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公开(公告)号：US10918732B2
公开(公告)日：2021-02-16
申请号：US16523688
申请日：2019-07-26
IPC分类号： A61K47/64 , G01N33/569
摘要： Certain embodiments are directed to method for synthesizing and using glycoconjugates based on the immunodominant epitope Galα(1,3)Galβ(1,4)GlcNAcα (Galα3LNα).
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公开(公告)号：US20170071948A1
公开(公告)日：2017-03-16
申请号：US15363440
申请日：2016-11-29
IPC分类号： A61K31/519 , A61K31/4409
CPC分类号： A61K31/519 , A61K31/122 , A61K31/4409 , A61K31/47 , A61K31/506 , A61K31/5383 , C07C50/24 , C07D213/86 , C07D215/28 , C07D401/04 , C07D495/04 , C07D498/04
摘要： The present invention relates to methods for treating an infectious disease in a subject in need thereof via administration of a therapeutically effective amount of compounds described herein. The methods may utilize particular compounds, for example, a quinoline, a hydrazone, a quinone, or a pyrimidine derivative thereof or a pharmaceutical salt thereof.
摘要翻译： 本发明涉及通过施用治疗有效量的本文所述化合物治疗有需要的受试者的感染性疾病的方法。 该方法可以使用特定的化合物，例如喹啉，腙，醌或其嘧啶衍生物或其药学盐。
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公开(公告)号：US11224645B2
公开(公告)日：2022-01-18
申请号：US15555369
申请日：2016-03-22
IPC分类号： A61K39/008 , A61K47/64 , A61K39/00 , A61K39/385
摘要： Certain embodiments are directed to an immunogenic composition comprising an immunogenic glycoconjugate comprising a glycan having the chemical formula of galactopyranose (Galp)-α(1,2)-R, Galp-α(1,3)-R, Galp-α(1,4)-R, or Galp-α(1,6)-R, wherein in R is any monosaccharide, oligosaccharide, or polysaccharide, coupled to a carrier peptide or protein. Certain aspects described herein are directed to compounds and therapies for treating Leishmania infections. In certain aspects, the glycoconjugates as described herein, are incorporated into pharmaceutical compositions or vaccines
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公开(公告)号：US20180043002A1
公开(公告)日：2018-02-15
申请号：US15555369
申请日：2016-03-22
IPC分类号： A61K39/008 , A61K39/385
CPC分类号： A61K39/008 , A61K39/385 , A61K47/6415 , A61K47/643 , A61K47/646 , A61K2039/545 , A61K2039/6037 , A61K2039/6081 , Y02A50/41
摘要： Certain embodiments are directed to an immunogenic composition comprising an immunogenic glycoconjugate comprising a glycan having the chemical formula of galactopyranose (Galp)-α(1,2)-R, Galp-α(1,3)-R, Galp-α(1,4)-R, or Galp-α(1,6)-R, wherein in R is any monosaccharide, oligosaccharide, or polysaccharide, coupled to a carrier peptide or protein. Certain aspects described herein are directed to compounds and therapies for treating Leishmania infections. In certain aspects, the glycoconjugates as described herein, are incorporated into pharmaceutical compositions or vaccines
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公开(公告)号：US20170071940A1
公开(公告)日：2017-03-16
申请号：US15363719
申请日：2016-11-29
IPC分类号： A61K31/506 , A61K31/122
CPC分类号： A61K31/519 , A61K31/122 , A61K31/4409 , A61K31/47 , A61K31/506 , A61K31/5383 , C07C50/24 , C07D213/86 , C07D215/28 , C07D401/04 , C07D495/04 , C07D498/04
摘要： The present invention relates to methods for treating an infectious disease in a subject in need thereof via administration of a therapeutically effective amount of compounds described herein. The methods may utilize particular compounds, for example, a quinoline, a hydrazone, a quinone, or a pyrimidine derivative thereof or a pharmaceutical salt thereof.
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公开(公告)号：US20150141415A1
公开(公告)日：2015-05-21
申请号：US14536024
申请日：2014-11-07
申请人： Omonike Arike Olaleye , Sarah Finney John , Adaugo Chimzurum Isichei , Jun O Liu , Rosa Maldonado , Janice Endsley
发明人： Omonike Arike Olaleye , Sarah Finney John , Adaugo Chimzurum Isichei , Jun O Liu , Rosa Maldonado , Janice Endsley
IPC分类号： C07D498/04 , C07C50/24 , C07D401/04 , C07D215/28 , C07D213/86 , C07D495/04
CPC分类号： A61K31/519 , A61K31/122 , A61K31/4409 , A61K31/47 , A61K31/506 , A61K31/5383 , C07C50/24 , C07D213/86 , C07D215/28 , C07D401/04 , C07D495/04 , C07D498/04
摘要： The present invention relates to methods for treating an infectious disease in a subject in need thereof via administration of a therapeutically effective amount of compounds described herein. The methods may utilize particular compounds, for example, a quinoline, a hydrazone, a quinone, or a pyrimidine derivatives thereof or a pharmaceutical salts thereof.
摘要翻译： 本发明涉及通过施用治疗有效量的本文所述化合物治疗有需要的受试者的感染性疾病的方法。 该方法可以使用特定的化合物，例如喹啉，腙，醌或其嘧啶衍生物或其药用盐。
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