公开(公告)号：US20160215345A1

公开(公告)日：2016-07-28

申请号：US15089299

申请日：2016-04-01

申请人： Paul D. Coleman

发明人： Paul D. Coleman

IPC分类号： C12Q1/68

CPC分类号： C12Q1/6883 ,  C12Q2600/112 ,  C12Q2600/118 ,  C12Q2600/154 ,  C12Q2600/158 ,  G01N33/5308 ,  G01N33/6863 ,  G01N33/6896 ,  G01N2800/2821 ,  G01N2800/54 ,  G16B20/00 ,  G16B40/00

摘要： Various embodiments provide methods for the detection, the diagnosis, and/or the prediction of disease onset of Alzheimer's disease. Methods for determining a state of Alzheimer's disease are provided. Accordingly, these methods can comprise the steps of placing a sample comprising at least one blood component onto a substrate, labeling the sample to identify at least one epigenetic marker and at least one of an inflammation marker and a cellular stress marker; determining an amount of the markers; performing a multivariate statistical analysis to produce an output value; comparing the output value to a reference value; and determining a state of Alzheimer's disease.

公开(公告)号：US20120232016A1

公开(公告)日：2012-09-13

申请号：US13043182

申请日：2011-03-08

申请人： PAUL D. COLEMAN

发明人： PAUL D. COLEMAN

IPC分类号： A61K38/00 ,  G06F17/18 ,  G01N33/48 ,  A61P25/28 ,  G06F19/00

CPC分类号： C12Q1/6883 ,  C12Q2600/112 ,  C12Q2600/118 ,  C12Q2600/154 ,  C12Q2600/158 ,  G01N33/5308 ,  G01N33/6863 ,  G01N33/6896 ,  G01N2800/2821 ,  G01N2800/54 ,  G16B20/00 ,  G16B40/00

摘要： Various embodiments provide methods for the detection, the diagnosis, and/or the prediction of disease onset of Alzheimer's disease. Methods for determining a state of Alzheimer's disease are provided. Accordingly, these methods can comprise the steps of placing a sample comprising at least one blood component onto a substrate, labeling the sample to identify at least one epigenetic marker and at least one of an inflammation marker and a cellular stress marker; determining an amount of the markers; performing a multivariate statistical analysis to produce an output value; comparing the output value to a reference value; and determining a state of Alzheimer's disease.

摘要翻译： 各种实施方案提供了用于阿尔茨海默氏病发病的检测，诊断和/或预测的方法。 提供了确定阿尔茨海默病状态的方法。 因此，这些方法可以包括以下步骤：将包含至少一种血液成分的样品放置在底物上，标记样品以鉴定至少一种表观遗传标记和炎症标记和细胞应激标记中的至少一个; 确定标记的量; 执行多变量统计分析以产生输出值; 将输出值与参考值进行比较; 并确定阿尔茨海默病的状态。

公开(公告)号：US5605605A

公开(公告)日：1997-02-25

申请号：US379045

申请日：1995-01-27

申请人： Paul D. Coleman ,  John R. Robertson

发明人： Paul D. Coleman ,  John R. Robertson

IPC分类号： D21H19/24 ,  D21H23/50 ,  D21H19/16

CPC分类号： D21H19/24 ,  D21H23/50

摘要： A process is disclosed for strengthening and sizing paper which comprises the step of applying a composition comprising (a) an isocyanate and (b) an isocyanate-reactive component comprising at least one polyol having an ethylene oxide content of at least 1%, wherein said composition does not contain water to the paper by means of an electrostatic spraying device having a linear orifice.

摘要翻译： 公开了一种用于加强和确定纸张尺寸的方法，该方法包括施加包含（a）异氰酸酯和（b）包含至少一种环氧乙烷含量至少为1％的至少一种多元醇的异氰酸酯反应性组分的组合物的步骤，其中所述 组合物通过具有线性孔口的静电喷涂装置不含有水。

公开(公告)号：US09314947B2

公开(公告)日：2016-04-19

申请号：US12600876

申请日：2008-05-22

申请人： Christopher J. Moriarty ,  Sachchida N. Singh ,  Paul D. Coleman

发明人： Christopher J. Moriarty ,  Sachchida N. Singh ,  Paul D. Coleman

IPC分类号： C08L97/02 ,  B29C43/36 ,  C08G18/48 ,  C08G18/64 ,  C08G18/76 ,  C09J175/08 ,  B29K311/14 ,  B29C70/44 ,  B29K1/00 ,  C08L61/28 ,  C08L91/06

CPC分类号： C09J175/08 ,  B29C43/3642 ,  B29C70/44 ,  B29K2001/00 ,  B29K2311/14 ,  C08G18/4837 ,  C08G18/6492 ,  C08G18/7664 ,  C08L61/28 ,  C08L91/06 ,  C08L97/02

摘要： Adhesives, reaction systems, and processes for the production of lignocellulosic composites. The reaction system comprises a multi-component adhesive and a lignocellulosic substrate. The lignocellulosic substrate comprises a plurality of lignocellulosic adherends and is preferably a mass of wood particles. The multi-component adhesive comprises a multi-functional isocyanate, a hydrophilic polyahl, and an organotransition metal catalyst. The multi-component adhesive is characterized by being formulated into at least two mutually reactive chemical component streams. The process comprises the separate application of the mutually reactive chemical component streams of the multi-component adhesive to the lignocellulosic substrate, followed by forming and pressing the adhesive treated substrate under conditions appropriate for curing the adhesive and forming a lignocellulosic composite article. The adhesives, reaction systems, and processes are particularly well suited for the production of oriented strand board (OSB).

