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30 条记录 (耗时 0.209 秒)

    55053, a novel human eukaryotic kinase and uses therefor
    1.
    发明授权
    55053, a novel human eukaryotic kinase and uses therefor 失效
    55053，一种新型人类真核激酶，并用于此

    公开(公告)号：US06787345B1

    公开(公告)日：2004-09-07

    申请号：US10003690

    申请日：2001-11-15

    申请人： Rory A. J. Curtis

    发明人： Rory A. J. Curtis

    IPC分类号： C12N912

    CPC分类号： C12N9/1205

    摘要： The invention provides isolated nucleic acids molecules, designated EPK-55053 nucleic acid molecules, which encode novel protein kinase polypeptides. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing EPK-55053 nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which an EPK-55053 gene has been introduced or disrupted. The invention still further provides isolated EPK-55053 proteins, fusion proteins, antigenic peptides and anti-EPK-55053 antibodies. Diagnostic, screening, and therapeutic methods utilizing compositions of the invention are also provided.

    摘要翻译： 本发明提供编码新蛋白激酶多肽的分离的核酸分子，命名为EPK-55053核酸分子。 本发明还提供了反义核酸分子，含有EPK-55053核酸分子的重组表达载体，其中引入了表达载体的宿主细胞，以及EPK-55053基因导入或破坏的非人类转基因动物。 本发明还进一步提供了分离的EPK-55053蛋白，融合蛋白，抗原肽和抗EPK-55053抗体。 还提供了利用本发明组合物的诊断，筛选和治疗方法。

    Nucleic acids corresponding to 46798 a novel human matrix metalloproteinase and uses thereof
    2.
    发明授权
    Nucleic acids corresponding to 46798 a novel human matrix metalloproteinase and uses thereof 失效
    对应于46798的新型人类基质金属蛋白酶的核酸及其用途

    公开(公告)号：US06740514B2

    公开(公告)日：2004-05-25

    申请号：US09950510

    申请日：2001-09-10

    申请人： Rory A. J. Curtis

    发明人： Rory A. J. Curtis

    IPC分类号： C12N964

    CPC分类号： C12N9/6489

    摘要： The invention provides isolated nucleic acids molecules, designated 46798 nucleic acid molecules, which encode a novel matrix metalloproteinase. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing 46798 nucleic acid molecules, host cells into which the expression vectors have been introduced, and non-human transgenic animals in which a 46798 gene has been introduced or disrupted. The invention still further provides isolated 46798 proteins, fusion proteins, antigenic peptides and anti-46798 antibodies. Diagnostic methods utilizing compositions of the invention are also provided.

    摘要翻译： 本发明提供编码新基质金属蛋白酶的分离的核酸分子，命名为46798核酸分子。 本发明还提供了反义核酸分子，含有46798个核酸分子的重组表达载体，已导入其中的表达载体的宿主细胞，以及导入或破坏46798基因的非人转基因动物。 本发明还进一步提供分离的46798蛋白，融合蛋白，抗原肽和抗-46798抗体。 还提供了利用本发明组合物的诊断方法。

    2504, 15977, and 14760, novel protein kinase family members and uses therefor
    3.
    发明授权
    2504, 15977, and 14760, novel protein kinase family members and uses therefor 失效
    2504,15977和14760，新型蛋白激酶家族成员及其用途

    公开(公告)号：US06730491B2

    公开(公告)日：2004-05-04

    申请号：US09797039

    申请日：2001-02-28

    申请人： Rosana Kapeller-Libermann ,  Rachel A. Meyers ,  Rory A. J. Curtis

    发明人： Rosana Kapeller-Libermann ,  Rachel A. Meyers ,  Rory A. J. Curtis

    IPC分类号： C12Q148

    CPC分类号： C12N9/1205 ,  A61K38/00 ,  A61K2039/505 ,  C07K16/40

    摘要： The invention provides isolated nucleic acids molecules, designated 2504, 15977, or 14760 nucleic acid molecules, which encode novel protein kinase family members. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing 2504, 15977, or 14760 nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a 2504, 15977, or 14760 gene has been introduced or disrupted. The invention still further provides isolated 2504, 15977, or 14760 proteins, fusion proteins, antigenic peptides and anti-2504, 15977, or 14760 antibodies. Diagnostic methods utilizing compositions of the invention are also provided.

