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    Treatment of stress-induced skin disease by corticotropin releasing hormone antagonists and skin mast cell degranulation inhibitors
    3.
    发明授权
    Treatment of stress-induced skin disease by corticotropin releasing hormone antagonists and skin mast cell degranulation inhibitors 失效
    通过促肾上腺皮质激素释放激素拮抗剂和皮肤肥大细胞脱颗粒抑制剂治疗应激诱导的皮肤病

    公开(公告)号：US6020305A

    公开(公告)日：2000-02-01

    申请号：US689277

    申请日：1996-08-06

    Applicant: Theoharis C. Theoharides

    Inventor： Theoharis C. Theoharides

    IPC: A61K38/22 ,  A61K37/00 ,  A61K31/35

    CPC classification number: A61K45/06 ,  A61K31/352 ,  A61K31/495 ,  A61K38/2228

    Abstract: A method of reducing or blocking a stress-related atopic skin disease such as exzema or uticaria in a subject comprising administering to the patient an agent that antagonizes CRH-induced activation of skin mast cells, the agent being used alone or together with a second agent that inhibits activation of skin mast cells. Such agents include compositions that reduce the production or secretion of CRH, neurotensin or somatostatin or an agent that inhibitos the physiological action of CRH, neurotensin or somostatin on skin mast cells. The effects of CRH on skin mast cells can also be inhibited by histamine-3 receptor antagonists and by inhibitors of the phosphorylation of skin mast cell moesin.

    Abstract translation: 一种在受试者中减少或阻断与应激相关的特应性皮肤疾病如风疹或uticaria的方法，包括向患者施用拮抗CRH诱导的皮肤肥大细胞活化的药剂，所述药剂单独使用或与第二药剂一起使用 其抑制皮肤肥大细胞的活化。 这些试剂包括减少CRH，神经丝氨酸或生长抑素的产生或分泌的组合物或抑制CRH，神经降压素或生长抑素在皮肤肥大细胞上的生理作用的试剂。 组织胺-3受体拮抗剂和皮肤肥大细胞moesin磷酸化抑制剂也可以抑制CRH对皮肤肥大细胞的作用。

    Method of treatment for interstitial cystitis
    4.
    发明授权
    Method of treatment for interstitial cystitis 失效
    间质性膀胱炎的治疗方法

    公开(公告)号：US5994357A

    公开(公告)日：1999-11-30

    申请号：US351883

    申请日：1994-12-08

    Applicant: Theoharis C. Theoharides

    Inventor： Theoharis C. Theoharides

    IPC: A61K31/495 ,  A61K31/445

    CPC classification number: A61K31/495

    Abstract: A method of treating patients suffering from interstitial cystitis comprising the administration to such patients of an inhibitor of neurohormonal activation of mast cell secretion selected from the group of histamine-1 receptor antagonists consisting of azatadine, azelastine, cetirizine, hydroxyzine and ketotifen, by oral, parenteral, transmucosal, and transdermal routes of administration.

    Abstract translation: 一种治疗患有间质性膀胱炎的患者的方法，其包括向所述患者施用选自由阿扎他定，氮卓斯汀，西替立嗪，羟嗪和酮替芬组成的组的组织胺-1受体拮抗剂的组合物，其通过口服， 肠胃外，经粘膜和经皮给药途径。

    Method for protecting humans against superficial vasodilator flush syndrome
    5.
    发明授权
    Method for protecting humans against superficial vasodilator flush syndrome 有权
    保护人类免受浅表血管扩张剂冲洗综合征的方法

    公开(公告)号：US07923043B2

    公开(公告)日：2011-04-12

    申请号：US12151268

    申请日：2008-05-06

    Applicant: Theoharis C. Theoharides

    Inventor： Theoharis C. Theoharides

    IPC: A61K36/00 ,  A61K36/63

    CPC classification number: A61K31/352 ,  A61K31/445 ,  A61K31/4545 ,  A61K31/517 ,  A61K31/5415 ,  A61K31/70 ,  A61K45/06 ,  A61K2300/00

