知搜-全球专利检索

  1. 登录
  2. 注册

搜索结果

18 条记录 (耗时 0.023 秒)

    METHOD FOR HARVESTING, PROCESSING, AND STORAGE OF PROTEINS FROM THE MAMMALIAN FETO-PLACENTAL UNIT AND USE OF SUCH PROTEINS IN COMPOSITIONS AND MEDICAL TREATMENT
    1.
    发明申请
    METHOD FOR HARVESTING, PROCESSING, AND STORAGE OF PROTEINS FROM THE MAMMALIAN FETO-PLACENTAL UNIT AND USE OF SUCH PROTEINS IN COMPOSITIONS AND MEDICAL TREATMENT 审中-公开
    捕食，加工和储存来自MAMMALIAN FETO-PLACENTAL UNIT的蛋白质的方法以及这些蛋白质在组合物和医疗处理中的应用

    公开(公告)号：US20150079062A1

    公开(公告)日：2015-03-19

    申请号：US14551612

    申请日：2014-11-24

    申请人： Patrick J. Casey ,  Murray Hoare

    发明人： Patrick J. Casey ,  Murray Hoare

    IPC分类号： A61K35/54 ,  A61K38/17 ,  A01N1/02 ,  A61K35/50

    CPC分类号： A61K35/54 ,  A01N1/0284 ,  A61K35/50 ,  A61K38/00

    摘要： The invention provides a method of harvesting, processing and storing a plurality of proteins from a mammalian feto-placental unit. The method includes dissecting a mammalian uterus to harvest at least one component of the mammalian feto-placental unit; blast freezing the component; and storing the blast frozen component; wherein the blast frozen component includes the proteins. In one embodiment, the method includes lyophilizing the blast frozen component to remove at least some water from the blast frozen component thereby creating a freeze-dried form; and storing the lyophilized component; wherein the lyophilized component includes the proteins. The invention also provides a composition including proteins from at least one lyophilized, blast frozen component of a harvested mammalian feto-placental unit reconstituted with a fluid. The invention further provides method of treatment of a disease or aging in a mammalian subject including administering to the mammalian subject a plurality of proteins from at least one blast frozen component harvested from a mammalian feto-placental unit; and reducing an accumulation of at least one intracellular protein in the subject.

    摘要翻译： 本发明提供从哺乳动物胎盘胎单元收获，加工和储存多种蛋白质的方法。 该方法包括解剖哺乳动物子宫以收获哺乳动物胎盘胎单元的至少一个组分; 爆炸冻结组件; 并储存喷砂冷冻组分; 其中所述鼓风冷冻组分包括所述蛋白质。 在一个实施方案中，所述方法包括冻干所述鼓风冷冻组分以从所述鼓风冷冻组分中除去至少一些水，从而产生冷冻干燥形式; 并储存所述冻干组分; 其中所述冻干组分包括所述蛋白质。 本发明还提供一种组合物，其包含来自用流体重构的收获的哺乳动物胎盘胎单元的至少一种冻干的，高温冷冻组分的蛋白质。 本发明还提供了治疗哺乳动物受试者疾病或衰老的方法，包括向哺乳动物受试者施用从哺乳动物胎盘组织收获的至少一种胚芽冷冻组分的多种蛋白质; 并减少受试者中至少一种细胞内蛋白质的积累。

    Methods for treating glaucoma and macular degeneration
    2.
    发明授权
    Methods for treating glaucoma and macular degeneration 有权
    治疗青光眼和黄斑变性的方法

    公开(公告)号：US08669253B2

    公开(公告)日：2014-03-11

    申请号：US11716724

    申请日：2007-03-12

    申请人： Vasantha P. Rao ,  Patrick J. Casey ,  Peifeng Deng ,  Yuri K. Peterson

    发明人： Vasantha P. Rao ,  Patrick J. Casey ,  Peifeng Deng ,  Yuri K. Peterson

    IPC分类号： A61K31/41 ,  A61K31/53

    CPC分类号： G01N33/5044 ,  G01N33/5088 ,  G01N2333/4709 ,  G01N2333/91 ,  G01N2800/168

    摘要： Inhibition of geranylgeranylation of Rho GTPases and heterotrimeric G-proteins in the aqueous outflow pathway increases aqueous humor outflow, possibly through the tissue relaxation, and through altered cell adhesive interactions and actin cytoskeletal organization in cells of the outflow pathway. In addition, such inhibition is useful for treating age-related macular degeneration. The GGTase-I enzyme is a molecular target for lowering increased ocular pressure in glaucoma patients.

    摘要翻译： 抑制Rho GTP酶和异源三聚体G蛋白在水流出途径中的香叶基刺激，可能通过组织松弛以及通过流出途径细胞中细胞粘附相互作用和肌动蛋白细胞骨架组织的改变引起房水流出。 此外，这种抑制对于治疗年龄相关性黄斑变性是有用的。 GGTase-I酶是降低青光眼患者眼压升高的分子靶点。

    Method for growing adult cells
    3.
    发明授权
    Method for growing adult cells 有权
    成长细胞生长方法

    公开(公告)号：US08372644B2

    公开(公告)日：2013-02-12

    申请号：US11702895

    申请日：2007-02-06

    申请人： Patrick J. Casey ,  Richard Fry ,  Kerri Fry

    发明人： Patrick J. Casey ,  Richard Fry ,  Kerri Fry

    IPC分类号： C12N5/00

    CPC分类号： C12N5/00

    摘要： A method for growing adult cells includes harvesting a tissue sample from a subject and breaking the tissue sample into fragments. The fragments are placed into a culture vessel, and at least some of the fragments are induced to adhere to the culture vessel. The fragments are supplied with nutrients so that adult cells contained therein divide and grow.

