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公开(公告)号：US09603909B2
公开(公告)日：2017-03-28
申请号：US14404158
申请日：2012-05-29
申请人： Seong Jun Yoon , Soo Youn Jun , Gi Mo Jung , Sang Hyeon Kang
发明人： Seong Jun Yoon , Soo Youn Jun , Gi Mo Jung , Sang Hyeon Kang
CPC分类号： A61K38/47 , A61K38/162 , A61K47/02 , A61K47/34 , C12N7/00 , C12N2795/10122 , C12N2795/10151 , C12Y302/01017
摘要： The present invention relates to a composition for improving the stability of bacteriophage originated lysin proteins greatly even when the composition contains the bacteriophage originated lysin proteins at a high concentration. More precisely, the present invention relates to a method and a composition for improving significantly the stability of SAL-1 or LysK, the bacteriophage originated lysin protein, included at a high concentration in the composition.
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公开(公告)号：US09402873B2
公开(公告)日：2016-08-02
申请号：US14343926
申请日：2011-09-09
申请人： Seong Jun Yoon , Soo Youn Jun , Hyoun Rok Paik , Dong Hwan Kim , Sang Hyeon Kang
发明人： Seong Jun Yoon , Soo Youn Jun , Hyoun Rok Paik , Dong Hwan Kim , Sang Hyeon Kang
IPC分类号： A61K39/112 , A61K35/76 , A61K38/16
CPC分类号： A61K35/76 , A23K10/16 , A61K38/162 , Y02A50/411 , Y02A50/481
摘要： The present invention relates to a composition comprising STP-1, a bacteriophage isolated from nature, capable of infecting Salmonella Typhimurium so as to kill the same as an active ingredient, and a method for preventing and treating Salmonella Typhimurium infection using the said composition. According to the present invention, the bacteriophage STP-1, an active ingredient of the composition, has a killing activity against Salmonella Typhimurium and has the genome represented by SEQ. ID. NO: 1.
摘要翻译： 本发明涉及一种组合物，其包含STP-1，从自然界分离的能够感染鼠伤寒沙门氏菌以杀死与活性成分相同的噬菌体，以及使用所述组合物预防和治疗鼠伤寒沙门氏菌感染的方法。 根据本发明，组合物的活性成分的噬菌体STP-1对鼠伤寒沙门氏菌具有杀伤活性，并具有SEQ ID NO： ID。 NO：1。
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公开(公告)号：US20140363401A1
公开(公告)日：2014-12-11
申请号：US14343926
申请日：2011-09-09
申请人： Seong Jun Yoon , Soo Youn Jun , Hyoun Rok Paik , Dong Hwan Kim , Sang Hyeon Kang
发明人： Seong Jun Yoon , Soo Youn Jun , Hyoun Rok Paik , Dong Hwan Kim , Sang Hyeon Kang
CPC分类号： A61K35/76 , A23K10/16 , A61K38/162 , Y02A50/411 , Y02A50/481
摘要： The present invention relates to a composition comprising STP-1, a bacteriophage isolated from nature, capable of infecting Salmonella Typhimurium so as to kill the same as an active ingredient, and a method for preventing and treating Salmonella Typhimurium infection using the said composition. According to the present invention, the bacteriophage STP-1, an active ingredient of the composition, has a killing activity against Salmonella Typhimurium and has the genome represented by SEQ. ID. NO: 1.
摘要翻译： 本发明涉及一种组合物，其包含STP-1，从自然界分离的能够感染鼠伤寒沙门氏菌以杀死与活性成分相同的噬菌体，以及使用所述组合物预防和治疗鼠伤寒沙门氏菌感染的方法。 根据本发明，组合物的活性成分的噬菌体STP-1对鼠伤寒沙门氏菌具有杀伤活性，并具有SEQ ID NO： ID。 NO：1。
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4.发明申请公开(公告)号：US20150224179A1
公开(公告)日：2015-08-13
申请号：US14404158
申请日：2012-05-29
申请人： Seong Jun Yoon , Soo Youn Jun , Gi Mo Jung , Sang Hyeon Kang
发明人： Seong Jun Yoon , Soo Youn Jun , Gi Mo Jung , Sang Hyeon Kang
CPC分类号： A61K38/47 , A61K38/162 , A61K47/02 , A61K47/34 , C12N7/00 , C12N2795/10122 , C12N2795/10151 , C12Y302/01017
摘要： The present invention relates to a composition for improving the stability of bacteriophage originated lysin proteins greatly even when the composition contains the bacteriophage originated lysin proteins at a high concentration. More precisely, the present invention relates to a method and a composition for improving significantly the stability of SAL-1 or LysK, the bacteriophage originated lysin protein, included at a high concentration in the composition.
