公开(公告)号：US06321164B1

公开(公告)日：2001-11-20

申请号：US09001647

申请日：1997-12-31

申请人： Paul Braun ,  Thomas B. Givens ,  Timothy J. Fischer

发明人： Paul Braun ,  Thomas B. Givens ,  Timothy J. Fischer

IPC分类号： G01N2100

CPC分类号： G01N33/86 ,  G01N33/4905 ,  G01N2800/226 ,  G01N2800/385 ,  G06F19/00 ,  G16H50/20

摘要： A method is disclosed for predicting the presence of an abnormal level of one or more proteins in the clotting cascade from at least one time-dependent measurement profile. At least one time-dependent measurement on an unknown sample is performed and a respective property of said sample is measured over time so as to derive a time-dependent measurement profile. A set of a plurality of predictor variables are defined which sufficiently define the data of the time-dependent measurement profile. A model is then derived that represents the relationship between the abnormality and the set of predictor variables. Subsequently, the model is utilized to predict which protein or proteins in the clotting cascade are at an abnormal level, with the prediction being a more informative prediction than clot time alone.

摘要翻译： 公开了一种用于从至少一个时间依赖的测量轮廓预测凝血级联中的一种或多种蛋白质的异常水平的存在的方法。 对未知样品进行至少一次时间依赖性测量，并随时间测量所述样品的相应性质，以便导出时间依赖性测量分布。 定义了一组多个预测变量，其充分地定义了时间依赖性测量轮廓的数据。 然后导出代表异常和预测变量集之间的关系的模型。 随后，该模型用于预测凝血级联中的哪些蛋白质或蛋白质处于异常水平，预测比单独凝血时间更有信息。

公开(公告)号：US6101449A

公开(公告)日：2000-08-08

申请号：US859773

申请日：1997-05-21

申请人： Thomas B. Givens ,  Paul Braun ,  Timothy J. Fischer

发明人： Thomas B. Givens ,  Paul Braun ,  Timothy J. Fischer

IPC分类号： G01N33/48 ,  C07K16/18 ,  G01N33/49 ,  G01N33/50 ,  G01N33/86 ,  G01N35/00 ,  G06F15/18 ,  G06F19/00 ,  G06N3/00 ,  G06Q50/00 ,  G01N21/00

CPC分类号： G01N33/4905 ,  C07K16/18 ,  G01N33/86 ,  G01N35/00 ,  G06F19/3437 ,  G06F19/366 ,  G01N2800/226 ,  G01N2800/385 ,  G06F19/322 ,  G06F19/345

摘要： A method and apparatus are disclosed for predicting the presence of at least one congenital or acquired imbalances or therapeutic condition associated with thrombosis/hemostasis from at least one time-dependent measurement profile. At least one time-dependent measurement in a sample is performed and a respective property of sample is measured over time so as to derive a time-dependent measurement profile. A set of a plurality of predictor variables are defined which sufficiently define the data of the time-dependent measurement profile. A model is then derived that represents the relationship between the congenital or acquired imbalance or therapeutic condition, and the set of predictor variables. Subsequently, the model is utilized to predict the existence of the congenital or acquired imbalance or therapeutic condition in a sample.

摘要翻译： 公开了一种用于从至少一个时间依赖的测量轮廓预测与血栓形成/止血有关的至少一种先天性或获得性不平衡或治疗条件的存在的方法和装置。 在样品中进行至少一次时间依赖性测量，并随时间测量样品的相应性质，从而导出时间依赖性测量曲线。 定义了一组多个预测变量，其充分地定义了时间依赖性测量轮廓的数据。 然后导出代表先天性或获得性不平衡或治疗条件之间的关系的模型以及预测变量的集合。 随后，该模型用于预测样品中先天性或获得性不平衡或治疗条件的存在。

