received in the bore when the mandrel, the torque element and the driver are assembled together. Upon rotation of the mandrel, the inner member of the torque element rotates with respect to the outer member of the torque element only while the spokes are intact. The number of spokes and the placement of the spokes relative to the inner and outer members of the torque element are predetermined such that upon rotation of the mandrel the spokes remain intact provided the torque applied to the mandrel is below a predetermined level.

摘要翻译： 用于在牙修复修复体中驱动和紧固组件的系统。 所述系统包括至少第一驱动器，所述第一驱动器具有主体部分和从主体部分悬垂的柄部分，所述主体部分包括插座和轴向设置穿过所述主体部分并且穿过所述插座的孔，所述柄部分具有预定的 司机结构一端 所述系统至少包括第一扭矩元件，所述第一扭矩元件包括外部构件和内部构件，所述内部构件相对于所述外部构件对准并且通过一个或多个轮辐与其连接，所述外部构件具有预定几何形状， 被接收在驱动器的插座中。 还提供了心轴，并且包括容纳在扭矩元件的内部构件中的第一部分和当心轴，扭矩元件和驱动器组装在一起时容纳在孔中的第二部分。 在心轴旋转时，扭矩元件的内部构件仅在轮辐完好的情况下相对于扭矩元件的外部构件旋转。 轮辐的数量和轮辐相对于扭矩元件的内部和外部构件的放置是预定的，使得当心轴旋转时，辐条保持完整，只要施加到心轴的扭矩低于预定水平。

公开(公告)号：US5222892A

公开(公告)日：1993-06-29

申请号：US870146

申请日：1992-04-17

申请人： William L. Perry

发明人： William L. Perry

IPC分类号： A61C1/08 ,  A61C19/055

CPC分类号： A61C1/084 ,  A61C19/055

摘要： A laboratory attachment jig is described for use in accurately positioning an attachment relative to an implant abutment/fixture analog of a working model. This jig comprises an orientation arm having a first end and a second end, the orientation arm including a fastener for securing the orientation arm to the abutment/fixture analog of the working model. A primary support member is attached to the second end of the orientation arm, with the primary support member and the orientation arm being supported transversely in a first plane. The primary support member includes a vertical positioning sleeve and a fastener for the vertical positioning sleeve. A lateral support arm is attached to the vertical positioning sleeve of the primary support member and includes an end. A mandrel support member is attached to the end of the lateral support member for retaining the attachment. The lateral support arm includes a lateral positioning sleeve and a fastener for the lateral positioning sleeve. In use, the lateral support arm is adapted to be movable up or down on the primary support member upon loosening of the fastener for the vertical positioning sleeve and is adapted to be movable forward or backward relative to the primary support member upon loosening of the fastener for the lateral positioning sleeve.

摘要翻译： 描述了一种实验室连接夹具，用于相对于工作模型的植入物邻接/夹具模拟物精确地定位附件。 该夹具包括具有第一端和第二端的定向臂，所述定向臂包括用于将定向臂固定到工作模型的邻接/固定模拟的紧固件。 主支撑构件附接到定向臂的第二端，其中主支撑构件和定向臂横向地支撑在第一平面中。 主支撑构件包括垂直定位套筒和用于垂直定位套筒的紧固件。 横向支撑臂连接到主支撑构件的垂直定位套筒并且包括一端。 心轴支撑构件附接到侧向支撑构件的端部以保持附件。 横向支撑臂包括侧向定位套筒和用于横向定位套筒的紧固件。 在使用中，横向支撑臂适于在松动用于垂直定位套筒的紧固件时在主支撑构件上上下移动，并且适于在松开紧固件时相对于主支撑构件向前或向后移动 用于横向定位套筒。

公开(公告)号：US5215460A

公开(公告)日：1993-06-01

申请号：US795867

申请日：1991-11-20

申请人： William L. Perry

发明人： William L. Perry

IPC分类号： A61C1/08 ,  A61C19/055

CPC分类号： A61C19/055 ,  A61C1/084

摘要： A method is described for fabricating a dental prosthodontic restoration to be fitted on at least first and second implant fixtures, each of the implant fixtures supporting an abutment. The method begins by fitting a first abutment screw assembly to said first implant fixture, the first abutment screw assembly including a screw portion, and an attachment secured to the screw portion. The first abutment screw assembly is then tightened to retain the assembly in the first implant fixture. Then, the method continues by fitting a screw portion of a second abutment screw assembly to said second implant fixture and tightening the screw portion to the second implant fixture. Using an intra-oral jig mechanism, the attachment of the second abutment screw assembly is then located in a predetermined position relative to the screw portion thereof such that the attachments of the first and second abutment screw assemblies have a parallel orientation. The method can alternatively be practiced using two-piece assemblies.

