公开(公告)号：US08876740B2

公开(公告)日：2014-11-04

申请号：US13085368

申请日：2011-04-12

Applicant: Michael S. Canney ,  Michael R. Bailey ,  Lawrence A. Crum ,  Vera A. Khokhlova ,  Tatiana D. Khokhlova ,  Wayne Kreider ,  Joo Ha Hwang ,  Oleg A. Sapozhnikov

Inventor： Michael S. Canney ,  Michael R. Bailey ,  Lawrence A. Crum ,  Vera A. Khokhlova ,  Tatiana D. Khokhlova ,  Wayne Kreider ,  Joo Ha Hwang ,  Oleg A. Sapozhnikov

IPC: A61N7/02 ,  A61B17/00 ,  A61B19/00 ,  A61B18/00

CPC classification number: A61N7/02 ,  A61B2017/00084 ,  A61B2018/00005 ,  A61B2090/374 ,  A61B2090/378

Abstract: Methods and systems for non-invasive treatment of tissue using high intensity focused ultrasound (“HIFU”) therapy. A method of non-invasively treating tissue in accordance with an embodiment of the present technology, for example, can include positioning a focal plane of an ultrasound source at a target site in tissue. The ultrasound source can be configured to emit HIFU waves. The method can further include pulsing ultrasound energy from the ultrasound source toward the target site, and generating shock waves in the tissue to induce boiling of the tissue at the target site within milliseconds. The boiling of the tissue at least substantially emulsifies the tissue.

Abstract translation: 使用高强度聚焦超声（“HIFU”）治疗非侵入性治疗组织的方法和系统。 例如，根据本技术的实施例的非侵入性治疗组织的方法可以包括将超声源的焦平面定位在组织中的目标部位。 超声波源可被配置为发射HIFU波。 该方法还可以包括将来自超声源的超声能量脉冲向目标部位，并在组织内产生冲击波，以在毫秒内诱导目标部位的组织沸腾。 组织的沸腾至少基本上乳化组织。

公开(公告)号：US20120071795A1

公开(公告)日：2012-03-22

申请号：US13236531

申请日：2011-09-19

Applicant: Vera A. Khokhlova ,  Olga V. Bessonova ,  Michael S. Canney ,  Michael R. Bailey ,  Oleg A. Sapozhnikov ,  Lawrence A. Crum

Inventor： Vera A. Khokhlova ,  Olga V. Bessonova ,  Michael S. Canney ,  Michael R. Bailey ,  Oleg A. Sapozhnikov ,  Lawrence A. Crum

IPC: A61N7/00

CPC classification number: A61N7/02 ,  A61B2034/104

Abstract: Methods of derating a nonlinear ultrasound field and associated systems are disclosed herein. A method of derating a nonlinear ultrasound field in accordance with an embodiment of the present technology can include, for example, calibrating an ultrasound source to a first source voltage (Vw) and generating a nonlinear acoustic wave from the ultrasound source into water. The method can further include measuring a focal waveform of the nonlinear acoustic wave and determining a second source voltage (Vt) of the ultrasound source that generates the same focal waveform in tissue.

Abstract translation: 本文公开了降低非线性超声场和相关系统的方法。 根据本技术的实施例的降低非线性超声场的方法可以包括例如将超声源校准为第一源极电压（Vw）并且从超声源产生非线性声波到水中。 该方法还可以包括测量非线性声波的聚焦波形并确定在组织中产生相同焦点波形的超声源的第二源电压（Vt）。

公开(公告)号：US09498651B2

公开(公告)日：2016-11-22

申请号：US13444466

申请日：2012-04-11

Applicant: Oleg A. Sapozhnikov ,  Michael R. Bailey ,  Lawrence A. Crum ,  Tatiana D. Khokhlova ,  Vera A. Khokhlova ,  Julianna C. Simon ,  Yak-Nam Wang

