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公开(公告)号：US20090313365A1
公开(公告)日：2009-12-17
申请号：US12307862
申请日：2007-07-09
申请人： Stephen Whitehead
发明人： Stephen Whitehead
IPC分类号： G06F3/147
摘要： A central management system exchanges data with a store at a remote site, where a display imparts visible and/or audible information to store customers. Monitoring means at the store monitors behavior of store customers. Predetermined content data is transmitted from the central management system to the remote store site for display. Monitored customer behaviour data is transmitted from the remote store site to the central management system, to enable evaluation of the customer behaviour in response to the content data. Data transmission between the central management system and the remote store site is effected without using the in-store IT system. Stock may be monitored at a Point of Purchase (POP) display. Barcode readers may be monitored passively. Brand means may impart visible or audible information to store customers or operatives. Compliance means may monitor whether a poster is displayed at a POP.
摘要翻译： 中央管理系统与远程站点上的商店交换数据，其中显示器输入可见和/或可听信息以存储客户。 商店的监控手段监控商店客户的行为。 预定内容数据从中央管理系统发送到远程存储站点进行显示。 监控的客户行为数据从远程存储站点传输到中央管理系统，以便响应于内容数据来评估客户行为。 在不使用店内IT系统的情况下实现中央管理系统与远程存储站点之间的数据传输。 可以在采购点（POP）显示屏监控库存。 条形码阅读器可能被动被监视。 品牌手段可以传播可见或听觉信息来存储客户或操作人员。 合规手段可以监控是否在POP上显示海报。
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公开(公告)号：USD580176S1
公开(公告)日：2008-11-11
申请号：US29317539
申请日：2008-05-01
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3.发明申请Production of attenuated respiratory syncytial virus vaccines from cloned nucleotide sequences 有权从克隆的核苷酸序列产生减毒呼吸道合胞病毒疫苗公开(公告)号：US20060159703A1
公开(公告)日：2006-07-20
申请号：US10934003
申请日：2004-09-02
申请人： Brian Murphy , Peter Collins , Stephen Whitehead , Alexander Bukreyev , Katalin Juhasz , Michael Teng
发明人： Brian Murphy , Peter Collins , Stephen Whitehead , Alexander Bukreyev , Katalin Juhasz , Michael Teng
IPC分类号： A61K39/155 , C12N7/00 , C07K14/115
CPC分类号： C07K14/005 , A61K39/00 , C12N7/00 , C12N2760/18522 , C12N2760/18561
摘要： Attenuated respiratory syncytial virus (RSV) and vaccine compositions thereof are produced by introducing specific mutations associated with attenuating phenotypes into wild-type or RSV which is incompletely attenuated by cold-passage or introduction of mutations which produce virus having a temperature sensitive (ts) or cold adapted (ca) phenotype. Alternatively, recombinant RSV and vaccine compositions thereof incorporate attenuating and other mutations specifying desired structural and or phenotypic characteristics in an infectious RSV. Recombinant RSV incorporate desired mutations specified by insertion, deletion, substitution or rearrangement of a selected nucleotide sequence, gene, or gene segment in an infectious RSV clone. The immune system of an individual is stimulated to induce protection against natural RSV infection, or multivalently against infection by RSV and another pathogen, such as PIV, by administration of attenuated, biologically derived or recombinant RSV.
