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1.发明公开公开(公告)号：US20240252726A1
公开(公告)日：2024-08-01
申请号：US18561507
申请日：2022-05-18
Applicant: THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA , The United States of America as Represented by the Department of Veterans Affairs
Inventor： Daniel Kacy Cullen , Wisberty J. Gordian-Velez , H. Isaac Chen , Jason A. Burdick
CPC classification number: A61L27/52 , A61K35/30 , A61L27/20 , A61L27/3633 , A61L27/3675 , A61L27/383 , A61L27/3878 , A61L27/58 , G06N3/061
Abstract: In various aspects and embodiments the present disclosure provides a construct comprising a pre-formed neural network, the construct comprising a micro-column comprising an outer sheath comprising a hyaluronic acid (HA) hydrogel, and a core comprising an extracellular matrix (ECM); a plurality of neurons within the micro-column. The present disclosure further provides methods of making and using the same.
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公开(公告)号：US11911392B2
公开(公告)日：2024-02-27
申请号：US17740248
申请日：2022-05-09
Applicant: University of Maryland, Baltimore , The United States of America as represented by the Department of Veterans Affairs
Inventor： Paul S. Shapiro , Alexander D. Mackerell, Jr. , Jeffrey D. Hasday
CPC classification number: A61K31/5375 , A61K31/18 , A61K31/54 , A61P19/02 , A61P29/00 , A61P31/00 , A61P35/00
Abstract: Compounds that inhibit p38α MAPK protein, and methods of using the same, are provided for treating or preventing diseases such as cancer or inflammatory diseases.
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公开(公告)号：US20240033254A1
公开(公告)日：2024-02-01
申请号：US18483225
申请日：2023-10-09
Applicant: YALE UNIVERSITY , The United States of America as represented by the Department of Veterans Affairs
Inventor： Chadi Abdallah , John Krystal , Ronald Duman , Gerard Sanacora
IPC: A61K31/436 , A61P25/24 , A61K9/00 , A61K9/08 , A61K31/135 , A61K45/06
CPC classification number: A61K31/436 , A61P25/24 , A61K9/0053 , A61K9/08 , A61K31/135 , A61K45/06
Abstract: The present invention provides compositions and methods for treating diseases or disorders using a therapeutically effective amount of a rapid-acting antidepressant (RAAD) and a therapeutically effective amount of a mTOR inhibitor and/or immunosuppressant. In certain embodiments, the RAAD and the mTOR inhibitor and/or immunosuppressant are part of a single pharmaceutical composition.
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公开(公告)号：US20230420110A1
公开(公告)日：2023-12-28
申请号：US18037457
申请日：2021-11-18
Applicant: Indiana University Research and Technology Corporation , The United States of America as represented by the Department of Veterans Affairs
Inventor： Alexander B. Niculescu, III
Abstract: Methods for objective and precise assessment, risk prediction, monitoring of disease course and response to treatment, and precise matching to existing, and to new method of use repurposed drugs, in mood disorders, such as for patients with depression or bipolar disorder. These methods are based on an objective analysis of specific biomarker panels, as well as on the integration of the biomarker panel data with clinical measures of mood, life satisfaction, psycho-socio-demographic risk factors, and clinical history severity. These methods provide a foundation for precision medicine for mood disorders.
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5.发明授权公开(公告)号：US11550014B2
公开(公告)日：2023-01-10
申请号：US17673003
申请日：2022-02-16
Applicant: The Board of Trustees of the Leland Stanford Junior University , The United States of America as represented by The Department Of Veterans Affairs
Inventor： Daniel B. Ennis , Matthew J. Middione , Julio A. Oscanoa Aida , Shreyas S. Vasanawala
IPC: G01R33/563 , G01R33/56 , G06N3/04 , A61B5/00 , A61B5/026
Abstract: A method for phase-contrast magnetic resonance imaging (PC-MRI) acquires undersampled PC-MRI data using a magnetic resonance imaging scanner and reconstructs MRI images from the undersampled PC-MRI data by reconstructing a first flow-encoded image using a first convolutional neural network, reconstructing a complex difference image using a second convolutional neural network, combining the complex difference image and the first flow-encoded image to obtain a second flow-encoded image, and generating a velocity encoded image from the first flow-encoded image and second flow-encoded image using phase difference processing.
