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公开(公告)号：US08143305B2
公开(公告)日：2012-03-27
申请号：US12675897
申请日：2008-08-27
申请人： Gopinadhan N. Anilkumar , Frank Bennett , Tin-Yau Chan , Kevin X. Chen , Mousumi Sannigrahi , Francisco Velazquez , Srikanth Venkatraman , Qingbei Zeng , Jose S. Duca , Charles A. Lesburg , Joseph A. Kozlowski , F. George Njoroge , Stuart B. Rosenblum , Neng-Yang Shih , Stephen J. Gavalas , Yueheng Jiang , Patrick A. Pinto , Haiyan Pu , Oleg B. Selyutin , Bancha Vibulbhan , Li Wang , Wanli Wu , Weiying Yang , Yuhua Huang , Hsueh-Cheng Huang , Robert Palermo , Boris Feld
发明人： Gopinadhan N. Anilkumar , Frank Bennett , Tin-Yau Chan , Kevin X. Chen , Mousumi Sannigrahi , Francisco Velazquez , Srikanth Venkatraman , Qingbei Zeng , Jose S. Duca , Charles A. Lesburg , Joseph A. Kozlowski , F. George Njoroge , Stuart B. Rosenblum , Neng-Yang Shih , Stephen J. Gavalas , Yueheng Jiang , Patrick A. Pinto , Haiyan Pu , Oleg B. Selyutin , Bancha Vibulbhan , Li Wang , Wanli Wu , Weiying Yang , Yuhua Huang , Hsueh-Cheng Huang , Robert Palermo , Boris Feld
IPC分类号： A01N43/38 , A61K31/40 , C07D209/04
CPC分类号： C07D417/14 , C07D209/42 , C07D401/04 , C07D401/14 , C07D403/04 , C07D405/14 , C07D409/14 , C07D413/14
摘要： The present invention relates to 2,3-Substituted Indole Derivatives, compositions comprising at least one 2,3-Substituted Indole Derivative, and methods of using the 2,3-Substituted Indole Derivatives for treating or preventing a viral infection or a virus-related disorder in a patient.
摘要翻译： 本发明涉及2,3-取代的吲哚衍生物，包含至少一种2,3-取代的吲哚衍生物的组合物和使用2,3-取代的吲哚衍生物用于治疗或预防病毒感染或病毒相关的方法 病人无序。
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2.发明申请Novel ketoamides with cyclic P4's as inhibitors of NS3 serine protease of hepatitis C virus 失效具有循环P4的新型酮酰胺作为丙型肝炎病毒NS3丝氨酸蛋白酶的抑制剂公开(公告)号：US20070093430A1
公开(公告)日：2007-04-26
申请号：US11602174
申请日：2006-11-20
申请人： Kevin Chen , F. Njoroge , Mousumi Sannigrahi , Latha Nair , Weiying Yang , Bancha Vibulbhan , Srikanth Venkatraman , Ashok Arasappan , Stephane Bogen , Frank Bennett , Viyyoor Girijavallabhan
发明人： Kevin Chen , F. Njoroge , Mousumi Sannigrahi , Latha Nair , Weiying Yang , Bancha Vibulbhan , Srikanth Venkatraman , Ashok Arasappan , Stephane Bogen , Frank Bennett , Viyyoor Girijavallabhan
IPC分类号： A61K38/04 , C07K5/06 , C07D417/02
CPC分类号： C07K5/0202 , A61K31/40 , A61K38/00 , C07K5/0205 , C12Q1/707
摘要： The present invention discloses novel compounds which have HCV protease inhibitory activity as well as methods for preparing such compounds. In another embodiment, the invention discloses pharmaceutical compositions comprising such compounds as well as methods of using them to treat disorders associated with the HCV protease.
