公开(公告)号：US10364247B2

公开(公告)日：2019-07-30

申请号：US15567814

申请日：2015-04-21

申请人： Ruijin Hospital Affiliated to Shanghai Jiao Tong University School of Medicine ,  Xiamen University ,  Brandeis University

发明人： Ruibao Ren ,  Xianming Deng ,  Ping Liu ,  Bo Jiao ,  Wei Huang

IPC分类号： C07D487/04 ,  A61P35/00 ,  A61P35/02

摘要： The invention provides novel compounds and methods of using such compounds to treat or prevent cancer.

公开(公告)号：US20170252381A1

公开(公告)日：2017-09-07

申请号：US15515810

申请日：2014-09-30

申请人： RUIJIN HOSPITAL AFFILIATED TO SHANGHAI JIAO TONG UNIVERSITY SCHOOL OF MEDICINE

发明人： Guang NING ,  Jie HONG ,  Weiqing WANG ,  Ruixin LIU ,  Jiqiu WANG

IPC分类号： A61K35/74 ,  A61K47/26 ,  A23K20/10 ,  A23L33/135 ,  A23L33/00 ,  A61K35/747 ,  C12N1/20

CPC分类号： A61K35/74 ,  A23K20/10 ,  A23L33/135 ,  A23L33/30 ,  A23V2002/00 ,  A61K35/747 ,  A61K47/26 ,  C12N1/20

摘要： Provided are uses of Bacteroides in preparation of a medicament. The medicament is for use in treatment or prevention of obesity-related diseases. Also provided are a pharmaceutical composition, a medicament, a food product, and an animal feed that comprise Bacteroides, uses thereof in treatment or prevention of obesity-related diseases, and a method for treatment or prevention of obesity-related diseases.

公开(公告)号：US20170224744A1

公开(公告)日：2017-08-10

申请号：US15515343

申请日：2014-09-30

申请人： RUIJIN HOSPITAL AFFILIATED TO SHANGHAI JIAO TONG UNIVERSITY SCHOOL OF MEDICINE

发明人： Guang NING ,  Jie HONG ,  Weiqing WANG ,  Ruixin LIU ,  Jiqiu WANG

IPC分类号： A61K35/74 ,  A23K20/10 ,  A61K35/747 ,  A23L33/135 ,  A61K9/00 ,  A61K47/26

CPC分类号： A61K35/74 ,  A23K20/10 ,  A23L33/135 ,  A23V2002/00 ,  A61K9/0056 ,  A61K35/747 ,  A61K47/26 ,  C12N1/20

摘要： Provided are uses of Bacteroides in preparation of a medicament. The medicament is for use in treatment or prevention of obesity and obesity-related diseases. Also provided are a pharmaceutical composition, a medicament, a food product, and an animal feed that comprise Bacteroides, uses thereof in treatment or prevention of obesity and obesity-related diseases, and a method for treatment or prevention of obesity and obesity-related diseases.

公开(公告)号：US10350248B2

公开(公告)日：2019-07-16

申请号：US15515343

申请日：2014-09-30

申请人： RUIJIN HOSPITAL AFFILIATED TO SHANGHAI JIAO TONG UNIVERSITY SCHOOL OF MEDICINE

发明人： Guang Ning ,  Jie Hong ,  Weiqing Wang ,  Ruixin Liu ,  Jiqiu Wang

IPC分类号： A61K35/74 ,  A61K35/747 ,  A23L33/135 ,  C12N1/20 ,  A23K20/10 ,  A61K9/00 ,  A61K47/26

摘要： Provided are uses of Bacteroides in preparation of a medicament. The medicament is for use in treatment or prevention of obesity and obesity-related diseases. Also provided are a pharmaceutical composition, a medicament, a food product, and an animal feed that comprise Bacteroides, uses thereof in treatment or prevention of obesity and obesity-related diseases, and a method for treatment or prevention of obesity and obesity-related diseases.

公开(公告)号：US10781471B2

公开(公告)日：2020-09-22

申请号：US15532947

申请日：2015-12-04

申请人： Ruijin Hospital Affiliated to Shanghai Jiao Tong University School of Medicine ,  Brandeis University

发明人： Ruibao Ren

IPC分类号： C12Q1/48 ,  A61K45/06 ,  A61K31/513 ,  A01K67/027 ,  A61K49/00 ,  G01N33/573

摘要： The present invention encompasses the recognition that identification of alternative means to block RAS oncogenic signaling may be required for developing novel cancer therapies. Among other things, the present invention encompasses the recognition that targeting RAS palmitoylation can achieve effective therapy for RAS-related cancers. Furthermore, the present invention encompasses the recognition that reduction of ZDHHC9 level and/or activity can significantly reduce palmitoylation level of Ras protein. Among other things, the present invention encompasses the recognition that identification of agents that modulate expression and/or activity of ZDHHC9 can reduce palmitoylation level of Ras protein. In some embodiments, the present invention provides methods of treating a subject suffering from cancer by administering ZDHHC9 inhibition therapy.

公开(公告)号：US20180105528A1

公开(公告)日：2018-04-19

申请号：US15567814

申请日：2015-04-21

申请人： Ruijin Hospital Affiliated to Shanghai Jiao Tong University School of Medicine ,  Xiamen University ,  Brandeis University

发明人： Ruibao Ren ,  Xianming Deng ,  Ping Liu ,  Bo Jiao ,  Wei Huang

IPC分类号： C07D487/04

CPC分类号： C07D487/04

摘要： The invention provides novel compounds and methods of using such compounds to treat or prevent cancer.