Inventor： Oleg A. Sapozhnikov ,  Michael R. Bailey ,  Lawrence A. Crum ,  Tatiana D. Khokhlova ,  Vera A. Khokhlova ,  Julianna C. Simon ,  Yak-Nam Wang

IPC: A61B8/00 ,  A61N7/02 ,  A61N7/00

CPC classification number: A61N7/02 ,  A61B8/00 ,  A61N2007/0039

Abstract: The present technology is directed to methods of soft tissue emulsification using a mechanism of ultrasonic atomization inside gas or vapor cavities, and associated systems and devices. In several embodiments, for example, a method of non-invasively treating tissue includes pulsing ultrasound energy from the ultrasound source toward the target site in tissue. The ultrasound source is configured to emit high intensity focused ultrasound (HIFU) waves. The target site comprises a pressure-release interface of a gas or vapor cavity located within the tissue. The method continues by generating shock waves in the tissue to induce a lesion in the tissue at the target site. The method additionally includes characterizing the lesion based on a degree of at least one of a mechanical or thermal ablation of the tissue.

Abstract translation: 本技术涉及使用在气体或蒸气腔内的超声雾化机理以及相关系统和装置的软组织乳化方法。 在几个实施例中，例如，非侵入性治疗组织的方法包括将来自超声源的超声能量脉冲到组织中的靶位点。 超声波源被配置为发射高强度聚焦超声（HIFU）波。 靶位置包括位于组织内的气体或气体腔的压力释放界面。 该方法继续通过在组织中产生冲击波以在靶位点处的组织中引起损伤。 该方法还包括基于组织的机械或热消融中的至少一个程度来表征病变。

公开(公告)号：US08668658B2

公开(公告)日：2014-03-11

申请号：US13236531

申请日：2011-09-19

Applicant: Vera A. Khokhlova ,  Olga V. Bessonova ,  Michael S. Canney ,  Michael R. Bailey ,  Oleg A. Sapozhnikov ,  Lawrence A. Crum

Inventor： Vera A. Khokhlova ,  Olga V. Bessonova ,  Michael S. Canney ,  Michael R. Bailey ,  Oleg A. Sapozhnikov ,  Lawrence A. Crum

IPC: A61H1/00

CPC classification number: A61N7/02 ,  A61B2034/104

Abstract: Methods of derating a nonlinear ultrasound field and associated systems are disclosed herein. A method of derating a nonlinear ultrasound field in accordance with an embodiment of the present technology can include, for example, calibrating an ultrasound source to a first source voltage (Vw) and generating a nonlinear acoustic wave from the ultrasound source into water. The method can further include measuring a focal waveform of the nonlinear acoustic wave and determining a second source voltage (Vt) of the ultrasound source that generates the same focal waveform in tissue.

Abstract translation: 本文公开了降低非线性超声场和相关系统的方法。 根据本技术的实施例的降低非线性超声场的方法可以包括例如将超声源校准为第一源极电压（Vw）并且从超声源产生非线性声波到水中。 该方法还可以包括测量非线性声波的聚焦波形并确定在组织中产生相同焦点波形的超声源的第二源电压（Vt）。

公开(公告)号：US20170249932A1

公开(公告)日：2017-08-31

申请号：US15508841

申请日：2015-08-26

Applicant: Oleg A. SAPOZHNIKOV ,  Wayne KREIDER ,  Michael R. BAILEY ,  University of Washington

Inventor： Adam D. Maxwell ,  Oleg A. Sapozhnikov ,  Wayne Kreider ,  Michael R. Bailey

IPC: G10K11/00 ,  G10K11/30 ,  H03H9/64 ,  G10K11/20 ,  G10K11/24

CPC classification number: G10K11/008 ,  A61B17/225 ,  A61B17/2255 ,  A61B2017/22028 ,  G10K11/20 ,  G10K11/24 ,  G10K11/30 ,  G10K11/346 ,  G10K15/00 ,  H03H9/6483