    Abstract: Methods for protection of a human from SVFS comprise the administration of a flavonoid compound of the basic structures 2-phenyl-4H-1-benzopyran or 2-phenyl-4-keto-1-benzopyran or glycosides thereof, alone or, optionally, together with one or more of an olive kernel extract, a non-bovine sulfated proteoglycan, bitter willow extract, a D-hexosamine sulfate, S-adenosylmethionine, folic acid, vitamin B12 and a serotonin inhibitor. Such treatment prevents, reduces or eliminates SVFS in patients receiving as much as 300-3000 mg/day of niacin therapeutically, whether administered prior to, or along with, an anti-SVFS composition.

    Abstract translation: 从SVFS中保护人的方法包括单独或任选地一起施用2-苯基-4H-1-苯并吡喃或2-苯基-4-酮-1-苯并吡喃或其糖苷的基本结构的类黄酮化合物 与一种或多种橄榄核提取物，非牛硫酸化蛋白多糖，苦柳提取物，硫酸D-己糖胺，S-腺苷甲硫氨酸，叶酸，维生素B12和5-羟色胺抑制剂。 无论是在抗SVFS组合物之前还是与其一起施用，这种治疗可以预防，减少或消除接受多达300-3000mg /天烟酸的患者的SVFS。

    ANTI-INFLAMMATORY COMPOSITIONS FOR TREATING BRAIN INFLAMMATION
    6.
    发明申请
    ANTI-INFLAMMATORY COMPOSITIONS FOR TREATING BRAIN INFLAMMATION 有权
    用于治疗脑炎的抗炎组合物

    公开(公告)号：US20110044944A1

    公开(公告)日：2011-02-24

    申请号：US12861152

    申请日：2010-08-23

    Applicant: Theoharis C. THEOHARIDES

    Inventor： Theoharis C. THEOHARIDES

    IPC: A61K38/21 ,  A61P25/28 ,  A61K36/63 ,  A61K35/56

    CPC classification number: A61K31/225 ,  A61K31/522 ,  A61K31/685 ,  A61K31/7008 ,  A61K31/7048 ,  A61K31/737 ,  A61K36/63 ,  A61K36/76 ,  A61K2300/00

    Abstract: Compositions with synergistic anti-inflammatory effects in inflammatory diseases resulting from activation and consequent degranulation of mast cells and followed by secretion of inflammatory biochemicals from the activated mast cells, the compositions containing one or more of a flavone or flavonoid glycoside a heavily sulfated, non-bovine proteoglycan, an unrefined olive kernel extract that increases absorption of these compositions in various routes of administration, a hexosamine sulfate such as D-glucosamine sulfate, S-adenosylmethionine, a histamine-1 receptor antagonist, a histamine-3 receptor agonist, an antagonist of the actions of CRR, a long-chain unsaturated fatty acid, a phospholipid, Krill oil, a polyamine, glutiramer acetate and interferon. Certain of the present compositions are useful in protecting against the neuropathological components of multiple sclerosis and similar inflammatory neurological diseases.

    Abstract translation: 在由肥大细胞的活化和随后脱颗粒引起的炎性疾病中具有协同抗炎作用的组合物，随后从活化的肥大细胞中分泌炎症生物化学物质，所述组合物含有一种或多种黄酮或类黄酮糖苷， 牛蛋白多糖，一种在各种施用途径中增加这些组合物的吸收的未精制橄榄核提取物，硫酸己糖胺如硫酸D-葡糖胺，S-腺苷甲硫氨酸，组胺-1受体拮抗剂，组胺-3受体激动剂，拮抗剂 CRR，长链不饱和脂肪酸，磷脂，磷虾油，多胺，醋酸谷丙素和干扰素的作用。 本发明组合物中的某些可用于防止多发性硬化症和类似炎性神经疾病的神经病理学成分。

