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![4-oxo-4,7-dihydrofuro[2,3-b]pyridine-5-carboxamide antiviral agents](/abs-image/US/2005/04/12/US06878705B2/abs.jpg.150x150.jpg)
1.发明授权4-oxo-4,7-dihydrofuro[2,3-b]pyridine-5-carboxamide antiviral agents 失效4-氧代-4,7-二氢呋喃并[2,3-b]吡啶-5-甲酰胺抗病毒剂公开(公告)号：US06878705B2
公开(公告)日：2005-04-12
申请号：US10345062
申请日：2003-01-14
申请人： Michele M. Cudahy , Mark E. Schnute , Steven P. Tanis , William R. Perrault , Paul Matthew Herrinton , Sajiv K. Nair
发明人： Michele M. Cudahy , Mark E. Schnute , Steven P. Tanis , William R. Perrault , Paul Matthew Herrinton , Sajiv K. Nair
IPC分类号： C07D491/048 , A61K31/4355 , A61K31/437 , A61K31/444 , A61K31/4741 , A61K31/497 , A61K31/506 , A61K31/517 , A61K31/52 , A61K31/5377 , A61P9/10 , A61P31/12 , A61P31/22 , A61P43/00 , C07D491/02 , C07D491/04 , C07D519/00
CPC分类号： C07D491/04
摘要： The invention provides a compound of formula I: wherein G, R2, R3, and R4 have any of the values defined in the specification, or a pharmaceutically acceptable salt thereof, as well as processes and intermediates useful for preparing such compounds or salts, and methods of treating a herpesvirus infection using such compounds or salts.
摘要翻译： 本发明提供式I化合物：其中G，R 2，R 3和R 4具有说明书中定义的任何值，或其药学上可接受的盐，以及方法和中间体 可用于制备此类化合物或盐，以及使用这些化合物或盐治疗疱疹病毒感染的方法。
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公开(公告)号：US06458788B1
公开(公告)日：2002-10-01
申请号：US09808902
申请日：2001-03-15
IPC分类号： A61K315377
CPC分类号： C07D405/06 , C07D237/28 , C07D413/06
摘要： Certain novel 4-hydroxycinnoline-3-carboxyamides. The compounds are particularly effective in the treatment or prevention of viral infections, particularly infections caused by herpes viruses including herpes simplex virus types 1 and 2, human herpes virus types 6, 7 and 8, varicello zoster virus, human cytomegalovirus or Epstein-Barr virus.
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公开(公告)号：US06683181B2
公开(公告)日：2004-01-27
申请号：US10288117
申请日：2002-11-05
申请人： Valerie A. Vaillancourt , Sandra Staley , Audris Huang , Richard Allen Nugent , Ke Chen , Sajiv K. Nair , James A. Nieman , Joseph Walter Strohbach
发明人： Valerie A. Vaillancourt , Sandra Staley , Audris Huang , Richard Allen Nugent , Ke Chen , Sajiv K. Nair , James A. Nieman , Joseph Walter Strohbach
IPC分类号： C07D29503
CPC分类号： C07D471/06 , Y02P20/582
摘要： The present invention provides a compound of formula I which is useful as antiviral agents, in particular, as agents against viruses of the herpes family.
摘要翻译： 本发明提供式I化合物，其可用作抗病毒剂，特别是作为抗疱疹家族病毒的药剂。
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公开(公告)号：US06624160B2
公开(公告)日：2003-09-23
申请号：US09808836
申请日：2001-03-15
IPC分类号： A61K3154
CPC分类号： C07D403/04 , C07D237/28 , C07D403/06 , C07D405/06 , C07D405/12 , C07D413/06 , C07D413/14
摘要： This invention provides compounds of formula I; which are useful as antiviral agents.
摘要翻译： 本发明提供式I化合物，其可用作抗病毒剂。
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公开(公告)号：US06525049B2
公开(公告)日：2003-02-25
申请号：US09888283
申请日：2001-06-22
申请人： Valerie A. Vaillancourt , Sandra Staley , Audris Huang , Richard Allen Nugent , Ke Chen , Sajiv K. Nair , James A. Nieman , Joseph Walter Strohbach
发明人： Valerie A. Vaillancourt , Sandra Staley , Audris Huang , Richard Allen Nugent , Ke Chen , Sajiv K. Nair , James A. Nieman , Joseph Walter Strohbach
IPC分类号： A61K314745
CPC分类号： C07D471/06 , Y02P20/582
摘要： The present invention provides a compound of formula I which is useful as antiviral agents, in particular, as agents against viruses of the herpes family.
