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1.发明授权Cytotoxic factor as is associated with multiple sclerosis, its detection and its quantification 失效与多发性硬化相关的细胞毒性因子，其检测及其定量
公开(公告)号：US5876954A
公开(公告)日：1999-03-02
申请号：US389164
申请日：1995-02-15
IPC分类号： G01N33/53 , A61K38/00 , C07K1/18 , C07K14/47 , C12Q1/02 , G01N33/50 , G01N33/566 , C12Q1/37 , C12Q1/00 , C12Q1/34
CPC分类号： C07K14/4713 , G01N33/5091 , A61K38/00 , Y10S424/16 , Y10S435/964 , Y10S436/827 , Y10S436/828
摘要： Gliotoxic factor in the isolated or purified state, characterized in that it possesses toxic activity with respect to human or animal astrocytic cells, having the effect of a cytomorphological disorganization of their network of intermediate filaments and/or a degradation of the proteins of said intermediate filaments and/or cell death, in particular by apoptosis.
摘要翻译： 分离或纯化状态下的胶质毒性因子，其特征在于其对人或动物星形细胞细胞具有毒性活性，具有其中间丝的网络的细胞形态学紊乱和/或所述中间丝的蛋白质降解的作用 和/或细胞死亡，特别是凋亡。
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2.发明授权
公开(公告)号：US5728540A
公开(公告)日：1998-03-17
申请号：US468670
申请日：1995-06-06
IPC分类号： G01N33/53 , A61K38/00 , C07K1/18 , C07K14/47 , C12Q1/02 , G01N33/50 , G01N33/566 , C12Q1/37 , C12N5/00 , C12Q1/04 , G01N33/567
CPC分类号： C07K14/4713 , G01N33/5091 , A61K38/00 , Y10S424/16 , Y10S435/964 , Y10S436/827 , Y10S436/828
摘要： Gliotoxic factor in the isolated or purified state, characterized in that it possesses toxic activity with respect to human or animal astrocytic cells, having the effect of a cytomorphological disorganization of their network of intermediate filaments and/or a degradation of the proteins of said intermediate filaments and/or cell death, in particular by apoptosis.
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