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公开(公告)号：US10556935B2
公开(公告)日：2020-02-11
申请号：US15500803
申请日：2015-07-31
Applicant: PRIMORDIAL GENETICS INC. , Helge Zieler , Sabrina German , Animesh Ray , Biranchi Narayan Patra
Inventor： Helge Zieler , Sabrina German , Animesh Ray , Biranchi Narayan Patra
IPC: C07K14/395 , C12N15/81 , C12N15/70 , C12N15/10
Abstract: The present invention provides compositions comprising randomized in-frame fusion polynucleotides and methods for introducing them into a host organism to obtain desirable phenotypic changes that modulate tolerance to stress, thus creating novel characteristics of the transformed organism.
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Patent Agency Ranking
公开(公告)号：US20230076421A1
公开(公告)日：2023-03-09
申请号：US17614286
申请日：2020-05-23
Applicant: Primordial Genetics Inc.
Inventor： Dongxin Karen XU , Kadir Chir TUNG , Sabrina BAFFERT , Alan GREENER , Helge ZIELER
Abstract: The present disclosure provides compositions and methods for polynucleotide synthesis in vitro, specifically the use of single-subunit RNA polymerases for synthesis and manufacturing of RNA.
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公开(公告)号：US11198708B2
公开(公告)日：2021-12-14
申请号：US16785634
申请日：2020-02-09
Applicant: PRIMORDIAL GENETICS INC.
Inventor： Helge Zieler , Sabrina German , Animesh Ray , Biranchi Narayan Patra
IPC: C07K14/395 , C12N15/10 , C12N15/81 , C12N15/70
Abstract: The present invention provides compositions comprising randomized in-frame fusion polynucleotides and methods for introducing them into a host organism to obtain desirable phenotypic changes that modulate tolerance to stress, thus creating novel characteristics of the transformed organism.
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公开(公告)号：US20170218033A1
公开(公告)日：2017-08-03
申请号：US15500803
申请日：2015-07-31
Applicant: Helge Zieler , Sabrina German , Animesh Ray , Biranchi Narayan Patra , Primordial Genetics Inc.
Inventor： Helge ZIELER , Sabrina GERMAN , Animesh RAY , Biranchi Narayan PATRA
IPC: C07K14/395 , C12N15/81 , C12N15/70 , C12N15/10
CPC classification number: C07K14/395 , C07K2319/00 , C12N15/1034 , C12N15/1093 , C12N15/70 , C12N15/81
Abstract: The present invention provides compositions comprising randomized in-frame fusion polynucleotides and methods for introducing them into a host organism to obtain desirable phenotypic changes that modulate tolerance to stress, thus creating novel characteristics of the transformed organism.
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公开(公告)号：US20200270315A1
公开(公告)日：2020-08-27
申请号：US16785634
申请日：2020-02-09
Applicant: PRIMORDIAL GENETICS INC.
Inventor： Helge ZIELER , Sabrina GERMAN , Animesh RAY , Biranchi Narayan PATRA
IPC: C07K14/395 , C12N15/10 , C12N15/81 , C12N15/70
Abstract: The present invention provides compositions comprising randomized in-frame fusion polynucleotides and methods for introducing them into a host organism to obtain desirable phenotypic changes that modulate tolerance to stress, thus creating novel characteristics of the transformed organism.
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公开(公告)号：US20190002873A1
公开(公告)日：2019-01-03
申请号：US16131484
申请日：2018-09-14
Applicant: PRIMORDIAL GENETICS INC.
Inventor： Helge ZIELER
Abstract: The present invention relates to compositions involving randomized in-frame fusion polynucleotides and their introduction into a host organism to identify desirable phenotypic changes. The present invention further relates to methods of generating these randomized in-frame fusion polynucleotides by introducing randomized in-frame fusion polynucleotides into an organism, selecting for organisms with new or altered phenotypes, re-isolating the randomized in-frame fusion polynucleotides from the selected organisms, re-assembling the constituent polynucleotides of the re-isolated randomized in-frame fusion polynucleotides into new collections of randomized in-frame fusion polynucleotides, and repeating the selection for organisms with new or altered phenotypes.
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