知搜-全球专利检索

  1. Login
  2. Sign Up

Search Results

25 records (took 0.023 seconds)

    Tissue modification devices and methods
    2.
    发明授权
    Tissue modification devices and methods 有权
    组织修饰装置及方法

    公开(公告)号：US08409206B2

    公开(公告)日：2013-04-02

    申请号：US12773595

    申请日：2010-05-04

    Applicant: Michael P. Wallace ,  Robert Garabedian ,  Nestor C. Cantorna ,  Jeffery L. Bleich ,  Roy Leguidleguid ,  Ronald Leguidleguid

    Inventor： Michael P. Wallace ,  Robert Garabedian ,  Nestor C. Cantorna ,  Jeffery L. Bleich ,  Roy Leguidleguid ,  Ronald Leguidleguid

    IPC: A61B17/00

    CPC classification number: A61B17/025 ,  A61B5/4893 ,  A61B17/0218 ,  A61B17/7062 ,  A61B2017/0256 ,  A61B2017/32006 ,  A61M25/01 ,  A61M25/0105 ,  A61M25/0133 ,  A61M25/0136 ,  A61M25/09 ,  A61M29/02

    Abstract: Described herein are devices, systems and methods for cutting tissue in a patient. In some embodiments, a tissue modification region of a device includes a pair of flexible elongate cutting members extending along the length of the tissue modification region. Each elongate cutting member may be configured to cut a discrete trough into tissue to a depth that is greater than the thickness of the cutting member. In some embodiments, the device includes a spacer. The spacer may be sized and configured to operate in one of two modes. A first mode, in which the spacer is coupled to the cutting members such that it holds a portion of each of the two cutting members a distance from one another, and a second mode, in which at least a portion of the spacer is moved away from a cutting member to allow the cutting members to cut further into tissue.

    Abstract translation: 这里描述了用于切割患者组织的装置，系统和方法。 在一些实施例中，装置的组织修改区域包括沿着组织修改区域的长度延伸的一对柔性细长切割构件。 每个细长的切割构件可以被配置成将离散的槽切割成组织到比切割构件的厚度大的深度。 在一些实施例中，该装置包括间隔件。 间隔件的尺寸和构造可以以两种模式之一来操作。 第一模式，其中间隔件联接到切割构件，使得其将两个切割构件中的每一个的一部分保持彼此的距离，以及第二模式，其中至少一部分间隔件移开 从切割构件允许切割构件进一步切割成组织。

    Tissue modification devices
    3.
    发明授权
    Tissue modification devices 有权
    组织修饰装置

    公开(公告)号：US08192436B2

    公开(公告)日：2012-06-05

    申请号：US12324147

    申请日：2008-11-26

    Applicant: Gregory P. Schmitz ,  Michael P. Wallace ,  Ronald Leguidleguid ,  Nestor C. Cantorna ,  James Shapiro ,  Jeffery L. Bleich

    Inventor： Gregory P. Schmitz ,  Michael P. Wallace ,  Ronald Leguidleguid ,  Nestor C. Cantorna ,  James Shapiro ,  Jeffery L. Bleich

    IPC: A61B17/00 ,  A61B17/32

    CPC classification number: A61B17/1631 ,  A61B17/149 ,  A61B17/1659 ,  A61B17/1671 ,  A61B17/1735 ,  A61B17/320016 ,  A61B17/32002 ,  A61B17/3207 ,  A61B2017/00261 ,  A61B2017/320004 ,  A61B2017/320008 ,  A61B2017/32006

    Abstract: Described herein are elongate device for modifying tissue having a plurality of flexibly connected rungs or links, and methods of using them, including methods of using them to decompress stenotic spinal tissue. These devices may be included as part of a system for modifying tissue. In general, these devices include a plurality of blades positioned on (or formed from) rungs that are flexibly connected. The rungs are typically rigid, somewhat flat and wider than they are long (e.g., rectangular). The rungs may be arranged, ladder like, and may be connected by a flexible connector substrate or between two or more cables. Different sized rungs may be used. The blades (on the rungs) may be arranged in a staggered arrangement. A tissue-collection or tissue capture element (e.g., chamber, bag, or the like) may be used to collect the cut or modified tissue. In some variations the tissue modification devices may have a non-linear axial shape, or may be converted from a first axial shape to a second axial shape.

