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公开(公告)号：US20210353445A1
公开(公告)日：2021-11-18
申请号：US17335271
申请日：2021-06-01
发明人： Blayne A. Roeder , Andres Schanzer
摘要： A pre-loaded stent graft delivery device and stent graft, the stent graft delivery device. The stent graft has at least one fenestration or side arm and the fenestration is preloaded with an indwelling guide wire. Indwelling access sheaths are provided within auxiliary lumens of a pusher catheter and dilators are preloaded into the access sheaths along with the indwelling guide wire. The auxiliary lumens have an oblong cross-section. A handle assembly at a distal end of the guide wire catheter. The handle includes a multiport manifold with access ports to the auxiliary lumens in the pusher catheter. Upon deployment of the stent graft, the indwelling guide wire can be used to facilitate catheterization of a side branch or target vessel through the fenestration or be used to stabilize the access sheath during catheterization, advancement of the access sheath into the target vessel and deployment of a stent therein.
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公开(公告)号：US20210079068A1
公开(公告)日：2021-03-18
申请号：US17024424
申请日：2020-09-17
摘要： Disclosed are compositions, vectors, and methods for treating and preventing rabies lyssavirus infection in a subject in need thereof, including rabies lyssavirus encephalitis. The disclosed compositions relate to anti-rabies immunoglobulins and vectors for expressing anti-rabies immunoglobulins such as adeno-associated virus (AAV) vectors that express anti-rabies immunoglobulins in a subject in need thereof. In some embodiments, the disclosed methods relate to treating and/or preventing an infection by rabies lyssavirus in a subject in need thereof, the methods comprising administering to the subject a dose of an adeno-associated virus (AAV) vector that expresses an immunoglobulin that binds and neutralizes rabies lyssavirus in the subject.
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公开(公告)号：US20190099505A1
公开(公告)日：2019-04-04
申请号：US16212346
申请日：2018-12-06
摘要： The invention provides novel biocompatible upconversion nanoparticle (UCNP) that comprises a core of cubic nanocrystals (e.g., comprising α-Na Lna, Lnb Lnc F4) and an epitaxial shell (e.g., formed from CaF2; wherein Lnb is Yb), and related methods of preparation and uses thereof.
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公开(公告)号：US20180192961A1
公开(公告)日：2018-07-12
申请号：US15715113
申请日：2017-09-25
发明人： David Paydarfar , Joshua Chang
CPC分类号： A61B5/7235 , A61B5/04001 , A61B5/4094 , A61B5/7203 , A61M2021/0055
摘要： A system is described that observes a signal from a subject of interest, converts the signal to an electrical representation, uses the electrical representation to compute a synthetic control signal, and applies the synthetic control signal to control some aspect of operation of the subject. The procedure used to generate the synthetic control signal involves subjecting the electrical representation of the observed signal to random noise, allowing the extrema of the electrical representation to move, and obtaining a converged solution as the synthetic control signal.
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公开(公告)号：US09333271B2
公开(公告)日：2016-05-10
申请号：US13902298
申请日：2013-05-24
CPC分类号： A61K49/0019 , A61K41/008 , A61K49/0052 , A61K49/0065 , A61K49/0067 , A61K49/0093 , B82Y5/00 , C01F17/0031 , C01P2002/72 , C01P2002/84 , C01P2004/02 , C01P2004/04 , C01P2004/64 , C09K11/025 , C09K11/7773
摘要： The invention provides novel biocompatible upconversion nanoparticle (UCNP) that comprises a core of cubic nanocrystals (e.g., comprising α-Na Lna, Lnb Lnc F4) and an epitaxial shell (e.g., formed from CaF2; wherein Lnb is Yb), and related methods of preparation and uses thereof.
摘要翻译： 本发明提供了新颖的生物相容性上转换纳米颗粒（UCNP），其包含立方晶体的核心（例如，包括α-Na Lna，Lnb Lnc F4）和外延壳（例如，由CaF 2形成;其中Lnb是Yb），以及相关方法 的制备和用途。
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公开(公告)号：US20150174200A1
公开(公告)日：2015-06-25
申请号：US14511667
申请日：2014-10-10
发明人： JACK L. LEONARD
IPC分类号： A61K38/17
CPC分类号： C07K14/4703 , A01K67/0276 , A01K2217/075 , A01K2217/15 , A01K2217/203 , A01K2227/105 , A01K2267/0331 , A01K2267/0393 , A61K35/76 , A61K38/00 , A61K38/1709 , C07K14/00 , C07K14/82 , C07K2319/10 , C07K2319/21 , C12N2740/15043
摘要： The invention relates to novel therapeutic approaches to cancer treatment that exploits tumor suppressor functions of DKK3b by site-specific delivery of DKK3b. Novel therapeutics and methods for treating tumors and cancers utilizing DKK3b tumor suppressor functions are disclosed.