摘要翻译： 本发明涉及一种用于提高噬菌体来源的赖氨酸蛋白质的稳定性的组合物，甚至当该组合物含有高浓度的噬菌体来源的赖氨酸蛋白质时。 更准确地说，本发明涉及用于显着提高组合物中高浓度包含的噬菌体来源的赖氨酸蛋白质的SAL-1或LysK的稳定性的方法和组合物。
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5.发明授权MRI contrast agent coated with carboxylated mannan and method for producing the same 有权涂有羧化甘露聚糖的MRI造影剂及其制备方法公开(公告)号：US08961935B2
公开(公告)日：2015-02-24
申请号：US13087816
申请日：2011-04-15
申请人： Seong Jun Yoon , Soo Youn Jun , An Sung Kwon , Sang Hyeon Kang , Yong Yeon Jeong , In Kyu Park , Chong Su Cho , You Kyoung Kim , Won Jong Kim , Ran Namgung
发明人： Seong Jun Yoon , Soo Youn Jun , An Sung Kwon , Sang Hyeon Kang , Yong Yeon Jeong , In Kyu Park , Chong Su Cho , You Kyoung Kim , Won Jong Kim , Ran Namgung
CPC分类号： A61K49/1863 , B82Y15/00 , B82Y40/00 , Y10S977/773 , Y10S977/89 , Y10S977/93
摘要： The present invention relates to a magnetic resonance imaging (MRI) contrast agent coated with carboxylated mannan, particularly a carboxylated mannan coated superparamagnetic MRI contrast agent specifically targeting antigen presenting cells and having excellent in vivo stability, and a method for producing the same. The MRI contrast agent coated with carboxylated mannan of the present invention can provide excellent in vivo stability and biocompatibility owing to its high surface negative charge, and can be introduced specifically into antigen presenting cells owing to mannose of mannan, so as to visualize the antigen presenting cells and the tissue containing the antigen presenting cells in MRI.
摘要翻译： 本发明涉及涂覆有羧化甘露聚糖，特别是特异性靶向抗原呈递细胞并且具有优异的体内稳定性的羧化甘露聚糖包被的超顺磁性MRI造影剂的磁共振成像（MRI）造影剂及其制备方法。 用本发明的羧化甘露聚糖涂覆的MRI造影剂可以由于其高表面负电荷而提供优异的体内稳定性和生物相容性，并且由于甘露聚糖的甘露糖可以特异性地引入抗原呈递细胞中，从而使抗原呈递 细胞和含有抗原呈递细胞的组织。
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6.发明授权Bacteriophage having bactericidal activity with respect to Actinobacillus pleuropneumoniae 有权对放线杆菌胸膜肺炎放线芽孢杆菌具有杀菌活性的噬菌体公开(公告)号：US09309498B2
公开(公告)日：2016-04-12
申请号：US14349899
申请日：2012-03-22
申请人： Ji Hoon Kim , Tae Gyu Kim , Seong Jun Yoon , Soo Youn Jun , Sang Hyeon Kang , Jung Min Kim , Shuk Ho Kim
发明人： Ji Hoon Kim , Tae Gyu Kim , Seong Jun Yoon , Soo Youn Jun , Sang Hyeon Kang , Jung Min Kim , Shuk Ho Kim
CPC分类号： C12N7/00 , A61K35/76 , C12N2795/00021 , C12N2795/00032 , C12N2795/10032
摘要： The present invention relates to a bacteriophage having bactericidal activity against Actinobacillus pleuropneumoniae. Bacteriophage PA1Φ can infect Actinobacillus pleuropneumoniae and kill the same bacteria and is characterized by the genome of 34,553 by represented by SEQ ID NO: 1.
