公开(公告)号：US20110230455A1

公开(公告)日：2011-09-22

申请号：US13149260

申请日：2011-05-31

Applicant: Soo-Il KIM

Inventor： Soo-Il KIM

IPC: A61K31/58 ,  A61P11/02

CPC classification number: A61K9/0043 ,  A61K9/006 ,  A61K9/08 ,  A61K31/573 ,  A61K31/58 ,  A61K47/32 ,  A61K47/36 ,  A61K47/38 ,  B05B11/3018 ,  Y10S514/951 ,  Y10S514/975

Abstract: An aqueous pharmaceutical composition which is capable of being sprayed into the nasal cavity of an individual and which comprises: (A) a pharmaceutically effective amount of solid particles of medicament which is effective in treating a bodily condition by virtue of its being present on the mucosal surfaces of the nasal cavity; and (B) a suspending agent in an amount effective to maintain said particles dispersed uniformly in the composition and to impart to the composition the following thixotropic properties: (i) the viscosity of the position in unsheared form is relatively high, with the composition being in gel-like form; (ii) as the composition is subjected to shear (shaken) in preparation for spraying, the viscosity of the composition becomes relatively low and such that the composition in the form of a mist flows readily into the nasal passages for deposit on the mucosal surfaces of the nasal cavity; and (D) in deposited form on the mucosal surfaces, the viscosity of the composition is relatively high and such that it resists being cleared from the mucosal surfaces by the inherent mucocillary forces which are present in the nasal cavity, a method of use of the composition and a method for preparation of the composition, including in preferred form the use of anti-inflammatory steroid, for example, triamcinoline acetonide, and an odorless form of the composition.

Abstract translation: 一种能够喷洒到个体鼻腔中的水性药物组合物，其包含：（A）药物有效量的药物固体颗粒，其通过存在于粘膜上而有效地治疗身体状况 鼻腔表面; 和（B）有效维持所述颗粒均匀分散在组合物中并赋予组合物以下触变性能的悬浮剂：（i）以非HEED形式的位置的粘度相对较高，其组成为 呈凝胶状; （ii）当组合物经过剪切（摇动）制备用于喷雾时，组合物的粘度变得相对较低，并且使得雾状形式的组合物容易地流入鼻道以沉积在粘膜表面上 鼻腔; 和（D）沉积形式在粘膜表面上，组合物的粘度相对较高，使得其抵抗通过存在于鼻腔中的固有粘膜毛孔而从粘膜表面清除，使用 组合物和组合物的制备方法，包括优选形式使用抗炎类固醇，例如曲安奈德，以及无味形式的组合物。

公开(公告)号：US07122206B2

公开(公告)日：2006-10-17

申请号：US10128154

申请日：2002-04-23

Applicant: Soo-Il Kim

Inventor： Soo-Il Kim

IPC: A61K9/14

CPC classification number: A61K9/0043 ,  A61K9/006 ,  A61K9/08 ,  A61K31/573 ,  A61K31/58 ,  A61K47/32 ,  A61K47/36 ,  A61K47/38 ,  B05B11/3018 ,  Y10S514/951 ,  Y10S514/975

Abstract: An aqueous pharmaceutical composition which is capable of being sprayed into the nasal cavity of an individual and which comprises: (A) a pharmaceutically effective amount of solid particles of medicament which is effective in treating a bodily condition by virtue of its being present on the mucosal surfaces of the nasal cavity; and (B) a suspending agent in an amount effective to maintain said particles dispersed uniformly in the composition and to impart to the composition the following thixotropic properties: (i) the viscosity of the position in unsheared form is relatively high, with the composition being in gel-like form; (ii) as the composition is subjected to shear (shaken) in preparation for spraying, the viscosity of the composition becomes relatively low and such that the composition in the form of a mist flows readily into the nasal passages for deposit on the mucosal surfaces of the nasal cavity; and (D) in deposited form on the mucosal surfaces, the viscosity of the composition is relatively high and such that it resists being cleared from the mucosal surfaces by the inherent mucocillary forces which are present in the nasal cavity, a method of use of the composition and a method for preparation of the composition, including in preferred form the use of anti-inflammatory steroid, for example, triamcinoline acetonide, and an odorless form of the composition.

