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    Game apparatus and method of play for manual or computer application
    2.
    发明申请
    Game apparatus and method of play for manual or computer application 审中-公开
    用于手动或计算机应用的游戏装置和播放方法

    公开(公告)号：US20080227510A1

    公开(公告)日：2008-09-18

    申请号：US12075426

    申请日：2008-03-11

    申请人： Patricia McLaughlin

    发明人： Patricia McLaughlin

    IPC分类号： A63F9/24 ,  A63F3/00

    CPC分类号： A63F3/00533 ,  A63F3/00176 ,  A63F2003/004 ,  A63F2003/00558 ,  A63F2003/00583

    摘要： A game apparatus for play by at least two players, having game pieces that are manually placed in at least four slideably mounted, apertured slats, each having at least four apertures for receiving one or more of the game pieces, and a base assembly for slideably mounting the slats, such that the slats can be moved, and the game pieces placed in the apertures, at the option of each of the players who take turns in playing the game. The game pieces are generally grouped in two different colors. The number of slats are generally the same as the number of apertures, and are preferably four or eight in number. The method of play by two players of apparatus involves each of the players taking turns that are selected from two possible moves: placing a game piece in one of the apertures on one of the slats or linearly displacing one of the slats one stop. The game commences with no pieces on the board, and with no home area for determining opening and winning of the game. A winner is determined when a player has a predetermined number of game pieces in a predetermined arrangement, generally four or eight in a row, or in a diamond or other configuration and where the configuration is not a home area. Also included is a virtual game board in which the game is controlled by a computer or group of computers as well as on the Internet.

    摘要翻译： 一种用于由至少两名玩家进行游戏的游戏装置，具有手动放置在至少四个可滑动地安装的多孔板条中的游戏件，每个棋盘具有用于接收一个或多个游戏件的至少四个孔，以及用于可滑动地 安装板条，使得板条可以移动，并且游戏件放置在孔中，每个玩家轮流玩游戏的选项。 游戏件通常分为两种不同的颜色。 板条的数量通常与孔的数量相同，优选数量为四个或八个。 两个装置的玩家玩的方法涉及从两个可能的移动中选出的每个玩家轮流：将一个游戏件放置在其中一个板条上的一个孔中，或者一个板条中的一个线性地移动。 游戏开始没有棋子，没有家庭区域确定开场和赢得比赛。 当玩家具有预定排列的预定数量的游戏棋子时，确定一般胜利者，一般为四个或八个，或者以钻石或其它配置，并且其中该配置不是归属区域。 还包括虚拟游戏板，其中游戏由计算机或一组计算机以及因特网来控制。

    Combinatorial therapies for the treatment of neoplasias using the opioid growth factor receptor
    3.
    发明申请
    Combinatorial therapies for the treatment of neoplasias using the opioid growth factor receptor 审中-公开
    组合治疗使用阿片样生长因子受体治疗肿瘤

    公开(公告)号：US20050191241A1

    公开(公告)日：2005-09-01

    申请号：US11061932

    申请日：2005-02-21

    申请人： Ian Zagon ,  Patricia McLaughlin ,  Jill Smith

    发明人： Ian Zagon ,  Patricia McLaughlin ,  Jill Smith

    IPC分类号： A61K31/337 ,  A61K31/4745 ,  A61K31/505 ,  A61K31/573 ,  A61K31/663 ,  A61K31/704 ,  A61K31/7048 ,  A61K31/7072 ,  A61K38/00 ,  A61K45/06 ,  A61K51/00

    摘要： The present invention relates to pharmaceutical compositions for treating neoplasias in an animal or human comprised of a carrier and therapeutically effective amounts of at least one chemotherapeutic agent along with the biotherapeutic endogenous pentapeptide Met-enkephalin, referred to as opioid growth factor. Also provided are methods of treating neoplasias in an animal or human in need of such treatment, comprising the administration to the animal or human therapeutically effective amounts of a pharmaceutical composition comprised of a carrier and therapeutically effective amounts of at least one neoplasia-treating agent, such as a chemotherapeutic agent or radiation, along with opioid growth factor.

