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    NOVEL PEPTIDES, USE THEREOF IN COSMETIC AND COSMECEUTIC APPLICATIONS, AND COMPOSITIONS COMPRISING SAME
    1.
    发明申请
    NOVEL PEPTIDES, USE THEREOF IN COSMETIC AND COSMECEUTIC APPLICATIONS, AND COMPOSITIONS COMPRISING SAME 审中-公开

    公开(公告)号：US20100310484A1

    公开(公告)日：2010-12-09

    申请号：US12452381

    申请日：2008-06-30

    申请人： Michel Hocquaux ,  Estelle Loing ,  Philippe Bedos

    发明人： Michel Hocquaux ,  Estelle Loing ,  Philippe Bedos

    IPC分类号： A61K8/64 ,  C07K5/11 ,  C07K5/083 ,  C07K7/06 ,  C07K5/117 ,  A61K38/07 ,  A61K38/06 ,  A61Q17/04 ,  A61Q19/08 ,  A61P17/02 ,  C12N5/07

    CPC分类号： C07K5/1019 ,  A61K8/64 ,  A61K38/00 ,  A61Q17/04 ,  A61Q19/08 ,  C07K5/0806 ,  Y02P20/55

    摘要： A peptide of formula I (SEQ ID NO: 1): Lip-A-Gly-His-B-R (I) wherein: Lip is a lipoyl residue of R or S configuration; A is absent or is a lysine residue of configuration L or D; GIy is a glycine residue; His is a histidine residue of configuration L or D; B is a lysine residue of configuration L or D, or a lysine residue of configuration L or D in which the NH2 group of the side chain comprises a modification, wherein said modification is (i) a replacement with a hydrogen or (ii) a modification with a protecting group selected from the group consisting of acetyl, benzoyl, tosyl, sulfonyl benzene, benzyloxycarbonyle and palmitoyl; wherein R is O(Z) or N(Z′)(Z′), and wherein Z, Z′ and Z′ are independently of each other a hydrogen or a protecting group selected from the group consisting of methyl, ethyl, propyl, phenyl, hexyl, decyl and hexadecyl, or a racemate, an enantiomer or a diastereomer thereof, or a mixture thereof, or a salt thereof. A peptide of formula II (SEQ ID NO: 2): Lip-A-His-B-C-Trp-R (II) wherein: Lip is a lipoyl residue of configuration R or S; His is a histidine residue of configuration L; Trp is a tryptophane residue of configuration L; A is absent, is an amino acid residue of configuration L or D selected from the group consisting of a lysine residue, an alanine residue, a glutamic acid residue and a glycine residue, or is a spacer of formula: NH—(CH2)n-CO— wherein n is an integer comprised between 2 and 14; B is an aromatic amino acid residue of configuration D selected from the group consisting of a phenylalanine residue, a homophenylalanine residue, a tryptophane residue, a β-(1-Naphthyl)-alanine residue, a β-(2-Naphthyl)-alanine residue and a phenylglycine residue; C is a basic amino acid residue of configuration L selected from the group consisting of an arginine residue, a lysine residue, an ornithine residue and a homoarginine residue; wherein R is O(Z) or N(Z′)(Z′),

    NOVEL COMPOUNDS, USE THEREOF IN COSMETIC AND COSMECEUTIC APPLICATIONS, AND COMPOSITIONS COMPRISING SAME
    2.
    发明申请
    NOVEL COMPOUNDS, USE THEREOF IN COSMETIC AND COSMECEUTIC APPLICATIONS, AND COMPOSITIONS COMPRISING SAME 有权
    新化合物，其在化妆品和化妆品应用中的应用，以及包含其的组合物