    Abstract translation: 本文描述的是用于修改具有多个柔性连接的梯级或链节的组织的细长装置，以及使用它们的方法，包括使用它们来减压狭窄的脊髓组织的方法。 可以将这些装置作为用于修改组织的系统的一部分。 通常，这些装置包括位于柔性连接的（或由）梯级形成的多个叶片。 梯级通常是刚性的，稍微平坦并且比它们长（例如矩形）更宽。 梯级可以布置成梯子，并且可以通过柔性连接器基板或两根或更多根电缆连接。 可以使用不同尺寸的梯级。 刀片（在梯级上）可以以交错排列布置。 可以使用组织收集或组织捕获元件（例如，室，袋等）来收集切割或修饰的组织。 在一些变型中，组织改变装置可以具有非线性轴向形状，或者可以从第一轴向形状转换成第二轴向形状。

    Analyte detection system
    4.
    发明申请
    Analyte detection system 审中-公开
    分析物检测系统

    公开(公告)号：US20050037384A1

    公开(公告)日：2005-02-17

    申请号：US10824946

    申请日：2004-04-15

    Applicant: James Braig ,  Michael Munrow ,  Kenneth Witte ,  Mark Wechsler ,  Jennifer Gable ,  Igor Nemchuk ,  Peng Zheng ,  Kenneth Li ,  Maria Isaac ,  Robert Gaffney ,  Ronald Leguidleguid ,  Fiona Sander

    Inventor： James Braig ,  Michael Munrow ,  Kenneth Witte ,  Mark Wechsler ,  Jennifer Gable ,  Igor Nemchuk ,  Peng Zheng ,  Kenneth Li ,  Maria Isaac ,  Robert Gaffney ,  Ronald Leguidleguid ,  Fiona Sander

    IPC: G01N21/03 ,  G01N21/35 ,  G01N21/86 ,  C12Q1/68 ,  C12M1/34

    CPC classification number: G01N21/8483 ,  G01N21/0303 ,  G01N21/35 ,  G01N21/3577

    Abstract: Disclosed herein is a system for estimating the concentration of an analyte in a material sample. The system comprises a source of electromagnetic radiation; a detector positioned to detect radiation emitted by the source, so that the source and the detector define an optical path therebetween; and a sample element configured to be positioned in the optical path. The sample element comprises a sample chamber at least partially defined by opposed first and second windows which are substantially transmissive of at least a portion of the radiation emitted by the source, and which define an optical pathlength through the sample element. The sample chamber has an internal volume of less than 2 microliters. When the material sample is positioned in the sample chamber and the sample chamber is positioned in the optical path, the system computes estimated concentrations of the analyte in the material sample. The estimated concentrations deviate from corresponding actual concentrations of the analyte in the material sample by an RMS error of less than 15 mg/dL.

    Abstract translation: 本文公开了一种用于估计材料样品中分析物浓度的系统。 该系统包括电磁辐射源; 检测器，定位成检测由源发射的辐射，使得源和检测器在其间限定光路; 以及构造成定位在光路中的样本元件。 样品元件包括至少部分地由相对的第一和第二窗口限定的样品室，其基本上透射由源发射的辐射的至少一部分，并且通过样品元件限定光程长度。 样品室的体积小于2微升。 当材料样品定位在样品室中并且样品室位于光路中时，系统计算材料样品中分析物的估计浓度。 估计的浓度偏离材料样品中分析物的相应实际浓度，RMS误差小于15 mg / dL。

    TISSUE MODIFICATION DEVICES
    5.
    发明申请
    TISSUE MODIFICATION DEVICES 有权
    组织修改设备

    公开(公告)号：US20140180293A1

    公开(公告)日：2014-06-26

    申请号：US14195197

    申请日：2014-03-03

    Applicant: Gregory P. SCHMITZ ,  Michael P. WALLACE ,  Ronald LEGUIDLEGUID ,  Nestor C. CANTORNA ,  James SHAPIRO ,  Jeffery L. BLEICH