摘要翻译： 减毒的呼吸道合胞病毒（RSV）及其疫苗组合物通过将与将减毒表型相关的特异性突变引入野生型或RSV，通过冷通道或引入产生具有温度敏感性（ts）或 冷适应（ca）表型。 或者，重组RSV及其疫苗组合物结合了在感染性RSV中指定所需结构和/或表型特征的减毒和其它突变。 重组RSV包含通过在感染性RSV克隆中选择的核苷酸序列，基因或基因片段的插入，缺失，取代或重排而指定的所需突变。 通过施用减毒的，生物衍生的或重组的RSV，刺激个体的免疫系统以诱导针对天然RSV感染的保护，或多重抗RSV和另一种病原体如PIV的感染。
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4.发明申请Production of attenuated, human-bovine chimeric respiratory syncytial viruses for use in immunogenic compositions 失效用于免疫原性组合物的减毒的人 - 牛嵌合呼吸道合胞病毒的生产公开(公告)号：US20050158338A1
公开(公告)日：2005-07-21
申请号：US10704116
申请日：2003-11-07
CPC分类号： C12N15/86 , A61K39/00 , A61K39/12 , A61K39/155 , A61K2039/5254 , A61K2039/5256 , A61K2039/543 , A61K2039/544 , C07K14/005 , C07K2319/00 , C12N7/00 , C12N2760/18521 , C12N2760/18522 , C12N2760/18534 , C12N2760/18543 , C12N2760/18561 , C12N2840/203
摘要： Chimeric human-bovine respiratory syncytial virus (RSV) are infectious and attenuated in humans and other mammals and useful in immunogenic compositions for eliciting an anti-RSV immune response. Also provided are isolated polynucleotide molecules and vectors incorporating a chimeric RSV genome or antigenome which includes a partial or complete human or bovine RSV “background” genome or antigenome combined or integrated with one or more heterologous gene(s) or genome segment(s) of a different RSV strain. Chimeric human-bovine RSV of the invention include a partial or complete “background” RSV genome or antigenome derived from or patterned after a human or bovine RSV strain or subgroup virus combined with one or more heterologous gene(s) or genome segment(s) of a different RSV strain or subgroup virus to form the human-bovine chimeric RSV genome or antigenome. In preferred aspects of the invention, chimeric RSV incorporate a partial or complete bovine RSV background genome or antigenome combined with one or more heterologous gene(s) or genome segment(s) from a human RSV. Genes of interest include any of the NS1, NS2, N, P, M, SH, M2(ORF1), M2(ORF2), L, F or G genes or a genome segment including a protein or portion thereof. A variety of additional mutations and nucleotide modifications are provided within the human-bovine chimeric RSV of the invention to yield desired phenotypic and structural effects.
摘要翻译： 嵌合人 - 牛呼吸道合胞病毒（RSV）在人和其他哺乳动物中具有感染性和减毒性，并且可用于引发抗RSV免疫应答的免疫原性组合物。 还提供了分离的多核苷酸分子和掺入嵌合RSV基因组或抗原组的载体，其包括部分或完整的人或牛RSV“背景”基因组或与一个或多个异源基因或基因组片段 不同的RSV菌株。 本发明的嵌合人类牛RSV包括部分或完整的“背景”RSV基因组或在与一个或多个异源基因或基因组片段组合的人或牛RSV病毒株或亚组病毒之后衍生或构图的部分或完整的“背景” 的不同RSV株或亚组病毒形成人 - 牛嵌合RSV基因组或抗原组。 在本发明的优选方面，嵌合RSV包含与来自人RSV的一个或多个异源基因或基因组片段组合的部分或完整的牛RSV背景基因组或反义基因组。 感兴趣的基因包括任何NS1，NS2，N，P，M，SH，M2（ORF1），M2（ORF2），L，F或G基因或包含蛋白质或其部分的基因组片段。 在本发明的人 - 牛嵌合RSV内提供了多种额外的突变和核苷酸修饰，以产生所需的表型和结构效果。
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公开(公告)号：US20050102402A1
公开(公告)日：2005-05-12
申请号：US10398708
申请日：2001-10-05
申请人： Stephen Whitehead
发明人： Stephen Whitehead
IPC分类号： H04L29/06 , H04L29/08 , G06F15/173
CPC分类号： H04L67/06 , G07F9/026 , G07F11/002 , H04L29/06 , H04L67/12 , H04L67/14 , H04L67/34 , H04L69/329
摘要： In a communications system, a computer network server (2) is arranged to communicate simultaneously with a plurality of remote computers 201 . . . 20n. A remote embedded application in the form of a vending machine (1) has a module (12) that is arranged to communicate with the computer network server (2) such that file transfer sessions are carried out between the server and the vending machine (1). The server (2) is arranged to cause call request data to be transmitted to the module (12) and the module (12) is arranged to initiate a call back to the server (2) or other designated server, in response to the call request data. The call request data is transmitted using calling line identification (CLI). The module (12) is arranged to detect the call and the CLI; to not answer the call; and to initiate a call back to the server (2) or other designated server, after having received the call with CLI. The call request data may alternatively be transmitted to the module (12) in the form of a short message service (SMS) message.
