公开(公告)号：US07998681B2

公开(公告)日：2011-08-16

申请号：US10038509

申请日：2002-01-03

申请人： Terry J. Smith ,  William W. Cruikshank

发明人： Terry J. Smith ,  William W. Cruikshank

IPC分类号： G01N33/53 ,  G01N33/00 ,  C12N5/071

CPC分类号： C07K16/244 ,  A61K2039/505 ,  C07K16/2869

摘要： The present invention describes diagnosis and treatment of antibody-mediated inflammatory auto-immune diseases. The biochemical mechanisms underlying such disorders are described as characteristic molecular markers and antibody-mediated ligand-receptor interactions. Specifically, the activation of T-cells by disease specific IgG binding to the IGF-1 receptor is shown to underlie thyroid associated ophthalmopathy associated with Graves' disease and rheumatoid arthritis. Diagnostics for detection of disease are provided, as are therapeutics based on the determination of the mechanisms underlying a particular pathology.

摘要翻译： 本发明描述了抗体介导的炎性自身免疫疾病的诊断和治疗。 这种疾病的生化机制被描述为特征性分子标记和抗体介导的配体 - 受体相互作用。 具体地，通过疾病特异性IgG与IGF-1受体结合的T细胞的活化显示为与格雷夫斯病和类风湿性关节炎相关的甲状腺相关性眼病的基础。 提供用于疾病检测的诊断，以及基于特定病理学的机制的确定的治疗剂。

公开(公告)号：US5677977A

公开(公告)日：1997-10-14

申请号：US649010

申请日：1996-05-16

申请人： Terry J. Smith

发明人： Terry J. Smith

IPC分类号： G02B6/26 ,  G02B6/36

CPC分类号： G02B6/266

摘要： The apparatus is an attenuator for use in an optical fiber link. The attenuator is a full circular loop of continuous optical fiber with connection means at the ends of the loop to interconnect with the other optical fiber components in the system. The attenuation of optical transmission through the loop is continuously variable by twisting the loop out of its original planar configuration. A lockable rotating shaft clamped to the side of the loop remote from the connection means is turned to rotate the loop.

摘要翻译： 该装置是用于光纤链路的衰减器。 衰减器是连续光纤的全圆形回路，在环路的两端具有连接装置，以与系统中的其他光纤部件互连。 通过环路的光学传输的衰减可以通过将环路从其原始平面配置中扭转来连续变化。 夹紧在远离连接装置的环路侧的可锁定旋转轴被转动以旋转环路。

公开(公告)号：US4380171A

公开(公告)日：1983-04-19

申请号：US220926

申请日：1980-12-29

申请人： Terry J. Smith

发明人： Terry J. Smith

IPC分类号： G01L1/22 ,  G01L5/00 ,  G01M99/00

CPC分类号： G01M99/007 ,  G01L1/22 ,  G01L5/0057

摘要： An apparatus for measuring the contact force of a terminal mounted in a multi-terminal circuit board connector, the measured force being applied normal to the surface of a circuit board received in the connector, has a transducer employing four strain gauges connected in a bridge arrangement with pairs of the gauges being positioned at opposite ends of a fully supported beam. The strain at the end points of the beam are averaged by the strain gauges so that no matter where the forces are applied normal to the beam by the terminal being measured, the deflection is always negligible and the area of the beam upon which the contact force is applied is not critical.

摘要翻译： 一种用于测量安装在多端子电路板连接器中的端子的接触力的装置，所测量的力垂直于接收在连接器中的电路板的表面施加，具有使用四个应变计连接在桥式布置中的换能器 成对的量规位于完全支撑的梁的相对端。 梁的端点处的应变由应变计平均化，使得无论在被测量的端子处施加垂直于梁的力的情况下，偏转总是可忽略的，并且梁的接触力的面积 被应用并不重要。

