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公开(公告)号：US12016900B2
公开(公告)日：2024-06-25
申请号：US16712816
申请日：2019-12-12
Inventor： Yuval Shaked
CPC classification number: A61K38/1774 , A61K31/38 , A61P35/00 , C07K16/22 , C07K16/2818 , C07K16/2827 , G16B15/20 , G16H20/10 , A61K45/06
Abstract: A method is provided for treating a cancer patient non-responsive to treatment with a immune checkpoint inhibitor (ICI) by treating the patient with said ICI in combination with an agent that blocks the activity of a dominant factor selected among the plurality of host-driven resistance factors generated in response to treatment of the cancer patient with the ICI, these factors having a fold-change predictive of a non-favorable response of the cancer patient to the treatment with the ICI.
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2.发明申请公开(公告)号：US20180055907A1
公开(公告)日：2018-03-01
申请号：US15803790
申请日：2017-11-05
Inventor： Gera NEUFELD , Boaz Kigel , Ofra Kessler , Asya Varshavsky
IPC: A61K38/17 , G01N33/574
CPC classification number: A61K38/177 , A61K38/1709 , G01N33/57484 , G01N2333/71 , G01N2800/52
Abstract: A method of selecting a semaphorin for treating cancer in a subject is disclosed. The method comprises determining an expression of a semaphorin receptor on tumor cells of a tumor sample of the subject wherein an amount of the semaphorin receptor is indicative of the semaphorin suitable for treating the cancer in the subject. Kits for treating cancer and pharmaceutical compositions comprising semaphorins are also disclosed.
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公开(公告)号：US20170336420A1
公开(公告)日：2017-11-23
申请号：US15524054
申请日：2015-11-04
Inventor： Andrew LEVY , Shany BLUM
IPC: G01N33/68 , A61K31/355 , A61K31/455
CPC classification number: G01N33/6893 , A61K31/167 , A61K31/355 , A61K31/366 , A61K31/421 , A61K31/455 , A61K31/4706 , A61K31/55 , A61K38/44 , A61K45/06 , G01N33/68 , G01N2333/4713 , G01N2800/32 , A61K2300/00
Abstract: The present invention is directed to methods and compositions of treating cardiovascular disease or disorder in a subject in need thereof, comprising steps of determining and identifying the haptoglobin phenotype of the subject and thereby selecting the course of treatment with an agent capable of raising HDL.
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4.发明申请公开(公告)号：US20170304436A1
公开(公告)日：2017-10-26
申请号：US15529095
申请日：2015-11-11
Inventor： Nathan KARIN , Gizi WILDBAUM
IPC: A61K39/395 , C07K16/28 , C07K14/705 , C07K7/06 , G01N33/564 , A61K38/17 , C07K16/00 , C07K14/435 , A61K38/00
CPC classification number: A61K39/395 , A61K38/00 , A61K38/17 , A61K2039/505 , A61P29/00 , A61P37/00 , A61P37/06 , C07K7/06 , C07K14/435 , C07K14/705 , C07K16/00 , C07K16/28 , C07K2317/33 , G01N33/564
Abstract: The present invention relates to a peptide comprising an epitope within the macrophage scavenger receptor B-I, a method of using the same, a nucleic acid encoding the same and an antibody that binds to the epitope.
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5.发明申请公开(公告)号：US20170247422A1
公开(公告)日：2017-08-31
申请号：US15596396
申请日：2017-05-16
Applicant: MOR - RESEARCH APPLICATIONS LTD. , RAPPAPORT FAMILY INSTITUTE FOR RESEARCH IN THE MEDICAL SCIENCES
Inventor： Michal A. RAHAT , Nitza LAHAT , Miriam WALTER , Haim BITTERMAN
IPC: C07K14/435 , C07K16/28 , G01N33/68 , C12N15/62 , G01N33/574 , C07K14/705 , C07K7/08
CPC classification number: C07K14/435 , A61K38/00 , A61K2039/505 , C07K7/06 , C07K7/08 , C07K14/705 , C07K16/2803 , C07K2317/34 , C07K2317/76 , C12N15/62 , G01N33/57484 , G01N33/68 , G01N2333/70596 , G16H50/30 , Y02A90/26
Abstract: Isolated peptides from the protein EMMPRIN (CD147/Basigin) and antibodies directed against antigenic determinants within the peptides. Pharmaceutical compositions including the peptides and antibodies and methods of their production and use in vaccination, immunotherapy and diagnosis of proliferative, hyperpermeability, inflammatory, and angiogenesis-related diseases and disorders.