Abstract: A method includes transmitting a focused ultrasound wave into a medium to form (i) an ultrasound intensity well within the medium that exhibits a first range of acoustic pressure and (ii) a surrounding region of the medium that surrounds the ultrasound intensity well and exhibits a second range of acoustic pressure that exceeds the first range of acoustic pressure. The method further includes confining an object within the ultrasound intensity well. Additionally, an acoustic lens is configured to be acoustically coupled to an acoustic transducer. The acoustic lens has a varying longitudinal thickness that increases proportionally with respect to increasing azimuth angle of the acoustic lens. Another acoustic lens is configured to be acoustically coupled to an acoustic that increases proportionally with respect to increasing azimuth angle of the segment.

公开(公告)号：US20120259250A1

公开(公告)日：2012-10-11

申请号：US13444466

申请日：2012-04-11

Applicant: Oleg A. Sapozhnikov ,  Michael R. Bailey ,  Lawrence A. Crum ,  Tatiana D. Khokhlova ,  Vera A. Khokhlova ,  Julianna C. Simon ,  Yak-Nam Wang

Inventor： Oleg A. Sapozhnikov ,  Michael R. Bailey ,  Lawrence A. Crum ,  Tatiana D. Khokhlova ,  Vera A. Khokhlova ,  Julianna C. Simon ,  Yak-Nam Wang

IPC: A61N7/00

CPC classification number: A61N7/02 ,  A61B8/00 ,  A61N2007/0039

Abstract: The present technology is directed to methods of soft tissue emulsification using a mechanism of ultrasonic atomization inside gas or vapor cavities, and associated systems and devices. In several embodiments, for example, a method of non-invasively treating tissue includes pulsing ultrasound energy from the ultrasound source toward the target site in tissue. The ultrasound source is configured to emit high intensity focused ultrasound (HIFU) waves. The target site comprises a pressure-release interface of a gas or vapor cavity located within the tissue. The method continues by generating shock waves in the tissue to induce a lesion in the tissue at the target site. The method additionally includes characterizing the lesion based on a degree of at least one of a mechanical or thermal ablation of the tissue.

Abstract translation: 本技术涉及使用在气体或蒸气腔内的超声雾化机理以及相关系统和装置的软组织乳化方法。 在几个实施例中，例如，非侵入性治疗组织的方法包括将来自超声源的超声能量脉冲到组织中的靶位点。 超声波源被配置为发射高强度聚焦超声（HIFU）波。 靶位置包括位于组织内的气体或气体腔的压力释放界面。 该方法继续通过在组织中产生冲击波以在靶位点处的组织中引起损伤。 该方法还包括基于组织的机械或热消融中的至少一个程度来表征病变。

公开(公告)号：US20110251528A1

公开(公告)日：2011-10-13

申请号：US13085368

申请日：2011-04-12

Applicant: Michael S. Canney ,  Michael R. Bailey ,  Lawrence A. Crum ,  Vera A. Khokhlova ,  Tatiana D. Khokhlova ,  Wayne Kreider ,  Joo Ha Hwang ,  Oleg A. Sapozhnikov

Inventor： Michael S. Canney ,  Michael R. Bailey ,  Lawrence A. Crum ,  Vera A. Khokhlova ,  Tatiana D. Khokhlova ,  Wayne Kreider ,  Joo Ha Hwang ,  Oleg A. Sapozhnikov

IPC: A61N7/02

CPC classification number: A61N7/02 ,  A61B2017/00084 ,  A61B2018/00005 ,  A61B2090/374 ,  A61B2090/378

Abstract: Methods and systems for non-invasive treatment of tissue using high intensity focused ultrasound (“HIFU”) therapy. A method of non-invasively treating tissue in accordance with an embodiment of the present technology, for example, can include positioning a focal plane of an ultrasound source at a target site in tissue. The ultrasound source can be configured to emit HIFU waves. The method can further include pulsing ultrasound energy from the ultrasound source toward the target site, and generating shock waves in the tissue to induce boiling of the tissue at the target site within milliseconds. The boiling of the tissue at least substantially emulsifies the tissue.