公开(公告)号：US08178304B2

公开(公告)日：2012-05-15

申请号：US11709334

申请日：2007-02-20

申请人： Terry J. Smith ,  Raymond S. Douglas

发明人： Terry J. Smith ,  Raymond S. Douglas

IPC分类号： G01N33/00 ,  G01N33/53 ,  G01N33/567

CPC分类号： G01N33/564

摘要： The invention provides methods of diagnosing Graves' disease (GD), Rheumatoid Arthritis (RA) and other autoimmune diseases in an individual by detecting a disproportionately large fraction of peripheral blood T cells express IGF-1R (CD3+ IGF-R+) compared to normal control samples. In a further embodiment, the invention provides methods of diagnosing, prognosing, staging, and/or monitoring GD, RA and other autoimmune diseases. Or a predisposition thereto in an individual by detecting a disproportionately large fraction of CD3+ IGF-1R+ T cells that express CD45RO+ compared to normal control samples. In a further embodiment, the invention provides a method of diagnosing, prognosing, staging, and/or monitoring GD, RA and other autoimmune diseases or a predisposition thereto in an individual by detecting an increased CD45RO+/RA+ ratio in peripheral blood T cells compared to normal control samples. In addition to peripheral blood T cells, the methods of the invention also can be practiced with test samples comprising T cells harvested from affected orbital tissues. Embodiments directed to the prognosis, staging, and/or monitoring of GD, RA and other autoimmune diseases or a predisposition thereto also are provided, along with diagnostic kits for practicing the various embodiments of the invention.

摘要翻译： 本发明提供了通过检测与正常对照相比表达IGF-1R（CD3 + IGF-R +）的不成比例的大部分外周血T细胞来诊断个体中的格雷夫斯病（GD），类风湿关节炎（RA）和其他自身免疫性疾病的方法 样品。 在另一个实施方案中，本发明提供诊断，预后，分期和/或监测GD，RA和其它自身免疫性疾病的方法。 或者通过检测与正常对照样品相比表达CD45RO +的不成比例的大部分CD3 + IGF-1R + T细胞在个体中的倾向。 在另一个实施方案中，本发明提供了通过检测外周血T细胞中增加的CD45RO + / RA +比率来诊断，预后，分期和/或监测个体中GD，RA和其它自身免疫性疾病或其倾向的方法， 正常对照样品。 除了外周血T细胞外，本发明的方法也可以用包含从受影响的轨道组织收获的T细胞的测试样品来实施。 还提供了涉及GD，RA和其它自身免疫性疾病或其倾向的预后，分期和/或监测的实施例以及用于实践本发明的各种实施方案的诊断试剂盒。

公开(公告)号：US06936426B2

公开(公告)日：2005-08-30

申请号：US10046651

申请日：2001-10-19

申请人： Terry J. Smith ,  William W. Cruikshank

发明人： Terry J. Smith ,  William W. Cruikshank

IPC分类号： C07K16/24 ,  C07K16/28 ,  G01N33/53

CPC分类号： C07K16/2869 ,  A61K2039/505 ,  C07K16/244

摘要： The present invention describes a method to detect connective tissue pathologies associated with Graves' disease ophthalmopathy and other antibody mediated inflammatory autoimmune diseases. The detection method comprises obtaining a sample from a patient suffering from an antibody-mediated inflammatory autoimmune disorder and measuring Interleukin 16 (IL-16) or RANTES produced by thyroid associated ophthalmopathy fibroblasts to indicate the presence or severity.

摘要翻译： 本发明描述了一种检测与格雷夫斯病眼病和其他抗体介导的炎性自身免疫性疾病相关的结缔组织病变的方法。 检测方法包括从患有抗体介导的炎性自身免疫病症的患者获得样品，并测量由甲状腺相关性眼病成纤维细胞产生的白细胞介素16（IL-16）或RANTES以指示存在或严重性。

