公开(公告)号：US20070072264A1

公开(公告)日：2007-03-29

申请号：US11421433

申请日：2006-05-31

申请人： Sin Hyeog Im ,  Hwa-Joong Yi ,  Jae So

发明人： Sin Hyeog Im ,  Hwa-Joong Yi ,  Jae So

IPC分类号： A61K38/17 ,  C07K14/705 ,  C07H21/04 ,  C12P21/06

CPC分类号： C07K14/4756

摘要： The present invention relates to recombinant acetylcholine receptor polypeptides recognized by CD4 T cells of a myasthenia gravis patient and compositions for the treatment of myasthenia gravis containing the same as an effective ingredient, more precisely, recombinant acetylcholine receptor polypeptides deficient in B cell epitope, recombinant acetylcholine polypeptides in which two or more T cell epitopes are fused, a composition for the treatment of myasthenia gravis containing the above recombinant polypeptides as an effective ingredient and a treatment method for myasthenia gravis using the composition. The composition containing one or more recombinant polypeptides above can be effectively used as a myasthenia gravis specific therapeutic agent or immunomodulator without side effects.

摘要翻译： 本发明涉及由重症肌无力患者的CD4T细胞识别的重组乙酰胆碱受体多肽和用于治疗重症肌无力的组合物，其含有与有效成分相同的重组乙酰胆碱受体多肽，更确切地说，是缺乏B细胞表位的重组乙酰胆碱受体多肽，重组乙酰胆碱 其中两个或多个T细胞表位融合的多肽，用于治疗含有上述重组多肽作为有效成分的重症肌无力的组合物和使用该组合物的重症肌无力治疗方法。 含有上述一种或多种重组多肽的组合物可以有效地用作重症肌无力特异性治疗剂或免疫调节剂而没有副作用。

公开(公告)号：US20110052644A1

公开(公告)日：2011-03-03

申请号：US12914613

申请日：2010-10-28

申请人： Byoung Seob KO ,  Won Kyung JEON ,  Sin-Hyeog IM ,  Ho-Keun KWON ,  Ji-Sun HWANG ,  Dae Young KWON

发明人： Byoung Seob KO ,  Won Kyung JEON ,  Sin-Hyeog IM ,  Ho-Keun KWON ,  Ji-Sun HWANG ,  Dae Young KWON

IPC分类号： A61K36/54 ,  A61P37/04 ,  A61P1/00

CPC分类号： A61K36/54 ,  A23L33/105

摘要： The present invention relates to a composition for improving intestinal flora and enhancing immune response containing Cinnamomum cassia bark extract as an effective ingredient, more precisely, a composition containing Cinnamomum cassia bark extract is an effective ingredient that has the effects of increasing the growth of such intestinal beneficial bacteria as Bifidobacterium longum, Lacotobacillus sp. and Lactobacillus acidophilus and enhancing the proliferation of immune cells such as lymphocytes of general immune system as well as increasing the activity of intestinal immune cells. The composition of the present invention can be effectively used as a therapeutic agent for constipation or other intestine-related diseases and an immune enhancer owing to its activity of increasing immunity, particularly intestinal immunity, by increasing immune cell proliferation.

摘要翻译： 本发明涉及一种用于改善肠道菌群并增强含有肉桂樟树皮提取物的免疫应答的组合物作为有效成分，更确切地说，含有肉桂肉桂树皮提取物的组合物是具有增加肠道生长的作用的有效成分 有益菌作为长双歧杆菌，Lacotobacillus sp。 和嗜酸乳杆菌，并增强免疫细胞如淋巴细胞免疫系统的增殖，增加肠道免疫细胞的活性。 由于增加免疫细胞增殖，本发明的组合物可以有效地用作便秘或其它肠道相关疾病和免疫增强剂的治疗剂，因为其增加免疫力，特别是肠道免疫的活性。

公开(公告)号：US20090028840A1

公开(公告)日：2009-01-29

申请号：US12091257

申请日：2006-09-22

申请人： Sin Hyeog Im ,  Jae Seon So ,  Hwa Joong Yi

发明人： Sin Hyeog Im ,  Jae Seon So ,  Hwa Joong Yi

IPC分类号： A61K35/74

CPC分类号： A61K35/747 ,  A23L33/105 ,  A23L33/135 ,  A23L33/17 ,  A23Y2220/03 ,  A23Y2220/15 ,  A23Y2220/17 ,  A23Y2220/29 ,  A23Y2220/35 ,  A23Y2220/37 ,  A23Y2220/39 ,  A23Y2240/33 ,  A23Y2240/41 ,  A23Y2240/75 ,  A23Y2300/25 ,  A23Y2300/29 ,  A23Y2300/45 ,  A23Y2300/55 ,  A61K31/7008 ,  A61K35/744 ,  A61K36/185 ,  A61K36/46 ,  A61K36/732 ,  A61K36/8994 ,  A61K38/014 ,  A61K38/39 ,  A61K2300/00

摘要： The present invention relates to a composition for preventing or treating arthritis, which comprises a lactic acid bacterium and collagen as major active ingredients. The present composition shows excellent prevention or treatment efficacies on arthritis of animal models. In addition, since the active ingredients used in the composition of this invention have been recognized to be safe to human, the present composition has considerable safety with enhanced immunomodulatory effect in patients with arthritis.

