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    DRUG-TRANSFER DEVICE, DRUG-DELIVERY SYSTEM INCORPORATING THE SAME, METHODS OF FABRICATING THE SAME, AND METHODS OF ENABLING ADMINISTRATION OF A DRUG
    2.
    发明申请
    DRUG-TRANSFER DEVICE, DRUG-DELIVERY SYSTEM INCORPORATING THE SAME, METHODS OF FABRICATING THE SAME, AND METHODS OF ENABLING ADMINISTRATION OF A DRUG 有权
    药物转移装置，与其同时使用的药物递送系统，其制备方法和使用药物管理的方法

    公开(公告)号：US20100331772A1

    公开(公告)日：2010-12-30

    申请号：US12495470

    申请日：2009-06-30

    申请人： Philipp Helmut Schmaelzle ,  Scott Albert Uhland

    发明人： Philipp Helmut Schmaelzle ,  Scott Albert Uhland

    IPC分类号： A61M37/00 ,  G06F17/00

    CPC分类号： A61J1/1437 ,  A61J3/00 ,  A61J7/0076 ,  B65B55/24

    摘要： Devices capable of deterring or preventing bulk extraction of drugs from, for example, drug-delivery systems are exemplarily disclosed. In one embodiment, such a device may include a package releasably retaining a drug and an agent. The agent is configured to suppress a physiological effect of the drug when the agent contacts the drug or is coadministered with the drug. The cell package is configured such that an amount of the drug is selectively releasable with respect to the agent when the package is operably proximate to an encoded key. The package, however, may be configured to impose a relatively high likelihood that either the drug will not be accessed or the drug will be contaminated by the agent if access to the contents of the package is sought without the use of an encoded key.

    摘要翻译： 示例性地公开了能够阻止或防止药物从例如药物递送系统中大量提取的装置。 在一个实施例中，这种装置可以包括可释放地保持药物和药剂的包装。 药剂配置成当药剂接触药物或与药物共同施用时抑制药物的生理作用。 细胞包装配置成使得当包装件可操作地接近编码的钥匙时，药物的量可以相对于药剂选择性地释放。 然而，该包装可能被配置为施加相对较高的可能性，即药物不会被访问，或者药物将被代理人污染，如果在不使用编码密钥的情况下访问包装的内容物。

    DRUG DEACTIVATION SYSTEM AND METHOD OF DEACTIVATING A DRUG USING THE SAME
    3.
    发明申请
    DRUG DEACTIVATION SYSTEM AND METHOD OF DEACTIVATING A DRUG USING THE SAME 有权
    药物消除系统及使用该药物的药物的消除方法

    公开(公告)号：US20100185037A1

    公开(公告)日：2010-07-22

    申请号：US12357224

    申请日：2009-01-21

    申请人： Scott Albert Uhland ,  Eric Peeters ,  Francisco E. Torres ,  Philipp Helmut Schmaelzle

    发明人： Scott Albert Uhland ,  Eric Peeters ,  Francisco E. Torres ,  Philipp Helmut Schmaelzle

    IPC分类号： A62D3/11

    CPC分类号： A61N7/00 ,  A61F7/00 ,  Y10S588/90

    摘要： A drug deactivation system according to some embodiments includes at least one drug-retaining region of a drug delivery device and at least one energy source coupled to the at least one drug-retaining region. The at least one drug-retaining region may be configured to retain a drug. The at least one energy source may be configured to transmit energy to the drug. The drug is capable of being rendered ineffective in the presence of the transmitted energy.

    摘要翻译： 根据一些实施方案的药物失活系统包括药物递送装置的至少一个药物保持区域和与至少一个药物保持区域耦合的至少一个能量源。 至少一个药物保持区域可以被配置为保留药物。 所述至少一个能量源可以被配置为向所述药物传输能量。 药物能够在传播能量的存在下变得无效。

    Drug-transfer device, drug-delivery system incorporating the same, methods of fabricating the same, and methods of enabling administration of a drug
    4.
    发明授权
    Drug-transfer device, drug-delivery system incorporating the same, methods of fabricating the same, and methods of enabling administration of a drug 有权
    药物转移装置，包含其的药物输送系统，其制备方法和能够施用药物的方法

    公开(公告)号：US08257736B2

    公开(公告)日：2012-09-04

    申请号：US12495494

    申请日：2009-06-30

    申请人： Philipp Helmut Schmaelzle ,  Scott Albert Uhland

    发明人： Philipp Helmut Schmaelzle ,  Scott Albert Uhland

    IPC分类号： B65D1/09

    CPC分类号： A61J3/00 ,  A61J1/1437 ,  A61J3/002 ,  A61J7/0076 ,  B65B11/50 ,  B65B55/24 ,  B65B2220/14 ,  B65B2230/02

    摘要： A method of fabricating a drug-transfer device includes forming a package having a first component retaining multiple volumes of a drug and a second component retaining an agent. The first component and the second component are integrally formed together. The agent is configured to suppress a physiological effect of the drug when the agent contacts the drug or is coadministered with the drug. The method allows exterior surfaces of the first and second components to be cleanable (e.g., prior to final assembly). After such cleaning, either no or substantially no amount of drug and agent is present outside the package. According to some embodiments, the package may be fabricated such that either no or substantially no amount of the drug is present within the second component and such that either no or substantially no amount of the agent is present within the first component.