公开(公告)号：US5364592A

公开(公告)日：1994-11-15

申请号：US916712

申请日：1992-07-22

申请人： Gregory D. Lewis ,  Roger G. Roberts ,  Thomas B. Givens

发明人： Gregory D. Lewis ,  Roger G. Roberts ,  Thomas B. Givens

IPC分类号： G01N1/00 ,  B01L9/00 ,  B01L9/06 ,  G01N1/28 ,  G01N21/13 ,  G01N35/04 ,  B65H1/08

CPC分类号： B01L9/00 ,  B01L9/06 ,  G01N2035/0465 ,  G01N21/13 ,  Y10T436/113332 ,  Y10T436/114165

摘要： A cassette for storing and dispensing cuvettes and comprising an enclosable frame defining an interior volume for storing cuvettes. The frame includes a removable cover to aid in loading a plurality of cuvettes into the cassette. The frame also includes a side wall having a pivotally mounted door for pivoting between a closed position and an open position for dispensing the cuvettes from the cassette. And, the frame includes a locking mechanism for locking the door in the closed position to avoid an inadvertent dispensing of cuvettes. According to another aspect of the invention, a mechanism is provided for loading the cassette into an operative relationship with a machine for dispensing contents of the cassette for use by the machine. The loading mechanism includes a base adapted for being fixedly mounted on the machine. The loading mechanism also includes a holder for releasably holding the cassette. The holder has one end pivotally connected to the base for pivoting about an axis for moving the cassette between a first position at which the holder releasably receives the cassette and a second position at which the cassette is placed in an operative relationship with the machine. The loading mechanism further includes a linkage mechanism coupled between the base and the holder for translating the holder along the axis as the holder is pivoted between the first and second positions.

摘要翻译： 一种用于存储和分配比色皿的盒，包括限定用于存储比色皿的内部容积的封闭框架。 框架包括可移除的盖子，以帮助将多个比色杯装载到盒中。 框架还包括具有枢转安装的门的侧壁，用于在关闭位置和用于从盒中分配比色杯的打开位置之间枢转。 并且，该框架包括用于将门锁定在关闭位置中的锁定机构，以避免无意中分配比色皿。 根据本发明的另一方面，提供了一种用于将盒装载到与机器进行操作关系的机构，用于分配用于机器的盒的内容物。 装载机构包括适于固定地安装在机器上的基座。 装载机构还包括用于可释放地保持盒的保持器。 保持器具有一端可枢转地连接到基座，用于围绕一轴线枢转，用于在保持器可释放地容纳盒的第一位置和与该机器处于可操作关系的第二位置之间移动盒。 装载机构还包括联接机构，其联接在基座和保持器之间，用于当保持器在第一和第二位置之间枢转时沿着轴线平移托架。

公开(公告)号：USD325090S

公开(公告)日：1992-03-31

申请号：US443784

申请日：1989-11-30

申请人： Joseph G. Karp ,  Thomas B. Givens ,  John Link

设计人： Joseph G. Karp ,  Thomas B. Givens ,  John Link

公开(公告)号：US5040894A

公开(公告)日：1991-08-20

申请号：US443956

申请日：1989-12-01

申请人： Joseph G. Karp ,  Thomas B. Givens ,  John G. Link

发明人： Joseph G. Karp ,  Thomas B. Givens ,  John G. Link

IPC分类号： G01N21/03 ,  G01N21/13 ,  G01N35/02 ,  G01N35/04

CPC分类号： G01N21/03 ,  G01N35/04 ,  G01N2035/0413 ,  G01N2035/0487 ,  G01N35/026

摘要： A cuvette for use in an optical instrument which includes a linear drive mechanism formed of a lead screw for positioning the cuvette along a linear path in the instrument. The cuvette has a body including at least one reaction well and an engaging feature for operatively engaging the threads of the lead screw so that the cuvette can be positioned along the linear path of the instrument. Preferably the reaction well of the cuvette has a trapezoid-shape cross section in a plane parallel to the optical path of the instrument in order to maximize the optical viewing area.

摘要翻译： 一种用于光学仪器的比色皿，其包括由用于沿所述仪器中的线性路径定位所述比色杯的导螺杆形成的线性驱动机构。 试管具有包括至少一个反应井的主体和用于可操作地接合导螺杆的螺纹的接合特征，使得反应杯可以沿着仪器的线性路径定位。 优选地，比色皿的反应井在平行于仪器的光路的平面中具有梯形截面，以便最大化光学观察面积。