公开(公告)号：US5408238A

公开(公告)日：1995-04-18

申请号：US32301

申请日：1993-03-17

申请人： Terry J. Smith

发明人： Terry J. Smith

IPC分类号： B63C9/00 ,  G01S5/00 ,  G01S5/14 ,  G01S19/17 ,  H04B7/185 ,  G01S5/02

CPC分类号： G01S19/17 ,  B63C9/0005 ,  G01S19/35 ,  G01S5/0027

摘要： Apparatus for determining and broadcasting the approximate location of a person or other object that has fallen overboard from a boat or other structure into a body of water. The apparatus includes a floatable object that is thrown into the water near the overboard person/object to broadcast the location of the object and the nearby overboard person. The floatable object includes: an activatable Satellite Positioning System (SPS) receiver/processor and antenna to receive SPS signals from two or more SPS satellites; an activatable location transmitter and transmitter interface to receive the SPS-determined location information from the SPS receiver/processor; a power supply to supply power to the SPS receiver/processor and the location transmitter; and activation means to activate the SPS receiver/processor and location transmitter. The floatable object may be attached to or include a drogue, unfurled in the water, to encourage the floatable object to move with the same velocity and in the same direction as the local water current. In another embodiment, the apparatus may include a chemical analyzer, positioned to be in contact with the ambient liquid, to analyze the local concentration of a target chemical in this liquid and to cause this concentration value to be broadcast. This embodiment is useful for monitoring the present location and/or rate of movement of the boundary between the ambient water and a chemical (such as oil) intentionally or unintentionally released into the water. The SPS receiver/processor and location transmitter can be activated by a water immersion switch, by a manually operable switch, by transmission of an activation signal from a nearby structure, such as a boat, or by any other suitable action. The SPS may be a Global Positioning System (GPS), a Global Orbital Navigational System (GLONASS), or any other suitable satellite-based location and navigation system.

公开(公告)号：US08153121B2

公开(公告)日：2012-04-10

申请号：US10140003

申请日：2002-05-06

申请人： Terry J. Smith ,  William W. Cruikshank

发明人： Terry J. Smith ,  William W. Cruikshank

IPC分类号： A61K39/35 ,  A61K39/00 ,  A61K39/395

CPC分类号： C07K16/2869 ,  A61K2039/505 ,  C07K16/244

摘要： The invention provides a method of reducing the severity of an autoimmune condition associated with T-lymphocyte infiltration. The invention also provides a method of diagnosing or predicting the susceptibility to an autoimmune disease associated with fibroblast mediated T-lymphocyte infiltration. Methods of identifying a substance capable of modulating T-lymphocyte recruitment associated with an autoimmune condition also are provided.

摘要翻译： 本发明提供了降低与T淋巴细胞浸润相关的自身免疫病症的严重程度的方法。 本发明还提供诊断或预测与成​​纤维细胞介导的T淋巴细胞浸润相关的自身免疫疾病的易感性的方法。 还提供了鉴定能够调节与自身免疫病症相关的T淋巴细胞募集物质的方法。

公开(公告)号：USRE35920E

公开(公告)日：1998-10-13

申请号：US644423

申请日：1996-05-10

申请人： James L. Sorden ,  Terry J. Smith ,  Eric Klein

发明人： James L. Sorden ,  Terry J. Smith ,  Eric Klein

IPC分类号： B60R25/102 ,  G01S1/68 ,  G01S5/00 ,  G01S5/14 ,  G01S19/48 ,  G08B25/01 ,  G08G1/123 ,  G08G9/00 ,  G01S3/02

CPC分类号： G08G9/00 ,  B60R25/102 ,  G01S1/68 ,  G01S5/0027 ,  G08B25/016 ,  G08G1/205 ,  B60R2021/0027 ,  G01S19/17 ,  G01S2205/006

摘要： Apparatus that is carried on a land vehicle, a marine vehicle or vessel, or an airborne vehicle or vessel for notifying others that a vehicle accident or other abnormal situation has occurred and for notifying others of the location of the vehicle at the time of the accident. The vehicle carries an distance measuring system (DMS) signal antenna and receiver/processor that receives DMS-type signals from one or more DMS signal broadcasters and determines the present position of the vehicle, plus an activatable transmitter. The vehicle also carries an abnormality sensing means that senses the occurrence of an accident or other abnormal situation involving the vehicle or a vehicle occupant. When an abnormal situation is sensed, the abnormality sensing means automatically activates the transmitter, which then communicates the fact that an abnormal situation has occurred and the location of the vehicle at the time the event occurred. Alternatively, the abnormality sensing means can activate the transmitter only after a vehicle operator has taken affirmative action indicating that the transmitter should be activated. Optionally, the transmitter can also communicate the time the event occurred. If the abnormal situation is (1) a vehicle accident, (2) inoperability of the vehicle, (3) inability of the vehicle operator or other vehicle occupant to continue (e.g., because of a rapid change in a present health condition of the occupant), the transmitter can also communicate information on (1) the severity of the accident, (2) the type or cause of vehicle inoperability, (3) the reason the operator or other occupant is unable to continue. Optionally, the system can also transmit, or hold for future analysis, the values of one or more vehicle operating parameters sensed at a sequence of times preceding occurrence of the abnormal situation. The DMS may be a Satellite Positioning System, such as the Global Positioning System (GPS) or the Global Orbiting Navigation System (GLONASS), or a ground-based radionavigation system, such as LORAN, Shoran, Decca or TACAN.

