-
公开(公告)号：US20140011212A1
公开(公告)日：2014-01-09
申请号：US13982596
申请日：2012-01-30
Applicant: Andreas Frei , Bernd Wollscheid , Ock-Youm Jeon , Erick Carreira
Inventor： Andreas Frei , Bernd Wollscheid , Ock-Youm Jeon , Erick Carreira
IPC: G01N33/566
CPC classification number: G01N33/566 , C07D495/04 , G01N33/582 , G01N2333/70596 , Y02P20/55
Abstract: The present invention relates to trifunctional crosslinking reagents carrying (i) a ligand-reactive group for conjugation to a ligand of interest having at least one binding site on a target glycoprotein receptor, (ii) an optionally protected aromatic hydrazine group for the capturing of oxidized receptor-glycopeptides and (iii) an affinity group for the detection, isolation and purification of captured glycopeptides, their methods of production, as well as their use in methods for detecting, identifying and characterizing interactions between ligands and their corresponding glycoprotein target receptors on living cells and in biological fluids.
Abstract translation: 本发明涉及三官能交联剂，其携带（i）用于与靶糖配位体上至少有一个结合位点缀合的目的配体的配体 - 反应性基团，（ii）任选保护的芳族肼基团，用于捕获氧化的 受体 - 糖肽和（iii）用于检测，分离和纯化捕获的糖肽，其生产方法的亲和基团，以及它们用于检测，鉴定和表征配体与其相应的生物体内糖蛋白靶受体之间的相互作用的方法 细胞和生物液体。
-
2.发明授权Molecular transporters based on sugar and its analogues and processes for the preparation thereof 有权基于糖及其类似物的分子转运蛋白及其制备方法公开(公告)号：US08058413B2
公开(公告)日：2011-11-15
申请号：US12860538
申请日：2010-08-20
Applicant: Sung-Kee Chung , Kaustabh Kumar Maiti , Woo Sirl Lee , Ock-Youm Jeon , Seok-Ho Lee
Inventor： Sung-Kee Chung , Kaustabh Kumar Maiti , Woo Sirl Lee , Ock-Youm Jeon , Seok-Ho Lee
Abstract: The inventive molecular transporter compound shows significantly high permeability through a biological membrane such as a plasma membrane, nuclear membrane and blood-brain barrier, and accordingly, can be effectively used in delivering various biologically active molecules.
Abstract translation: 本发明的分子转运体化合物通过诸如质膜，核膜和血脑屏障的生物膜显示出显着高的渗透性，因此可以有效地用于递送各种生物活性分子。
-
3.发明申请MOLECULAR TRANSPORTERS BASED ON SUGAR AND ITS ANALOGUES AND PROCESSES FOR THE PREPARATION THEREOF 有权基于糖的分子运输机及其制备方法及其制备方法公开(公告)号：US20100330608A1
公开(公告)日：2010-12-30
申请号：US12860439
申请日：2010-08-20
Applicant: Sung-Kee Chung , Kaustabh Kumar Maiti , Woo Sirl Lee , Ock-Youm Jeon , Seok-Ho Lee
Inventor： Sung-Kee Chung , Kaustabh Kumar Maiti , Woo Sirl Lee , Ock-Youm Jeon , Seok-Ho Lee
IPC: C12Q1/02 , C07C229/12 , C07H19/213 , C12N5/00
Abstract: The inventive molecular transporter compound shows significantly high permeability through a biological membrane such as a plasma membrane, nuclear membrane and blood-brain barrier, and accordingly, can be effectively used in delivering various biologically active molecules.
Abstract translation: 本发明的分子转运体化合物通过诸如质膜，核膜和血脑屏障的生物膜显示出显着高的渗透性，因此可以有效地用于递送各种生物活性分子。
-
Patent Agency Ranking
4.发明申请公开(公告)号：US20080249296A1
公开(公告)日：2008-10-09
申请号：US11815339
申请日：2005-06-29
Applicant: Sung-Kee Chung , Kaustabh Kumar Maiti , Woo Sirl Lee , Ock-Youm Jeon , Seok-Ho Lee
Inventor： Sung-Kee Chung , Kaustabh Kumar Maiti , Woo Sirl Lee , Ock-Youm Jeon , Seok-Ho Lee
IPC: C07H15/04
Abstract: The inventive molecular transporter compound shows significantly high permeability through a biological membrane such as a plasma membrane, nuclear membrane and blood-brain barrier, and accordingly, can be effectively used in delivering various biologically active molecules.
