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公开(公告)号：US06602970B2
公开(公告)日：2003-08-05
申请号：US09878928
申请日：2001-06-13
Applicant: Yushi Ando , Seitaro Tajima , Yoshiharu Ohashi , Haruhiko Takeya , Setsuko Miyanari , Toshihiro Kobori
Inventor： Yushi Ando , Seitaro Tajima , Yoshiharu Ohashi , Haruhiko Takeya , Setsuko Miyanari , Toshihiro Kobori
IPC: C08F22236
CPC classification number: C08F222/32 , C09J4/00
Abstract: A 2-cyanoacrylate composition comprising a cyclic phenol sulfide derivative. The composition has a high curing rate and is excellent in moist-heat resistance, surface curability and clearance curability.
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公开(公告)号：US08563605B2
公开(公告)日：2013-10-22
申请号：US12736782
申请日：2009-05-13
Applicant: Setsuko Miyanari , Masumi Takahashi , Masahiro Ishizuka , Tohru Tanaka
Inventor： Setsuko Miyanari , Masumi Takahashi , Masahiro Ishizuka , Tohru Tanaka
IPC: A01N55/02 , A61K31/295
CPC classification number: A61K31/197 , A23L33/10 , A23L33/16 , A61K33/26 , A61K2300/00
Abstract: The present invention is intended to provide an agent for treating male infertility which is highly effective to male infertility, and having few side effects. To achieve the object, an agent for treating male infertility comprising δ-amino levulinic acid shown by general formula (1), its derivative or salt thereof: R2R1NCH2COCH2CH2COR3 (1) [wherein R1 and R2 independently represent a hydrogen atom, alkyl group, acyl group, alkoxycarbonyl group, aryl group, or aralkyl group; R3 represents a hydroxy group, alkoxy group, acyloxy group, alkoxycarbonyloxy group, aryloxy group, aralkyloxy group or amino group] can be used.
Abstract translation: 本发明旨在提供一种治疗男性不育症的药剂，其对男性不育症具有高度有效性，并且副作用很少。 为了达到上述目的，本发明提供一种治疗男性不育症的药剂，其含有通式（1）所示的δ-氨基乙酰丙酸，其衍生物或其盐：R2R1NCH2COCH2CH2COR3（1）[其中R1和R2独立地表示氢原子，烷基，酰基 基团，烷氧基羰基，芳基或芳烷基; R3表示羟基，烷氧基，酰氧基，烷氧基羰基氧基，芳氧基，芳烷氧基或氨基]。
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公开(公告)号：US20100173780A1
公开(公告)日：2010-07-08
申请号：US12376865
申请日：2007-07-18
Applicant: Masao Kondo , Naomi Aiba , Setsuko Miyanari , Masahiro Ishizuka , Tohru Tanaka
Inventor： Masao Kondo , Naomi Aiba , Setsuko Miyanari , Masahiro Ishizuka , Tohru Tanaka
IPC: C07C229/24 , A01N37/02
CPC classification number: A01N37/44
Abstract: To provide a polyphenol-content-increasing agent which increases the content of polyphenol in a plant. A polyphenol-content-increasing agent for plant, containing, as an active ingredient, a 5-aminolevulinic acid or a derivative thereof represented by the following formula (1):(Chem 1) R2R1NCH2COCH2CH2COR3 (1) wherein R1 and R2 each independently represents a hydrogen atom, an alkyl group, an acyl group, an alkoxycarbonyl group, an aryl group, or an aralkyl group; R3 represents a hydroxyl group, an alkoxy group which may have a substituent, an acyloxy group, an alkoxycarbonyloxy group, an aryloxy group, an aralkyloxy group, or an amino group, or a salt thereof.