摘要翻译： 描述了一种用于制造待装配在至少第一和第二植入物固定装置上的牙修复修复体的方法，每个植入物夹具支撑基台。 该方法开始于将第一基台螺钉组件装配到所述第一植入物夹具上，第一基台螺钉组件包括螺纹部分和固定到螺钉部分的附件。 然后紧固第一基台螺钉组件以将组件保持在第一植入固定器中。 然后，该方法通过将第二基台螺丝组件的螺纹部分装配到所述第二植入物夹具并将螺钉部分紧固到第二植入物夹具来继续。 使用口内夹具机构，第二基台螺丝组件的附接件然后相对于其螺纹部分定位在预定位置，使得第一和第二基台螺钉组件的附接件具有平行取向。 该方法可以替代地使用两件式组件来实施。

公开(公告)号：US5108288A

公开(公告)日：1992-04-28

申请号：US715507

申请日：1991-06-14

申请人： William L. Perry

发明人： William L. Perry

IPC分类号： A61C8/00

CPC分类号： A61C8/0018 ,  A61C8/001 ,  A61C8/0022 ,  A61C8/0048 ,  A61C8/005 ,  A61C8/0059 ,  A61C8/006 ,  A61C8/0068 ,  A61C8/0001 ,  A61C8/0054

摘要： A dental prosthodontic restoration includes at least one implant fixture adapted to be implanted in a jawbone of a patient. The implant fixture has a threaded bore axially disposed therethrough and opening centrally through its gingival end. In one embodiment, the restoration includes a standard abutment having an abutment base having a fitting at its inferior end, a socket at its superior end, and a bore axially disposed through the base and opening centrally through the fitting and the socket. The abutment base is supported on the implant fixture, preferably in a non-rotational manner. The restoration further includes an abutment screw having an externally-threaded shaft for mating with the threaded bore of the implant fixture, a male fitting at its superior end having a polygonal cross-section, and a secondary bore opening through the superior end coaxial with and extending toward the shaft. Preferably, a locking sleeve is provided and has an outer periphery formed in a predetermined shape for mating with the superior socket of the abutment base. A bore is axially disposed through the sleeve and has the same polygonal cross-section as the male fitting at the superior end of the abutment screw. When the abutment base, the abutment screw and the locking sleeve are assembled intra-orally in the patient's mouth, the locking sleeve locks the abutment screw to the abutment base to prevent rotation, movement and loosening of the abutment screw. A similar locking mechanism is provided for coping screw.

摘要翻译： 牙修复修复体包括适于植入患者颚骨中的至少一个植入物夹具。 植入物夹具具有轴向设置在其中的螺纹孔，并且通过其牙龈端中心地开口。 在一个实施例中，修复体包括具有在其下端具有配件的邻接基座的标准基座，在其上端处具有插座，以及轴向地设置穿过基座并通过配件和插座中心地开口的孔。 抵靠基座优选以非旋转方式支撑在植入物夹具上。 所述修复体还包括具有外螺纹轴的邻接螺钉，用于与所述植入物夹具的所述螺纹孔配合，在其上端处具有多边形横截面的阳配件，以及通过所述上端同轴 向轴延伸。 优选地，提供锁定套筒并且具有形成为预定形状的外周边，用于与抵靠基座的上插座配合。 孔通过套筒轴向设置，并且具有与在基台螺钉的上端处的阳配件相同的多边形横截面。 当邻接基座，基台螺钉和锁定套筒内部组装在患者口中时，锁定套筒将抵接螺钉锁定到邻接基座，以防止基台螺钉的旋转，移动和松动。 为应对螺钉提供了类似的锁定机构。

公开(公告)号：US5989885A

公开(公告)日：1999-11-23

申请号：US874186

申请日：1997-06-13

申请人： David H. -F. Teng ,  Sean V. Tavtigian ,  William L. Perry, III ,  Mark H. Skolnick

发明人： David H. -F. Teng ,  Sean V. Tavtigian ,  William L. Perry, III ,  Mark H. Skolnick

IPC分类号： C12N9/12 ,  C12N15/00 ,  C12N15/52

CPC分类号： C12N9/1205

摘要： The present invention relates to mutations in the MKK4 gene in human cancers and their use in the diagnosis and prognosis of human cancer. Specific mutations in the MKK4 gene which are associated with breast, pancreatic, colorectal and testicular cancers have been identified. The invention also relates to the therapy of human cancers which have a mutation in the MKK4 gene, including gene therapy, protein replacement therapy and protein mimetics. Finally, the invention relates to the screening of drugs for cancer therapy.

摘要翻译： 本发明涉及人类癌症中MKK4基因的突变及其在人类癌症诊断和预后中的应用。 已经鉴定了与乳腺癌，胰腺癌，结肠直肠癌和睾丸癌相关的MKK4基因的特异性突变。 本发明还涉及在MKK4基因中具有突变的人类癌症的治疗，包括基因治疗，蛋白质替代疗法和蛋白质模拟物。 最后，本发明涉及用于癌症治疗的药物的筛选。