    Inventor： Gregory P. SCHMITZ ,  Michael P. WALLACE ,  Ronald LEGUIDLEGUID ,  Nestor C. CANTORNA ,  James SHAPIRO ,  Jeffery L. BLEICH

    IPC: A61B17/16

    CPC classification number: A61B17/1631 ,  A61B17/149 ,  A61B17/1659 ,  A61B17/1671 ,  A61B17/1735 ,  A61B17/320016 ,  A61B17/32002 ,  A61B17/3207 ,  A61B2017/00261 ,  A61B2017/320004 ,  A61B2017/320008 ,  A61B2017/32006

    Abstract: Described herein are elongate devices for modifying tissue having a plurality of flexibly connected rungs or links, and methods of using them, including methods of using them to decompress stenotic spinal tissue. These devices may be included as part of a system for modifying tissue. In general, these devices include a plurality of blades positioned on (or formed from) rungs that are flexibly connected. The rungs are typically rigid, somewhat flat and wider than they are long (e.g., rectangular). The rungs may be arranged, ladder like, and may be connected by a flexible connector substrate or between two or more cables. Different sized rungs may be used. The blades (on the rungs) may be arranged in a staggered arrangement. A tissue-collection or tissue capture element may be used to collect the cut or modified tissue.

    Abstract translation: 本文描述的是用于修改具有多个柔性连接的梯级或链节的组织的细长装置，以及使用它们的方法，包括使用它们来减压狭窄的脊髓组织的方法。 可以将这些装置作为用于修改组织的系统的一部分。 通常，这些装置包括位于柔性连接的（或由）梯级形成的多个叶片。 梯级通常是刚性的，稍微平坦并且比它们长（例如矩形）更宽。 梯级可以布置成梯子，并且可以通过柔性连接器基板或两根或更多根电缆连接。 可以使用不同尺寸的梯级。 刀片（在梯级上）可以以交错排列布置。 可以使用组织收集或组织捕获元件来收集切割或修饰的组织。

    SURGICAL TOOLS FOR TREATMENT OF SPINAL STENOSIS
    6.
    发明申请
    SURGICAL TOOLS FOR TREATMENT OF SPINAL STENOSIS 有权
    用于治疗脊柱狭窄的手术工具

    公开(公告)号：US20100331900A1

    公开(公告)日：2010-12-30

    申请号：US12824043

    申请日：2010-06-25

    Applicant: Robert Garabedian ,  Amie R. Borgstrom ,  Gregory B. Arcenio ,  Ronald Leguidleguid ,  Michael P. Wallace ,  Bryan Knodel

    Inventor： Robert Garabedian ,  Amie R. Borgstrom ,  Gregory B. Arcenio ,  Ronald Leguidleguid ,  Michael P. Wallace ,  Bryan Knodel

    IPC: A61B17/56

    CPC classification number: A61B17/00234 ,  A61B17/1659 ,  A61B17/1671 ,  A61B2017/00469 ,  A61B2017/320044

    Abstract: Described herein are pullwire handle devices for securing to a tissue-penetrating pullwire. In some embodiments, the device includes a handle body, a pullwire lock configured to removably lock the pullwire handle device onto a pullwire within the handle body, and a tip containment element configured to retain the distal tip of the pullwire. In some embodiments, the handle body further comprises a storage chamber configured to store a distal portion of the pullwire. Also described herein are methods for capturing a pullwire using a pullwire handle device. In some embodiments, the method includes the steps of inserting the distal end of a pullwire into the pullwire handle device, advancing the pullwire further into the pullwire handle device while the distal portion of the pullwire is contained within the pullwire handle device, and locking the distal portion of the pullwire within the pullwire handle device.