Abstract translation: 提供增加植物中多酚含量的多酚含量增加剂。 含有下述式（1）所示的5-氨基乙酰丙酸或其衍生物作为活性成分的植物多酚含量增加剂：（化学式1）R2R1NCH2COCH2CH2COR3（1）其中R1和R2各自独立地表示 氢原子，烷基，酰基，烷氧基羰基，芳基或芳烷基; R3表示羟基，可以具有取代基的烷氧基，酰氧基，烷氧基羰基氧基，芳氧基，芳烷氧基或氨基，或其盐。
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公开(公告)号：US20080026075A1
公开(公告)日：2008-01-31
申请号：US11661688
申请日：2005-08-26
Applicant: Masao Kondo , Naomi Aiba , Setsuko Miyanari , Tohru Tanaka , Takaya Suzuki , Masahiro Ishizuka
Inventor： Masao Kondo , Naomi Aiba , Setsuko Miyanari , Tohru Tanaka , Takaya Suzuki , Masahiro Ishizuka
CPC classification number: A61K31/197 , A23K20/142 , A23K20/24 , A23K20/30 , A23L33/16 , A23L33/175 , A61K33/26 , A61K33/34 , A61K45/06 , A61K2300/00
Abstract: Health function-improving agents, such as an immunological function-improving agent, an antioxidation function-improving agent, a exercise function-improving agent and a liver function-improving agent, comprising, as an effective ingredient, a δ-amino acid, a derivative thereof or a salt thereof
Abstract translation: 健康功能改善剂，诸如免疫功能改善剂，抗氧化功能改善剂，运动功能改善剂和肝功能改善剂，其包含作为有效成分的δ-氨基酸， 衍生物或其盐
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Patent Agency Ranking5.发明授权Cyclic phenol sulfide having at least one sulfinyl or sulfonyl group and process for producing the same 失效具有至少一个亚磺酰基或磺酰基的环状苯酚硫化物及其制备方法
公开(公告)号：US05998631A
公开(公告)日：1999-12-07
申请号：US68583
申请日：1998-05-06
Applicant: Hitoshi Kumagai , Setsuko Miyanari , Sotaro Miyano
Inventor： Hitoshi Kumagai , Setsuko Miyanari , Sotaro Miyano
IPC: C07D341/00 , C07D409/14
CPC classification number: C07D341/00
Abstract: A cyclic phenol sulfide containing at least one sulfinyl or sulfonyl group represented by formula (1): ##STR1## wherein X represents a hydrogen atom, a hydrocarbon group, or an acyl group; Y represents a hydrogen atom, a hydrocarbon group, a halogenated hydrocarbon group, --COR.sup.1, --OR.sup.2, --COOR.sup.3, --CN, --CONH.sub.2, --NO.sub.2, --NR.sup.4 R.sup.5, a halogen atom, --SO.sub.4 R.sup.6, or --SO.sub.3 R.sup.7, in which R.sup.1, R.sup.2, R.sup.3, R.sup.4, R.sup.5, R.sup.6, and R.sup.7 each represents a hydrogen atom or a hydrocarbon group; Z represents one member selected from the group consisting of S, a sulfinyl group, and a sulfonyl group; and n represents an integer of 4 to 12, provided that the plural X's or the plural Y's are the same or different, and that at least one of the plural Z's is a sulfinyl group or a sulfonyl group, and a process for producing the same.