公开(公告)号：US4705035A

公开(公告)日：1987-11-10

申请号：US902766

申请日：1986-09-02

申请人： Thomas B. Givens

发明人： Thomas B. Givens

IPC分类号： A61B19/00 ,  A61F9/013 ,  A61F9/00

CPC分类号： A61F9/0136 ,  A61B2090/3937

摘要： A parallax-free optical zone marker for use in radial karatotomy cornea surgery for impressing a temporary circular indentation into the cornea, the circular indentation to be used as a reference for radial incisions therefrom. The marker, integrally molded, includes an elongated handle and a collar portion disposed at one end of the handle. The lower end margin of the collar is preferrably circular an adapted to impress the circular indentation into the cornea with normal hand pressure applied through the handle. A passageway extends through the collar from its upper end margin to its lower end margin. Disposed within the passageway are a pair of crossplanes intersecting, preferably at ninety degrees one to another, along the longitudinal axis of the passageway, which axis intersects the center of the circular lower end margin. These crossplanes extend along substantially the entire length of the passageway but not to the lower end margin of the collar so as to prevent contact of the crossplanes with the cornea. The intersection of the crossplanes provides the user with viewable alignment means for assisting in the accurate orientation of the circular indentation. These crossplanes preferably taper in thickness toward their intersection for enhanced accuracy in the placement of the circular indentation. The marker is molded preferably of plastic in a wide range of sizes and may also be molded of clear or translucent material to increase light availability to the cornea as the circular indentation is made.

摘要翻译： 用于径向卡拉切瘤角膜手术中的无视差光学区标记，用于将临时圆形凹陷压印到角膜中，该圆形凹槽用作其径向切口的参考。 整体模制的标记包括细长手柄和设置在手柄一端的套环部分。 衣领的下端边缘优选地是圆形的，适于通过手柄施加的普通手压施加圆形凹陷进入角膜。 通道从其上端边缘延伸穿过套环到其下端边缘。 在通道内设置一对交叉线，沿着通道的纵向轴线相交，最好相互相交90度，该轴线与圆形下端边缘的中心相交。 这些交叉平面沿通道的整个长度大致延伸，但不延伸到套环的下端边缘，以防止交叉面与角膜的接触。 交叉平面的交叉点为用户提供了可视对准装置，用于辅助圆形凹痕的精确取向。 这些交叉平面优选地朝着它们的交点逐渐变细，以提高圆形凹痕的放置精度。 该标记物优选地以大范围尺寸的塑料成型，并且还可以由透明或半透明的材料模制，以增加作为圆形凹痕的角膜的光可用性。

公开(公告)号：US06564153B2

公开(公告)日：2003-05-13

申请号：US09850255

申请日：2001-05-07

申请人： Paul Braun ,  Thomas B. Givens ,  Timothy J. Fischer

发明人： Paul Braun ,  Thomas B. Givens ,  Timothy J. Fischer

IPC分类号： G01N2100

CPC分类号： G01N33/86 ,  G01N33/4905 ,  G01N2800/226 ,  G01N2800/385 ,  G06F19/00 ,  G16H50/20

摘要： A method is disclosed for predicting the presence of an abnormal level of one or more proteins in the clotting cascade from at least one time-dependent measurement profile. At least one time-dependent measurement on an unknown sample is performed and a respective property of said sample is measured over time so as to derive a time-dependent measurement profile. A set of a plurality of predictor variables are defined which sufficiently define the data of the time-dependent measurement profile. A model is then derived that represents the relationship between the abnormality and the set of predictor variables. Subsequently, the model is utilized to predict which protein or proteins in the clotting cascade are at an abnormal level, with the prediction being a more informative prediction than clot time alone.

摘要翻译： 公开了一种用于从至少一个时间依赖的测量轮廓预测凝血级联中的一种或多种蛋白质的异常水平的存在的方法。 对未知样品进行至少一次时间依赖性测量，并随时间测量所述样品的相应性质，以便导出时间依赖性测量分布。 定义了一组多个预测变量，其充分地定义了时间依赖性测量轮廓的数据。 然后导出代表异常和预测变量集之间的关系的模型。 随后，该模型用于预测凝血级联中的哪些蛋白质或蛋白质处于异常水平，预测比单独凝血时间更有信息。

公开(公告)号：US5456884A

公开(公告)日：1995-10-10

申请号：US261129

申请日：1994-06-14

申请人： Gregory D. Lewis ,  Roger G. Roberts ,  Thomas B. Givens

发明人： Gregory D. Lewis ,  Roger G. Roberts ,  Thomas B. Givens

IPC分类号： G01N1/00 ,  B01L9/00 ,  B01L9/06 ,  G01N1/28 ,  G01N21/13 ,  G01N35/04

CPC分类号： B01L9/00 ,  B01L9/06 ,  G01N2035/0465 ,  G01N21/13 ,  Y10T436/113332 ,  Y10T436/114165

摘要： A mechanism is provided for loading the cassette into an operative relationship with a machine for dispensing contents of the cassette for use by the machine. The loading mechanism includes a base adapted for being fixedly mounted on the machine. The loading mechanism also includes a holder for releasably holding the cassette. The holder has one end pivotally connected to the base for pivoting about an axis for moving the cassette between a first position at which the holder releasably receives the cassette and a second position at which the cassette is placed in an operative relationship with the machine. The loading mechanism further includes a linkage mechanism coupled between the base and the holder for translating the holder along the axis as the holder is pivoted between the first and second positions.

