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公开(公告)号：US20120021532A1
公开(公告)日：2012-01-26
申请号：US13120189
申请日：2009-09-23
Applicant: Csanky Eszter , Ralph Ruhl , Laszlo Takacs , William Hempel
Inventor： Csanky Eszter , Ralph Ruhl , Laszlo Takacs , William Hempel
CPC classification number: G01N33/6893 , G01N2800/122
Abstract: The present invention relates to the treatment of pulmonary diseases. More specifically, the invention relates to new methods of detecting and treating chronic obstructive pulmonary disease (COPD). In particular, the invention relates to a method of measuring one or more lipid metabolites in human body fluids as an indicator/biomarker of the progress of chronic obstructive pulmonary disease. The present invention also relates to a method of detecting and/or monitoring chronic obstructive pulmonary disease in a subject, the method comprising measuring the level of at least one lipid metabolite in a sample from the subject, wherein said level is indicative of COPD. The present invention also relates to a method of assessing the efficacy of a COPD treatment in a subject, the method comprising a step of measuring the level of at least one lipid metabolite in a sample from the subject, wherein said level is indicative of COPD severity or status.
Abstract translation: 本发明涉及肺部疾病的治疗。 更具体地，本发明涉及检测和治疗慢性阻塞性肺疾病（COPD）的新方法。 特别地，本发明涉及测量人体液体中的一种或多种脂质代谢物作为慢性阻塞性肺疾病进展的指标/生物标志物的方法。 本发明还涉及一种检测和/或监测受试者中慢性阻塞性肺病的方法，所述方法包括测量来自受试者的样品中至少一种脂质代谢物的水平，其中所述水平指示COPD。 本发明还涉及一种评价受试者中COPD治疗功效的方法，所述方法包括测量来自受试者的样品中至少一种脂质代谢物的水平的步骤，其中所述水平指示COPD严重性 或状态。
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2.发明授权公开(公告)号：US08501422B2
公开(公告)日：2013-08-06
申请号：US13120189
申请日：2009-09-23
Applicant: Csanky Eszter , Ralph Ruhl , Laszlo Takacs , William Hempel
Inventor： Csanky Eszter , Ralph Ruhl , Laszlo Takacs , William Hempel
CPC classification number: G01N33/6893 , G01N2800/122
Abstract: The present invention relates to the treatment of pulmonary diseases. More specifically, the invention relates to new methods of detecting and treating chronic obstructive pulmonary disease (COPD). In particular, the invention relates to a method of measuring one or more lipid metabolites in human body fluids as an indicator/biomarker of the progress of chronic obstructive pulmonary disease. The present invention also relates to a method of detecting and/or monitoring chronic obstructive pulmonary disease in a subject, the method comprising measuring the level of at least one lipid metabolite in a sample from the subject, wherein said level is indicative of COPD. The present invention also relates to a method of assessing the efficacy of a COPD treatment in a subject, the method comprising a step of measuring the level of at least one lipid metabolite in a sample from the subject, wherein said level is indicative of COPD severity or status.
Abstract translation: 本发明涉及肺部疾病的治疗。 更具体地，本发明涉及检测和治疗慢性阻塞性肺疾病（COPD）的新方法。 特别地，本发明涉及测量人体液体中的一种或多种脂质代谢物作为慢性阻塞性肺疾病进展的指标/生物标志物的方法。 本发明还涉及检测和/或监测受试者中慢性阻塞性肺病的方法，所述方法包括测量来自受试者的样品中至少一种脂质代谢物的水平，其中所述水平指示COPD。 本发明还涉及一种评估受试者中COPD治疗功效的方法，所述方法包括测量来自受试者的样品中至少一种脂质代谢物的水平的步骤，其中所述水平指示COPD严重性 或状态。
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