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    Ex-vivo priming for generating cytotoxic T lymphocytes specific for non-tumor antigens to treat autoimmune and allergic disease
    4.
    发明申请
    Ex-vivo priming for generating cytotoxic T lymphocytes specific for non-tumor antigens to treat autoimmune and allergic disease 审中-公开
    用于产生特异于非肿瘤抗原的细胞毒性T淋巴细胞用于治疗自身免疫性和过敏性疾病的体外引发

    公开(公告)号：US20070098734A1

    公开(公告)日：2007-05-03

    申请号：US11580358

    申请日：2006-10-13

    申请人： Zeling Cai ,  Michael Jackson ,  Per Peterson ,  Wei-Xing Shi ,  Yan Kong ,  Juli DeGraw

    发明人： Zeling Cai ,  Michael Jackson ,  Per Peterson ,  Wei-Xing Shi ,  Yan Kong ,  Juli DeGraw

    IPC分类号： A61K39/00 ,  C12N5/08

    CPC分类号： A61K39/0008 ,  A61K2035/122 ,  C12N5/0636 ,  C12N2501/23 ,  C12N2501/51 ,  C12N2501/58 ,  C12N2502/50 ,  C12N2502/99

    摘要： Cytotoxic T lymphocytes (CTLs) specific for antigenic peptides derived from IgE molecule can be generated in vitro by stimulating resting naive CD8 T cells with IgE peptides presented by artificial antigen presenting cells. The IgE specific CTLs lyse the target cells loaded with IgE peptides in vitro and inhibit antigen specific IgE response in vivo. In addition, adoptive transfer of the IgE specific CTL to an asthmatic mouse model can inhibit the development of lung inflammation and airway hypersensitivity. IgE specific CTL provides a treatment for allergic asthma and other IgE-mediated allergic diseases. Antigenic peptides identified from non-tumor self-antigens induce specific cytotoxic T lymphocyte (CTL) in vitro. The CTL induced by peptides identified from CD40L can kill activated CD4 T cells. In vitro generated CTL specific for CD40L inhibit CD4-dependent antibody responses of all isotypes in vivo. In contrast, CTL induced by antigenic peptides derived from IgE specifically inhibit IgE responses, and adoptive transfer of CD40L-specific CTL to NOD mice at early age delay the development of diabetes in NOD mice. In vitro generated CTL specific for non-tumor self-antigens expressed on activated CD4 T cells regulate immune responses in vivo.

    摘要翻译： 可以通过用人造抗原呈递细胞呈递的IgE肽刺激静息幼稚CD8T细胞在体外产生来自IgE分子的抗原肽特异性的细胞毒性T淋巴细胞（CTL）。 IgE特异性CTL在体外裂解装载有IgE肽的靶细胞，并在体内抑制抗原特异性IgE反应。 此外，将IgE特异性CTL过继转移至哮喘小鼠模型可以抑制肺部炎症和气道超敏反应的发展。 IgE特异性CTL提供过敏性哮喘和其他IgE介导的过敏性疾病的治疗。 从非肿瘤自身抗原鉴定的抗原肽在体外诱导特异性细胞毒性T淋巴细胞（CTL）。 由CD40L鉴定的肽诱导的CTL可以杀死活化的CD4T细胞。 体外产生的CD40L特异性CTL可抑制体内所有同种型的CD4依赖性抗体反应。 相比之下，来自IgE的抗原肽诱导的CTL特异性抑制IgE应答，CD40L特异性CTL过早转移到NOD小鼠早期延迟NOD小鼠的糖尿病发展。 在活化的CD4T细胞上表达的非肿瘤自身抗原的体外产生的CTL调节体内的免疫应答。

    Purification of antigen-specific T cells
    5.
    发明申请
    Purification of antigen-specific T cells 审中-公开

    公开(公告)号：US20060134125A1

    公开(公告)日：2006-06-22

    申请号：US11219967

    申请日：2005-09-06

    申请人： Alain Luxembourg ,  Michael Jackson ,  Per Peterson

    发明人： Alain Luxembourg ,  Michael Jackson ,  Per Peterson

    IPC分类号： A61K39/00

    CPC分类号： A61K39/39 ,  A61K2039/5158 ,  C07K16/2818 ,  C12N5/0636 ,  C12N2501/51 ,  G01N33/5094 ,  G01N33/54326 ,  G01N33/56977