公开(公告)号：US06375984B1

公开(公告)日：2002-04-23

申请号：US09561371

申请日：2000-04-28

Applicant: Soo-Il Kim

Inventor： Soo-Il Kim

IPC: A61K914

CPC classification number: A61K9/0043 ,  A61K9/006 ,  A61K9/08 ,  A61K31/573 ,  A61K31/58 ,  A61K47/32 ,  A61K47/36 ,  A61K47/38 ,  B05B11/3018 ,  Y10S514/951 ,  Y10S514/975

Abstract: An aqueous pharmaceutical composition which is capable of being sprayed into the nasal cavity of an individual and which comprises: (A) a pharmaceutically effective amount of solid particles of medicament which is effective in treating a bodily condition by virtue of its being present on the mucosal surfaces of the nasal cavity; and (B) a suspending agent in an amount effective to maintain said particles dispersed uniformly in the composition and to impart to the composition the following thixotropic properties: (i) the viscosity of the position in unsheared form is relatively high, with the composition being in gel-like form; (ii) as the composition is subjected to shear (shaken) in preparation for spraying, the viscosity of the composition becomes relatively low and such that the composition in the form of a mist flows readily into the nasal passages for deposit on the mucosal surfaces of the nasal cavity; and (iii) in deposited form on the mucosal surfaces, the viscosity of the composition is relatively high and such that it resists being cleared from the mucosal surfaces by the inherent mucocillary forces which are present in the nasal cavity, a method of use of the composition and a method for preparation of the composition, including in preferred form the use of anti-inflammatory steroid, for example, triamcinolone acetonide, and an odorless form of the composition.

Abstract translation: 一种能够喷洒到个体鼻腔中的水性药物组合物，其包含：（A）药物有效量的药物固体颗粒，其通过存在于粘膜上而有效地治疗身体状况 鼻腔表面; 和（B）有效维持所述颗粒均匀分散在组合物中并赋予组合物以下触变性能的悬浮剂：（i）以非HEED形式的位置的粘度相对较高，其组成为 以凝胶状形式; （ii）当组合物经过剪切（摇动）制备用于喷雾时，组合物的粘度变得相对较低，并且使得雾状形式的组合物容易地流入鼻道以沉积在粘膜表面上 鼻腔; 和（iii）沉积形式在粘膜表面上，组合物的粘度相对较高，使得其抵抗通过存在于鼻腔中的固有粘膜毛孔而从粘膜表面清除，使用 组合物和组合物的制备方法，包括优选形式使用抗炎类固醇，例如曲安奈德和组合物的无味形式。

公开(公告)号：US6143329A

公开(公告)日：2000-11-07

申请号：US315454

申请日：1999-05-20

Applicant: Soo-Il Kim

Inventor： Soo-Il Kim

IPC: A61K9/14 ,  A61L9/00 ,  A61K9/00 ,  A61K9/08 ,  A61K9/10 ,  A61K9/16 ,  A61K31/573 ,  A61K31/58 ,  A61K47/32 ,  A61K47/36 ,  A61K47/38 ,  A61P11/02 ,  A61P37/06 ,  B05B11/00 ,  A61K39/58

CPC classification number: A61K9/0043 ,  A61K31/573 ,  A61K31/58 ,  A61K47/32 ,  A61K47/36 ,  A61K47/38 ,  A61K9/006 ,  A61K9/08 ,  B05B11/3018 ,  Y10S514/951 ,  Y10S514/975