Abstract translation: 使用高强度聚焦超声（“HIFU”）治疗非侵入性治疗组织的方法和系统。 例如，根据本技术的实施例的非侵入性治疗组织的方法可以包括将超声源的焦平面定位在组织中的目标部位。 超声波源可被配置为发射HIFU波。 该方法还可以包括将来自超声源的超声能量脉冲向目标部位，并在组织内产生冲击波，以在毫秒内诱导目标部位的组织沸腾。 组织的沸腾至少基本上乳化组织。

公开(公告)号：US20130301383A1

公开(公告)日：2013-11-14

申请号：US13894333

申请日：2013-05-14

Applicant: Oleg A. Sapozhnikov ,  Michael R. Bailey ,  Peter J. Kaczkowski ,  Vera A. Khokhlova ,  Wayne Kreider

Inventor： Oleg A. Sapozhnikov ,  Michael R. Bailey ,  Peter J. Kaczkowski ,  Vera A. Khokhlova ,  Wayne Kreider

IPC: G03H3/00

CPC classification number: G03H3/00 ,  A61B8/00 ,  G01N29/0663 ,  Y10S359/901

Abstract: The present technology relates generally to portable acoustic holography systems for therapeutic ultrasound sources, and associated devices and methods. In some embodiments, a method of characterizing an ultrasound source by acoustic holography includes the use of a transducer geometry characteristic, a transducer operation characteristic, and a holography system measurement characteristic. A control computer can be instructed to determine holography measurement parameters. Based on the holography measurement parameters, the method can include scanning a target surface to obtain a hologram. Waveform measurements at a plurality of points on the target surface can be captured. Finally, the method can include processing the measurements to reconstruct at least one characteristic of the ultrasound source.

Abstract translation: 本技术一般涉及用于治疗性超声源的便携式声全息系统，以及相关的装置和方法。 在一些实施例中，通过声全息技术来表征超声源的方法包括使用换能器几何特征，换能器操作特性和全息系统测量特性。 可以指示控制计算机来确定全息测量参数。 基于全息测量参数，该方法可以包括扫描目标表面以获得全息图。 可以捕获目标表面上的多个点处的波形测量。 最后，该方法可以包括处理测量以重建超声源的至少一个特征。

公开(公告)号：US20120302927A1

公开(公告)日：2012-11-29

申请号：US13479067

申请日：2012-05-23

Applicant: Vera A. Khokhlova ,  Petr Yuldashev ,  Oleg A. Sapozhnikov ,  Michael R. Bailey ,  Lawrence A. Crum

Inventor： Vera A. Khokhlova ,  Petr Yuldashev ,  Oleg A. Sapozhnikov ,  Michael R. Bailey ,  Lawrence A. Crum

IPC: A61N7/00

CPC classification number: A61N7/02 ,  A61N2007/0065 ,  A61N2007/0095

Abstract: The present technology is directed to methods for characterizing nonlinear ultrasound fields and associated systems and devices. In several embodiments, for example, a method of calculating output of a high intensity focused ultrasound (HIFU) device comprises treating a target site with a multi-element HIFU array. In some embodiments, the array comprises a generally spherical segment. The method can further include simulating a field of the array by setting a boundary condition for the array. The boundary condition can be set by simplifying at least one geometrical aspect of the generally spherical segment.

Abstract translation: 本技术涉及用于表征非线性超声场和相关系统和装置的方法。 在几个实施例中，例如，计算高强度聚焦超声（HIFU）装置的输出的方法包括用多元素HIFU阵列处理靶位点。 在一些实施例中，阵列包括大致球形的段。 该方法还可以包括通过设置数组的边界条件来模拟阵列的一个字段。 可以通过简化大致球形段的至少一个几何方面来设定边界条件。