公开(公告)号：US4826319A

公开(公告)日：1989-05-02

申请号：US197336

申请日：1988-05-23

Applicant: Akihiro Namba ,  Fumio Uchino ,  Hitoshi Tateoka ,  Masahiro Ohno ,  Outaro Ando ,  Kouichi Karaki ,  Tatsuo Nagasaki

Inventor： Akihiro Namba ,  Fumio Uchino ,  Hitoshi Tateoka ,  Masahiro Ohno ,  Outaro Ando ,  Kouichi Karaki ,  Tatsuo Nagasaki

IPC: G01J3/44 ,  G01N15/02 ,  G01N21/03 ,  G01N21/25 ,  G01N21/51 ,  G01N21/59 ,  G01N33/53 ,  G01N35/00 ,  G01N33/557 ,  G01N35/02

CPC classification number: G01N21/51 ,  G01N21/253 ,  G01N21/82 ,  G01N33/53 ,  G01J3/4412 ,  G01N15/0205 ,  G01N2015/0216 ,  G01N2021/0325 ,  G01N2021/5969 ,  G01N2021/825 ,  G01N2201/08 ,  G01N35/00029

Abstract: A coherent laser light flux is projected into a cell made of transparent quartz and light scattered from particles suspended in an antigen-antibody reaction liquid contained in the cell is detected by a photomultiplier by means of a collimator. An output electrical signal from the photomultiplier is sampled at different time instances and samplings are supplied to a fast Fourier transformer to derive a plurality of power spectrum desnities of fluctuation in intensity of the scattered light. A plurality of power spectrum densities are averaged to generate a mean power spectrum density. An amount of antigen contained in the reaction liquid is measured in accordance with the mean power spectrum density.

Abstract translation: 将相干的激光光束投射到由透明石英制成的电池中，并且通过光电倍增管通过准直器检测悬浮在包含在电池中的抗原 - 抗体反应液体中的颗粒散射的光。 来自光电倍增器的输出电信号在不同的时间实例被采样，并且采样被提供给快速傅立叶变换器以导出散射光强度波动的多个功率谱散射。 对多个功率谱密度进行平均以产生平均功率谱密度。 根据平均功率谱密度测量反应液中含有的抗原量。

公开(公告)号：US4762413A

公开(公告)日：1988-08-09

申请号：US769965

申请日：1985-08-27

Applicant: Akihiro Namba ,  Fumio Uchino ,  Hitoshi Tateoka ,  Masahiro Ohno ,  Outaro Ando ,  Kouichi Karaki ,  Tatsuo Nagasaki

Inventor： Akihiro Namba ,  Fumio Uchino ,  Hitoshi Tateoka ,  Masahiro Ohno ,  Outaro Ando ,  Kouichi Karaki ,  Tatsuo Nagasaki

IPC: G01J3/44 ,  G01N15/02 ,  G01N21/03 ,  G01N21/25 ,  G01N21/51 ,  G01N21/59 ,  G01N33/53 ,  G01N35/00 ,  G01N33/557 ,  G01N35/02

CPC classification number: G01N21/51 ,  G01N21/253 ,  G01N21/82 ,  G01N33/53 ,  G01J3/4412 ,  G01N15/0205 ,  G01N2015/0216 ,  G01N2021/0325 ,  G01N2021/5969 ,  G01N2021/825 ,  G01N2201/08 ,  G01N35/00029

Abstract: A coherent laser light flux is projected into a cell made of transparent quartz and light scattered from particles suspended in an antigen-antibody reaction liquid contained in the cell is detected by a photomultiplier by means of a collimator. An output electrical signal from the photomultiplier is sampled at different time instances and samplings are supplied to a fast Fourier transformer to derive a plurality of power spectrum densities of fluctuation in intensity of the scattered light. A plurality of power spectrum densities are averaged to generate a mean power spectrum density. An amount of antigen contained in the reaction liquid is measured in accordance with the mean power spectrum density.

Abstract translation: 将相干的激光光束投射到由透明石英制成的电池中，并且通过光电倍增管通过准直器检测悬浮在包含在电池中的抗原 - 抗体反应液体中的颗粒散射的光。 来自光电倍增管的输出电信号在不同的时间采样，并将采样提供给快速傅立叶变换器以导出散射光强度波动的多个功率谱密度。 对多个功率谱密度进行平均以产生平均功率谱密度。 根据平均功率谱密度测量反应液中含有的抗原量。