公开(公告)号：US20130023680A1

公开(公告)日：2013-01-24

申请号：US13574715

申请日：2011-01-26

申请人： Prasad Muppa ,  Ron Postma ,  Bart Van Den Berg ,  Juergen Stock ,  Holger Wiederhold ,  Hans Rausch ,  Jorg Schallenberg ,  Stefan Bernhardt

发明人： Prasad Muppa ,  Ron Postma ,  Bart Van Den Berg ,  Juergen Stock ,  Holger Wiederhold ,  Hans Rausch ,  Jorg Schallenberg ,  Stefan Bernhardt

IPC分类号： C07D301/12 ,  C07D301/03 ,  B01J19/00

CPC分类号： C07D301/14 ,  B01D17/0208 ,  B01F5/061 ,  B01J4/00 ,  B01J19/2435 ,  B01J2219/00094 ,  B01J2231/72 ,  C07D301/03 ,  C07D301/12 ,  Y02P20/582

摘要： Apparatus and processes are provided for forming epoxide compounds. In one embodiment, a process for the manufacture of an epoxide is provided including adding an oxidant, a water-soluble manganese complex and a terminal olefin to form a multiphasic reaction mixture, reacting the terminal olefin with the oxidant in the multiphasic reaction mixture having at least one organic phase in the presence of the water-soluble manganese complex, separating the reaction mixture into the at least one organic phase and an aqueous phase, and reusing at least part of the aqueous phase. The invention is also related to a device for performing the above process.

摘要翻译： 提供了用于形成环氧化合物的装置和方法。 在一个实施方案中，提供了制备环氧化物的方法，包括加入氧化剂，水溶性锰络合物和末端烯烃以形成多相反应混合物，使末端烯烃与氧化剂在多相反应混合物中反应，所述多相反应混合物具有 在水溶性锰络合物的存在下的至少一个有机相，将反应混合物分离成至少一个有机相和水相，并重新使用至少部分水相。 本发明还涉及用于执行上述过程的装置。

公开(公告)号：US20120330041A1

公开(公告)日：2012-12-27

申请号：US13574704

申请日：2011-01-26

申请人： Prasad Muppa ,  Ron Postma ,  Caspar Schoolderman ,  Sandra Rens ,  Kostas Stoitsas

发明人： Prasad Muppa ,  Ron Postma ,  Caspar Schoolderman ,  Sandra Rens ,  Kostas Stoitsas

IPC分类号： C07D301/12 ,  C07D301/03

CPC分类号： C07D301/12

摘要： Processes are provided for the formation of an epoxyethyl ether or a glycidyl ether. In one embodiment, a process is provided for the manufacture of an epoxyethyl ether or glycidyl ether including reacting a vinyl ether or an allyl ether with an oxidant in the presence of a water-soluble manganese complex in an aqueous reaction medium, wherein the water-soluble manganese complex comprises an oxidation catalyst, characterized in that the water-soluble manganese complex is a mononuclear complex of the general formula (I): [LMnX3]Y (I), or a binuclear complex of the general formula (II): [LMn(μ-X)3MnL](Y)n (II), wherein Mn is a manganese; L or each L independently is a polydentate ligand, each X independently is a coordinating species and each μ-X independently is a bridging coordinating species, Y is a non-coordinating counter ion, and wherein the epoxidation is carried out at a pH in the range of from 1.0 to 6.0. The invention also relates to epoxyethyl ethers.