摘要翻译： 粘合剂，反应体系和生产木质纤维素复合材料的方法。 反应体系包括多组分粘合剂和木质纤维素基质。 木质纤维素基质包含多个木质素纤维素被粘物，并且优选为大量的木质颗粒。 多组分粘合剂包括多官能异氰酸酯，亲水多烯烃和有机转移金属催化剂。 多组分粘合剂的特征在于配制成至少两种相互反应的化学组分流。 该方法包括将多组分粘合剂的相互反应的化学组分物流单独施加到木质纤维素基质，随后在适于固化粘合剂并形成木质纤维素复合制品的条件下形成和压制经粘合剂处理的基材。 粘合剂，反应体系和工艺特别适用于生产定向刨花板（OSB）。

公开(公告)号：US20110086925A1

公开(公告)日：2011-04-14

申请号：US12797591

申请日：2010-06-09

申请人： Diego Mastroeni ,  Joseph Rogers ,  Andrew Grover ,  Paul D. Coleman

发明人： Diego Mastroeni ,  Joseph Rogers ,  Andrew Grover ,  Paul D. Coleman

IPC分类号： A61K47/00 ,  G01N33/53 ,  C12Q1/68 ,  A61P25/28

CPC分类号： G01N33/5308 ,  C12Q1/6883 ,  G01N33/56972 ,  G01N33/6896 ,  G01N2800/2821

摘要： Various embodiments provide methods for the detection, the diagnosis, and/or the progression monitoring of Alzheimer's disease by observing the epigenetic markers in leukocytes. Methods for determining a state of Alzheimer's disease are provided. Accordingly, these methods can comprise the steps of placing a sample comprising at least one blood component onto a substrate labeling the sample to identify at least one epigenetic marker; determining an amount of the at least one epigenetic marker; comparing the amount to a reference value; and determining a state of Alzheimer's disease.

摘要翻译： 各种实施方案通过观察白细胞中的表观遗传标记来提供用于阿尔茨海默氏病的检测，诊断和/或进展监测的方法。 提供了确定阿尔茨海默病状态的方法。 因此，这些方法可以包括以下步骤：将包含至少一种血液成分的样品放置在标记样品的底物上，以鉴定至少一种表观遗传标记; 确定所述至少一种表观遗传标记的量; 将数量与参考值进行比较; 并确定阿尔茨海默病的状态。

公开(公告)号：US20100168287A1

公开(公告)日：2010-07-01

申请号：US12600876

申请日：2008-05-22

申请人： Christopher J. Moriarty ,  Sachchida N. Singh ,  Paul D. Coleman

发明人： Christopher J. Moriarty ,  Sachchida N. Singh ,  Paul D. Coleman

IPC分类号： C08L1/00 ,  C09J175/04 ,  B32B37/12

CPC分类号： C09J175/08 ,  B29C43/3642 ,  B29C70/44 ,  B29K2001/00 ,  B29K2311/14 ,  C08G18/4837 ,  C08G18/6492 ,  C08G18/7664 ,  C08L61/28 ,  C08L91/06 ,  C08L97/02

摘要： Adhesives, reaction systems, and processes for the production of lignocellulosic composites. The reaction system comprises a multi-component adhesive and a lignocellulosic substrate. The lignocelluosic substrate comprises a plurality of lignocellulosic adherends and is preferably a mass of wood particles. The multi-component adhesive comprises a multi-functional isocyanate, a hydrophilic polyahl, and an organotransition metal catalyst. The multi-component adhesive is characterized by being formulated into at least two mutually reactive chemical component streams. The process comprises the separate application of the mutually reactive chemical component streams of the multi-component adhesive to the lignocellulosic substrate, followed by forming and pressing the adhesive treated substrate under conditions appropriate for curing the adhesive and forming a lignocellulosic composite article. The adhesives, reaction systems, and processes are particularly well suited for the production of oriented strand board (OSB).

摘要翻译： 粘合剂，反应体系和生产木质纤维素复合材料的方法。 反应体系包括多组分粘合剂和木质纤维素基质。 木质纤维素基质包含多个木质纤维素被粘物，并且优选是木质颗粒的质量。 多组分粘合剂包括多官能异氰酸酯，亲水多烯烃和有机转移金属催化剂。 多组分粘合剂的特征在于配制成至少两种相互反应的化学组分流。 该方法包括将多组分粘合剂的相互反应的化学组分物流单独施加到木质纤维素基质，随后在适于固化粘合剂并形成木质纤维素复合制品的条件下形成和压制经粘合剂处理的基材。 粘合剂，反应体系和工艺特别适用于生产定向刨花板（OSB）。