    摘要翻译： 本发明提供分离的核酸分子，命名为2504,15977或14760核酸分子，其编码新的蛋白激酶家族成员。 本发明还提供了反义核酸分子，含有2504,15977或14760个核酸分子的重组表达载体，已经引入了表达载体的宿主细胞，以及其中已经存在2504,15977或14760基因的非人转基因动物 引入或中断 本发明还进一步提供分离的2504,15977或14760蛋白，融合蛋白，抗原肽和抗2504,15977或14760抗体。 还提供了利用本发明组合物的诊断方法。

    TWIK-5 potassium channel polypeptides and uses therefor
    4.
    发明授权
    TWIK-5 potassium channel polypeptides and uses therefor 失效
    TWIK-5钾通道多肽及其用途

    公开(公告)号：US06664373B1

    公开(公告)日：2003-12-16

    申请号：US09561763

    申请日：2000-04-28

    申请人： Rory A. J. Curtis ,  Inmaculada Silos-Santiago

    发明人： Rory A. J. Curtis ,  Inmaculada Silos-Santiago

    IPC分类号： C07K1400

    CPC分类号： C07K14/705 ,  A61K38/00

    摘要： The invention provides isolated nucleic acids molecules, designated TWIK nucleic acid molecules, which encode proteins involved in potassium channel mediated activities. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing TWIK nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a TWIK gene has been introduced or disrupted. The invention still further provides isolated TWIK proteins, fusion proteins, antigenic peptides and anti-TWIK antibodies. Diagnostic methods utilizing compositions of the invention are also provided.

    摘要翻译： 本发明提供分离的核酸分子，命名为TWIK核酸分子，其编码参与钾通道介导的活性的蛋白质。 本发明还提供了反义核酸分子，含有TWIK核酸分子的重组表达载体，其中引入了表达载体的宿主细胞，以及引入或破坏TWIK基因的非人类转基因动物。 本发明还进一步提供了分离的TWIK蛋白，融合蛋白，抗原肽和抗TWIK抗体。 还提供了利用本发明组合物的诊断方法。

    Members of the capsaicin/vanilloid receptor family of proteins and uses thereof
    5.
    发明授权
    Members of the capsaicin/vanilloid receptor family of proteins and uses thereof 失效

    公开(公告)号：US08158769B2

    公开(公告)日：2012-04-17

    申请号：US12895052

    申请日：2010-09-30

    申请人： Rory A. J. Curtis

    发明人： Rory A. J. Curtis

    IPC分类号： C12N15/12 ,  C07K14/705

    CPC分类号： C07K14/705 ,  Y10T436/143333

    摘要： The invention provides isolated nucleic acids molecules, designated hVR-1, hVR-2, and rVR-2 nucleic acid molecules, which encode novel members of the Capsaicin/Vanilloid receptor family. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing hVR-1, hVR-2, and rVR-2 nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which an hVR-1, hVR-2, and rVR-2 gene has been introduced or disrupted. The invention still further provides isolated hVR-1, hVR-2, and rVR-2 proteins, fusion proteins, antigenic peptides and anti-hVR-1, anti-hVR-2, and anti-rVR-2 antibodies. Diagnostic methods utilizing compositions of the invention are also provided.

    NOVEL MEMBERS OF THE CAPSAICIN/VANILLOID RECEPTOR FAMILY OF PROTEINS AND USES THEREOF
    6.
    发明申请
    NOVEL MEMBERS OF THE CAPSAICIN/VANILLOID RECEPTOR FAMILY OF PROTEINS AND USES THEREOF 失效