摘要翻译： 提供了形成环氧乙醚或缩水甘油醚的方法。 在一个实施方案中，提供了制备环氧乙醚或缩水甘油醚的方法，包括在水性反应介质中在水溶性锰络合物存在下使乙烯基醚或烯丙基醚与氧化剂反应， 可溶性锰络合物包括氧化催化剂，其特征在于水溶性锰络合物是通式（I）：[LMnX 3] Y（I）或通式（II）的双核络合物的单核络合物：[ LMn（μ-X）3MnL]（Y）n（II），其中Mn是锰; L或每个L独立地是多齿配体，每个X独立地是配位物质，每个μ-X独立地是桥联配位物质，Y是非配位抗衡离子，并且其中环氧化在 范围从1.0到6.0。 本发明还涉及环氧乙醚。

公开(公告)号：US08729282B2

公开(公告)日：2014-05-20

申请号：US13056793

申请日：2009-07-09

申请人： Ron Postma ,  Prasad Muppa

发明人： Ron Postma ,  Prasad Muppa

IPC分类号： C07D301/12

CPC分类号： C07D301/12

摘要： The invention relates to a process for the manufacture of a 1,2-epoxide by catalytic oxidation of a terminal olefin with hydrogen peroxide wherein the catalytic oxidation is performed in a biphasic system comprising an organic phase and an aqueous reaction medium, wherein a water-soluble manganese complex is used as oxidation catalyst, wherein a terminal olefin is used with a solubility at 20° C. of at least 0.01 to 100 g in 1 liter water, and wherein the molar ratio of terminal olefin to hydrogen peroxide is in the range of from 1:0.1 to 1:2.

摘要翻译： 本发明涉及通过用过氧化氢催化氧化末端烯烃制备1,2-环氧化物的方法，其中催化氧化在包含有机相和含水反应介质的双相体系中进行，其中， 可溶性锰络合物用作氧化催化剂，其中在1升水中使用在20℃下的溶解度为至少0.01至100g的末端烯烃，并且其中末端烯烃与过氧化氢的摩尔比在 为1：0.1至1：2。

公开(公告)号：US09024048B2

公开(公告)日：2015-05-05

申请号：US14124989

申请日：2012-06-13

申请人： Mark Kapellen ,  Bart Van Den Berg ,  Prasad Muppa ,  Paul Haesakkers

发明人： Mark Kapellen ,  Bart Van Den Berg ,  Prasad Muppa ,  Paul Haesakkers

IPC分类号： C07D301/06 ,  C07D301/12 ,  B01J31/40

CPC分类号： B01J31/4092 ,  C07D301/12

摘要： Apparatus and methods are provided for forming and processing multiphasic systems. In one embodiment, the invention provides a process for the manufacture of an epoxide, including reacting an olefinically unsaturated compound with an oxidant in the presence of a buffer component and a water-soluble manganese complex disposed in an aqueous phase having a first pH level in a first multiphasic system, adjusting the pH of the aqueous phase to a second pH level less than the first pH level, isolating at least a portion of the aqueous phase from the first multiphasic system, adjusting the pH of the at least a portion of the aqueous phase to a third pH level greater than the second pH level, and introducing the at least a portion of the aqueous phase into a second multiphasic system.

摘要翻译： 提供了用于形成和处理多相系统的装置和方法。 在一个实施方案中，本发明提供了一种制备环氧化物的方法，包括使烯属不饱和化合物与氧化剂在缓冲组分和水溶性锰络合物存在下反应，所述水溶性锰络合物处于水相中，其具有第一pH值 第一多相系统，将水相的pH调节到小于第一pH值的第二pH值，从第一多相系统中分离出至少一部分水相，调节至少部分该水相的pH 水相至大于第二pH水平的第三pH水平，并将至少一部分水相引入第二多相体系中。

公开(公告)号：US20140113801A1

公开(公告)日：2014-04-24

申请号：US14124989

申请日：2012-06-13

申请人： Mark Kapellen ,  Bert Van Den Bert ,  Prasad Muppa ,  Paul Haesakkers

发明人： Mark Kapellen ,  Bert Van Den Bert ,  Prasad Muppa ,  Paul Haesakkers

IPC分类号： B01J31/40

CPC分类号： B01J31/4092 ,  C07D301/12

摘要： Apparatus and methods are provided for forming and processing multiphasic systems. In one embodiment, the invention provides a process for the manufacture of an epoxide, including reacting an olefinically unsaturated compound with an oxidant in the presence of a buffer component and a water-soluble manganese complex disposed in an aqueous phase having a first pH level in a first multiphasic system, adjusting the pH of the aqueous phase to a second pH level less than the first pH level, isolating at least a portion of the aqueous phase from the first multiphasic system, adjusting the pH of the at least a portion of the aqueous phase to a third pH level greater than the second pH level, and introducing the at least a portion of the aqueous phase into a second multiphasic system.