    摘要翻译： 用于生长成年细胞的方法包括从受试者收获组织样品并将组织样品破碎成碎片。 将片段置于培养容器中，至少部分片段被诱导粘附于培养容器。 这些片段被提供营养，使其中包含的成体细胞分裂和生长。

    Method for treating an animal having damaged tissue structure
    7.
    发明申请
    Method for treating an animal having damaged tissue structure 审中-公开
    用于治疗损伤组织结构的动物的方法

    公开(公告)号：US20080311085A1

    公开(公告)日：2008-12-18

    申请号：US12005153

    申请日：2007-12-21

    申请人： Patrick J. Casey ,  Kerri Fry

    发明人： Patrick J. Casey ,  Kerri Fry

    IPC分类号： A61K35/12 ,  A61P19/04

    CPC分类号： A61K35/32 ,  A61K35/12 ,  C12N5/066

    摘要： A method for treating an animal having damaged tissue structure includes harvesting a tissue sample from a subject harvesting a tissue sample from the animal, growing tendon-like cells from the tissue sample, and transplanting the tendon-like cells into the damaged tissue structure. Growing the tendon-like cells from the tissue sample can be accomplished by breaking the tissue sample into fragments, placing the fragments into a culture vessel, inducing at least some of the fragments to adhere to the culture vessel, and supplying the fragments with nutrients so that tendon-like cells contained therein divide and grow.

    摘要翻译： 用于治疗具有损伤的组织结构的动物的方法包括从收集来自动物的组织样品的受试者收集组织样品，从组织样品生长腱样细胞，以及将腱样细胞移植到损伤的组织结构中。 从组织样品生长肌腱样细胞可以通过将组织样品破碎成片段，将片段放入培养容器中，诱导至少一些片段粘附到培养容器上，并将片段供应营养物质来实现 其中包含的肌腱样细胞分裂和生长。

    METHOD FOR THE HARVESTING, PROCESSING, AND STORAGE OF PROTEINS FROM THE MAMMALIAN FETO-PLACENTAL UNIT AND USE OF SUCH PROTEINS IN COMPOSITIONS AND MEDICAL TREATMENT
    10.
    发明申请
    METHOD FOR THE HARVESTING, PROCESSING, AND STORAGE OF PROTEINS FROM THE MAMMALIAN FETO-PLACENTAL UNIT AND USE OF SUCH PROTEINS IN COMPOSITIONS AND MEDICAL TREATMENT 审中-公开
    用于从MAMMALIAN FETO-PLACENTAL单位收集，处理和储存蛋白质的方法以及这些蛋白质在组合物和医疗处理中的使用方法

    公开(公告)号：US20150079061A1

    公开(公告)日：2015-03-19

    申请号：US14330818

    申请日：2014-07-14

    申请人： Patrick J. Casey ,  Murray Hoare

    发明人： Patrick J. Casey ,  Murray Hoare

    IPC分类号： A61K35/54 ,  A61K38/17 ,  A61K35/50

    CPC分类号： A61K35/54 ,  A61K35/50 ,  A61K38/00 ,  A61K38/1709

    摘要： The invention provides a method of harvesting, processing and storing a plurality of proteins from a mammalian feto-placental unit. The method includes dissecting a mammalian uterus to harvest at least one component of the mammalian feto-placental unit; blast freezing the component; and storing the blast frozen component; wherein the blast frozen component includes the proteins. In one embodiment, the method includes lyophilizing the blast frozen component to remove at least some water from the blast frozen component thereby creating a freeze-dried form; and storing the lyophilized component; wherein the lyophilized component includes the proteins. The invention also provides a composition including proteins from at least one lyophilized, blast frozen component of a harvested mammalian feto-placental unit reconstituted with a fluid. The invention further provides method of treatment of a disease or aging in a mammalian subject including administering to the mammalian subject a plurality of proteins from at least one blast frozen component harvested from a mammalian feto-placental unit; and reducing an accumulation of at least one intracellular protein in the subject.

    摘要翻译： 本发明提供从哺乳动物胎盘胎单元收获，加工和储存多种蛋白质的方法。 该方法包括解剖哺乳动物子宫以收获哺乳动物胎盘胎单元的至少一个组分; 爆炸冻结组件; 并储存喷砂冷冻组分; 其中所述鼓风冷冻组分包括所述蛋白质。 在一个实施方案中，所述方法包括冻干所述鼓风冷冻组分以从所述鼓风冷冻组分中除去至少一些水，从而产生冷冻干燥形式; 并储存所述冻干组分; 其中所述冻干组分包括所述蛋白质。 本发明还提供一种组合物，其包含来自用流体重构的收获的哺乳动物胎盘胎单元的至少一种冻干的，高温冷冻组分的蛋白质。 本发明还提供了治疗哺乳动物受试者疾病或衰老的方法，包括向哺乳动物受试者施用从哺乳动物胎盘组织收获的至少一种胚芽冷冻组分的多种蛋白质; 并减少受试者中至少一种细胞内蛋白质的积累。