摘要翻译： 本发明提供式I化合物，其可用作抗病毒剂，特别是作为抗疱疹家族病毒的药剂。
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公开(公告)号：US06603015B2
公开(公告)日：2003-08-05
申请号：US10014754
申请日：2001-12-11
申请人： Gunda I. Georg , Sajiv K. Nair , Emily Reiff , Ashok Rao Tunoori
发明人： Gunda I. Georg , Sajiv K. Nair , Emily Reiff , Ashok Rao Tunoori
IPC分类号： C07D27722
CPC分类号： C07D417/06 , C07B2200/07 , C07C45/29 , C07C67/31 , C07C67/343 , C07D277/24 , C07D493/04 , C07F7/1892 , C07C47/21 , C07C69/734 , C07C69/675
摘要： Commercially feasible methods for synthesizing various epothilones precursors needed for the preparation of final epothilones are provided, including techniques for the synthesis of epothilone segment A and C precursors. Segment C precursors are prepared using starting nitriles, which can alternately be oxidized to ketones and converted, or reacted to form the diol with subsequent conversion to the segment. Segment A precursors are prepared by reacting a starting enone with a chiral catalyst to give an intermediate alcohol in high enantomeric excess, followed by conversion of the alcohol to the desired Segment A precursor.
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公开(公告)号：US06457303B1
公开(公告)日：2002-10-01
申请号：US09798196
申请日：2001-03-02
申请人： Gunda I Georg , Sajiv K. Nair , Emily Reiff , Ashok Rao Tunoori , John T. Henri
发明人： Gunda I Georg , Sajiv K. Nair , Emily Reiff , Ashok Rao Tunoori , John T. Henri
IPC分类号： C07F708
CPC分类号： C07D417/06 , C07B2200/07 , C07C45/29 , C07C67/31 , C07D277/24 , C07D493/04 , C07F7/1892 , C07C47/21 , C07C69/734
摘要： Various epothilone precursors needed for the preparation of final epothilones are provided.
摘要翻译： 提供了制备最终埃坡霉素所需的各种埃坡霉素前体
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公开(公告)号：US06211412B1
公开(公告)日：2001-04-03
申请号：US09280207
申请日：1999-03-29
申请人： Gunda I. Georg , Sajiv K. Nair , Emily Reiff , Ashok Rao Tunoori , John T. Henri
发明人： Gunda I. Georg , Sajiv K. Nair , Emily Reiff , Ashok Rao Tunoori , John T. Henri
IPC分类号： C07C4541
CPC分类号： C07D417/06 , C07B2200/07 , C07C45/29 , C07C67/31 , C07D277/24 , C07D493/04 , C07F7/1892 , C07C47/21 , C07C69/734
摘要： Commercially feasible methods for synthesizing various epothilones precursors needed for the preparation of final epothilones are provided, including techniques for the synthesis of epothilone segment C using a stereoselective Noyori-type reduction, and the coupling of epothilone segments B and C using an aldol condensation reaction. The synthesis methods may be used to prepare naturally occurring segments as well as a large number of related analogs and homologs thereof. Final epothilones in accordance with the invention may also be of the naturally occurring variety (16-membered macrolides), while the homologs and analogs thereof are preferably up to 20-membered macrolides.
摘要翻译： 提供了用于合成制备最终埃坡霉素所需的各种埃坡霉素前体的商业上可行的方法，包括使用立体选择性Noyori型还原合成埃坡霉素片段C的技术，以及使用醛醇缩合反应偶联埃坡霉素片段B和C. 合成方法可用于制备天然存在的片段以及大量相关的类似物及其同系物。 根据本发明的最终埃坡霉素也可以是天然存在的品种（16-元大环内酯），而其同系物和类似物优选为至多20-元大环内酯。
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