公开(公告)号：US20240382753A1

公开(公告)日：2024-11-21

申请号：US18692517

申请日：2022-09-14

Applicant: CORNELL UNIVERSITY ,  THE UNIVERSITY OF UTAH ,  THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY

Inventor： Nicholas SCHIFF ,  Jonathan BAKER ,  Christopher BUTSON ,  Andrew JANSON ,  Kyle O'SULLIVAN ,  Jaimie HENDERSON ,  Eun Young CHOI ,  Brian RUTT ,  Matthew RADOVAN ,  Jason SU

IPC: A61N1/36 ,  A61N1/05

Abstract: Methods and devices for vector-based targeting of the human central thalamus (CT) to guide deep brain stimulation (DBS) are disclosed. In some examples, electrode(s) each with a plurality contacts are provided. A three-dimensional orientation of a dominant axis of a central lateral nucleus dorsal tegmental tract medial component (CL/DTTm) fiber bundle of a human subject is determined. The contacts of the electrode(s) are positioned in the subject's CT fibers in substantial alignment with the three-dimensional orientation. An electrical stimulus is applied to the contacts to selectively activate the CT fibers. The positioning and the applying are carried out to maximize activation of a central lateral nucleus and medial dorsal tegmental tract fiber pathway in the subject and to minimize activation of a centromedian-parafascicularis fiber pathway in the subject. Methods and devices for surgical planning involving for vector-based targeting of the human CT to guide DBS are also disclosed.

公开(公告)号：US20240358804A1

公开(公告)日：2024-10-31

申请号：US18397180

申请日：2023-12-27

Applicant: LUNDQUIST INSTITUTE FOR BIOMEDICAL INNOVATION AT HARBOR-UCLA MEDICAL CENTER ,  THE UNIVERSITY OF UTAH

Inventor： Ashraf S. IBRAHIM ,  June L. ROUND ,  Kyla OST

IPC: A61K39/00 ,  A61K9/00 ,  A61P1/00

CPC classification number: A61K39/0002 ,  A61K9/0019 ,  A61K9/0073 ,  A61P1/00 ,  A61K2039/545

Abstract: The invention provides a vaccine against inflammatory bowel disease (IBD), such as Crohn's disease, ulcerative colitis, and the like. The vaccine comprises a polypeptide comprising a Candida adhesin antigen, typically an isolated agglutinin-like sequence (Als) protein antigen, formulated with one or more pharmaceutically acceptable carriers or excipients.

公开(公告)号：US20240050369A1

公开(公告)日：2024-02-15

申请号：US17766318

申请日：2020-10-05

Applicant: THE UNIVERSITY OF CHICAGO ,  THE UNIVERSITY OF UTAH

Inventor： Yun Fang ,  Matthew V. Tirrell ,  Yan-Ting Shiu

IPC: A61K9/107 ,  A61K47/10 ,  A61K47/18 ,  A61K47/42 ,  A61K45/06 ,  A61K31/7105 ,  A61P9/14

CPC classification number: A61K9/1075 ,  A61K47/10 ,  A61K47/183 ,  A61K47/42 ,  A61K45/06 ,  A61K31/7105 ,  A61P9/14

Abstract: This disclosure relates to compositions and methods for treating vascular disorders, including, for example, arteriovenous fistula (AVF) failure, stenosis, restenosis, and atherosclerosis.

公开(公告)号：US10849901B2

公开(公告)日：2020-12-01

申请号：US15313884

申请日：2015-05-27

Applicant: Navigen, Inc. ,  The University of Utah Research Founcation

Inventor： Kirill Ostanin ,  Mark Shenderovich ,  Ashok Bajji ,  Christopher L. Cioffi ,  Neil Moss ,  Hariprasad Vankayalapati ,  Dean Li

IPC: A61K31/519 ,  A61K31/5377

Abstract: Disclosed herein are compounds and methods for inhibiting Arf6. Pharmaceutical compositions and methods for treating a subject with an inhibitor of Arf6 are also disclosed herein.

公开(公告)号：US20190031655A1

公开(公告)日：2019-01-31

申请号：US16047915

申请日：2018-07-27

Applicant: Stingray Therapeutics, Inc. ,  The University of Utah

Inventor： Hariprasad Vankayalapati ,  Xiaohui Liu ,  Gurusankar Ramamoorthy ,  Sunil Sharma ,  Mohan Rao Kaadige ,  Alexis Weston ,  Trason Thode

IPC: C07D471/04

Abstract: Substituted-3H-imidazo[4,5-c]pyridine and 1H-pyrrolo[2,3-c]pyridine series of novel Ectonucleotide Pyrophosphatase/Phosphodiesterase-1 (ENPP1) and related compounds, which are useful as inhibitors of ENPP1; synthetic methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of using the compounds and compositions to treat disorders associated with dysfunction of the ENPP1.

公开(公告)号：US10172909B2

公开(公告)日：2019-01-08

申请号：US15183389

申请日：2016-06-15

Applicant: NeuroAdjuvants, Inc. ,  The University of Utah Research Foundation

Inventor： H. Steve White ,  Brian Donald Klein ,  Cameron Spencer Metcalf ,  Daniel Ryan McDougle ,  Erika Adkins Scholl ,  Misty Danielle Smith ,  Grzegorz Bulaj ,  Liuyin Zhang

IPC: A61K38/10 ,  A61K38/22 ,  A61K38/31 ,  C07K7/08 ,  C07K14/575 ,  C07K14/655 ,  A61K47/48

Abstract: Neuropeptide analogs and compositions including neuropeptide analogs are described herein. Also provided are methods of producing and using the neuropeptide analogs and compositions including one or more neuropeptide analogs.