    公开(公告)号：US20100311667A1

    公开(公告)日：2010-12-09

    申请号：US12452368

    申请日：2008-06-30

    申请人： Michel Hocquaux ,  Estelle Loing ,  Philippe Bedos

    发明人： Michel Hocquaux ,  Estelle Loing ,  Philippe Bedos

    IPC分类号： A61K8/64 ,  C07K5/10 ,  A61K38/07 ,  A61P17/02 ,  A61Q19/08 ,  C12N5/071

    CPC分类号： C07K5/1019 ,  A61K8/64 ,  A61K38/00 ,  A61Q19/08

    摘要： A compound of the formula I: R-A-Gly-His-B (I) wherein: A and B are independently of each other a L-lysine residue, a D-lysine residue, or a L- or D-lysine residue in which the NH2 group of the side chain comprises a modification, where-in said modification is (i) a replacement with a hydrogen, (ii) an acetylation, (iii) a benzoylation, or (iv) a palmitoylation; GIy is a glycine residue; His is a L- or D-histidine residue; R is CH3—(CH2)n—CO—, wherein n=2, 3, 4, 5, 6, 7 or 8; R′ is a group of formula (II): N(Z)(Z′) (II) wherein: Z and Z′ is hydrogen, a methyl group, an ethyl group, a phenyl group, an hexyl group, a decyl group or an hexadecyl group; or a racemate, an enantiomer or a diastereomer thereof, or mixtures thereof, or a salt thereof.

    摘要翻译： 式I的化合物：其中：A和B彼此独立地为L-赖氨酸残基，D-赖氨酸残基或L-或D-赖氨酸残基，其中 侧链的NH 2基团包括修饰​​，其中所述修饰是（i）用氢取代，（ii）乙酰化，（iii）苯甲酰化或（iv）棕榈酰化; Gly是甘氨酸残基; 他是一个L-或D-组氨酸残基; R是CH 3 - （CH 2）n -CO-，其中n = 2,3,4,5,6,7或8; R'是式（II）的基团：N（Z）（Z'）（II）其中：Z和Z'是氢，甲基，乙基，苯基，己基，癸基 或十六烷基; 或其外消旋物，对映体或非对映异构体，或其混合物，或其盐。

    Compounds, use thereof in cosmetic and cosmeceutic applications, and compositions comprising same
    3.
    发明授权
    Compounds, use thereof in cosmetic and cosmeceutic applications, and compositions comprising same 有权
    化合物，其在化妆品和药妆品应用中的用途，以及包含它们的组合物

    公开(公告)号：US09115176B2

    公开(公告)日：2015-08-25

    申请号：US12452368

    申请日：2008-06-30

    申请人： Michel Hocquaux ,  Estelle Loing ,  Philippe Bedos

    发明人： Michel Hocquaux ,  Estelle Loing ,  Philippe Bedos

    IPC分类号： C07K5/11 ,  A61K8/64 ,  A61Q19/08 ,  A61K38/00

    CPC分类号： C07K5/1019 ,  A61K8/64 ,  A61K38/00 ,  A61Q19/08

    摘要： A compound of the formula I: R-A-Gly-His-B (I) wherein: A and B are independently of each other a L-lysine residue, a D-lysine residue, or a L- or D-lysine residue in which the NH2 group of the side chain comprises a modification, where-in said modification is (i) a replacement with a hydrogen, (ii) an acetylation, (iii) a benzoylation, or (iv) a palmitoylation; GIy is a glycine residue; His is a L- or D-histidine residue; R is CH3—(CH2)n—CO—, wherein n=2, 3, 4, 5, 6, 7 or 8; R′ is a group of formula (II): N(Z)(Z′) (II) wherein: Z and Z′ is hydrogen, a methyl group, an ethyl group, a phenyl group, an hexyl group, a decyl group or an hexadecyl group; or a racemate, an enantiomer or a diastereomer thereof, or mixtures thereof, or a salt thereof.

    摘要翻译： 式I的化合物：其中：A和B彼此独立地为L-赖氨酸残基，D-赖氨酸残基或L-或D-赖氨酸残基，其中 侧链的NH 2基团包括修饰​​，其中所述修饰是（i）用氢取代，（ii）乙酰化，（iii）苯甲酰化或（iv）棕榈酰化; Gly是甘氨酸残基; 他是一个L-或D-组氨酸残基; R是CH 3 - （CH 2）n -CO-，其中n = 2,3,4,5,6,7或8; R'是式（II）的基团：N（Z）（Z'）（II）其中：Z和Z'是氢，甲基，乙基，苯基，己基，癸基 或十六烷基; 或其外消旋物，对映体或非对映异构体，或其混合物，或其盐。