公开(公告)号：US20060239947A1

公开(公告)日：2006-10-26

申请号：US10566210

申请日：2004-07-30

Applicant: Monica Dias ,  Philip Guffogg ,  Derek Wheeler ,  Mark Whitebread-Jordan

Inventor： Monica Dias ,  Philip Guffogg ,  Derek Wheeler ,  Mark Whitebread-Jordan

IPC: A61K8/00

CPC classification number: A61K9/1075

Abstract: A biliquid foam comprising from 10% to 98% by weight of a non-polar liquid other than a fuel and from 2 to 88% by weight of a continuous phase polar liquid comprising a C1-C4 alcohol, a liquid polyethylene glycol, ethylene glycol or propylene glycol, or mixtures thereof, in an amount of at least 65% by weight, relative to the weight of the continuous phase, wherein the biliquid foam is stabilized with an amount of from 0.05% to 2% by weight based on the total formulation of a surfactant which is selected from castor oil/poly(alkylene glycol) adducts containing from 20 to 50 alkoxy groups, a C8-C24 fatty acid or hydrogenated castor oil/poly(alkylene glycol) adducts containing from 20 to 60 alkoxy groups, or mixtures thereof. A stable dispersion having a content of at least 65% by weight with regard to C1-C4 alcohol, liquid polyethylene glycol, ethylene glycol or propylene glycol which dispersion comprises from 1-80% by weight of a biliquid foam and from 99-20% by weight of an aqueous gel.

Abstract translation: 包含10％至98％重量的除燃料以外的非极性液体和2至88％重量的连续相极性液体的双液泡沫，其包含C 1 -C 6烷基， 相对于连续相的重量，至少65重量％的量的液体聚乙二醇，乙二醇或丙二醇或其混合物，其中双液泡沫体被稳定 基于选自含有20至50个烷氧基的蓖麻油/聚（亚烷基二醇）加合物的表面活性剂的总配方，其量为0.05重量％至2重量％，C 8 -C 20脂肪酸或氢化蓖麻油/含有20至60个烷氧基的聚（亚烷基二醇）加合物或其混合物。 相对于C 1 -C 4醇，含量至少为65重量％的稳定分散体，液体聚乙二醇，乙二醇或丙二醇，其分散体包含 1-80重量％的双液泡沫和99-20重量％的水性凝胶。

公开(公告)号：US20060228408A1

公开(公告)日：2006-10-12

申请号：US10566209

申请日：2004-07-30

Applicant: William Charman ,  Monica Dias ,  Michelle Georgiou ,  Philip Guffogg ,  Christopher Porter ,  Colin Pouton ,  Fraser Steele ,  Derek Wheeler

Inventor： William Charman ,  Monica Dias ,  Michelle Georgiou ,  Philip Guffogg ,  Christopher Porter ,  Colin Pouton ,  Fraser Steele ,  Derek Wheeler

IPC: A61K9/48 ,  A61K9/64

CPC classification number: A61K9/1075 ,  A61K9/122 ,  A61K9/4858

Abstract: An oral drug delivery system which comprises a biliquid foam comprising: from 1 to 20% by weight of a continuous hydrophilic phase, from 70 to 98% by weight of a pharmaceutically acceptable oil which forms a discontinuous phase, the said pharmaceutically acceptable oil having dissolved or dispersed therein a poorly water-soluble drug in an amount of from 0.1 to 20% by weight and the biliquid foam including therein from 0.5 to 10% by weight of a surfactant to enable the formation of a stable biliquid foam, all percentages being based upon the total weight of the formulation.

Abstract translation: 一种口服药物递送系统，其包含双液泡沫，其包含：1-20重量％的连续亲水相，70-98重量％的形成不连续相的药学上可接受的油，所述药学上可接受的油具有溶解的 或分散其中0.1-20重量％的不良水溶性药物，其中包含其中的液体泡沫体含有0.5-10重量％的表面活性剂，以形成稳定的双液泡沫体，所有百分比都是基于 基于制剂的总重量。

公开(公告)号：US20050049315A1

公开(公告)日：2005-03-03

申请号：US10503091

申请日：2003-01-31

Applicant: Philip Guffogg ,  Derek Wheeler

Inventor： Philip Guffogg ,  Derek Wheeler

IPC: B01J13/00 ,  A61K8/04 ,  A61Q19/00 ,  C09K3/00 ,  C10L1/02 ,  C10L1/18 ,  C10L1/28 ,  C10L1/32 ,  B01F17/00

CPC classification number: C10L1/328 ,  A61K8/046 ,  A61Q19/00 ,  C10L1/02 ,  C10L1/023 ,  C10L1/026 ,  C10L1/1985 ,  C10L1/285 ,  Y10S516/925

Abstract: A method for the preparation of a biliquid foam which does not rely upon the initial formation of a gas foam, in which a stirrer having a single or a multiplicity of blades is used, the stirrer being operated in a manner such that at least one part of the stirrer mechanism breaks the interface between the continuous polar phase used to form the biliquid foam and the air, the non-polar phase being added dropwise at least initially whilst stirring the continuous polar phase and the rate of addition of the non-polar phase being controlled so that a biliquid foam composition is formed.