摘要翻译： 提供了用于形成和处理多相系统的装置和方法。 在一个实施方案中，本发明提供了一种制备环氧化物的方法，包括使烯属不饱和化合物与氧化剂在缓冲组分和水溶性锰络合物存在下反应，所述水溶性锰络合物处于水相中，其具有第一pH值 第一多相系统，将水相的pH调节到小于第一pH值的第二pH值，从第一多相系统中分离出至少一部分水相，调节至少部分该水相的pH 水相至大于第二pH水平的第三pH水平，并将至少一部分水相引入第二多相体系中。

公开(公告)号：US20120330042A1

公开(公告)日：2012-12-27

申请号：US13574685

申请日：2011-01-26

申请人： Prasad Muppa ,  Mark Kapellen ,  Caspar Schoolderman

发明人： Prasad Muppa ,  Mark Kapellen ,  Caspar Schoolderman

IPC分类号： C07D301/03 ,  C07D301/12

CPC分类号： C07D301/12

摘要： Processes and compositions are provided for epoxidizing an olefinically unsaturated compound. In one embodiment, a process is provided for reacting an olefinically unsaturated compound with an oxidant in the presence of a catalyst at acidic conditions, wherein the catalyst is activated prior to the reaction at a pH that is higher than the pH during the reaction.

摘要翻译： 提供用于环氧化烯属不饱和化合物的方法和组合物。 在一个实施方案中，提供了在酸性条件下在催化剂存在下使烯属不饱和化合物与氧化剂反应的方法，其中催化剂在反应之前在pH高于反应期间的pH下被活化。

公开(公告)号：US08802873B2

公开(公告)日：2014-08-12

申请号：US13056835

申请日：2009-07-09

申请人： Ron Postma ,  Prasad Muppa

发明人： Ron Postma ,  Prasad Muppa

IPC分类号： C07D301/12 ,  B01J21/00 ,  B01J23/34

CPC分类号： C07D301/12 ,  B01J21/00 ,  B01J23/34 ,  C07D255/02

摘要： The invention relates to a process for the manufacture of epichlorohydrin (“ECH”) by catalytic oxidation of allyl chloride (“AC”) with an oxidant wherein the catalytic oxidation is performed in an aqueous reaction medium, wherein a water-soluble manganese complex is used as oxidation catalyst, followed by the isolation of epichlorohydrin.

摘要翻译： 本发明涉及通过用氧化剂催化氧化烯丙基氯（“AC”）制备表氯醇（“ECH”）的方法，其中催化氧化在水性反应介质中进行，其中水溶性锰络合物为 用作氧化催化剂，然后分离表氯醇。

公开(公告)号：US20120289722A1

公开(公告)日：2012-11-15

申请号：US13512167

申请日：2010-11-24

申请人： Prasad Muppa ,  Caspar Schoolderman ,  Sandra Rens Van Der Lee ,  Ron Postma

发明人： Prasad Muppa ,  Caspar Schoolderman ,  Sandra Rens Van Der Lee ,  Ron Postma

IPC分类号： C07D301/12

CPC分类号： C07D301/12 ,  Y02P20/52

摘要： A process for the manufacture of propylene oxide (“PO”) by catalytic oxidation of propylene with an oxidant wherein the catalytic oxidation is performed in an aqueous reaction medium, comprising water with less than 10% by volume of cosolvents, wherein a water-soluble manganese complex is used as oxidation catalyst,characterized in that the water-soluble manganese complex is a mononuclear species of the general formula (I): [LMnX3]Y   (I) or a binuclear species of the general formula (II): [LMn(μ-X)3MnL]Y2   (II) wherein Mn is a manganese; L or each L independently is a polydentate ligand, each X independently is a coordinating species and each μ-X independently is a bridging coordinating species, whereas Y is an non-coordinating counterion, and wherein the catalytic oxidation is carried out at a pH in the range of from 1.5 to 6.0.