摘要翻译： 本发明涉及一种用于预防或治疗关节炎的组合物，其包含乳酸菌和胶原作为主要活性成分。 本发明组合物对动物模型的关节炎具有优异的预防或治疗功效。 此外，由于本发明组合物中使用的活性成分已经被认为对人来说是安全的，所以本发明的组合物具有相当大的安全性，并且在患有关节炎的患者中具有增强的免疫调节作用。

公开(公告)号：US07777003B2

公开(公告)日：2010-08-17

申请号：US11421433

申请日：2006-05-31

申请人： Sin Hyeog Im ,  Hwa Joong Yi ,  Jae Seon So

发明人： Sin Hyeog Im ,  Hwa Joong Yi ,  Jae Seon So

IPC分类号： C07K14/705 ,  C07K19/00

CPC分类号： C07K14/4756

摘要： The present invention relates to recombinant acetylcholine receptor polypeptides recognized by CD4 T cells of a myasthenia gravis patient and compositions for the treatment of myasthenia gravis containing the same as an effective ingredient, more precisely, recombinant acetylcholine receptor polypeptides deficient in B cell epitope, recombinant acetylcholine polypeptides in which two or more T cell epitopes are fused, a composition for the treatment of myasthenia gravis containing the above recombinant polypeptides as an effective ingredient and a treatment method for myasthenia gravis using the composition. The composition containing one or more recombinant polypeptides above can be effectively used as a myasthenia gravis specific therapeutic agent or immunomodulator without side effects.

摘要翻译： 本发明涉及由重症肌无力患者的CD4T细胞识别的重组乙酰胆碱受体多肽和用于治疗重症肌无力的组合物，其含有与有效成分相同的重组乙酰胆碱受体多肽，更确切地说，是缺乏B细胞表位的重组乙酰胆碱受体多肽，重组乙酰胆碱 其中两个或多个T细胞表位融合的多肽，用于治疗含有上述重组多肽作为有效成分的重症肌无力的组合物和使用该组合物的重症肌无力治疗方法。 含有上述一种或多种重组多肽的组合物可以有效地用作重症肌无力特异性治疗剂或免疫调节剂而没有副作用。

公开(公告)号：US20090317498A1

公开(公告)日：2009-12-24

申请号：US11916189

申请日：2006-10-25

申请人： Byoung Seob Ko ,  Won Kyung Jeon ,  Sin-Hyeog Im ,  Ho-Keun Kwon ,  Ji-Sun Hwang ,  Dae Young Kwon

发明人： Byoung Seob Ko ,  Won Kyung Jeon ,  Sin-Hyeog Im ,  Ho-Keun Kwon ,  Ji-Sun Hwang ,  Dae Young Kwon

IPC分类号： A61K36/54 ,  A61P1/00

CPC分类号： A61K36/54 ,  A23L33/105

摘要： The present invention relates to a composition for improving intestinal flora and enhancing immune response containing Cinnamomum cassia bark extract as an effective ingredient, more precisely, a composition containing Cinnamomum cassia bark extract is an effective ingredient that has the effects of increasing the growth of such intestinal beneficial bacteria as Bifidobacterium longum, Lactobacillus sp. and Lactobacillus acidophilus and enhancing the proliferation of immune cells such as lymphocytes of general immune system as well as increasing the activity of intestinal immune cells. The composition of the present invention can be effectively used as a therapeutic agent for constipation or other intestine-related diseases and an immune enhancer owing to its activity of increasing immunity, particularly intestinal immunity, by increasing immune cell proliferation.

摘要翻译： 本发明涉及一种用于改善肠道菌群并增强含有肉桂樟树皮提取物的免疫应答的组合物作为有效成分，更确切地说，含有肉桂肉桂树皮提取物的组合物是具有增加肠道生长的作用的有效成分 有益菌长双歧杆菌，乳杆菌属 和嗜酸乳杆菌，并增强免疫细胞如淋巴细胞免疫系统的增殖，增加肠道免疫细胞的活性。 由于增加免疫细胞增殖，本发明的组合物可以有效地用作便秘或其它肠道相关疾病和免疫增强剂的治疗剂，因为其增加免疫力，特别是肠道免疫的活性。