    摘要： A new method to capture, purify and expand antigen-specific T lymphocytes has been developed using magnetic beads coated with recombinant MHC class I molecules. This method was optimized using homogenous populations of naive T cells purified from mice transgenic for the 2C T cell receptor (TCR). These T cells were captured on beads coated with MHC class I molecules and the relevant antigenic peptides. MHC and peptide specificity was confirmed by the usage of irrelevant MHC peptide combinations. An enrichment of 800 to 1600 fold was measured, using 2C T cells mixed with irrelevant T cells, starting from a 2C T cell frequency of 1/3000. The same approach was used to purify antigen-specific CD8+ T cells from total CD8+ T cells from naive mice. The recovered cells could be expanded and specifically kill target cells in vitro; they had a significant effect in vivo as well. We expect this procedure to be suitable to purify and expand in vitro tumor- and virus-specific killer T cells for use in cell therapy.

    Camera platform and track
    7.
    发明授权
    Camera platform and track 有权

    公开(公告)号：US12025905B2

    公开(公告)日：2024-07-02

    申请号：US17725235

    申请日：2022-04-20

    申请人： Per Peterson

    发明人： Per Peterson

    IPC分类号： G03B17/56 ,  E01B23/02

    CPC分类号： G03B17/561 ,  E01B23/02

    摘要： A camera platform track provides running surfaces for independent movement of two or more camera platforms, improves strength to weight ratio, improves torsional rigidity, restricts camera platforms from wandering during filming, and improves traction. The camera platform track includes top running surfaces for a first camera platform, and one or more lower running surfaces for additional camera platforms, allowing desired versatility in filming. The camera platform tracks include a box base and an I-beam reaching up from the base to provide strength and torsional rigidity without excessive weight. The running surface lateral spacing may vary from camera platform wheel spacing providing centering to reduce or eliminate wandering, and may include grooves to improve traction. wandering, and may include grooves to improve traction.

    Camera Platform and Track
    8.
    发明申请
    Camera Platform and Track 有权

    公开(公告)号：US20220342284A1

    公开(公告)日：2022-10-27

    申请号：US17725235

    申请日：2022-04-20

    申请人： Per Peterson

    发明人： Per Peterson

    IPC分类号： G03B17/56 ,  E01B23/02

    摘要： A camera platform track provides running surfaces for independent movement of two or more camera platforms, improves strength to weight ratio, improves torsional rigidity, restricts camera platforms from wandering during filming, and improves traction. The camera platform track includes top running surfaces for a first camera platform, and one or more lower running surfaces for additional camera platforms, allowing desired versatility in filming. The camera platform tracks include a box base and an I-beam reaching up from the base to provide strength and torsional rigidity without excessive weight. The running surface lateral spacing may vary from camera platform wheel spacing providing centering to reduce or eliminate wandering, and may include grooves to improve traction. wandering, and may include grooves to improve traction.

    Continuously refining raw fibrous material to produce mechanical refiner pulp
    10.
    发明授权
    Continuously refining raw fibrous material to produce mechanical refiner pulp 失效
    连续精炼原纤维材料以生产机械磨浆机

    公开(公告)号：US4037792A

    公开(公告)日：1977-07-26

    申请号：US609226

    申请日：1975-09-02

    申请人： Viking Per Peterson

    发明人： Viking Per Peterson

    IPC分类号： D21B1/12 ,  D21D1/30 ,  B02C23/26 ,  D21B1/14

    CPC分类号： D21D1/30 ,  D21B1/12

    摘要： Raw fibrous material is preheated in a preheater in the presence of steam under a pressure greater than atmospheric pressure and then continuously introduced into a disc refiner, without prior defibration, whereby steam is generated in said disc refiner. The generated steam is continuously conducted away from said disc refiner as subsequent fibrous material is continuously being introduced into the disc refiner in order to obtain a pressure in the disc refiner which is greater than atmospheric pressure but less than the pressure in said preheater.

    摘要翻译： 原料纤维材料在预热器中在压力大于大气压力的情况下在蒸汽存在下预热，然后连续地引入圆盘磨浆机中，而无需先前的分离，从而在所述圆盘磨浆机中产生蒸汽。 所产生的蒸汽被连续地从所述圆盘磨浆机中导出，因为随后的纤维材料被连续地引入圆盘磨浆机中，以便获得大于大气压但小于所述预热器的压力的圆盘磨浆机中的压力。