摘要翻译： 一种通过用氧化剂催化氧化丙烯来生产环氧丙烷（PO）的方法，其中催化氧化在水性反应介质中进行，其中包含少于10体积％共溶剂的水，其中水溶性锰络合物 用作氧化催化剂，其特征在于水溶性锰络合物是通式（I）：[LMnX 3] Y（I）或通式（II）的双核物种的单核物种：[LMn（μ -X）3MnL] Y2（II）其中Mn是锰; L或每个L独立地是多齿配体，每个X独立地是配位物质，每个μ-X独立地是桥联配位物质，而Y是非配位抗衡离子，并且其中催化氧化在pH 范围从1.5到6.0。

公开(公告)号：US20110137055A1

公开(公告)日：2011-06-09

申请号：US13056835

申请日：2009-07-09

申请人： Ron Postma ,  Prasad Muppa

发明人： Ron Postma ,  Prasad Muppa

IPC分类号： C07D301/12

CPC分类号： C07D301/12 ,  B01J21/00 ,  B01J23/34 ,  C07D255/02

摘要： The invention relates to a process for the manufacture of epichlorohydrin (“ECH”) by catalytic oxidation of allyl chloride (“AC”) with an oxidant wherein the catalytic oxidation is performed in an aqueous reaction medium, wherein a water-soluble manganese complex is used as oxidation catalyst, followed by the isolation of epichlorohydrin.

摘要翻译： 本发明涉及通过用氧化剂催化氧化烯丙基氯（“AC”）制备表氯醇（“ECH”）的方法，其中催化氧化在水性反应介质中进行，其中水溶性锰络合物为 用作氧化催化剂，然后分离表氯醇。

公开(公告)号：US09174955B2

公开(公告)日：2015-11-03

申请号：US13574693

申请日：2011-01-26

申请人： Prasad Muppa ,  Ron Postma ,  Caspar Schoolderman ,  Sandra Rens ,  Kostas Stoitsas

发明人： Prasad Muppa ,  Ron Postma ,  Caspar Schoolderman ,  Sandra Rens ,  Kostas Stoitsas

IPC分类号： C07D303/12 ,  C07D301/12 ,  C07D303/48

CPC分类号： C07D301/12 ,  C07D303/48

摘要： The invention relates to a process for the manufacture of an epoxyethyl carboxylate or glycidyl carboxylate, including reacting a vinyl carboxylate or an allyl carboxylate using an oxidant and a water-soluble manganese complex in an aqueous reaction medium, and the water-soluble manganese complex comprises an oxidation catalyst, characterized in that the water-soluble manganese complex is a mononuclear species of the general formula (I) [LMnX3]Y (I), or a binuclear species of the general formula (II): [LMn(μ-X)3MnL]Yn (II), wherein Mn is a manganese; L is a ligand and each L is independently a polydentate ligand, each X is independently a coordinating species and each μ-X is independently a bridging coordinating species, Y is a non-coordinating counter ion, and wherein the epoxidation is carried out at a pH in the range of from 1.0 to 7.0.

摘要翻译： 本发明涉及一种制备环氧乙基羧酸酯或缩水甘油羧酸酯的方法，包括在水性反应介质中使用氧化剂和水溶性锰络合物使羧酸乙烯酯或烯丙基羧酸酯反应，并且水溶性锰络合物包括 其特征在于所述水溶性锰络合物是通式（I）[LMnX 3] Y（I）的单核物种或通式（II）的双核物种：[LMn（μ-X ）3MnL] Yn（II），其中Mn是锰; L是配体，每个L独立地是多齿配体，每个X独立地是配位物质，每个μ-X独立地是桥联配位物质，Y是非配位抗衡离子，其中环氧化在 pH范围为1.0-7.0。