摘要翻译： 本发明涉及通过DKK3b的位点特异性递送来利用DKK3b的肿瘤抑制功能的癌症治疗的新型治疗方法。 公开了利用DKK3b肿瘤抑制功能治疗肿瘤和癌症的新型疗法和方法。
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公开(公告)号：US20150125388A1
公开(公告)日：2015-05-07
申请号：US14400757
申请日：2013-05-27
发明人： Brian D. Gray , Mary Rusckowski , Koon Y. Pak
IPC分类号： A61K51/04 , G01N33/58 , C07D209/20 , C07B59/00 , C07D403/14 , G01N33/50
CPC分类号： A61K51/0485 , A61K49/0032 , A61K51/0446 , A61K51/0478 , A61K51/0482 , C07B59/002 , C07D209/14 , C07D209/20 , C07D403/14 , G01N33/5005 , G01N33/52 , G01N33/56966 , G01N33/582
摘要： The invention relates to novel multi-modality probes for imaging, tracking and analyzing stem cells and related biological samples, and methods of preparation and use thereof. The molecular probes of the invention are constructed, for example, by utilizing (a) the high selectivity of long hydrocarbon chains for binding to plasma membranes of cells, (b) a near-infrared (NIR) dye for optical imaging, and (c) a radionuclide for PET or SPECT imaging. The in vitro and in vivo data of the optical and radiolabeled probes demonstrated their utility for detecting the presence of stem cells with multiple imaging modalities.
摘要翻译： 本发明涉及用于成像，跟踪和分析干细胞和相关生物样品的新型多模态探针及其制备和使用方法。 本发明的分子探针例如通过利用（a）长烃链的高选择性结合细胞质膜，（b）用于光学成像的近红外（NIR）染料和（c ）用于PET或SPECT成像的放射性核素。 光学和放射性标记的探针的体外和体内数据证明了它们用于以多种成像方式检测干细胞的存在。
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8.发明申请THERMAL-RESPONSIVE POLYMER NETWORKS, COMPOSITIONS, AND METHODS AND APPLICATIONS RELATED THERETO 审中-公开热响应聚合物网络，组合物及其相关方法和应用公开(公告)号：US20140357806A1
公开(公告)日：2014-12-04
申请号：US14058336
申请日：2013-10-21
发明人： Jie Song , Jianwen Xu
IPC分类号： C08G63/91
CPC分类号： C08G63/912 , A61F2002/30242 , A61F2002/444 , A61F2230/0071 , C08G63/08 , C08G83/002 , C08G2280/00
摘要： The invention relates to materials comprising polymer network containing siloxanes or organic-based core structures, preferably the materials have thermal-responsive properties. In some embodiments, the invention relates to an organic core functionalized with polymers. In another embodiment, organic core-polymer conjugates comprise polylactone segments. The organic core-polymer conjugates may be crosslinked together to form a material, and these materials may be functionalized with bioactive compounds so that the materials have desirable biocompatibility or bioactivity when used in medical devices.
摘要翻译： 本发明涉及包含含有硅氧烷或有机基核心结构的聚合物网络的材料，优选该材料具有热响应特性。 在一些实施方案中，本发明涉及用聚合物官能化的有机核。 在另一个实施方案中，有机核 - 聚合物缀合物包含聚内酯片段。 有机核 - 聚合物共轭物可以一起交联以形成材料，并且这些材料可以用生物活性化合物官能化，使得当用于医疗装置时，这些材料具有期望的生物相容性或生物活性。
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公开(公告)号：US20140316246A1
公开(公告)日：2014-10-23
申请号：US14258912
申请日：2014-04-22
CPC分类号： A61B5/0263 , A61B5/055 , G01R33/5605 , G01R33/5635
摘要： The invention provides a novel approach for effective ex vivo and in vivo imaging of blood and establishes the feasibility of blood as an effective agent for CEST to generate sufficient CEST contrast relative to surrounding tissue.
摘要翻译： 本发明提供了一种用于血液有效离体和体内成像的新方法，并且确定了血液作为CEST的有效试剂以相对于周围组织产生足够的CEST对比度的可行性。
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公开(公告)号：US10506983B2
公开(公告)日：2019-12-17
申请号：US15715113
申请日：2017-09-25
发明人： David Paydarfar , Joshua Chang
摘要： A system is described that observes a signal from a subject of interest, converts the signal to an electrical representation, uses the electrical representation to compute a synthetic control signal, and applies the synthetic control signal to control some aspect of operation of the subject. The procedure used to generate the synthetic control signal involves subjecting the electrical representation of the observed signal to random noise, allowing the extrema of the electrical representation to move, and obtaining a converged solution as the synthetic control signal.
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