Abstract: An aqueous pharmaceutical composition which is capable of being sprayed into the nasal cavity of an individual and which comprises: (A) a pharmaceutically effective amount of solid particles of medicament which is effective in treating a bodily condition by virtue of its being present on the mucosal surfaces of the nasal cavity; and (B) a suspending agent in an amount effective to maintain said particles dispersed uniformly in the composition and to impart to the composition the following thixotropic properties: (i) the viscosity of the position in unsheared form is relatively high, with the composition being in gel-like form; (ii) as the composition is subjected to shear (shaken) in preparation for spraying, the viscosity of the composition becomes relatively low and such that the composition in the form of a mist flows readily into the nasal passages for deposit on the mucosal surfaces of the nasal cavity; and (iii) in deposited form on the mucosal surfaces, the viscosity of the composition is relatively high and such that it resists being cleared from the mucosal surfaces by the inherent mucocillary forces which are present in the nasal cavity, a method of use of the composition and a method for preparation of the composition, including in preferred form the use of anti-inflammatory steroid, for example, trimcindone acetonide, and an odorless form of the composition.

Abstract translation: 一种水性药物组合物，其能够喷洒到个体的鼻腔中，其包含：（A）药学上有效量的药物固体颗粒，其通过存在于粘膜上而有效治疗身体状况 鼻腔表面; 和（B）有效维持所述颗粒均匀分散在组合物中并赋予组合物以下触变性能的悬浮剂：（i）以非HEED形式的位置的粘度相对较高，其组成为 以凝胶状形式; （ii）当组合物经过剪切（摇动）制备用于喷雾时，组合物的粘度变得相对较低，并且使得雾状形式的组合物容易地流入鼻道以沉积在粘膜表面上 鼻腔; 和（iii）沉积形式在粘膜表面上，组合物的粘度相对较高，使得其抵抗通过存在于鼻腔中的固有粘膜毛孔而从粘膜表面清除，使用 组合物和组合物的制备方法，包括优选形式使用抗炎类固醇，例如，美沙酮，和无味形式的组合物。

公开(公告)号：US07977045B2

公开(公告)日：2011-07-12

申请号：US12728984

申请日：2010-03-22

Applicant: Soo-Il Kim

Inventor： Soo-Il Kim

IPC: C12Q1/70

CPC classification number: A61K9/0043 ,  A61K9/006 ,  A61K9/08 ,  A61K31/573 ,  A61K31/58 ,  A61K47/32 ,  A61K47/36 ,  A61K47/38 ,  B05B11/3018 ,  Y10S514/951 ,  Y10S514/975

Abstract: An aqueous pharmaceutical composition which is capable of being sprayed into the nasal cavity of an individual and which comprises: (A) a pharmaceutically effective amount of solid particles of medicament which is effective in treating a bodily condition by virtue of its being present on the mucosal surfaces of the nasal cavity; and (B) a suspending agent in an amount effective to maintain said particles dispersed uniformly in the composition and to impart to the composition the following thixotropic properties: (i) the viscosity of the position in unsheared form is relatively high, with the composition being in gel-like form; (ii) as the composition is subjected to shear (shaken) in preparation for spraying, the viscosity of the composition becomes relatively low and such that the composition in the form of a mist flows readily into the nasal passages for deposit on the mucosal surfaces of the nasal cavity; and (D) in deposited form on the mucosal surfaces, the viscosity of the composition is relatively high and such that it resists being cleared from the mucosal surfaces by the inherent mucocillary forces which are present in the nasal cavity, a method of use of the composition and a method for preparation of the composition, including in preferred form the use of anti-inflammatory steroid, for example, triamcinolone acetonide, and an odorless form of the composition.