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Patent Agency Ranking
公开(公告)号：US11453725B2
公开(公告)日：2022-09-27
申请号：US16544625
申请日：2019-08-19
Inventor： Richard H. Weisbart , Robert N. Nishimura
Abstract: The invention provides methods for selective targeting of live cells, which have undergone or are undergoing radiation or chemotherapy, at a site of interest with a cell-penetrating polypeptide. In one embodiment of the invention, the method comprises contacting the live cells with a cell-penetrating polypeptide comprising cell-penetrating determinants so that the cell-penetrating polypeptide binds extracellular DNA near or around the live cells so as to form a complex or association therewith such that the complex or associated polypeptide-DNA so bound bind the live cells and penetrates the live cells thereby selectively targeting live cells at a site of interest with a cell-penetrating polypeptide.
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公开(公告)号：US11337622B2
公开(公告)日：2022-05-24
申请号：US15738611
申请日：2016-06-20
Applicant: UNIVERSITY OF MARYLAND, BALTIMORE , The United States of America as represented by the Department of Veterans Affairs
Inventor： Richard F. Macko , Anindo Roy
Abstract: A method is described for providing deficit-adjusted adaptive assistance during movement phases of an impaired ankle. The method includes determining, on the processor, a value for a deficit parameter for each movement phase of a compound ankle function based on a difference between a parameter trace for a normal subject and the parameter trace for an impaired subject. The method further includes determining, on the processor, an adaptive magnitude for the robot-applied torque based on the value for the deficit parameter. The method further includes applying, to the robot joint, the adaptive magnitude for the robot-applied torque in only a first plane for the current movement phase, based on an adaptive timing. An apparatus is also described for providing deficit-adjusted adaptive assistance during movement phases of the impaired ankle.
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公开(公告)号：US20210353833A1
公开(公告)日：2021-11-18
申请号：US17382786
申请日：2021-07-22
Applicant: THE REGENTS OF THE UNIVERSITY OF MICHIGAN , THE REGENTS OF THE UNIVERSITY OF CALIFORNIA , THE UNITED STATES OF AMERICA AS REPRESENTED BY THE DEPARTMENT OF VETERANS AFFAIRS
Inventor： Jeffrey S. SAKAMOTO , Dena SHAHRIARI , Mark H. TUSZYNSKI , Wendy CAMPANA , Yacov KOFFLER
Abstract: Tissue scaffolds for neural tissue growth have a plurality of microchannels disposed within a sheath. Each microchannel comprises a porous wall having a thickness of ≤about 100 μm that is formed from a biocompatible and biodegradable material comprising a polyester polymer. The polyester polymer may be polycaprolactone, poly(lactic-co-glycolic acid) polymer, and combinations thereof. The tissue scaffolds have high open volume % enabling superior (linear and high fidelity) neural tissue growth, while minimizing inflammation near the site of implantation in vivo. In other aspects, methods of making such tissue scaffolds are provided. Such a method may include mixing a reduced particle size porogen with a polymeric precursor solution. The material is cast onto a template and then can be processed, including assembly in a sheath and removal of the porogen, to form a tissue scaffold having a plurality of porous microchannels.
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公开(公告)号：US20210290148A1
公开(公告)日：2021-09-23
申请号：US16334571
申请日：2017-09-18
Applicant: Baylor College of Medicine , The United States of America as represented by the Department of Veterans Affairs , Arizona Board of Regents on behalf of Arizona State University, a body corporate duly formed in a...
Inventor： Bijan Najafi , Javad Razjouyan , He Zhou , Mark Kunik
Abstract: An instrumented trail-making task (iTMT) platform includes a wearable sensor and interactive interface technology configured to identify cognitive-cognitive impairment in individuals such as older adults. The iTMT platform may be programmed with neuropsychological tests for assessing individuals. The iTMT may provide information on visual search, scanning, speed of processing, mental flexibility, and/or executive functions as well as physical biomarkers of motor performance including slowness, weakness, exclusion, and/or motor planning error. Results of tests administered by the iTMT system may be reported to a patient or caregiver and used in identifying cognitive-motor impairment among individuals suffering from cognitive impairment, dementia, and/or those with frailty status, and/or cognitive frailty, and/or high risk of falling, and/or high likelihood of decline in cognitive-motor over time.
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公开(公告)号：US20210267987A1
公开(公告)日：2021-09-02
申请号：US17231598
申请日：2021-04-15
Applicant: University of Maryland, Baltimore , The United States of America as represented by the Department of Veterans Affairs
Inventor： Paul S. SHAPIRO , Alexander D. MACKERELL, JR. , Jeffrey D. HASDAY
Abstract: Compounds that inhibit p38α MAPK protein, and methods of using the same, are provided for treating or preventing diseases such as cancer or inflammatory diseases.
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