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公开(公告)号：US20240149268A1
公开(公告)日：2024-05-09
申请号：US18387625
申请日：2023-11-07
发明人： David Beebe , Patrick McMinn , Brianna Mullins , Jay Warrick
IPC分类号： B01L3/00
CPC分类号： B01L3/5085 , B01L2300/023 , B01L2300/0829 , B01L2300/16 , B01L2400/043
摘要： Devices for isolating, collecting and/or transferring target molecules to an assay area, comprising an enclosure having a top section adapted to receive a sample, a central hollow body section or other area or cavity suitable for receiving a magnet or magnetic field(s) or force(s), at least one aqueous phase or layer and at least one oil/wax or gaseous phase or layer stabilized in proximity to one another within the enclosure with a target-permeable structural material associated with the aqueous phase/layer or the gaseous or oil/wax phase/layer or both, and a lower section containing or adapted to contain one or more reagents for carrying out an assay.
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公开(公告)号：US20240117452A1
公开(公告)日：2024-04-11
申请号：US18270440
申请日：2022-01-05
发明人： Jay Warrick , Brianna Mullins , Patrick McMinn , Dave Beebe , Ryan Shogren , Mitch Geiger , Franklin Zhong , Duane S. Juang , Terry D. Juang
IPC分类号： C12Q1/70 , B01L3/00 , B01L3/02 , C12Q1/6844
CPC分类号： C12Q1/701 , B01L3/0237 , B01L3/5085 , C12Q1/6844 , C12Q1/6806
摘要： Provided herein are systems and methods for isolating a target from a biological sample. In some aspects, provided herein are automated systems and methods for isolating a target from a plurality of biological samples. For example, provided herein are automated systems and methods for isolating viral nucleic acid from a biological sample using a magnetic force to draw the nucleic acid out of a liquid biological sample.
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公开(公告)号：US20220355273A1
公开(公告)日：2022-11-10
申请号：US17737808
申请日：2022-05-05
发明人： Dave Beebe , Patrick McMinn , Brianna Mullins , Jay Warrick
摘要： Stabilized interface systems and compositions for positioning target(s), comprising fluids, associated structural material(s) having a pore that permits passage and positioning of targets and related compositions, and a fluid phase, layer, or interface stabilized with the associated structural material. Miscible interface systems and compositions for positioning target(s) for detection comprising two or more fluid regions with different properties within a phase or layer where the fluid regions are stabilized with respect to each other using a solid or semi-solid structure or material with at least one pore that allows passage of said target(s) wherein stabilization allows mass transport of a fluid constituent via diffusion to prevail over bulk fluid motion.
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公开(公告)号：US20200231961A1
公开(公告)日：2020-07-23
申请号：US16784898
申请日：2020-02-07
IPC分类号： C12N15/10 , G01N33/543
摘要： A method and a device are provided for facilitating the disaggregation of a plurality of solid phase substrate as the plurality of solid phase substrate are transferred from a first location to a second location. A plurality of solid phase substrate are deposited at the first location and a plurality of particles are added to the plurality of solid phase substrate. A force is generated to draw the plurality of solid phase substrate from the first location to a second location. The plurality of particles causes clumps of the plurality of solid phase substrate to break apart as the plurality of solid phase substrate are moved in response to the force.
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公开(公告)号：US10590409B2
公开(公告)日：2020-03-17
申请号：US15370375
申请日：2016-12-06
IPC分类号： C12N15/10 , G01N33/543 , C12Q1/6806
摘要： A method and a device are provided for facilitating the disaggregation of a plurality of solid phase substrate as the plurality of solid phase substrate are transferred from a first location to a second location. A plurality of solid phase substrate are deposited at the first location and a plurality of particles are added to the plurality of solid phase substrate. A force is generated to draw the plurality of solid phase substrate from the first location to a second location. The plurality of particles causes clumps of the plurality of solid phase substrate to break apart as the plurality of solid phase substrate are moved in response to the force.