摘要翻译： 本发明公开了具有HCV蛋白酶抑制活性的新型化合物及其制备方法。 在另一个实施方案中，本发明公开了包含这些化合物的药物组合物以及使用它们来治疗与HCV蛋白酶相关的病症的方法。
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3.发明申请Novel ketoamides with cyclic P4'S as inhibitors of NS3 protease of hepatitis C virus 有权具有环状P4'S的新型酮酰胺作为丙型肝炎病毒NS3蛋白酶的抑制剂公开(公告)号：US20050222047A1
公开(公告)日：2005-10-06
申请号：US11065647
申请日：2005-02-24
申请人： Kevin Chen , F. Njoroge , Mousumi Sannigrahi , Latha Nair , Weiying Yang , Bancha Vibulbhan , Srikanth Venkatraman , Ashok Arasappan , Stephane Bogen , Frank Bennett , Viyyoor Girijavallabhan
发明人： Kevin Chen , F. Njoroge , Mousumi Sannigrahi , Latha Nair , Weiying Yang , Bancha Vibulbhan , Srikanth Venkatraman , Ashok Arasappan , Stephane Bogen , Frank Bennett , Viyyoor Girijavallabhan
IPC分类号： A61K31/40 , A61K38/00 , A61K38/04 , C07D209/52 , C07D401/12 , C07D417/02 , C07D417/12 , C07D513/04 , C07K5/02 , C07K5/04 , C07K5/08 , C12Q1/70 , C07D43/02 , C07D49/02
CPC分类号： C07K5/0202 , A61K31/40 , A61K38/00 , C07K5/0205 , C12Q1/707
摘要： The present invention discloses novel compounds which have HCV protease inhibitory activity as well as methods for preparing such compounds. In another embodiment, the invention discloses pharmaceutical compositions comprising such compounds as well as methods of using them to treat disorders associated with the HCV protease.
摘要翻译： 本发明公开了具有HCV蛋白酶抑制活性的新型化合物及其制备方法。 在另一个实施方案中，本发明公开了包含这些化合物的药物组合物以及使用它们来治疗与HCV蛋白酶相关的病症的方法。
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4.发明授权Ketoamides with cyclic P4's as inhibitors of NS3 serine protease of hepatitis C virus 失效具有环状P4的酮酰胺作为丙型肝炎病毒的NS3丝氨酸蛋白酶的抑制剂公开(公告)号：US07619094B2
公开(公告)日：2009-11-17
申请号：US11602174
申请日：2006-11-20
申请人： Kevin X Chen , F George Njoroge , Mousumi Sannigrahi , Latha G Nair , Weiying Yang , Bancha Vibulbhan , Srikanth Venkatraman , Ashok Arasappan , Stephane L. Bogen , Frank Bennett , Viyyoor M. Girijavallabhan
发明人： Kevin X Chen , F George Njoroge , Mousumi Sannigrahi , Latha G Nair , Weiying Yang , Bancha Vibulbhan , Srikanth Venkatraman , Ashok Arasappan , Stephane L. Bogen , Frank Bennett , Viyyoor M. Girijavallabhan
IPC分类号： C07D209/02 , C07D403/12 , A61K31/403
CPC分类号： C07K5/0202 , A61K31/40 , A61K38/00 , C07K5/0205 , C12Q1/707
摘要： The present invention discloses novel compounds which have HCV protease inhibitory activity as well as methods for preparing such compounds. In another embodiment, the invention discloses pharmaceutical compositions comprising such compounds as well as methods of using them to treat disorders associated with the HCV protease.
摘要翻译： 本发明公开了具有HCV蛋白酶抑制活性的新型化合物及其制备方法。 在另一个实施方案中，本发明公开了包含这些化合物的药物组合物以及使用它们来治疗与HCV蛋白酶相关的病症的方法。
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5.发明授权Ketoamides with cyclic P4'S as inhibitors of NS3 protease of hepatitis C virus 有权具有环状P4'S的酮酰胺作为丙型肝炎病毒NS3蛋白酶的抑制剂公开(公告)号：US07173057B2
公开(公告)日：2007-02-06
申请号：US11065647
申请日：2005-02-24
申请人： Kevin X. Chen , F. George Njoroge , Mousumi Sannigrahi , Latha G. Nair , Weiying Yang , Bancha Vibulbhan , Srikanth Venkatraman , Ashok Arasappan , Stephane L. Bogen , Frank Bennett , Viyyoor M. Girijavallabhan
发明人： Kevin X. Chen , F. George Njoroge , Mousumi Sannigrahi , Latha G. Nair , Weiying Yang , Bancha Vibulbhan , Srikanth Venkatraman , Ashok Arasappan , Stephane L. Bogen , Frank Bennett , Viyyoor M. Girijavallabhan
IPC分类号： A61K31/4035 , A61K31/403 , A61K31/407 , A61K31/454 , A61K31/5355 , A61K31/4725 , A61K31/4166 , C07D209/48 , C07D209/52 , C07D209/02 , C07D471/02 , C07D401/12 , C07D413/12 , C07D217/24 , C07D233/02 , C07D233/74
CPC分类号： C07K5/0202 , A61K31/40 , A61K38/00 , C07K5/0205 , C12Q1/707
摘要： The present invention discloses novel compounds which have HCV protease inhibitory activity as well as methods for preparing such compounds. In another embodiment, the invention discloses pharmaceutical compositions comprising such compounds as well as methods of using them to treat disorders associated with the HCV protease.
