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    Octahydrophenanthrene hydrazinde derivatives useful as glucocorticoid receptor modulators
    1.
    发明申请
    Octahydrophenanthrene hydrazinde derivatives useful as glucocorticoid receptor modulators 审中-公开
    用作糖皮质激素受体调节剂的八氢菲吖啶衍生物

    公开(公告)号：US20070129410A1

    公开(公告)日：2007-06-07

    申请号：US10579354

    申请日：2004-11-08

    申请人： Ralph Robinson ,  Edward Kleinman ,  Henry Cheng

    发明人： Ralph Robinson ,  Edward Kleinman ,  Henry Cheng

    IPC分类号： A61K31/44 ,  C07D211/68

    CPC分类号： C07D213/77 ,  C07D417/12

    摘要： The present invention relates to compounds of the formula (I) their isomer, prodrugs of these compounds or isomers, or a pharmaceutically acceptable salts of these compounds, isomers or prodrugs; wherein R1, R2, R3, R4, R5, R6, R7, R8, R9, and X are defined as in the specification, to pharmaceutical compositions containing them and methods of using these compounds, their isomer, prodrugs of these compounds or isomers, or a pharmaceutically acceptable salts of these compounds, isomers or prodrugs to treat obesity, diabetes, anxiety, or inflammatory diseases or for modulating a process mediated by GR in mammals.

    摘要翻译： 本发明涉及式（I）化合物的异构体，这些化合物或异构体的前药，或这些化合物，异构体或前药的药学上可接受的盐; 其中R 1，R 2，R 3，R 4，R 5， R 6，R 7，R 8，R 9和X如说明书中所定义， 含有它们的药物组合物和使用这些化合物的方法，它们的异构体，这些化合物或异构体的前药，或这些化合物的药学上可接受的盐，异构体或前药来治疗肥胖症，糖尿病，焦虑症或炎性疾病或调节过程 由GR在哺乳动物中介导。