    摘要翻译： 制备药物转移装置的方法包括形成具有保持多倍体积的药物的第一成分和保留药剂的第二成分的包装。 第一部件和第二部件一体地形成在一起。 药剂配置成当药剂接触药物或与药物共同施用时抑制药物的生理作用。 该方法允许第一和第二部件的外表面是可清洁的（例如，在最终组装之前）。 在这样的清洁之后，在包装之外没有或基本上没有量的药物和药剂存在。 根据一些实施方案，可以制造包装，使得在第二组分中不存在或基本上没有量的药物存在，并且使得在第一组分中不存在或基本上没有量的药剂存在。

    DRUG-TRANSFER DEVICE, DRUG-DELIVERY SYSTEM INCORPORATING THE SAME, METHODS OF FABRICATING THE SAME, AND METHODS OF ENABLING ADMINISTRATION OF A DRUG
    5.
    发明申请
    DRUG-TRANSFER DEVICE, DRUG-DELIVERY SYSTEM INCORPORATING THE SAME, METHODS OF FABRICATING THE SAME, AND METHODS OF ENABLING ADMINISTRATION OF A DRUG 有权
    药物转移装置，与其同时使用的药物递送系统，其制备方法以及使用药物管理的方法

    公开(公告)号：US20100326020A1

    公开(公告)日：2010-12-30

    申请号：US12495494

    申请日：2009-06-30

    申请人： Philipp Helmut Schmaelzle ,  Scott Albert Uhland

    发明人： Philipp Helmut Schmaelzle ,  Scott Albert Uhland

    IPC分类号： B65B5/10

    CPC分类号： A61J3/00 ,  A61J1/1437 ,  A61J3/002 ,  A61J7/0076 ,  B65B11/50 ,  B65B55/24 ,  B65B2220/14 ,  B65B2230/02

    摘要： A method of fabricating a drug-transfer device includes forming a package having a first component retaining multiple volumes of a drug and a second component retaining an agent. The first component and the second component are integrally formed together. The agent is configured to suppress a physiological effect of the drug when the agent contacts the drug or is coadministered with the drug. The method allows exterior surfaces of the first and second components to be cleanable (e.g., prior to final assembly). After such cleaning, either no or substantially no amount of drug and agent is present outside the package. According to some embodiments, the package may be fabricated such that either no or substantially no amount of the drug is present within the second component and such that either no or substantially no amount of the agent is present within the first component.

    摘要翻译： 制备药物转移装置的方法包括形成具有保持多倍体积的药物的第一成分和保留药剂的第二成分的包装。 第一部件和第二部件一体地形成在一起。 药剂配置成当药剂接触药物或与药物共同施用时抑制药物的生理作用。 该方法允许第一和第二部件的外表面是可清洁的（例如，在最终组装之前）。 在这样的清洁之后，在包装之外没有或基本上没有量的药物和药剂存在。 根据一些实施方案，可以制造包装，使得在第二组分中不存在或基本上没有量的药物存在，并且使得在第一组分中不存在或基本上没有量的药剂存在。

    Drug deactivation system and method of deactivating a drug using the same
    6.
    发明授权
    Drug deactivation system and method of deactivating a drug using the same 有权
    药物失活系统和使用其停用药物的方法

    公开(公告)号：US07838715B2

    公开(公告)日：2010-11-23

    申请号：US12357108

    申请日：2009-01-21

    申请人： Scott Albert Uhland ,  Eric Peeters ,  Francisco E. Torres ,  Philipp Helmut Schmaelzle

    发明人： Scott Albert Uhland ,  Eric Peeters ,  Francisco E. Torres ,  Philipp Helmut Schmaelzle

    IPC分类号： A62D3/30

    CPC分类号： A61K9/0002

    摘要： A drug deactivation system according to some embodiments includes at least one degradable capsule exposed to at least one drug-retaining region of a drug delivery device and an agent. The agent is configured to render a drug ineffective upon degradation of the at least one capsule. The at least one drug-retaining region is configured to retain one of the drug and the agent and the at least one capsule is configured to retain the other of the drug and the agent.

