公开(公告)号：US20240424136A1

公开(公告)日：2024-12-26

申请号：US18696810

申请日：2022-10-18

Applicant: OBSIDIAN THERAPEUTICS, INC.

Inventor： Dhruv Sethi ,  Sean Smith ,  Michelle Ols ,  Dexue Sun ,  Dan Jun Li ,  Jan ter Meulen ,  Michael Schebesta

IPC: A61K48/00 ,  A61K38/17 ,  A61K38/19 ,  A61K47/64 ,  C12N15/86

Abstract: Provided herein are engineered, regulatable polypeptides comprising a payload and a modulation hub with at least two drug responsive domains (DRD), wherein the modulation hub is operably linked to the payload and wherein the at least two DRDs are responsive to a ligand. Also provided are engineered monomers comprising an oligomerization domain and a payload, a DRD or both a payload and DRD, wherein the monomers are configured to assemble into oligomers by way of the oligomerization domain and the oligomers comprise at least one payload operably linked to a modulation hub. The abundance, availability and/or biological activity of the payload is regulated by interaction of the one or more DRDs and an effective amount of ligand.

公开(公告)号：US12104178B2

公开(公告)日：2024-10-01

申请号：US17646212

申请日：2021-12-28

Applicant: Obsidian Therapeutics, Inc.

Inventor： Vipin Suri ,  Dan Jun Li ,  Dexue Sun ,  Byron Delabarre ,  Vijaya Balakrishnan ,  Brian Dolinski ,  Mara Christine Inniss ,  Grace Y. Olinger

IPC: A61K35/17 ,  C07K14/54 ,  C07K14/705 ,  C07K14/715 ,  C12N9/06 ,  C12N15/85 ,  C12N15/86

CPC classification number: C12N9/003 ,  A61K35/17 ,  C07K14/5434 ,  C07K14/5443 ,  C07K14/70503 ,  C07K14/7155 ,  C12N15/85 ,  C12Y105/01003 ,  C07K2319/30 ,  C07K2319/33

Abstract: The present invention is related to compositions and methods for the regulated and controlled expression of proteins.

公开(公告)号：US20230056856A1

公开(公告)日：2023-02-23

申请号：US17791091

申请日：2021-01-08

Applicant: OBSIDIAN THERAPEUTICS, INC.

Inventor： Vipin Suri ,  Mara Christine Inniss ,  Samantha Fleury

IPC: C12N15/63 ,  C12N9/06 ,  C12N5/0783 ,  A61K48/00 ,  A61K35/17 ,  C07K14/72

Abstract: The present disclosure provides compositions and methods related to transcription factor systems. Such systems provide for modular and tunable protein expression driven by regulated transcriptional activity.

公开(公告)号：US20230026259A1

公开(公告)日：2023-01-26

申请号：US17436892

申请日：2020-03-06

Applicant: Obsidian Therapeutics, Inc.

Inventor： Vipin SURI ,  Celeste RICHARDSON ,  Brian DOLINSKI ,  Abhishek KULKARNI ,  Mara Christine Inniss ,  Dexue SUN ,  Elizabeth Jane WEISMAN ,  Grace Y. Olinger ,  Scott Francis HELLER ,  Jennifer Leah GORI ,  Michelle Lynn OLS ,  Kutlu Goksu ELPEK ,  Tucker Read EZELL ,  Michael SCHEBESTA ,  Michelle Lois FLEURY ,  Dhruv Kam SETHI

IPC: C12N9/88 ,  A61K39/00 ,  C07K14/705

Abstract: The present disclosure provides regulatable biocircuit systems. Such systems provide modular and tunable protein expression systems in support of the discovery and development of therapeutic modalities. In particular, the present application is directed to fusion proteins comprising a fragment of human human carbonic anhydrase 2 and a chimeric antigen receptor (CAR). The activity of the destabilizing domain can be regulated by externally administered agents.