Abstract translation: 一种制备双液泡沫的方法，其不依赖于初始形成气泡，其中使用具有单个或多个叶片的搅拌器，所述搅拌器以使得至少一个部分 的搅拌器机构破坏用于形成双液泡沫的连续极性相与空气之间的界面，至少在初始时逐滴加入非极性相，同时搅拌连续极性相和非极性相的加入速率 被控制以形成双液泡沫组合物。

公开(公告)号：US08603503B2

公开(公告)日：2013-12-10

申请号：US10566210

申请日：2004-07-30

Applicant: Monica Dias ,  Philip Guffogg ,  Derek Wheeler ,  Mark Whitbread-Jordan

Inventor： Monica Dias ,  Philip Guffogg ,  Derek Wheeler ,  Mark Whitbread-Jordan

IPC: A61K8/02 ,  A61K9/00

CPC classification number: A61K9/1075

Abstract: A biliquid foam includes from 10% to 98% by weight of a non-polar liquid other than a fuel and from 2 to 88% by weight of a continuous phase polar liquid comprising a C1-C4 alcohol, a liquid polyethylene glycol, ethylene glycol or propylene glycol, or mixtures thereof, in an amount of at least 65% by weight, relative to the weight of the continuous phase, wherein the biliquid foam is stabilized with an amount of from 0.05% to 2% by weight based on the total formulation of a surfactant which is selected from castor oil/poly(alkylene glycol) adducts containing from 20 to 50 alkoxy groups, a C8-C24 fatty acid or hydrogenated castor oil/poly(alkylene glycol) adducts containing from 20 to 60 alkoxy groups, or mixtures thereof.

Abstract translation: 双液泡沫包括10至98重量％的除燃料以外的非极性液体和2至88重量％的包含C1-C4醇，液体聚乙二醇，乙二醇的连续相极性液体 或丙二醇，或其混合物，其量相对于连续相的重量为至少65重量％，其中基于总计，双液体泡沫以0.05重量％至2重量％的量被稳定 选自含有20〜50个烷氧基的蓖麻油/聚（亚烷基二醇）加合物，含有20〜60个烷氧基的C8-C24脂肪酸或氢化蓖麻油/聚（亚烷基二醇）加合物的表面活性剂的配方， 或其混合物。

公开(公告)号：US20050097812A1

公开(公告)日：2005-05-12

申请号：US10503085

申请日：2003-01-31

Applicant: Philip Guffogg ,  Stephen Lenon ,  Derek Wheeler

Inventor： Philip Guffogg ,  Stephen Lenon ,  Derek Wheeler

IPC: B01J13/00 ,  A61K8/04 ,  A61Q19/00 ,  C09K3/00 ,  C10L1/02 ,  C10L1/18 ,  C10L1/28 ,  C10L1/32 ,  C10L1/00 ,  B01F3/04

CPC classification number: C10L1/328 ,  A61K8/046 ,  A61Q19/00 ,  C10L1/02 ,  C10L1/023 ,  C10L1/026 ,  C10L1/1985 ,  C10L1/285 ,  Y10S516/925

Abstract: A fuel composition which comprises a biliquid foam consisting of from 10% to 97.5% by weight of non-coalescing droplets of a non-polar liquid comprising a petroleum derivative, paraffin or a liquid halogenated hydrocarbon and from 2 to 87% by weight of a continuous phase polar liquid comprising a C1-C3 alcohol, a C4 alcohol containing at least two hydroxy groups, or ethylene glycol, or mixtures thereof, in an amount of from 60% to 100% by weight thereof, wherein the biliquid foam is stabilized with an amount of from 0.5 to 3.0% by weight based on the total formulation of a surfactant which is selected from castor oil/poly(alkylene glycol) adducts containing from 20 to 50 alkoxy groups, or hydrogenated castor oil/poly(alkylene glycol) adducts containing from 20 to 60 alkoxy groups, or mixtures thereof.

Abstract translation: 一种燃料组合物，其包含由10重量％至97.5重量％的包含石油衍生物，石蜡或液体卤代烃的非极性液体的非聚结液滴和2至87重量％ 包含C 1 -C 3醇的连续相极性液体，含有至少两个羟基的C 4醇或乙二醇，或 其混合物的量为60重量％至100重量％，其中基于表面活性剂的总配方，所述双液泡沫体以0.5-3.0重量％的量被稳定，所述表面活性剂选自蓖麻油/聚 含有20至50个烷氧基的（亚烷基二醇）加合物，或含有20至60个烷氧基的氢化蓖麻油/聚（亚烷基二醇）加合物或其混合物。