    Proteoglycan compositions for treatment of cardiovascular inflammatory diseases
    7.
    发明授权
    Proteoglycan compositions for treatment of cardiovascular inflammatory diseases 失效
    用于治疗心血管炎性疾病的蛋白多糖组合物

    公开(公告)号：US06624148B2

    公开(公告)日：2003-09-23

    申请号：US10329367

    申请日：2002-12-27

    Applicant: Theoharis C. Theoharides

    Inventor： Theoharis C. Theoharides

    IPC: A01N4304

    CPC classification number: A61K31/13 ,  A61K31/202 ,  A61K31/353 ,  A61K31/522 ,  A61K31/7008 ,  A61K31/7048 ,  A61K31/728 ,  A61K31/737 ,  A61K36/63 ,  A61K36/76 ,  A61K36/886 ,  A61K45/06 ,  Y10S514/825 ,  Y10S514/886 ,  Y10S514/887 ,  Y10S514/901 ,  A61K2300/00

    Abstract: Compositions with synergistic anti-inflammatory effects in inflammatory diseases resulting from activation and consequent degranulation of mast cells and followed by secretion of inflammatory biomolecules from the activated mast cells, composed of a heavily sulfated, non-bovine proteoglycan such as shark cartilage chondroitin sulfate C, and one or more of a hexosamine sulfate such as D-glucosamine sulfate, a flavone such as quercetin, an unrefined olive kernel extract that increases absorption of these compositions in various routes of administration, S-adenosylmethionine, a histamine-1 receptor antagonist, a histamine-3 receptor agonist, an antagonist of the actions of CRH, caffeine, and a polyamine.

    Abstract translation: 在由肥大细胞的激活和随后脱颗粒引起的炎性疾病中具有协同抗炎作用的组合物，随后由活化的肥大细胞分泌炎症生物分子，其由高度硫酸化的非牛蛋白聚糖如鲨鱼软骨硫酸软骨素C组成， 以及一种或多种硫酸己糖胺，如D-葡糖胺硫酸盐，黄酮如槲皮素，在各种施用途径中增加这些组合物的吸收的未精制的橄榄核提取物，S-腺苷甲硫氨酸，组胺-1受体拮抗剂， 组胺3受体激动剂，CRH，咖啡因和多胺的作用的拮抗剂。

    H.sub.3 -receptor agonists as therapeutic agents
    8.
    发明授权
    H.sub.3 -receptor agonists as therapeutic agents 失效
    H3受体激动剂作为治疗剂

    公开(公告)号：US5821259A

    公开(公告)日：1998-10-13

    申请号：US524023

    申请日：1995-09-06

    Applicant: Theoharis C. Theoharides

    Inventor： Theoharis C. Theoharides

    IPC: A61K31/00 ,  A61K31/417 ,  A61K31/415

    CPC classification number: A61K31/417 ,  A61K31/00

    Abstract: The invention provides a method for preventing and alleviating the harmful biological effects of secretion of chemicals from mast cells in the organism of mammals which leads to clinical conditions namely allergy, asthma, arthritis, dermatitis, interstitial cystitis, inflammatory and irritable bowel disease, migraines, multiple sclerosis, scleroderma or systemic sclerosis, ulcerative disease of the gastro-intestinal tract and urticaria, among others. The method consists in administering to said mammals and especially to human beings an amount, effective against said conditions, of an H.sub.3 receptor agonist which has inhibitory activity of neurohormonal activation of mast cell secretion.

    Abstract translation: 本发明提供一种预防和减轻哺乳动物生物体中肥大细胞分泌化学物质的有害生物学效应的方法，其导致临床条件即过敏，哮喘，关节炎，皮炎，间质性膀胱炎，炎症性肠易激综合征，偏头痛， 多发性硬化症，硬皮病或系统性硬化症，胃肠道溃疡性疾病和荨麻疹等。 该方法包括向所述哺乳动物，特别是对人体施用一种有效抵抗所述病症的H3受体激动剂，其具有对肥大细胞分泌的神经激素激活的抑制活性。

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