公开(公告)号：US20050154190A1

公开(公告)日：2005-07-14

申请号：US10499172

申请日：2002-12-13

Applicant: Masaaki Mori ,  Tomoko Chikatsu ,  Shuji Sato ,  Toshimi Nagi ,  Tsukasa Sugo

Inventor： Masaaki Mori ,  Tomoko Chikatsu ,  Shuji Sato ,  Toshimi Nagi ,  Tsukasa Sugo

IPC: A61K31/00 ,  A61P25/00 ,  A61P29/00 ,  A61P37/00 ,  A61P43/00 ,  C07K14/705 ,  C12N1/15 ,  C12N1/19 ,  C12N1/21 ,  C12N15/12 ,  G01N33/53 ,  A01K67/00 ,  C07F9/10 ,  C07H21/04 ,  G01N33/567

CPC classification number: C07K14/705 ,  A61K31/00 ,  G01N2500/02 ,  Y10S435/975

Abstract: The present invention relates to a screening method/screening kit for screening a compound or its salt that changes the binding properties of (a) a protein containing the same or substantially the same amino acid sequence as the amino acid sequence represented by SEQ ID NO: 1 or SEQ ID NO: 19, its partial peptides, or salts thereof, and (b) a ligand capable of binding specifically to the protein; compounds obtained by the screening or salts thereof; pharmaceuticals comprising the compounds or salts thereof; a protein containing the same or substantially the same amino acid sequence as the amino acid sequence represented by SEQ ID NO: 19; etc. The compounds obtained by the screening of the present invention are useful as agents for the prevention/treatment of, for example, neurodegenerative diseases, immunological diseases, edema, acid indigestion, etc.

Abstract translation: 本发明涉及一种用于筛选化合物或其盐的筛选方法/筛选试剂盒，其改变（a）含有与SEQ ID NO：1所示的氨基酸序列相同或基本相同的氨基酸序列的蛋白质的结合特性。 1或SEQ ID NO：19，其部分肽或其盐，和（b）能够特异性结合蛋白质的配体; 通过筛选获得的化合物或其盐; 包含其化合物或其盐的药物; 含有与SEQ ID NO：19所示的氨基酸序列相同或基本相同的氨基酸序列的蛋白质; 通过本发明的筛选获得的化合物可用作预防/治疗例如神经变性疾病，免疫疾病，水肿，酸消化不良等的试剂。

公开(公告)号：US07202040B2

公开(公告)日：2007-04-10

申请号：US10499172

申请日：2002-12-13

Applicant: Masaaki Mori ,  Tomoko Chikatsu ,  Shuji Sato ,  Toshimi Nagi ,  Tsukasa Sugo

Inventor： Masaaki Mori ,  Tomoko Chikatsu ,  Shuji Sato ,  Toshimi Nagi ,  Tsukasa Sugo

IPC: G01N33/53 ,  G01N33/00 ,  C12Q1/68 ,  C12N15/00 ,  A61K38/02 ,  A61K38/16

CPC classification number: C07K14/705 ,  A61K31/00 ,  G01N2500/02 ,  Y10S435/975

Abstract: The present invention relates to a screening method/screening kit for screening a compound or its salt that changes the binding properties of (a) a protein containing the same or substantially the same amino acid sequence as the amino acid sequence represented by SEQ ID NO: 1 or SEQ ID NO: 19, its partial peptides, or salts thereof, and (b) a ligand capable of binding specifically to the protein; compounds obtained by the screening or salts thereof; pharmaceuticals comprising the compounds or salts thereof; a protein containing the same or substantially the same amino acid sequence as the amino acid sequence represented by SEQ ID NO: 19; etc. The compounds obtained by the screening of the present invention are useful as agents for the prevention/treatment of, for example, neurodegenerative diseases, immunological diseases, edema, acid indigestion, etc.

Abstract translation: 本发明涉及一种用于筛选化合物或其盐的筛选方法/筛选试剂盒，其改变（a）含有与SEQ ID NO：1所示的氨基酸序列相同或基本相同的氨基酸序列的蛋白质的结合特性。 1或SEQ ID NO：19，其部分肽或其盐，和（b）能够特异性结合蛋白质的配体; 通过筛选获得的化合物或其盐; 包含其化合物或其盐的药物; 含有与SEQ ID NO：19所示的氨基酸序列相同或基本相同的氨基酸序列的蛋白质; 通过本发明的筛选获得的化合物可用作预防/治疗例如神经变性疾病，免疫疾病，水肿，酸消化不良等的试剂。