    摘要翻译： 根据一些实施方案的药物失活系统包括暴露于药物递送装置和药剂的至少一个药物保持区域的至少一个可降解胶囊。 该药剂配置成使药物对至少一个胶囊的降解无效。 所述至少一个药物保持区被配置为保留药物和药剂中的一种，并且所述至少一个胶囊被配置为保留药物和药剂中的另一个。

    Thermally-activated microchip chemical delivery devices
    7.
    发明授权
    Thermally-activated microchip chemical delivery devices 有权
    热敏微芯片化学输送装置

    公开(公告)号：US06527762B1

    公开(公告)日：2003-03-04

    申请号：US09638109

    申请日：2000-08-11

    申请人： John T. Santini, Jr. ,  Michael J. Cima ,  Scott Albert Uhland

    发明人： John T. Santini, Jr. ,  Michael J. Cima ,  Scott Albert Uhland

    IPC分类号： A61K911

    CPC分类号： B01L3/50853 ,  A61K9/0009 ,  A61K9/0024 ,  A61K9/0097 ,  B01L2300/0819 ,  B01L2400/0677

    摘要： Microchip delivery devices are provided that control both the rate and time of release of molecules, wherein the device includes a substrate, at least one reservoir in the substrate containing the molecules, and a reservoir cap positioned on the reservoir over the molecules, wherein the molecules are released from the reservoir upon heating or cooling the device or a portion thereof sufficient to rupture the reservoir cap. In a preferred embodiment, the device includes a resistor integrated into the reservoir or mounted near the reservoir, which upon application of an electric current through the resistor, causes at least one of the contents of the reservoir to thermally expand, vaporize, phase change, or undergo a thermally driven reaction, such that the reservoir cap ruptures due to mechanical stress. In another preferred embodiment, application of an electric current to a resistor located on or near the reservoir cap causes the cap to expand, contract, or undergo a phase change that results in the rupture of the reservoir cap. The reservoirs can contain multiple drugs or other molecules in variable dosages. Each of the reservoirs of a single microchip can contain different molecules and/or different amounts and concentrations, which can be released independently.

    摘要翻译： 提供Microchip输送装置，其控制释放分子的速率和时间，其中所述装置包括底物，所述基质中含有所述分子的至少一个储存器和位于所述分子上的所述储存器上的储存器盖，其中所述分子 在加热或冷却装置或其一部分足以破坏储存器盖时从储存器释放。 在优选实施例中，该装置包括集成在储存器中或安装在储存器附近的电阻器，当施加电流通过电阻器时，储存器的至少一个内容物热膨胀，蒸发，相变， 或经历热驱动反应，使得储存器盖由于机械应力而破裂。 在另一个优选实施例中，将电流施加到位于储存器盖上或附近的电阻器使得盖膨胀，收缩或经历相变，导致储存器盖的破裂。 储层可以含有多种药物或其他可变剂量的分子。 单个微芯片的每个储存器可以包含不同的分子和/或不同的量和浓度，其可以独立释放。

    Drug-transfer device, drug-delivery system incorporating the same, methods of fabricating the same, and methods of enabling administration of a drug
    8.
    发明授权
    Drug-transfer device, drug-delivery system incorporating the same, methods of fabricating the same, and methods of enabling administration of a drug 有权
    药物转移装置，包含其的药物输送系统，其制备方法和能够施用药物的方法

    公开(公告)号：US08313456B2

    公开(公告)日：2012-11-20

    申请号：US12495470

    申请日：2009-06-30

    申请人： Philipp Helmut Schmaelzle ,  Scott Albert Uhland

    发明人： Philipp Helmut Schmaelzle ,  Scott Albert Uhland

    IPC分类号： A61M31/00

    CPC分类号： A61J1/1437 ,  A61J3/00 ,  A61J7/0076 ,  B65B55/24

    摘要： Devices capable of deterring or preventing bulk extraction of drugs from, for example, drug-delivery systems are exemplarily disclosed. In one embodiment, such a device may include a package releasably retaining a drug and an agent. The agent is configured to suppress a physiological effect of the drug when the agent contacts the drug or is coadministered with the drug. The cell package is configured such that an amount of the drug is selectively releasable with respect to the agent when the package is operably proximate to an encoded key. The package, however, may be configured to impose a relatively high likelihood that either the drug will not be accessed or the drug will be contaminated by the agent if access to the contents of the package is sought without the use of an encoded key.

    摘要翻译： 示例性地公开了能够阻止或防止药物从例如药物递送系统中大量提取的装置。 在一个实施例中，这种装置可以包括可释放地保持药物和药剂的包装。 药剂配置成当药剂接触药物或与药物共同施用时抑制药物的生理作用。 细胞包装配置成使得当包装件可操作地接近编码的钥匙时，药物的量可以相对于药剂选择性地释放。 然而，该包装可能被配置为施加相对较高的可能性，即药物将不被访问，或者药物将被代理人污染，如果在不使用编码的密钥的情况下访问包装的内容物。