摘要翻译： 本发明涉及对放线杆菌胸膜肺炎放线芽孢杆菌具有杀菌活性的噬菌体。 噬菌体PA1Φ可以感染放线杆菌胸膜肺炎放线芽孢杆菌并杀死相同的细菌，其特征在于由SEQ ID NO：1表示的34,553基因组。
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7.发明申请BACTERIOPHAGE HAVING BACTERICIDAL ACTIVITY WITH RESPECT TO ACTINOBACILLUS PLEUROPNEUMONIAE 有权对ACTINOBACILLUS PLEUROPNEUMONIAE具有杀菌活性的细菌公开(公告)号：US20140377842A1
公开(公告)日：2014-12-25
申请号：US14349899
申请日：2012-03-22
申请人： Ji Hoon Kim , Tae Gyu Kim , Seong Jun Yoon , Soo Youn Jun , Sang Hyeon Kang , Jung Min Kim , Shuk Ho Kim
发明人： Ji Hoon Kim , Tae Gyu Kim , Seong Jun Yoon , Soo Youn Jun , Sang Hyeon Kang , Jung Min Kim , Shuk Ho Kim
IPC分类号： C12N7/00
CPC分类号： C12N7/00 , A61K35/76 , C12N2795/00021 , C12N2795/00032 , C12N2795/10032
摘要： The present invention relates to a bacteriophage having bactericidal activity against Actinobacillus pleuropneumoniae. Bacteriophage PA1Φ can infect Actinobacillus pleuropneumoniae and kill the same bacteria and is characterized by the genome of 34,553 by represented by SEQ ID NO: 1.
摘要翻译： 本发明涉及对放线杆菌胸膜肺炎放线芽孢杆菌具有杀菌活性的噬菌体。 噬菌体PA1Φ可以感染放线杆菌胸膜肺炎放线芽孢杆菌并杀死相同的细菌，其特征在于由SEQ ID NO：1表示的34,553基因组。
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8.发明申请MRI CONTRAST AGENT COATED WITH CARBOXYLATED MANNAN AND METHOD FOR PRODUCING THE SAME 有权用对羧基苯甲酰胺涂覆的MRI对比剂及其生产方法公开(公告)号：US20120230919A1
公开(公告)日：2012-09-13
申请号：US13087816
申请日：2011-04-15
申请人： Seong Jun YOON , Soo Youn JUN , An Sung KWON , Sang Hyeon KANG , Yong Yeon JEONG , In Kyu PARK , Chong Su CHO , You Kyoung KIM , Won Jong KIM , Ran NAMGUNG
发明人： Seong Jun YOON , Soo Youn JUN , An Sung KWON , Sang Hyeon KANG , Yong Yeon JEONG , In Kyu PARK , Chong Su CHO , You Kyoung KIM , Won Jong KIM , Ran NAMGUNG
CPC分类号： A61K49/1863 , B82Y15/00 , B82Y40/00 , Y10S977/773 , Y10S977/89 , Y10S977/93
摘要： The present invention relates to a magnetic resonance imaging (MRI) contrast agent coated with carboxylated mannan, particularly a carboxylated mannan coated superparamagnetic MRI contrast agent specifically targeting antigen presenting cells and having excellent in vivo stability, and a method for producing the same. The MRI contrast agent coated with carboxylated mannan of the present invention can provide excellent in vivo stability and biocompatibility owing to its high surface negative charge, and can be introduced specifically into antigen presenting cells owing to mannose of mannan, so as to visualize the antigen presenting cells and the tissue containing the antigen presenting cells in MRI.
摘要翻译： 本发明涉及涂覆有羧化甘露聚糖，特别是特异性靶向抗原呈递细胞并且具有优异的体内稳定性的羧化甘露聚糖包被的超顺磁性MRI造影剂的磁共振成像（MRI）造影剂及其制备方法。 用本发明的羧化甘露聚糖涂覆的MRI造影剂可以由于其高表面负电荷而提供优异的体内稳定性和生物相容性，并且由于甘露聚糖的甘露糖可以特异性地引入抗原呈递细胞中，从而使抗原呈递 细胞和含有抗原呈递细胞的组织。
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