    公开(公告)号：US20110033892A1

    公开(公告)日：2011-02-10

    申请号：US12895052

    申请日：2010-09-30

    申请人： Rory A. J. Curtis

    发明人： Rory A. J. Curtis

    IPC分类号： C12P21/02 ,  C07H21/04 ,  C12N15/63 ,  C12N1/21 ,  C07K7/08 ,  C07K14/00 ,  C07K16/18 ,  G01N33/50

    CPC分类号： C07K14/705 ,  Y10T436/143333

    摘要： The invention provides isolated nucleic acids molecules, designated hVR-1, hVR-2, and rVR-2 nucleic acid molecules, which encode novel members of the Capsaicin/Vanilloid receptor family. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing hVR-1, hVR-2, and rVR-2 nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which an hVR-1, hVR-2, and rVR-2 gene has been introduced or disrupted. The invention still further provides isolated hVR-1, hVR-2, and rVR-2 proteins, fusion proteins, antigenic peptides and anti-hVR-1, anti-hVR-2, and anti-rVR-2 antibodies. Diagnostic methods utilizing compositions of the invention are also provided.

    52906 Potassium channel nucleic acids and uses therefor
    8.
    发明授权
    52906 Potassium channel nucleic acids and uses therefor 失效
    52906钾通道核酸及其用途

    公开(公告)号：US07078184B2

    公开(公告)日：2006-07-18

    申请号：US09875321

    申请日：2001-06-06

    申请人： Rory A. J. Curtis

    发明人： Rory A. J. Curtis

    IPC分类号： C12N15/12 ,  C12N15/62 ,  C12N5/10

    CPC分类号： C07K14/705

    摘要： The invention provides isolated nucleic acids molecules, designated 52906, 33408, or 12189 nucleic acid molecules, which encode novel potassium channel members. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing 52906, 33408, or 12189 nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a 52906, 33408, or 12189 gene has been introduced or disrupted. The invention still further provides isolated 52906, 33408, or 12189 proteins, fusion proteins, antigenic peptides and anti-52906, 33408, or 12189 antibodies. Diagnostic methods utilizing compositions of the invention are also provided.

    摘要翻译： 本发明提供编码新的钾通道成员的分离的核酸分子，命名为52906,33408或12189核酸分子。 本发明还提供反义核酸分子，含有52906,33408或12189核酸分子的重组表达载体，已经引入了表达载体的宿主细胞，以及已经引入了52906,33408或12189基因的非人类转基因动物 引入或中断 本发明还进一步提供了分离的52906,33408或12189蛋白，融合蛋白，抗原肽和抗52906,33408或12189抗体。 还提供了利用本发明组合物的诊断方法。

    Human protein kinase, phosphatase, and protease family members and uses thereof
    9.
    发明授权
    Human protein kinase, phosphatase, and protease family members and uses thereof 失效
    人蛋白激酶，磷酸酶和蛋白酶家族成员及其用途

    公开(公告)号：US07070947B2

    公开(公告)日：2006-07-04

    申请号：US10170789

    申请日：2002-06-13

    申请人： Rachel E. Meyers ,  Peter J. Olandt ,  Rosana Kapeller-Libermann ,  Rory A. J. Curtis ,  Mark Williamson ,  Nadine Weich

    发明人： Rachel E. Meyers ,  Peter J. Olandt ,  Rosana Kapeller-Libermann ,  Rory A. J. Curtis ,  Mark Williamson ,  Nadine Weich

    IPC分类号： C12N1/20 ,  C12N15/00 ,  C12N5/00 ,  C12N9/14 ,  C12Q1/34

    CPC分类号： C12N9/12 ,  A01K2217/05 ,  A61K38/00 ,  A61K48/00 ,  A61K2039/505 ,  C07K16/40 ,  C07K2319/00 ,  C12N9/1205 ,  C12N9/14 ,  C12N9/16 ,  C12N9/6424 ,  C12N9/6427 ,  C12N9/6437 ,  C12Q1/34 ,  C12Q1/44 ,  C12Y207/01001 ,  C12Y301/02015 ,  C12Y304/21004 ,  C12Y304/21021 ,  G01N33/5011 ,  G01N33/502 ,  G01N33/5041 ,  G01N33/6893 ,  G01N2500/00

