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公开(公告)号：US20210220396A1
公开(公告)日：2021-07-22
申请号：US16972090
申请日：2019-06-04
发明人： Darren Wolfe , James Connor
摘要： Disclosed is a composition comprising a microbe expressing ferritin. The composition also comprises elemental iron in an amount of at least 3% by weight on a dry matter basis of the microbe expressing ferritin and the elemental iron. Also disclosed are ingestibles, dietary supplements, and pharmaceutical compositions comprising the composition. Also disclosed are methods for treating a subject comprising administering the composition to the subject. Also disclosed are methods of altering the composition of the gut bacterial microbiome in a subject, the method comprising administering the composition to the subject.
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公开(公告)号：US20240238335A1
公开(公告)日：2024-07-18
申请号：US18561528
申请日：2022-05-19
发明人： James Connor , Ralph Keil , Darren Wolfe
IPC分类号： A61K33/26 , A61K36/064 , A61K38/17 , A61P7/06
CPC分类号： A61K33/26 , A61K36/064 , A61K38/1709 , A61P7/06
摘要： A method comprising administering to a subject a composition comprising a microbe expressing ferritin or (a) a microbe expressing ferritin and (b) elemental iron, wherein the amount of elemental iron in the composition administered (1) to a subject not diagnosed with an iron deficiency disorder can exceed or is in excess of a dosage of elemental iron recommended by a nutritional authority or (2) to a subject diagnosed with an iron deficiency disorder can exceed or is in excess of a dosage of elemental iron recommended by a medical professional without an adverse effect. A method or a method of altering a composition of a gut bacterial microbiome in a subject comprising administering to a subject a composition comprising of a microbe or host expressing ferritin, with the proviso that when a daily dosage of ferritin in the composition is less than 200 milligrams/day, the composition is free of elemental iron.
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公开(公告)号：US12064449B2
公开(公告)日：2024-08-20
申请号：US16972090
申请日：2019-06-04
发明人： Darren Wolfe , James Connor
摘要： Disclosed is a composition comprising a microbe expressing ferritin. The composition also comprises elemental iron in an amount of at least 3% by weight on a dry matter basis of the microbe expressing ferritin and the elemental iron. Also disclosed are ingestibles, dietary supplements, and pharmaceutical compositions comprising the composition. Also disclosed are methods for treating a subject comprising administering the composition to the subject. Also disclosed are methods of altering the composition of the gut bacterial microbiome in a subject, the method comprising administering the composition to the subject.
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公开(公告)号：US20240252568A1
公开(公告)日：2024-08-01
申请号：US18561439
申请日：2022-05-19
发明人： Ralph Keil , James Connor , Darren Wolfe
CPC分类号： A61K36/064 , A23L33/14 , A61K33/26 , C07K14/47 , C12N1/16 , A61K38/00 , C12R2001/865
摘要： Disclosed herein are recombinant hosts comprising at least a first set of chromosomes and a second set of chromosomes, wherein at least one of the first set of chromosomes and the second set of chromosomes comprises a recombinant gene encoding ferritin or a homologue thereof. Also disclosed herein are recombinant hosts comprising a prototroph comprising a recombinant gene encoding ferritin or a homologue thereof. The recombinant hosts may be included in compositions, ingestible items, dietary supplements or pharmaceutical compositions. Also disclosed herein are methods of administering to a subject a composition of the present invention.
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