公开(公告)号：US5311197A

公开(公告)日：1994-05-10

申请号：US011989

申请日：1993-02-01

申请人： James L. Sorden ,  Terry J. Smith ,  Eric Klein

发明人： James L. Sorden ,  Terry J. Smith ,  Eric Klein

IPC分类号： B60R25/102 ,  G01S1/68 ,  G01S5/00 ,  G01S5/14 ,  G01S19/48 ,  G08B25/01 ,  G08G1/123 ,  G08G9/00 ,  G01S3/02

CPC分类号： G08G9/00 ,  B60R25/102 ,  G01S1/68 ,  G01S5/0027 ,  G08B25/016 ,  G08G1/205 ,  B60R2021/0027 ,  G01S19/17 ,  G01S2205/006

摘要： Apparatus that is carried on a land vehicle, a marine vehicle or vessel, or an airborne vehicle or vessel for notifying others that a vehicle accident or other abnormal situation has occurred and for notifying others of the location of the vehicle at the time of the accident. The vehicle carries an distance measuring system (DMS) signal antenna and receiver/processor that receives DMS-type signals from one or more DMS signal broadcasters and determines the present position of the vehicle, plus an activatable transmitter. The vehicle also carries an abnormality sensing means that senses the occurrence of an accident or other abnormal situation involving the vehicle or a vehicle occupant. When an abnormal situation is sensed, the abnormality sensing means automatically activates the transmitter, which then communicates the fact that an abnormal situation has occurred and the location of the vehicle at the time the event occurred. Alternatively, the abnormality sensing means can activate the transmitter only after a vehicle operator has taken affirmative action indicating that the transmitter should be activated. Optionally, the transmitter can also communicate the time the event occurred. If the abnormal situation is (1) a vehicle accident, (2) inoperability of the vehicle, (3) inability of the vehicle operator or other vehicle occupant to continue (e.g., because of a rapid change in a present health condition of the occupant), the transmitter can also communicate information on (1) the severity of the accident, (2) the type or cause of vehicle inoperability, (3) the reason the operator or other occupant is unable to continue. Optionally, the system can also transmit, or hold for future analysis, the values of one or more vehicle operating parameters sensed at a sequence of times preceding occurrence of the abnormal situation. The DMS may be a Satellite Positioning System, such as the Global Positioning System (GPS) or the Global Orbiting Navigation System (GLONASS), or a ground-based radionavigation system, such as LORAN, Shoran, Decca or TACAN.

公开(公告)号：US09486286B2

公开(公告)日：2016-11-08

申请号：US12120550

申请日：2008-05-14

申请人： Michael R. Hodel ,  Terry J. Smith

发明人： Michael R. Hodel ,  Terry J. Smith

IPC分类号： A61B18/20 ,  A61B18/22 ,  A61B17/00

CPC分类号： A61B18/22 ,  A61B34/25 ,  A61B2017/00115 ,  A61B2017/00973 ,  A61B2018/00589 ,  A61B2018/00625 ,  A61B2018/207

摘要： The medical laser user interface of the present invention generally comprises a medical laser unit and a control system. The medical laser unit includes an optical probe for delivering laser light to a patient's tissue. The control system controls operation of the medical laser unit. Specifically, the control system provides a foot pedal system that enables the user to switch between the delivery of a first wavelength of laser light and a second wavelength of laser light through depression of a foot pedal. In a first embodiment, a single foot pedal can be used to toggle the wavelengths, where as in a second embodiment two foot pedals can be use, i.e., one for the first wavelength and one for the second wavelength. The two wavelengths provided include a wavelength for vaporization of tissue and a wavelength for coagulation.

摘要翻译： 本发明的医疗用激光用户界面通常包括医疗用激光单元和控制系统。 医疗激光单元包括用于将激光传送到患者组织的光学探针。 控制系统控制医疗用激光单元的动作。 具体地说，控制系统提供了一种脚踏踏板系统，其能够使用户通过按压脚踏板在第一波长的激光和第二波长的激光之间进行切换。 在第一实施例中，可以使用单脚踏板来切换波长，其中如在第二实施例中可以使用两个脚踏板，即，一个用于第一波长，一个用于第二波长。 所提供的两个波长包括用于组织蒸发的波长和用于凝结的波长。