Abstract translation: 一种能够喷洒到个体鼻腔中的水性药物组合物，其包含：（A）药物有效量的药物固体颗粒，其通过存在于粘膜上而有效地治疗身体状况 鼻腔表面; 和（B）有效维持所述颗粒均匀分散在组合物中并赋予组合物以下触变性能的悬浮剂：（i）以非HEED形式的位置的粘度相对较高，其组成为 呈凝胶状; （ii）当组合物经过剪切（摇动）制备用于喷雾时，组合物的粘度变得相对较低，并且使得雾状形式的组合物容易地流入鼻道以沉积在粘膜表面上 鼻腔; 和（D）沉积形式在粘膜表面上，组合物的粘度相对较高，使得其抵抗通过存在于鼻腔中的固有粘膜毛孔而从粘膜表面清除，使用 组合物和组合物的制备方法，包括优选形式使用抗炎类固醇，例如曲安奈德，以及组合物的无味形式。

公开(公告)号：US20100222314A1

公开(公告)日：2010-09-02

申请号：US12728984

申请日：2010-03-22

Applicant: Soo-Il Kim

Inventor： Soo-Il Kim

IPC: A61K31/56

CPC classification number: A61K9/0043 ,  A61K9/006 ,  A61K9/08 ,  A61K31/573 ,  A61K31/58 ,  A61K47/32 ,  A61K47/36 ,  A61K47/38 ,  B05B11/3018 ,  Y10S514/951 ,  Y10S514/975

Abstract: An aqueous pharmaceutical composition which is capable of being sprayed into the nasal cavity of an individual and which comprises: (A) a pharmaceutically effective amount of solid particles of medicament which is effective in treating a bodily condition by virtue of its being present on the mucosal surfaces of the nasal cavity; and (B) a suspending agent in an amount effective to maintain said particles dispersed uniformly in the composition and to impart to the composition the following thixotropic properties: (i) the viscosity of the position in unsheared form is relatively high, with the composition being in gel-like form; (ii) as the composition is subjected to shear (shaken) in preparation for spraying, the viscosity of the composition becomes relatively low and such that the composition in the form of a mist flows readily into the nasal passages for deposit on the mucosal surfaces of the nasal cavity; and (D) in deposited form on the mucosal surfaces, the viscosity of the composition is relatively high and such that it resists being cleared from the mucosal surfaces by the inherent mucocillary forces which are present in the nasal cavity, a method of use of the composition and a method for preparation of the composition, including in preferred form the use of anti-inflammatory steroid, for example, triamcinolone acetonide, and an odorless form of the composition.

Abstract translation: 一种能够喷洒到个体鼻腔中的水性药物组合物，其包含：（A）药物有效量的药物固体颗粒，其通过存在于粘膜上而有效地治疗身体状况 鼻腔表面; 和（B）有效维持所述颗粒均匀分散在组合物中并赋予组合物以下触变性能的悬浮剂：（i）以非HEED形式的位置的粘度相对较高，其组成为 呈凝胶状; （ii）当组合物经过剪切（摇动）制备用于喷雾时，组合物的粘度变得相对较低，并且使得雾状形式的组合物容易地流入鼻道以沉积在粘膜表面上 鼻腔; 和（D）沉积形式在粘膜表面上，组合物的粘度相对较高，使得其抵抗通过存在于鼻腔中的固有粘膜毛孔而从粘膜表面清除，使用 组合物和组合物的制备方法，包括优选形式使用抗炎类固醇，例如曲安奈德和组合物的无味形式。

公开(公告)号：US5976573A

公开(公告)日：1999-11-02

申请号：US678465

申请日：1996-07-03

Applicant: Soo-Il Kim

Inventor： Soo-Il Kim

IPC: A61K9/14 ,  A61L9/00 ,  A61K9/00 ,  A61K9/08 ,  A61K9/10 ,  A61K9/16 ,  A61K31/573 ,  A61K31/58 ,  A61K47/32 ,  A61K47/36 ,  A61K47/38 ,  A61P11/02 ,  A61P37/06 ,  B05B11/00 ,  A61K39/58