摘要翻译： 在通信系统中，计算机网络服务器（2）被布置成与多个远程计算机201同时通信。 。 。 20 n。 形式为自动售货机（1）的远程嵌入式应用程序具有一个模块（12），其被配置为与计算机网络服务器（2）进行通信，从而在服务器和自动售货机（1）之间执行文件传送会话 ）。 服务器（2）被配置为使得呼叫请求数据被发送到模块（12），并且模块（12）被安排为响应于呼叫而发起回服务器（2）或其他指定服务器的呼叫 请求数据。 通过呼叫线路识别（CLI）发送呼叫请求数据。 模块（12）被配置为检测呼叫和CLI; 不接电话; 并且在使用CLI接收到呼叫之后发起对服务器（2）或其他指定服务器的呼叫。 另外，呼叫请求数据可以以短消息服务（SMS）消息的形式发送到模块（12）。
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公开(公告)号：US4112823A
公开(公告)日：1978-09-12
申请号：US641370
申请日：1975-12-17
IPC分类号： F15B21/02
CPC分类号： F15B21/02 , Y10T307/983
摘要： Automated control apparatus for an intermittently extended hydraulic cylinder is disclosed which governs cylinder elongation such that the rate of elongation is essentially constant with respect to time. The control apparatus includes a preset continuously variable timer that regulates the timer interval between sequential length increments of the cylinder. The control apparatus also includes a second timer which is responsive to the timer interval interposed by the first timer and which operates a valve controlling communication of hydraulic fluid between a hydraulic cylinder and a pump. The second timer may be discretely variable so that one of a plurality of predetermined length increments can be selected. Alternatively, the second timer may adjust the time period during which the valve is opened such that successive stages of a telescopic hydraulic cylinder have equal length increments.
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7.发明申请公开(公告)号：US20130166342A1
公开(公告)日：2013-06-27
申请号：US13332565
申请日：2011-12-21
IPC分类号： G06Q10/06
CPC分类号： G06Q10/06
摘要： A computerized method for monitoring business processes is exemplified. Business process data and task data are stored in memory of a computer. The method further includes receiving a data request from a requesting party. The method additionally includes filtering business process data and task data based on the role of the requesting party. A first requesting party has a first monitoring role is designated a level of access limited to viewing task data for fewer than all tasks. A second requesting party has a second monitoring role is designated a level of access as viewing or editing task data limited to fewer than all tasks. A third requesting party has a third monitoring role is designated a level of access as viewing or editing task data for all tasks. The method furthermore includes returning the requested data to the requesting party based on the user credentials of the requesting party.
摘要翻译： 示例了用于监视业务流程的计算机化方法。 业务流程数据和任务数据存储在计算机的存储器中。 该方法还包括从请求方接收数据请求。 该方法还包括基于请求方的作用来过滤业务过程数据和任务数据。 第一个请求方具有第一个监视角色被指定为一个访问级别，限于仅查找少于所有任务的任务数据。 第二个请求方具有第二个监视角色，将访问级别指定为限制为少于所有任务的查看或编辑任务数据。 第三个请求方具有第三个监视角色，将访问级别指定为查看或编辑所有任务的任务数据。 该方法还包括基于请求方的用户凭证将请求的数据返回给请求方。
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公开(公告)号：US20100155520A1
公开(公告)日：2010-06-24
申请号：US12341827
申请日：2008-12-22
CPC分类号： B65H75/40 , B65H75/4407 , B65H75/4465 , B65H75/4471 , B65H75/4492 , B65H2402/412 , B65H2701/33 , Y10T137/6954
摘要： The present invention relates to hose reel carts for handling and storage of flexible hoses, such as garden or air hoses. The hose reel cart is primarily constructed of plastic components having a centrally rotatable spool for winding of the flexible hose, a frame for supporting the spool and a multi-position crank arm assembly allowing the consumer to place the crank handle in a lowered position or a raised position. The crank remotely drives the spool, for winding the hose, through a series of gears located within the crank arm assembly. The device may further include a reciprocating guide assembly that operates during rotation of the spool to rewind the hose into a compact configuration.