    摘要： The invention provides isolated nucleic acids molecules, designated 2504, 15977, 14760, 53070, 15985, 50365, 26583, 21953, m32404, 14089, and 23436 nucleic acid molecules, which encode novel human protein kinase family members, serine/threonine protein kinase family members, hexokinase family members, serine/threonine phosphatase family members, prolyl oligopeptidase family members, trypsin family members, trypsin serine protease family members, and ubiquitin protease family members. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing 2504, 15977, 14760, 53070, 15985, 50365, 26583, 21953, m32404, 14089, or 23436 nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a 2504, 15977, 14760, 53070, 15985, 50365, 26583, 21953, m32404, 14089, or 23436 gene has been introduced or disrupted. The invention still further provides isolated 2504, 15977, 14760, 53070, 15985, 50365, 26583, 21953, m32404, 14089, or 23436 proteins, fusion proteins, antigenic peptides and anti-2504, 15977, 14760, 53070, 15985, 50365, 26583, 21953, m32404, 14089, or 23436 antibodies. Diagnostic methods utilizing compositions of the invention are also provided.

    摘要翻译： 本发明提供编码新的人蛋白激酶家族成员，丝氨酸/苏氨酸蛋白激酶家族的分离的核酸分子，命名为2504,15977,14760,53070,15985,5042,56583,21953，m32404,14089和23436核酸分子 成员，己糖激酶家族成员，丝氨酸/苏氨酸磷酸酶家族成员，脯氨酰寡肽酶家族成员，胰蛋白酶家族成员，胰蛋白酶丝氨酸蛋白酶家族成员和泛素蛋白酶家族成员。 本发明还提供了反义核酸分子，含有2504,15977,14760,53070,15985,5042,26583,21953，m32404,14089或23436核酸分子的重组表达载体，已经引入表达载体的宿主细胞， 和非人类转基因动物，其中引入或破坏了2504,15977,14760,53070,15985,550365,26583,21953，m32404,14089或23436基因。 本发明还进一步提供分离的2504,15977,14760,53070,15985,5038,26583,21953，m32404,14089或23436蛋白，融合蛋白，抗原肽和抗2504,15977,14760,53070,15985,50365， 26583,21953，m32404,14089或23436抗体。 还提供了利用本发明组合物的诊断方法。

    Members of the capsaicin/vanilloid receptor family of proteins and uses thereof
    10.
    发明授权
    Members of the capsaicin/vanilloid receptor family of proteins and uses thereof 失效
    辣椒素/香草素受体家族蛋白质的成员及其用途

    公开(公告)号：US07063951B1

    公开(公告)日：2006-06-20

    申请号：US09587111

    申请日：2000-06-02

    申请人： Rory A. J. Curtis

    发明人： Rory A. J. Curtis

    IPC分类号： G01N33/567

    CPC分类号： C07K14/705 ,  Y10T436/143333

    摘要： The invention provides isolated nucleic acids molecules, designated hVR-1, hVR-2, and rVR-2 nucleic acid molecules, which encode novel members of the Capsaicin/Vanilloid receptor family. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing hVR-1, hVR-2, and rVR-2 nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which an hVR-1, hVR-2, and rVR-2 gene has been introduced or disrupted. The invention still further provides isolated hVR-1, hVR-2, and rVR-2 proteins, fusion proteins, antigenic peptides and anti-hVR-1, anti-hVR-2, and anti-rVR-2 antibodies. Diagnostic methods utilizing compositions of the invention are also provided.

    摘要翻译： 本发明提供编码辣椒素/香草素受体家族的新成员的分离的核酸分子，命名为hVR-1，hVR-2和rVR-2核酸分子。 本发明还提供反义核酸分子，含有hVR-1，hVR-2和rVR-2核酸分子的重组表达载体，其中引入了表达载体的宿主细胞，以及非人类转基因动物，其中hVR-1 ，hVR-2和rVR-2基因已被引入或破坏。 本发明还进一步提供了分离的hVR-1，hVR-2和rVR-2蛋白，融合蛋白，抗原肽和抗hVR-1，抗hVR-2和抗rVR-2抗体。 还提供了利用本发明组合物的诊断方法。