摘要翻译： 提供了一种用于将盒装载到与用于分配盒子的内容物以供机器使用的机器的操作关系中的机构。 装载机构包括适于固定地安装在机器上的基座。 装载机构还包括用于可释放地保持盒的保持器。 保持器具有一端可枢转地连接到基座，用于围绕一轴线枢转，用于在保持器可释放地容纳盒的第一位置和与该机器处于可操作关系的第二位置之间移动盒。 装载机构还包括联接机构，其联接在基座和保持器之间，用于当保持器在第一和第二位置之间枢转时沿着轴线平移托架。

公开(公告)号：US06269313B1

公开(公告)日：2001-07-31

申请号：US09517496

申请日：2000-03-02

申请人： Thomas B. Givens ,  Paul Braun ,  Timothy J. Fischer

发明人： Thomas B. Givens ,  Paul Braun ,  Timothy J. Fischer

IPC分类号： G01N3349

CPC分类号： G01N33/4905 ,  C07K16/18 ,  G01N33/86 ,  G01N35/00 ,  G01N2800/226 ,  G01N2800/385 ,  G06F19/00 ,  G16H10/40 ,  G16H10/60 ,  G16H50/20 ,  G16H50/50

摘要： A method and apparatus are disclosed for predicting the presence of at least one congenital or acquired imbalance or therapeutic condition associated with thrombosis/hemostasis from at least one time-dependent measurement profile. At least one time-dependent measurement on an unknown sample is performed and a respective property of said sample is measured over time so as to derive a time-dependent measurement profile. A set of a plurality of predictor variables are defined which sufficiently define the data of the time-dependent measurement profile. A model is then derived that represents the relationship between the congenital or acquired imbalance or therapeutic condition, and the set of predictor variables. Subsequently, the model is utilized to predict the existence of the congenital or acquired imbalance or therapeutic condition in the unknown sample.

公开(公告)号：US5708591A

公开(公告)日：1998-01-13

申请号：US477839

申请日：1995-06-07

申请人： Thomas B. Givens ,  Paul Braun ,  Timothy J. Fischer

发明人： Thomas B. Givens ,  Paul Braun ,  Timothy J. Fischer

IPC分类号： G01N33/48 ,  C07K16/18 ,  G01N33/49 ,  G01N33/50 ,  G01N33/86 ,  G01N35/00 ,  G06F15/18 ,  G06F19/00 ,  G06N3/00 ,  G06Q50/00

CPC分类号： G01N33/4905 ,  C07K16/18 ,  G01N33/86 ,  G01N35/00 ,  G06F19/3437 ,  G06F19/366 ,  G01N2800/226 ,  G01N2800/385 ,  G06F19/322 ,  G06F19/345

摘要： A method and apparatus are disclosed for predicting the presence of at least one congenital or acquired imbalance or therapeutic condition associated with thrombosis/hemostasis from at least one time-dependent measurement profile. At least one time-dependent measurement on an unknown sample is performed and a respective property of said sample is measured over time so as to derive a time-dependent measurement profile. A set of a plurality of predictor variables are defined which sufficiently define the data of the time-dependent measurement profile. A model is then derived that represents the relationship between the congenital or acquired imbalance or therapeutic condition, and the set of predictor variables. Subsequently, the model is utilized to predict the existence of the congenital or acquired imbalance or therapeutic condition in the unknown sample.

摘要翻译： 公开了一种用于从至少一个时间依赖的测量轮廓预测与血栓形成/止血相关的至少一种先天性或获得性不平衡或治疗状况的存在的方法和装置。 对未知样品进行至少一次时间依赖性测量，并随时间测量所述样品的相应性质，以便导出时间依赖性测量分布。 定义了一组多个预测变量，其充分地定义了时间依赖性测量轮廓的数据。 然后导出代表先天性或获得性不平衡或治疗条件之间的关系的模型以及预测变量的集合。 随后，该模型用于预测未知样本中先天性或获得性不平衡或治疗条件的存在。