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18 条记录 (耗时 0.05 秒)

    Amino Acid Derivatives
    2.
    发明申请
    Amino Acid Derivatives 审中-公开
    氨基酸衍生物

    公开(公告)号：US20090227680A1

    公开(公告)日：2009-09-10

    申请号：US12093503

    申请日：2006-11-06

    申请人： Simon John Mantell

    发明人： Simon John Mantell

    IPC分类号： A61K31/195 ,  C07C62/00

    CPC分类号： C07C229/22

    摘要： The present invention relates to a method of treating pain using a compound of formula (I), wherein Ar, R1, R3 and R3a are as defined herein. The invention also relates to certain novel compounds of formula (I).

    摘要翻译： 本发明涉及使用式（I）化合物治疗疼痛的方法，其中Ar，R 1，R 3和R 3a如本文所定义。 本发明还涉及某些新的式（I）化合物。

    Purine derivatives
    10.
    发明授权
    Purine derivatives 失效
    嘌呤衍生物

    公开(公告)号：US06624158B2

    公开(公告)日：2003-09-23

    申请号：US09933421

    申请日：2001-08-20

    申请人： Simon John Mantell ,  Peter Thomas Stephenson

    发明人： Simon John Mantell ,  Peter Thomas Stephenson

    IPC分类号： C07D47334

    CPC分类号： C07H19/16

    摘要： The present invention relates to compounds of the formula and pharmaceutically acceptable salts and solvates thereof, wherein R2 is —CH2NHSO2—A—R3, —CONR10—A1—R11, —X—NR12a—Y—NR13R14 or —CO—NR18—X1—NR12—Y—NR13R14; R19, where R19 is a C-linked, 5-membered aromatic heterocycle containing either (i) from 1 to 4 ring nitrogen atoms or (ii) 1 or 2 ring nitrogen atoms and 1 oxygen or 1 sulphur ring atom, said heterocycle being optionally substituted by C1-C6 alkyl, said C1-C6 alkyl being optionally substituted by phenyl, —OH, C1-C6 alkoxy or —NR20R21 and R1, A, R3, R10, R11, X, R12a, Y, R13, R14, R18, X1, R21 and R22 are as defined in the specification. The invention also relates to processes for the preparation of, intermediates used in the preparation of, and compositions containing such compounds and the uses of such compounds as adenosine A2a receptor agonists. The invention is particularly related to methods of treating respiratory diseases such as adult respiratory distress syndrome, bronchitis, chronic bronchitis, chronic obstructive pulmonary disease, cystic fibrosis, asthma, emphysema bronchiectasis, chronic sinusitis and rhinitis.

    摘要翻译： 本发明涉及式及其药学上可接受的盐和溶剂化物，其中R 2是-CH 2 NHSO 2 -AR 3，-CONR 10 -A 1 -R 11，-X-NR -Y-NR 13 R 14或-CO-NR 18 -X 1 -NR 12 -Y-NR 13 R 14; 其中R 19是含有（i）1至4个环氮原子或（ii）1或2个环氮原子和1个氧或1个硫环的C连接的5元芳族杂环 所述杂环任选被C 1 -C 6烷基取代，所述C 1 -C 6烷基任选被苯基，-OH，C 1 -C 6烷氧基或-NR 20 R 21和R 1取代，A，R R 10，R 11，X，R 12a，Y，R 13，R 14，R 18，X 1，R 21和R 11， 22>如说明书中所定义。 本发明还涉及用于制备用于制备中间体的方法和含有这些化合物的组合物以及这些化合物作为腺苷A2a受体激动剂的用途。 本发明特别涉及治疗呼吸系统疾病如成人呼吸窘迫综合征，支气管炎，慢性支气管炎，慢性阻塞性肺病，囊性纤维化，哮喘，肺气肿支气管扩张，慢性鼻窦炎和鼻炎的方法。