    Abstract translation: 这里描述的是拉丝手柄装置，用于固定到组织穿透的拉丝。 在一些实施例中，该装置包括手柄主体，拉线锁定，其被配置为将拉线手柄装置可移除地锁定到手柄主体内的拉线上，以及尖端容纳元件，其构造成保持拉线的远端。 在一些实施例中，手柄主体还包括被配置为存储拉丝的远端部分的储存室。 这里还描述了使用拉线手柄装置捕获拉线的方法。 在一些实施例中，该方法包括以下步骤：将拉线的远端插入拉线手柄装置中，将拉线进一步推入拉线手柄装置，同时拉线的远端部分包含在拉丝手柄装置内， 拉线手柄装置内的拉丝的远端部分。

    TISSUE MODIFICATION DEVICES AND METHODS
    7.
    发明申请
    TISSUE MODIFICATION DEVICES AND METHODS 有权
    组织修改设备和方法

    公开(公告)号：US20100274250A1

    公开(公告)日：2010-10-28

    申请号：US12773595

    申请日：2010-05-04

    Applicant: Michael P. Wallace ,  Robert Garabedian ,  Nestor C. Cantorna ,  Jeffery L. Bleich ,  Roy Leguidleguid ,  Ronald Leguidleguid

    Inventor： Michael P. Wallace ,  Robert Garabedian ,  Nestor C. Cantorna ,  Jeffery L. Bleich ,  Roy Leguidleguid ,  Ronald Leguidleguid

    IPC: A61B17/16

    CPC classification number: A61B17/025 ,  A61B5/4893 ,  A61B17/0218 ,  A61B17/7062 ,  A61B2017/0256 ,  A61B2017/32006 ,  A61M25/01 ,  A61M25/0105 ,  A61M25/0133 ,  A61M25/0136 ,  A61M25/09 ,  A61M29/02

    Abstract: Described herein are devices, systems and methods for cutting tissue in a patient. In some embodiments, a tissue modification region of a device includes a pair of flexible elongate cutting members extending along the length of the tissue modification region. Each elongate cutting member may be configured to cut a discrete trough into tissue to a depth that is greater than the thickness of the cutting member. In some embodiments, the device includes a spacer. The spacer may be sized and configured to operate in one of two modes. A first mode, in which the spacer is coupled to the cutting members such that it holds a portion of each of the two cutting members a distance from one another, and a second mode, in which at least a portion of the spacer is moved away from a cutting member to allow the cutting members to cut further into tissue.

    Abstract translation: 这里描述了用于切割患者组织的装置，系统和方法。 在一些实施例中，装置的组织修改区域包括沿着组织修改区域的长度延伸的一对柔性细长切割构件。 每个细长的切割构件可以被配置成将离散的槽切割成组织到比切割构件的厚度大的深度。 在一些实施例中，该装置包括间隔件。 间隔件的尺寸和构造可以以两种模式之一来操作。 第一模式，其中间隔件联接到切割构件，使得其将两个切割构件中的每一个的一部分保持彼此的距离，以及第二模式，其中至少一部分间隔件移开 从切割构件允许切割构件进一步切割成组织。

    ACCESS AND TISSUE MODIFICATION SYSTEMS AND METHODS
    8.
    发明申请
    ACCESS AND TISSUE MODIFICATION SYSTEMS AND METHODS 审中-公开
    访问和组织修改系统和方法

    公开(公告)号：US20100004654A1

    公开(公告)日：2010-01-07

    申请号：US12496094

    申请日：2009-07-01

    Applicant: Gregory P. SCHMITZ ,  Michael P. Wallace ,  Winnie Chung ,  Amie R. Borgstrom ,  Jeffery L. Bleich ,  Gregory B. Arcenio ,  Ronald Leguidleguid ,  Roy Leguidleguid

    Inventor： Gregory P. SCHMITZ ,  Michael P. Wallace ,  Winnie Chung ,  Amie R. Borgstrom ,  Jeffery L. Bleich ,  Gregory B. Arcenio ,  Ronald Leguidleguid ,  Roy Leguidleguid

    IPC: A61B17/60

    CPC classification number: A61B17/025 ,  A61B17/0218 ,  A61B17/7065 ,  A61B2017/0256 ,  A61B2017/32006 ,  A61M29/02

    Abstract: Described herein are methods and systems for precisely placing and/or manipulating devices within the body by first positioning a guidewire or pullwire through the body from a first location, around a curved pathway, and out of the body through a second location, so that the distal and proximal ends of the guidewire extend from the body, then pulling a device into position using the guidewire. The device to be positioned within the body is coupled to the proximal end of the guidewire, and the device is pulled into the body by pulling on the distal end of the guidewire that extends from the body. The device may be bimanually manipulated by pulling the guidewire distally, and an attachment to the device that extends proximally, allowing control of both the proximal and the distal ends. In this manner devices (and particularly implants such as innerspinous distracters, stimulating leads, and disc slings) may be positioned and/or manipulated within the body. Devices to modify tissue may also be positioned or manipulated so that a target tissue within the body is modified.