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Patent Agency Ranking
公开(公告)号：US09717777B2
公开(公告)日：2017-08-01
申请号：US15163689
申请日：2016-05-25
Inventor： Nathan Karin , Yiftah Barsheshet , Gizi Wildbaum
CPC classification number: A61K38/19 , A61K38/16 , A61K38/195 , C07K14/521 , C07K2319/30
Abstract: A method of treating a medical condition in which suppression of effector T cells is beneficial in a subject in need thereof is disclosed. The method comprising administering to the subject a therapeutically effective amount of a CCL1 polypeptide, thereby treating the medical condition in the subject.
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公开(公告)号：US09688732B2
公开(公告)日：2017-06-27
申请号：US14502757
申请日：2014-09-30
Applicant: Rappaport Family Institute for Research in the Medical Sciences , Mor-Research Applications Ltd.
Inventor： Michal A. Rahat , Nitza Lahat , Miriam Walter , Haim Bitterman
IPC: A61K39/00 , A61K38/00 , C07K14/435 , C07K14/705 , C12N15/62 , G01N33/574 , C07K16/28 , C07K7/06 , C07K7/08 , G01N33/68 , G06F19/00
CPC classification number: C07K14/435 , A61K38/00 , A61K2039/505 , C07K7/06 , C07K7/08 , C07K14/705 , C07K16/2803 , C07K2317/34 , C07K2317/76 , C12N15/62 , G01N33/57484 , G01N33/68 , G01N2333/70596 , G06F19/00 , G16H50/30 , Y02A90/26
Abstract: Isolated peptides from the protein EMMPRIN (CD147/Basigin) and antibodies directed against antigenic determinants within the peptides. Pharmaceutical compositions including the peptides and antibodies and methods of their production and use in vaccination, immunotherapy and diagnosis of proliferative, hyperpermeability, inflammatory, and angiogenesis-related diseases and disorders.
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8.发明申请公开(公告)号：US20170173111A1
公开(公告)日：2017-06-22
申请号：US15413991
申请日：2017-01-24
Inventor： Shira TOLEDANO , Ofra Kessler , Gera Neufeld , Yoreh Barak , Yelena Mumblat
CPC classification number: A61K38/1709 , A61K9/0048 , A61K45/06
Abstract: The present invention relates, according to some embodiments, method of treating eye diseases, such as AMD by administering Semaphorin 3C (Sema3C) or a variant thereof having amino acid modifications at furin-like pro-protein convertase cleavage sites, rendering these sites resistant to cleavage.
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公开(公告)号：US20150218272A1
公开(公告)日：2015-08-06
申请号：US14687928
申请日：2015-04-16
Inventor： Nathan KARIN , Gizi WILDBAUM , Rachel ANUNU , Yaniv ZOHAR , Nir NETZER
IPC: C07K16/28
CPC classification number: C07K16/28 , A61K39/3955 , A61K2039/505 , C07K16/2896 , C07K2317/21 , C07K2317/565 , C07K2317/567 , C07K2317/76 , G01N33/6893 , G01N2333/70596 , G01N2800/065 , G01N2800/202
Abstract: A method of reducing an inflammatory response in a subject is provided. The method comprising providing to a subject in need thereof a therapeutically effective amount of an agent capable of reducing activity and/or expression of a scavenger receptor or of an effector thereof, thereby reducing the inflammatory response in the subject.
Abstract translation: 提供减少受试者的炎症反应的方法。 所述方法包括向有需要的受试者提供治疗有效量的能够降低清道夫受体或其效应物的活性和/或表达的试剂，从而降低受试者的炎症反应。
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10.发明申请Compositions and methods for treating T-cell mediated autoimmune diseases 审中-公开用于治疗T细胞介导的自身免疫性疾病的组合物和方法公开(公告)号：US20040213786A1
公开(公告)日：2004-10-28
申请号：US10749515
申请日：2004-01-02
Inventor： Nathan Karin , Gizi Wildbaum
IPC: A61K039/395 , C07K016/24
CPC classification number: C07K16/244 , A61K2039/505 , C07K2317/34 , C07K2317/76
Abstract: Methods for treating autoimmune diseases are provided. The methods utilize antibodies, antibody fragments or antigenic portions of IGIF or polynucleotides encoding each for inducing protective immunity against the T-cell mediated diseases in individuals having or being predisposed to such diseases.
Abstract translation: 提供了治疗自身免疫性疾病的方法。 该方法利用IGIF的抗体，抗体片段或抗原部分或各自编码的多核苷酸来诱导具有或者易患这些疾病的个体的T细胞介导的疾病的保护性免疫。
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