Abstract translation: PCT No.PCT / JP97 / 02789第 371日期：1998年5月6日 102（e）日期1998年5月6日PCT提交1997年8月8日PCT公布。 公开号WO98 / 09959 日期：1998年3月12日一种含有至少一个由式（1）表示的亚磺酰基或磺酰基的环状苯酚硫化物：其中X表示氢原子，烃基或酰基; Y表示氢原子，烃基，卤代烃基，-COR1，-OR2，-COOR3，-CN，-CONH2，-NO2，-NR4R5，卤素原子，-SO4R6或-SO3R7，其中R1 ，R2，R3，R4，R5，R6和R7各自表示氢原子或烃基; Z表示选自S，亚磺酰基和磺酰基的一个基团; n表示4〜12的整数，条件是所述多个X或多个Y相同或不同，所述多个Z中的至少一个为亚磺酰基或磺酰基，其制造方法 。
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公开(公告)号：US08790712B2
公开(公告)日：2014-07-29
申请号：US11661688
申请日：2005-08-26
Applicant: Masao Kondo , Naomi Aiba , Setsuko Miyanari , Tohru Tanaka , Takaya Suzuki , Masahiro Ishizuka
Inventor： Masao Kondo , Naomi Aiba , Setsuko Miyanari , Tohru Tanaka , Takaya Suzuki , Masahiro Ishizuka
IPC: A61K33/34
CPC classification number: A61K31/197 , A23K20/142 , A23K20/24 , A23K20/30 , A23L33/16 , A23L33/175 , A61K33/26 , A61K33/34 , A61K45/06 , A61K2300/00
Abstract: The present invention is drawn to a method of inducing thymocyte proliferation in a vertebrate animal with an impaired immune system comprising administering δ-aminolevulinic acid or a salt thereof every day in succession. The method further comprises administering at least one mineral.
Abstract translation: 本发明涉及在具有受损免疫系统的脊椎动物中诱导胸腺细胞增殖的方法，包括每天连续施用δ-氨基乙酰丙酸或其盐。 该方法还包括施用至少一种矿物质。
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公开(公告)号：US08309493B2
公开(公告)日：2012-11-13
申请号：US12376865
申请日：2007-07-18
Applicant: Masao Kondo , Naomi Aiba , Setsuko Miyanari , Masahiro Ishizuka , Tohru Tanaka
Inventor： Masao Kondo , Naomi Aiba , Setsuko Miyanari , Masahiro Ishizuka , Tohru Tanaka
CPC classification number: A01N37/44
Abstract: To provide a polyphenol-content-increasing agent which increases the content of polyphenol in a plant.A polyphenol-content-increasing agent for plant, containing, as an active ingredient, a 5-aminolevulinic acid or a derivative thereof represented by the following formula (1):(Chem 1) R2R1NCH2COCH2CH2COR3 (1) wherein R1 and R2 each independently represents a hydrogen atom, an alkyl group, an acyl group, an alkoxycarbonyl group, an aryl group, or an aralkyl group; R3 represents a hydroxyl group, an alkoxy group which may have a substituent, an acyloxy group, an alkoxycarbonyloxy group, an aryloxy group, an aralkyloxy group, or an amino group, or a salt thereof.
Abstract translation: 提供增加植物中多酚含量的多酚含量增加剂。 含有下述式（1）所示的5-氨基乙酰丙酸或其衍生物作为活性成分的植物多酚含量增加剂：（化学式1）R2R1NCH2COCH2CH2COR3（1）其中R1和R2各自独立地表示 氢原子，烷基，酰基，烷氧基羰基，芳基或芳烷基; R3表示羟基，可以具有取代基的烷氧基，酰氧基，烷氧基羰基氧基，芳氧基，芳烷氧基或氨基，或其盐。
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公开(公告)号：US20110065787A1
公开(公告)日：2011-03-17
申请号：US12736782
申请日：2009-05-13
Applicant: Setsuko Miyanari , Masumi Takahashi , Masahiro Ishizuka , Tohru Tanaka
Inventor： Setsuko Miyanari , Masumi Takahashi , Masahiro Ishizuka , Tohru Tanaka
IPC: A61K31/295 , A61K31/197 , A61P15/08 , A61P15/10
CPC classification number: A61K31/197 , A23L33/10 , A23L33/16 , A61K33/26 , A61K2300/00
Abstract: The present invention is intended to provide an agent for treating male infertility which is highly effective to male infertility, and having few side effects. To achieve the object, an agent for treating male infertility comprising δ-amino levulinic acid shown by general formula (1), its derivative or salt thereof: R2R1NCH2COCH2CH2COR3 (1) [wherein R1 and R2 independently represent a hydrogen atom, alkyl group, acyl group, alkoxycarbonyl group, aryl group, or aralkyl group; R3 represents a hydroxy group, alkoxy group, acyloxy group, alkoxycarbonyloxy group, aryloxy group, aralkyloxy group or amino group] can be used.