摘要翻译： 本发明公开了具有HCV蛋白酶抑制活性的新型化合物及其制备方法。 在另一个实施方案中，本发明公开了包含这些化合物的药物组合物以及使用它们来治疗与HCV蛋白酶相关的病症的方法。
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6.发明授权公开(公告)号：US07449447B2
公开(公告)日：2008-11-11
申请号：US10925329
申请日：2004-08-24
申请人： Kevin X. Chen , F. George Njoroge , Weiying Yang , Bancha Vibulbhan , Viyyoor M. Girijavallabhan , Srikanth Venkatraman , Francisco Velazquez
发明人： Kevin X. Chen , F. George Njoroge , Weiying Yang , Bancha Vibulbhan , Viyyoor M. Girijavallabhan , Srikanth Venkatraman , Francisco Velazquez
IPC分类号： A61K38/06 , C07K5/08 , C07D209/02
CPC分类号： C07K5/0202 , A61K31/40 , A61K38/00 , C07K5/021 , C07K5/0827 , C07K7/06
摘要： The present application discloses a compound, or enantiomers, stereoisomers, rotamers, tautomers, racemates or prodrug of said compound, or pharmaceutically acceptable salts or solvates of said compound, or of said prodrug, said compound having the general structure shown in Formula 1: useful in the treatment or prevention or amelioration of one or more symptoms of hepatitis C.
摘要翻译： 本申请公开了所述化合物或所述前药的药学上可接受的盐或溶剂化物的化合物或其对映异构体，立体异构体，旋转异构体，互变异构体，前体药物，所述化合物具有式1所示的一般结构：有用的 治疗或预防或改善一种或多种丙型肝炎症状。
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7.发明申请Novel peptidomimetic NS3-serine protease inhibitors of hepatitis C virus 失效丙型肝炎病毒的新型拟肽NS3-丝氨酸蛋白酶抑制剂公开(公告)号：US20050085425A1
公开(公告)日：2005-04-21
申请号：US10925329
申请日：2004-08-24
申请人： Kevin Chen , F. Njoroge , Weiying Yang , Bancha Vibulbhan , Viyyoor Girijavallabhan , Srikanth Venkatraman , Francisco Velazquez
发明人： Kevin Chen , F. Njoroge , Weiying Yang , Bancha Vibulbhan , Viyyoor Girijavallabhan , Srikanth Venkatraman , Francisco Velazquez
IPC分类号： A61K31/40 , A61K31/519 , A61K38/00 , A61K38/04 , A61K38/06 , C07K5/02 , C07K5/04 , C07K5/08 , C07K7/06
CPC分类号： C07K5/0202 , A61K31/40 , A61K38/00 , C07K5/021 , C07K5/0827 , C07K7/06
摘要： The present application discloses a compound, or enantiomers, stereoisomers, rotamers, tautomers, racemates or prodrug of said compound, or pharmaceutically acceptable salts or solvates of said compound, or of said prodrug, said compound having the general structure shown in Formula 1: useful in the treatment or prevention or amelioration of one or more symptoms of hepatitis C.