摘要翻译： 本发明涉及用于处理和储存诸如花园或空气软管的柔性软管的软管卷轴车。 软管卷盘车主要由塑料部件构成，该塑料部件具有用于缠绕柔性软管的可中心旋转的卷轴，用于支撑卷轴的框架和多位置的曲柄臂组件，其允许消费者将曲柄手柄放置在降低的位置或 提高职位 曲柄通过位于曲柄臂组件内的一系列齿轮远程地驱动滑阀，用于卷绕软管。 该装置可以进一步包括往复式导向组件，该往复导向组件在卷轴的旋转期间操作以将软管重新卷成紧凑的构造。
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公开(公告)号：USD580612S1
公开(公告)日：2008-11-11
申请号：US29317540
申请日：2008-05-01
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10.发明申请Respiratory syncytial virus vaccines expressing protective antigens from promotor-proximal genes 有权呼吸道合胞病毒疫苗从启动子近端基因表达保护性抗原公开(公告)号：US20060024797A1
公开(公告)日：2006-02-02
申请号：US11033055
申请日：2005-01-10
CPC分类号： C07K14/005 , A61K39/00 , A61K2039/5254 , A61K2039/5256 , A61K2039/543 , A61K2039/545 , C07H21/02 , C07K2319/00 , C12N7/00 , C12N15/86 , C12N2760/18522 , C12N2760/18543 , C12N2760/18561 , C12N2760/18562
摘要： Recombinant respiratory syncytial virus (RSV) having the position of genes shifted within the genome or antigenome of the recombinant virus are infectious and attenuated in humans and other mammals. Gene shifted RSV are constructed by insertion, deletion or rearrangement of genes or genome segments within the recombinant genome or antigenome and are useful in vaccine formulations for eliciting an anti-RSV immune response. Also provided are isolated polynucleotide molecules and vectors incorporating a recombinant RSV genome or antigenome wherein a gene or gene segment is shifted to a more promoter-proximal or promoter-distal position within the genome or antigenome compared to a wild type position of the gene in the RSV gene map. Shifting the position of genes in this manner provides for a selected increase or decrease in expression of the gene, depending on the nature and degree of the positional shift. In one embodiment, RSV glycoproteins are upregulated by shifting one or more glycoprotein-encoding genes to a more promoter-proximal position. Genes of interest for manipulation to create gene position-shifted RSV include any of the NS1, NS2, N, P, M, SH, M2(ORF1), M2(ORF2), L, F or G genes or a genome segment that may be part of a gene or extragenic. A variety of additional mutations and nucleotide modifications are provided within the gene position-shifted RSV of the invention to yield desired phenotypic and structural effects.
摘要翻译： 重组呼吸道合胞病毒（RSV）具有在重组病毒的基因组或反向基因组内移位的基因位置，在人和其他哺乳动物中具有传染性和减毒性。 通过在重组基因组或反向原核基因组内的基因或基因组片段的插入，缺失或重排构建基因转移的RSV，并且可用于引发抗RSV免疫应答的疫苗制剂中。 还提供了分离的多核苷酸分子和掺入重组RSV基因组或反基因组的载体，其中与基因组或基因片段中的基因的野生型位置相比，基因或基因片段转移到基因组或反基因组内的更多启动子近端或启动子远端位置 RSV基因图。 以这种方式移动基因的位置提供基因的选择性增加或降低，这取决于位置偏移的性质和程度。 在一个实施方案中，通过将一个或多个编码糖蛋白的基因移位到更多的启动子近端位置来上调RSV糖蛋白。 用于产生基因位置偏移RSV的操作感兴趣的基因包括NS1，NS2，N，P，M，SH，M2（ORF1），M2（ORF2），L，F或G基因中的任何一个或可能 成为基因的一部分或非原生质体。 在本发明的基因位置偏移的RSV中提供了多种另外的突变和核苷酸修饰，以产生所需的表型和结构效应。
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