Abstract translation: 本发明旨在提供一种治疗男性不育症的药剂，其对男性不育症具有高度有效性，并且副作用很少。 为了达到上述目的，可以列举通式（1）所示的δ-氨基乙酰丙酸及其衍生物或其盐的治疗男性不育症的药剂：R2R1NCH2COCH2CH2COR3（1）[式中，R1和R2分别表示氢原子，烷基，酰基 基团，烷氧基羰基，芳基或芳烷基; R3表示羟基，烷氧基，酰氧基，烷氧基羰基氧基，芳氧基，芳烷氧基或氨基]。
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9.发明授权SULFONATED DERIVATIVES OF CYCLIC PHENOL SULFIDES, PROCESS FOR THE PREPARATION THEREOF, SEPARATING AND RECOVERING AGENTS CONTAINING CYCLIC PHENOL SULFIDES, METHODS FOR SEPARATION AND RECOVERY THEREWITH, AND DRUG COMPOSITIONS CONTAINING THE SULFIDES 有权循环酚硫化物的硫化衍生物，其制备方法，包含环状酚醛硫酸盐的分离和还原剂，其分离和回收方法以及含有硫化物的药物组合物公开(公告)号：US06355671B1
公开(公告)日：2002-03-12
申请号：US09581089
申请日：2000-06-09
Applicant: Sotaro Miyano , Nobuhiko Iki , Toyohisa Fujimoto , Fumio Hamada , Shingo Kato , Yoshiyuki Hiraishi , Hitoshi Kumagai , Mitsuharu Hasegawa , Setsuko Miyanari , Yoshihiro Sugawa , Masahiro Ishizuka
Inventor： Sotaro Miyano , Nobuhiko Iki , Toyohisa Fujimoto , Fumio Hamada , Shingo Kato , Yoshiyuki Hiraishi , Hitoshi Kumagai , Mitsuharu Hasegawa , Setsuko Miyanari , Yoshihiro Sugawa , Masahiro Ishizuka
IPC: A61K3138
Abstract: A sulfonic acid compound of a cyclic phenol sulfide represented by formula (1): (wherein X represents a hydrogen atom, a hydrocarbon group, or an acyl group; M represents a hydrogen atom, an alkyl group, a metal, ammonium, (lower-alkyl)ammonium, (lower-alkanol)ammonium, a nitrogen-containing heterocyclic group, or an amino acid residue; Z represents Sm, SO, or SO2; m is an integer of from 1 to 7; and n is an integer of from 4 to 12, with the proviso that the plural X's, M's and Z's are each the same or different, and at least one of the plural M's is neither a hydrogen atom nor an alkyl group), or a salt thereof; a composition for separating and recovering an organic halogen compound or a monocyclic aromatic compound, comprising a cyclic phenol sulfide or a salt thereof, and a carrier; and a pharmaceutical composition a cyclic phenol sulfide or a pharmaceutically acceptable salt, and a carrier.
Abstract translation: 由式（1）表示的环状苯酚硫化物的磺酸化合物:(其中X表示氢原子，烃基或酰基; M表示氢原子，烷基，金属，铵，（低级 - 烷基）铵，（低级链烷醇）铵，含氮杂环基或氨基酸残基; Z表示Sm，SO或SO2; m为1至7的整数; n为 4至12，条件是复数X，M和Z各自相同或不同，并且多个M中的至少一个既不是氢原子也不是烷基）或其盐; 用于分离和回收有机卤素化合物或单环芳族化合物的组合物，其包含环状苯酚硫化物或其盐和载体; 和药物组合物，环状苯酚硫化物或药学上可接受的盐，以及载体。
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