摘要翻译： 本申请公开了所述化合物或所述前药的药学上可接受的盐或溶剂化物的化合物或其对映异构体，立体异构体，旋转异构体，互变异构体，前体药物，所述化合物具有式1所示的一般结构：有用的 治疗或预防或改善一种或多种丙型肝炎症状。
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公开(公告)号：US20110033417A1
公开(公告)日：2011-02-10
申请号：US12675897
申请日：2008-08-27
申请人： Gopinadhan N. Anilkumar , Frank Bennett , Tin-Yau Chan , Kevin X. Chen , Mousumi Sannigrahi , Francisco Velazquez , Srikanth Venkatraman , Qingbei Zeng , Jose S. Duca , Charles A. Lesburg , Joseph A. Kozlowski , F. George Njoroge , Stuart B. Rosenblum , Neng-Yang Shih , Stephen J. Gavalas , Yueheng Jiang , Patrick A. Pinto , Haiyan Pu , Oleg B. Selyutin , Bancha Vibulbhan , Li Wang , Wanli Wu , Weiying Yang , Yuhua Huang , Hsueh-Cheng Huang , Robert Palermo , Boris Feld
发明人： Gopinadhan N. Anilkumar , Frank Bennett , Tin-Yau Chan , Kevin X. Chen , Mousumi Sannigrahi , Francisco Velazquez , Srikanth Venkatraman , Qingbei Zeng , Jose S. Duca , Charles A. Lesburg , Joseph A. Kozlowski , F. George Njoroge , Stuart B. Rosenblum , Neng-Yang Shih , Stephen J. Gavalas , Yueheng Jiang , Patrick A. Pinto , Haiyan Pu , Oleg B. Selyutin , Bancha Vibulbhan , Li Wang , Wanli Wu , Weiying Yang , Yuhua Huang , Hsueh-Cheng Huang , Robert Palermo , Boris Feld
IPC分类号： A61K38/21 , C07D401/04 , C07D413/14 , C07D209/42 , C07D401/14 , C07D417/14 , C07D407/14 , C07D409/14 , A61K31/4439 , A61K31/444 , A61K31/404 , A61K31/4545 , A61K31/513 , A61K31/443 , A61K31/4709 , A61K31/4436 , A61K31/5377 , A61K31/538 , A61K31/5415 , A61K31/7088 , A61K31/7052 , A61K39/12 , A61K39/42 , A61P31/12 , A61P31/14
CPC分类号： C07D417/14 , C07D209/42 , C07D401/04 , C07D401/14 , C07D403/04 , C07D405/14 , C07D409/14 , C07D413/14
摘要： The present invention relates to 2,3-Substituted Indole Derivatives, compositions comprising at least one 2,3-Substituted Indole Derivative, and methods of using the 2,3-Substituted Indole Derivatives for treating or preventing a viral infection or a virus-related disorder in a patient.
摘要翻译： 本发明涉及2,3-取代的吲哚衍生物，包含至少一种2,3-取代的吲哚衍生物的组合物和使用2,3-取代的吲哚衍生物用于治疗或预防病毒感染或病毒相关的方法 病人无序。
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公开(公告)号：US5358920A
公开(公告)日：1994-10-25
申请号：US155400
申请日：1993-11-19
申请人： Yongfu Ma , Peicheng Wu , Yong Sun , Sangjian Zhu , Yuexin Huang , Weiying Yang , Kaiwen Yao , Youreng Zou
发明人： Yongfu Ma , Peicheng Wu , Yong Sun , Sangjian Zhu , Yuexin Huang , Weiying Yang , Kaiwen Yao , Youreng Zou
CPC分类号： C07C5/325 , B01J23/626 , B01J35/0026 , B01J35/1076 , B01J35/109 , C07C5/3337 , B01J21/04
摘要： A dehydrogenating catalyst for saturated hydrocarbons comprising platinum, tin, sodium and .tau.-alumina. The support of the catalyst is a large pore diameter .tau.-Al.sub.2 O.sub.3 with dual pore diameter distribution. At least 40% of the total pore volume is contributed by pores with pore diameter in the range of 1000-10000 .ANG.. Platinum, tin, and sodium are impregnated onto support by co-impregnation method, followed by drying, calcinating, and steam-treating, as well as reducing by hydrogen, to prepare a long life dehydrogenating catalyst.
摘要翻译： 一种用于饱和烃的脱氢催化剂，包括铂，锡，钠和氧化钛。 催化剂的载体是具有双孔径分布的大孔径tau-Al2O3。 总细孔容积的至少40％由孔径在1000-10000安培范围内的孔隙贡献。 铂，锡和钠通过共浸渍方法浸渍在载体上，然后进行干燥，煅烧和蒸汽处理，以及通过氢还原，制备长寿命脱氢催化剂。
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