CPC classification number: A61K9/0043 ,  A61K31/573 ,  A61K31/58 ,  A61K47/32 ,  A61K47/36 ,  A61K47/38 ,  A61K9/006 ,  A61K9/08 ,  B05B11/3018 ,  Y10S514/951 ,  Y10S514/975

Abstract: An aqueous pharmaceutical composition which is capable of being sprayed into the nasal cavity of an individual and which comprises: (A) a pharmaceutically effective amount of solid particles of medicament which is effective in treating a bodily condition by virtue of its being present on the mucosal surfaces of the nasal cavity; and (B) a suspending agent in an amount effective to maintain said particles dispersed uniformly in the composition and to impart to the composition the following thixotropic properties: (i) the viscosity of the position in unsheared form is relatively high, with the composition being in gel-like form; (ii) as the composition is subjected to shear (shaken) in preparation for spraying, the viscosity of the composition becomes relatively low and such that the composition in the form of a mist flows readily into the nasal passages for deposit on the mucosal surfaces of the nasal cavity; and (iii) in deposited form on the mucosal surfaces, the viscosity of the composition is relatively high and such that it resists being cleared from the mucosal surfaces by the inherent mucocillary forces which are present in the nasal cavity, a method of use of the composition and a method for preparation of the composition, including in preferred form the use of anti-inflammatory steroid, for example, triamcinolone acetonide, and an odorless form of the composition.

公开(公告)号：US20070031887A1

公开(公告)日：2007-02-08

申请号：US11581565

申请日：2006-10-16

Applicant: Soo-Il Kim

Inventor： Soo-Il Kim

IPC: C12Q1/68

CPC classification number: A61K9/0043 ,  A61K9/006 ,  A61K9/08 ,  A61K31/573 ,  A61K31/58 ,  A61K47/32 ,  A61K47/36 ,  A61K47/38 ,  B05B11/3018 ,  Y10S514/951 ,  Y10S514/975

Abstract: An aqueous pharmaceutical composition which is capable of being sprayed into the nasal cavity of an individual and which comprises: (A) a pharmaceutically effective amount of solid particles of medicament which is effective in treating a bodily condition by virtue of its being present on the mucosal surfaces of the nasal cavity; and (B) a suspending agent in an amount effective to maintain said particles dispersed uniformly in the composition and to impart to the composition the following thixotropic properties: (i) the viscosity of the position in unsheared form is relatively high, with the composition being in gel-like form; (ii) as the composition is subjected to shear (shaken) in preparation for spraying, the viscosity of the composition becomes relatively low and such that the composition in the form of a mist flows readily into the nasal passages for deposit on the mucosal surfaces of the nasal cavity; and (D) in deposited form on the mucosal surfaces, the viscosity of the composition is relatively high and such that it resists being cleared from the mucosal surfaces by the inherent mucocillary forces which are present in the nasal cavity, a method of use of the composition and a method for preparation of the composition, including in preferred form the use of anti-inflammatory steroid, for example, triamcinoline acetonide, and an odorless form of the composition.

Abstract translation: 一种能够喷洒到个体鼻腔中的水性药物组合物，其包含：（A）药物有效量的药物固体颗粒，其通过存在于粘膜上而有效地治疗身体状况 鼻腔表面; 和（B）有效维持所述颗粒均匀分散在组合物中并赋予组合物以下触变性能的悬浮剂：（i）以非HEED形式的位置的粘度相对较高，其组成为 呈凝胶状; （ii）当组合物经过剪切（摇动）制备用于喷雾时，组合物的粘度变得相对较低，并且使得雾状形式的组合物容易地流入鼻道以沉积在粘膜表面上 鼻腔; 和（D）沉积形式在粘膜表面上，组合物的粘度相对较高，使得其抵抗通过存在于鼻腔中的固有粘膜毛孔而从粘膜表面清除，使用 组合物和组合物的制备方法，包括优选形式使用抗炎类固醇，例如曲安奈德，以及无味形式的组合物。