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公开(公告)号：US20170199107A1
公开(公告)日：2017-07-13
申请号：US14990972
申请日：2016-01-08
申请人： Gilson, Inc. , Salus Discovery LLC
CPC分类号： G01N1/40 , B01L3/502 , B01L2300/06 , B01L2300/0609 , B01L2300/0829 , B03C1/32 , B03C2201/18 , G01N35/0098 , G01N2001/4038 , G01N2035/00564
摘要： A magnetic base for a sample plate of a sample processing system is provided comprising a first plate comprising a first top surface; a bottom surface; and a sample plate mounting cavity wall mounted to the first top surface, wherein the first plate and the sample plate mounting cavity wall define a sample plate mounting cavity configured to accommodate a sample plate of a sample processing system. The magnetic base further comprises a second plate extending parallel to the first plate, the second plate comprising a second top surface; and a magnet mounting cavity wall extending between the bottom surface of the first plate and the second top surface of the second plate, wherein the first plate, the second plate, and the magnet mounting cavity wall define a magnet mounting cavity configured to accommodate a free floating magnet.
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公开(公告)号：US10337967B2
公开(公告)日：2019-07-02
申请号：US14990972
申请日：2016-01-08
申请人： Gilson, Inc. , Salus Discovery LLC
摘要： A magnetic base for a sample plate of a sample processing system is provided comprising a first plate comprising a first top surface; a bottom surface; and a sample plate mounting cavity wall mounted to the first top surface, wherein the first plate and the sample plate mounting cavity wall define a sample plate mounting cavity configured to accommodate a sample plate of a sample processing system. The magnetic base further comprises a second plate extending parallel to the first plate, the second plate comprising a second top surface; and a magnet mounting cavity wall extending between the bottom surface of the first plate and the second top surface of the second plate, wherein the first plate, the second plate, and the magnet mounting cavity wall define a magnet mounting cavity configured to accommodate a free floating magnet.
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公开(公告)号：US20210349084A1
公开(公告)日：2021-11-11
申请号：US17313715
申请日：2021-05-06
申请人： Salus Discovery, LLC
发明人： Jay Warrick , David Beebe
IPC分类号： G01N33/543 , G01N33/558
摘要： Provided herein are devices, systems, and methods for concentration and detection of sample components. In particular, provided herein are lateral flow devices, systems, and methods that utilize flow control of samples.
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公开(公告)号：US20180155706A1
公开(公告)日：2018-06-07
申请号：US15370375
申请日：2016-12-06
IPC分类号： C12N15/10 , C12Q1/68 , G01N33/553
CPC分类号： C12N15/1013 , C12Q1/6806 , G01N33/54333 , C12Q2523/303 , C12Q2563/143 , C12Q2563/149
摘要： A method and a device are provided for facilitating the disaggregation of a plurality of solid phase substrate as the plurality of solid phase substrate are transferred from a first location to a second location. A plurality of solid phase substrate are deposited at the first location and a plurality of particles are added to the plurality of solid phase substrate. A force is generated to draw the plurality of solid phase substrate from the first location to a second location. The plurality of particles causes clumps of the plurality of solid phase substrate to break apart as the plurality of solid phase substrate are moved in response to the force.
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公开(公告)号：US20240240268A1
公开(公告)日：2024-07-18
申请号：US18289354
申请日：2022-05-05
发明人： Jay Warrick , Brianna Mullins , Patrick McMinn , David Beebe
IPC分类号： C12Q1/70 , A61B5/08 , A61B5/097 , C12Q1/6844
CPC分类号： C12Q1/701 , A61B5/082 , A61B5/097 , C12Q1/6844
摘要： Provided herein are sample collection devices and methods of using the same for collecting a sample from a subject. In some aspects, provided herein are wearable sample collection devices. In some embodiments, provided herein are face masks containing a sample collection device and methods of using the same for collection and/or assessment of a sample. In some aspects, provided herein are sample collection devices and methods of using the same for detecting a pathogen in a sample collected from a subject.
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