    摘要翻译： 本发明涉及用于治疗动物或人类肿瘤的药物组合物，其包含载体和治疗有效量的至少一种化学治疗剂以及生物治疗性内源五肽Met-脑啡肽，称为阿片样生长因子。 还提供了在需要这种治疗的动物或人中治疗肿瘤的方法，包括向动物或人施用治疗有效量的由载体和治疗有效量的至少一种瘤形成治疗剂组成的药物组合物， 如化疗剂或辐射，以及阿片样生长因子。

    Semiconductor package having etched-back silver-copper braze
    4.
    发明授权
    Semiconductor package having etched-back silver-copper braze 失效
    具有蚀刻后的铜 - 铜钎焊的半导体封装

    公开(公告)号：US5896869A

    公开(公告)日：1999-04-27

    申请号：US784730

    申请日：1997-01-13

    申请人： Joseph Francis Maniscalco ,  Karen Patricia McLaughlin ,  Krystyna Waleria Semkow

    发明人： Joseph Francis Maniscalco ,  Karen Patricia McLaughlin ,  Krystyna Waleria Semkow

    IPC分类号： B23K1/20 ,  H01L21/48 ,  H01L23/498 ,  B08B6/00 ,  B23H3/00 ,  H01L21/302

    CPC分类号： B23K1/206 ,  H01L21/4853 ,  H01L23/49811 ,  H01L2924/0002

    摘要： An electroetching method for removing excess silver-copper braze material from the edges of I/O pads during the manufacture of chip carriers for microelectronic devices, and the product thereby produced, are disclosed. The disclosed method is preferably self-limiting, such that braze material is preferentially removed from all regions of the assembly. The method is particularly useful for producing a desirable sidewall profile, size, and extent of coverage of the I/O pad for the fillet of braze material surrounding the base of pins in a pin grid array device. Agitation control is important for producing the desired uniformity and profile.

    摘要翻译： 公开了一种用于在用于微电子器件的芯片载体的制造期间从I / O焊盘的边缘去除多余的银 - 铜钎焊材料的电蚀刻方法和由此生产的产品。 所公开的方法优选是自限制的，使得钎焊材料优选地从组件的所有区域移除。 该方法特别可用于产生围绕引脚格栅阵列器件中的引脚基部的钎焊材料的圆角的I / O焊盘的期望的侧壁轮廓，尺寸和覆盖范围。 搅拌控制对于产生所需的均匀性和轮廓是重要的。

    Novel nucleic acid molecules encoding opioid growth factor receptors
    6.
    发明申请
    Novel nucleic acid molecules encoding opioid growth factor receptors 有权
    编码阿片类生长因子受体的新型核酸分子

    公开(公告)号：US20060073565A1

    公开(公告)日：2006-04-06

    申请号：US11249993

    申请日：2005-10-13

    申请人： Ian Zagon ,  Patricia McLaughlin ,  Michael Verderame

    发明人： Ian Zagon ,  Patricia McLaughlin ,  Michael Verderame

    IPC分类号： A61K38/17 ,  C07K14/705 ,  C07H21/04 ,  C12P21/06

    CPC分类号： C12N15/1138 ,  A61K38/00 ,  C07K14/71 ,  C07K16/28 ,  C12N2310/11 ,  C12N2310/315

    摘要： This invention relates to novel nucleic acid molecules coding for opioid growth factor receptors. In particular, the present invention provides isolated nucleic acid molecules coding for human and rat OGF receptors. Antisense molecules, expression vectors and host cells, isolated proteins encoded by such nucleic acid molecules, antibodies directed against such proteins, as well as pharmaceutical compositions derived therefrom are also included. The invention further provides methods of modulating cell growth by using the isolated nucleic acid molecules, the antisense molecules and the antibodies directed against the encoded proteins.

    摘要翻译： 本发明涉及编码阿片类生长因子受体的新型核酸分子。 特别地，本发明提供编码人和大鼠OGF受体的分离的核酸分子。 还包括反义分子，表达载体和宿主细胞，由这种核酸分子编码的分离的蛋白质，针对这种蛋白质的抗体，以及由其衍生的药物组合物。 本发明还提供了通过使用分离的核酸分子，反义分子和针对编码的蛋白质的抗体来调节细胞生长的方法。