Abstract translation: 本发明的分子转运体化合物通过诸如质膜，核膜和血脑屏障的生物膜显示出显着高的渗透性，因此可以有效地用于递送各种生物活性分子。
-
5.发明授权公开(公告)号：US08048996B2
公开(公告)日：2011-11-01
申请号：US12860439
申请日：2010-08-20
Applicant: Sung-Kee Chung , Kaustabh Kumar Maiti , Woo Sirl Lee , Ock-Youm Jeon , Seok-Ho Lee
Inventor： Sung-Kee Chung , Kaustabh Kumar Maiti , Woo Sirl Lee , Ock-Youm Jeon , Seok-Ho Lee
Abstract: The inventive molecular transporter compound shows significantly high permeability through a biological membrane such as a plasma membrane, nuclear membrane and blood-brain barrier, and accordingly, can be effectively used in delivering various biologically active molecules.
-
6.发明申请公开(公告)号：US20100330671A1
公开(公告)日：2010-12-30
申请号：US12860538
申请日：2010-08-20
Applicant: Sung-Kee CHUNG , Kaustabh Kumar Maiti , Woo Sirl Lee , Ock-Youm Jeon , Seok-Ho Lee
Inventor： Sung-Kee CHUNG , Kaustabh Kumar Maiti , Woo Sirl Lee , Ock-Youm Jeon , Seok-Ho Lee
Abstract: The inventive molecular transporter compound shows significantly high permeability through a biological membrane such as a plasma membrane, nuclear membrane and blood-brain barrier, and accordingly, can be effectively used in delivering various biologically active molecules.
-
公开(公告)号：US09766235B2
公开(公告)日：2017-09-19
申请号：US13982596
申请日：2012-01-30
Applicant: Andreas Frei , Bernd Wollscheid , Ock-Youm Jeon , Erick Carreira
Inventor： Andreas Frei , Bernd Wollscheid , Ock-Youm Jeon , Erick Carreira
IPC: G01N33/566 , C07D495/04 , G01N33/58
CPC classification number: G01N33/566 , C07D495/04 , G01N33/582 , G01N2333/70596 , Y02P20/55
Abstract: The present invention relates to trifunctional crosslinking reagents carrying (i) a ligand-reactive group for conjugation to a ligand of interest having at least one binding site on a target glycoprotein receptor, (ii) an optionally protected aromatic hydrazine group for the capturing of oxidized receptor-glycopeptides and (iii) an affinity group for the detection, isolation and purification of captured glycopeptides, their methods of production, as well as their use in methods for detecting, identifying and characterizing interactions between ligands and their corresponding glycoprotein target receptors on living cells and in biological fluids.
-
8.发明授权Molecular transporters based on sugar and its analogues and processes for the preparation thereof 有权基于糖及其类似物的分子转运蛋白及其制备方法公开(公告)号：US07846975B2
公开(公告)日：2010-12-07
申请号：US11815339
申请日：2005-06-29
Applicant: Sung-Kee Chung , Kaustabh Kumar Maiti , Woo Sirl Lee , Ock-Youm Jeon , Seok-Ho Lee
Inventor： Sung-Kee Chung , Kaustabh Kumar Maiti , Woo Sirl Lee , Ock-Youm Jeon , Seok-Ho Lee
Abstract: The inventive molecular transporter compound shows significantly high permeability through a biological membrane such as a plasma membrane, nuclear membrane and blood-brain barrier, and accordingly, can be effectively used in delivering various biologically active molecules.
Abstract translation: 本发明的分子转运体化合物通过诸如质膜，核膜和血脑屏障的生物膜显示出显着高的渗透性，因此可以有效地用于递送各种生物活性分子。
-
-
-
-
-
-
-
Search Results
8
records
(took 0.023 seconds)
