公开(公告)号：US08603753B2

公开(公告)日：2013-12-10

申请号：US13056877

申请日：2009-07-02

Applicant: Paul Alan Cox ,  James S. Metcalf ,  Geoffrey A. Codd

Inventor： Paul Alan Cox ,  James S. Metcalf ,  Geoffrey A. Codd

IPC: G01N33/53

CPC classification number: G01N33/6812 ,  C07K16/44 ,  C07K2317/33

Abstract: An immunoassay for screening a sample to detect the presence of β-N-methylamino-L-alanine (BMAA) is disclosed. Antibodies specific for BMAA are disclosed. Antibodies that bind to BMAA on immunoblots are disclosed. Immunoassays and kits to detect the presence of BMAA in a sample by contacting the sample with an antibody that binds to BMAA, and detecting the antibody bound to the sample, are disclosed. Immunoassays and kits for screening for the presence of BMAA in a subject by analyzing a tissue sample obtained from the subject to detect the present of BMAA in the tissue sample, where the presence of BMAA in the tissue sample indicates exposure of the subject to an environmental source of BMAA, are disclosed. Immunoassays and kits for detecting an environmental source of BMAA, by screening an environmental sample to detect the presence of BMAA in the sample, wherein the presence of a detectable amount of BMAA in the sample indicates the sample is an environmental source of BMAA, are disclosed.

Abstract translation: 公开了用于筛选样品以检测β-N-甲基氨基-L-丙氨酸（BMAA）的存在的免疫测定。 公开了针对BMAA的抗体。 公开了在免疫印迹上结合BMAA的抗体。 公开了通过使样品与结合BMAA的抗体接触并检测与样品结合的抗体来检测样品中BMAA存在的免疫测定和试剂盒。 用于通过分析从受试者获得的组织样品来检测受试者中BMAA存在的免疫测定和试剂盒，以检测组织样品中BMAA的存在，其中组织样品中BMAA的存在表明受试者暴露于环境 BMAA的来源被披露。 通过筛选环境样品以检测样品中BMAA的存在来检测BMAA的环境来源的免疫测定和试剂盒，其中样品中可检测量的BMAA的存在表明样品是BMAA的环境来源，公开 。

公开(公告)号：US08541184B2

公开(公告)日：2013-09-24

申请号：US13015288

申请日：2011-01-27

Applicant: Paul Alan Cox ,  Sandra Banack ,  Susan Murch

Inventor： Paul Alan Cox ,  Sandra Banack ,  Susan Murch

IPC: G01N33/68

CPC classification number: G01N33/6896 ,  G01N33/6812 ,  G01N33/94 ,  G01N2410/00 ,  G01N2550/00 ,  G01N2800/28 ,  Y02A50/57

Abstract: Methods for screening for neurological disorders are disclosed. Specifically, methods are disclosed for screening for neurological disorders in a subject by analyzing a tissue sample obtained from the subject for the presence of elevated levels of neurotoxic amino acids or neurotoxic derivatives thereof associated with neurological disorders. In particular, methods are disclosed for diagnosing a neurological disorder in a subject, or predicting the likelihood of developing a neurological disorder in a subject, by determining the levels of β-N-methylamino-L-alanine (BMAA) in a tissue sample obtained from the subject. Methods for screening for environmental factors associated with neurological disorders are disclosed. Methods for inhibiting, treating or preventing neurological disorders are disclosed.

Abstract translation: 公开了筛选神经障碍的方法。 具体地，公开了通过分析从受试者获得的组织样品中存在与神经系统疾病相关的神经毒性氨基酸或神经毒性衍生物的升高水平来筛选受试者神经障碍的方法。 具体地，通过确定获得的组织样品中的β-N-甲基氨基-L-丙氨酸（BMAA）的水平，公开了用于诊断受试者的神经障碍或预测受试者发展神经障碍的可能性的方法 从主题。 公开了与神经障碍相关的环境因素的筛选方法。 公开了抑制，治疗或预防神经障碍的方法。

公开(公告)号：US20090224095A1

公开(公告)日：2009-09-10

申请号：US12042030

申请日：2008-03-04

Applicant: Paul Alan Cox ,  Emray Goossen

Inventor： Paul Alan Cox ,  Emray Goossen

IPC: B64C27/08

CPC classification number: B64C39/026 ,  B64C27/20 ,  B64C39/024 ,  B64C2201/027 ,  B64C2201/108

Abstract: A vertical take-off and landing (VTOL) vehicle includes a first thruster, a first duct, a second thruster, a second duct, an engine pod, and a transport unit. The first duct is configured to direct airflow generated by the first thruster. The second duct is configured to direct airflow generated by the second thruster. The engine pod is formed between the first duct and the second duct. The transport unit is formed between the first duct and the second duct, and is configured to transport a person or another payload. The transport unit is alternatively a person transport or a surveillance package pod.