    Abstract translation: 这里描述的是通过首先将引导线或拉线从第一位置，绕弯曲的路径定位穿过身体，并通过第二位置离开身体来精确地放置和/或操纵身体内的装置的方法和系统，使得 导丝的远端和近端从主体延伸，然后使用导丝将装置拉入位置。 定位在主体内的装置与导丝的近端相连，并且通过拉动从身体延伸的导丝的远端将装置拉入身体。 该装置可以通过向远侧拉动导丝线以及向近端延伸的装置的附件进行双手操纵，从而允许近端和远端的控制。 以这种方式，可以在体内定位和/或操纵装置（并且特别是植入物，例如内侧牵引器，刺激引线和盘吊带）。 修改组织的装置也可以被定位或操纵，从而改变身体内的目标组织。

    TISSUE MODIFICATION DEVICES
    9.
    发明申请
    TISSUE MODIFICATION DEVICES 有权
    组织修改设备

    公开(公告)号：US20090149865A1

    公开(公告)日：2009-06-11

    申请号：US12324147

    申请日：2008-11-26

    Applicant: Gregory P. Schmitz ,  Michael P. Wallace ,  Ronald Leguidleguid ,  Nestor C. Cantorna ,  James Shapiro ,  Jeffery L. Bleich

    Inventor： Gregory P. Schmitz ,  Michael P. Wallace ,  Ronald Leguidleguid ,  Nestor C. Cantorna ,  James Shapiro ,  Jeffery L. Bleich

    IPC: A61B17/32 ,  A61B17/08 ,  A61B19/00

    CPC classification number: A61B17/1631 ,  A61B17/149 ,  A61B17/1659 ,  A61B17/1671 ,  A61B17/1735 ,  A61B17/320016 ,  A61B17/32002 ,  A61B17/3207 ,  A61B2017/00261 ,  A61B2017/320004 ,  A61B2017/320008 ,  A61B2017/32006

    Abstract: Described herein are elongate device for modifying tissue having a plurality of flexibly connected rungs or links, and methods of using them, including methods of using them to decompress stenotic spinal tissue. These devices may be included as part of a system for modifying tissue. In general, these devices include a plurality of blades positioned on (or formed from) rungs that are flexibly connected. The rungs are typically rigid, somewhat flat and wider than they are long (e.g., rectangular). The rungs may be arranged, ladder like, and may be connected by a flexible connector substrate or between two or more cables. Different sized rungs may be used. The blades (on the rungs) may be arranged in a staggered arrangement. A tissue-collection or tissue capture element (e.g., chamber, bag, or the like) may be used to collect the cut or modified tissue. In some variations the tissue modification devices may have a non-linear axial shape, or may be converted from a first axial shape to a second axial shape.

    Abstract translation: 本文描述的是用于修改具有多个柔性连接的梯级或链节的组织的细长装置，以及使用它们的方法，包括使用它们来减压狭窄的脊髓组织的方法。 可以将这些装置作为用于修改组织的系统的一部分。 通常，这些装置包括位于柔性连接的（或由）梯级形成的多个叶片。 梯级通常是刚性的，稍微平坦并且比它们长（例如矩形）更宽。 梯级可以布置成梯子，并且可以通过柔性连接器基板或两根或更多根电缆连接。 可以使用不同尺寸的梯级。 刀片（在梯级上）可以以交错排列布置。 可以使用组织收集或组织捕获元件（例如，室，袋等）来收集切割或修饰的组织。 在一些变型中，组织改变装置可以具有非线性轴向形状，或者可以从第一轴向形状转换成第二轴向形状。

Patent Agency Ranking