公开(公告)号：US20180344703A1

公开(公告)日：2018-12-06

申请号：US15991561

申请日：2018-05-29

Applicant: THE UNIVERSITY OF UTAH RESEARCH FOUNDATION

Inventor： Tianxin Yang

IPC: A61K31/4178 ,  A61K31/201 ,  A61K31/401 ,  A61K31/41 ,  A61K45/06 ,  A61K31/20

Abstract: The present technology provides compositions and methods for treating chronic kidney disease, end-stage renal disease, or diabetic nephropathy. The compositions comprise a nitrated lipid and an inhibitor of the renin-angiotensin-aldosterone system. The methods comprise administering a nitrated lipid in combination with an inhibitor of the renin-angiotensin-aldosterone system to a subject in need thereof, in an amount effective to treat diabetic nephropathy, chronic kidney disease, and/or end-stage renal disease. The use of a nitrated lipid with an inhibitor of the renin-angiotensin-aldosterone system exhibits a synergistic effect in treating chronic kidney disease and diabetic nephropathy.

公开(公告)号：US09937162B2

公开(公告)日：2018-04-10

申请号：US15094561

申请日：2016-04-08

Applicant: THE UNIVERSITY OF UTAH RESEARCH FOUNDATION

Inventor： Christopher C. Gibson ,  Dean Y. Li

IPC: A61K31/445 ,  A61K31/4468 ,  A61K31/593 ,  A61B5/00

CPC classification number: A61K31/445 ,  A61B5/004 ,  A61K31/4468 ,  A61K31/45 ,  A61K31/593

Abstract: Methods are provided of treating and preventing stroke diseases, such as cerebral cavernous malformation, by the administration of tempol and/or cholecalciferol.

公开(公告)号：US09931724B2

公开(公告)日：2018-04-03

申请号：US15461049

申请日：2017-03-16

Applicant: The University of Utah Research Foundation

Inventor： Alagar Krishnan Balaji ,  Venugopal Raghavendra Ghatikar

IPC: B23Q11/10 ,  B23Q17/09 ,  G05D7/06

CPC classification number: B23Q11/1046 ,  B23Q11/10 ,  B23Q17/00 ,  B23Q17/0952 ,  G05D7/0629 ,  G05D7/0682 ,  Y02P70/169 ,  Y10T29/49995

Abstract: Devices, systems, and methods are provided for controlling a quantity of cutting fluid dispensed for a cutting tool within a CNC or other machining system. The devices, systems, and methods may include controlling multiple fluids such that coolant, lubricant, or other fluids can be delivered at different locations, at different flow rates, have their flow rates changed independently, and/or have their flow rates changed dynamically during a machining operation. In some embodiments, a feedback loop or input may be provided to obtain and/or provide information regarding the machining operation—such as cutting force, cutting temperature, cutting friction, machining operation, tool in use, work piece geometry, and/or material—and automatically and/or independently modify the fluid flow rates. The fluid may be atomized with air or other gases to minimize the quantities of fluid used. Components in the system may be modular to allow the system to be used with existing and new machining technologies.

公开(公告)号：US20160217252A1

公开(公告)日：2016-07-28

申请号：US15002085

申请日：2016-01-20

Applicant: Biofire Diagnostics, Inc. ,  The University of Utah Research Foundation

Inventor： Thomas Charles Robbins ,  Robert Andrew Palais ,  Carl Thomas Wittwer

IPC: G06F19/24 ,  G06F19/20 ,  G06F19/18

CPC classification number: G16B40/00 ,  C12Q1/6816 ,  G01N33/6803 ,  G16B20/00 ,  G16B25/00 ,  G16B25/20 ,  G16B40/10 ,  C12Q2527/107 ,  C12Q2537/165 ,  C12Q2539/101

Abstract: An experimental melting curve is modeled as a sum of a true melting curve and background fluorescence. A deviation function may be generated based upon the experimental melting curve data and a model of a background signal. The deviation function may be generated by segmenting a range of the experimental curve into a plurality of windows. Within each window, a fit between the model of the background signal and the experimental melting curve data may be calculated. The deviation function may be formed from the resulting fit parameters. The deviation function may include background signal compensation and, as such, may be used in various melting curve analysis operations, such as data visualization, clustering, genotyping, scanning, negative sample removal, and the like. The deviation function may be used to seed an automated background correction process. A background-corrected melting curve may be further processed to remove an aggregation signal.

Abstract translation: 实验熔解曲线被建模为真正的熔解曲线和背景荧光的总和。 可以基于实验熔解曲线数据和背景信号的模型产生偏差函数。 可以通过将实验曲线的范围分割成多个窗口来产生偏差函数。 在每个窗口内，可以计算背景信号的模型与实验解链曲线数据之间的拟合。 偏差函数可以由所得的拟合参数形成。 偏差函数可以包括背景信号补偿，并且因此可以用于各种熔解曲线分析操作中，例如数据可视化，聚类，基因分型，扫描，负样本去除等。 偏差函数可以用于种子自动背景校正过程。 可以进一步处理背景校正的熔解曲线以除去聚集信号。