Abstract translation: 垂直起降（VTOL）车辆包括第一推进器，第一管道，第二推进器，第二管道，发动机舱和运输单元。 第一管道构造成引导由第一推进器产生的气流。 第二管道构造成引导由第二推进器产生的气流。 发动机舱形成在第一管道和第二管道之间。 传送单元形成在第一管道和第二管道之间，并且被配置为运送人或另一有效载荷。 运输单元是人运输或监视包装盒。

公开(公告)号：US20110223624A1

公开(公告)日：2011-09-15

申请号：US13056877

申请日：2009-07-02

Applicant: Paul Alan Cox ,  James S. Metcalf ,  Geoffrey A. Codd

Inventor： Paul Alan Cox ,  James S. Metcalf ,  Geoffrey A. Codd

IPC: G01N33/566 ,  G01N33/577 ,  G01N21/64 ,  G01N21/76 ,  C07K16/18

CPC classification number: G01N33/6812 ,  C07K16/44 ,  C07K2317/33

Abstract: An immunoassay for screening a sample to detect the presence of β-N-methylamino-L-alanine (BMAA) is disclosed. Antibodies specific for BMAA are disclosed. Antibodies that bind to BMAA on immunoblots are disclosed. Immunoassays and kits to detect the presence of BMAA in a sample by contacting the sample with an antibody that binds to BMAA, and detecting the antibody bound to the sample, are disclosed. Immunoassays and kits for screening for the presence of BMAA in a subject by analyzing a tissue sample obtained from the subject to detect the present of BMAA in the tissue sample, where the presence of BMAA in the tissue sample indicates exposure of the subject to an environmental source of BMAA, are disclosed. Immunoassays and kits for detecting an environmental source of BMAA, by screening an environmental sample to detect the presence of BMAA in the sample, wherein the presence of a detectable amount of BMAA in the sample indicates the sample is an environmental source of BMAA, are disclosed.

Abstract translation: 公开了用于筛选样品以检测存在β-甲基氨基-L-丙氨酸（BMAA）的免疫测定。 公开了针对BMAA的抗体。 公开了在免疫印迹上结合BMAA的抗体。 公开了通过使样品与结合BMAA的抗体接触并检测与样品结合的抗体来检测样品中BMAA存在的免疫测定和试剂盒。 用于通过分析从受试者获得的组织样品来检测受试者中BMAA存在的免疫测定和试剂盒，以检测组织样品中BMAA的存在，其中组织样品中BMAA的存在表明受试者暴露于环境 BMAA的来源被披露。 通过筛选环境样品以检测样品中BMAA的存在来检测BMAA的环境来源的免疫测定和试剂盒，其中样品中可检测量的BMAA的存在表明样品是BMAA的环境来源，公开 。

公开(公告)号：US20110147533A1

公开(公告)日：2011-06-23

申请号：US12643839

申请日：2009-12-21

Applicant: Emray Goossen ,  Paul Alan Cox ,  Patrick O'Brien

Inventor： Emray Goossen ,  Paul Alan Cox ,  Patrick O'Brien

IPC: B64C29/00 ,  F04D29/56 ,  F04D27/00

CPC classification number: B64C11/001 ,  B64C39/024 ,  B64C2201/027 ,  B64C2201/108

Abstract: A morphing duct of a ducted fan for a vertical take-off and landing (VTOL) vehicle is configured to change shape as function of the flight mode of the vehicle to improve the thrust per unit energy input for the ducted fan. Additionally, the morphing duct may be configured to change shape to change the flight path of the VTOL vehicle.

Abstract translation: 用于垂直起飞和着陆（VTOL）车辆的管道风扇的变形管道被配置为根据车辆的飞行模式改变形状，以改善管道风扇的每单位能量输入的推力。 此外，变形管道可以被配置为改变形状以改变直升机车辆的飞行路径。