公开(公告)号：US20220348937A1

公开(公告)日：2022-11-03

申请号：US17753505

申请日：2020-09-04

Applicant: Obsidian Therapeutics, Inc.

Inventor： Mara Christine Inniss ,  Janine Elizabeth Elya ,  Grace Y. Olinger ,  Vipin Suri

IPC: C12N15/63 ,  A61K35/17 ,  C12N9/06 ,  A61K47/00

Abstract: The present disclosure is related to compositions and methods for the regulated and controlled expression of proteins.

公开(公告)号：US11446398B2

公开(公告)日：2022-09-20

申请号：US16092829

申请日：2017-04-11

Applicant: Obsidian Therapeutics, Inc.

Inventor： Peter Barrett ,  Michael N. Gladstone ,  Tariq A. Kassum ,  Vipin Suri ,  Dan Jun Li ,  Dexue Sun ,  Brian Dolinski

IPC: A61K38/52 ,  C12N9/90 ,  A61K48/00 ,  C07K16/28 ,  C07K14/00 ,  A61P3/08 ,  A61K35/17 ,  C07K14/195 ,  C07K14/54 ,  C07K14/605 ,  C07K14/725 ,  C07K14/705 ,  C12N5/0789 ,  C12N9/22 ,  C12N9/00 ,  C12N15/11 ,  A61K38/00

Abstract: The present invention provides regulatable biocircuit systems. Such systems provide modular and tunable protein expression systems in support of the discovery and development of therapeutic modalities.

公开(公告)号：US20220213449A1

公开(公告)日：2022-07-07

申请号：US17646212

申请日：2021-12-28

Applicant: Obsidian Therapeutics, Inc.

Inventor： Vipin SURI ,  Dan Jun LI ,  Dexue SUN ,  Byron DELABARRE ,  Vijaya BALAKRISHNAN ,  Brian DOLINSKI ,  Mara Christine INNISS ,  Grace Y. OLINGER

IPC: C12N9/06 ,  C07K14/54 ,  C07K14/715 ,  C12N15/85 ,  A61K35/17 ,  C07K14/705

Abstract: The present invention is related to compositions and methods for the regulated and controlled expression of proteins.

公开(公告)号：US11241485B2

公开(公告)日：2022-02-08

申请号：US16621593

申请日：2018-06-12

Applicant: Obsidian Therapeutics, Inc.

Inventor： Vipin Suri ,  Byron Delabarre ,  Michael N. Gladstone ,  Celeste Richardson ,  Brian Dolinski ,  Abhishek Kulkarni ,  Mara Christine Inniss ,  Dexue Sun ,  Dan Jun Li ,  Grace Y. Olinger ,  Scott Francis Heller

IPC: A61K38/46 ,  A61P35/00 ,  A61K31/4985 ,  A61K35/17 ,  A61K38/17 ,  A61K38/20 ,  A61K39/395 ,  C07K14/54 ,  C07K14/725 ,  C07K14/705 ,  C07K14/715 ,  C07K16/28 ,  C12N9/16 ,  A61K39/00 ,  A61P37/04 ,  C07K19/00

Abstract: The present invention relates to compositions and methods for the regulated and controlled expression of proteins. Methods for inducing anti-cancer immune responses in a subject are also provided.

公开(公告)号：US20210386788A1

公开(公告)日：2021-12-16

申请号：US17288373

申请日：2019-10-23

Applicant: Obsidian Therapeutics, Inc.

Inventor： Vipin SURI ,  Dexue SUN ,  Michelle Lynn OLS ,  Scott Francis HELLER ,  Dan Jun LI ,  Celeste RICHARDSON ,  Mara Christine INNISS ,  Jennifer Leah GORI ,  Benjamin J. PRIMACK ,  Abhishek KULKARNI ,  Brian DOLINSKI ,  Tucker Read EZELL ,  Michael SCHEBESTA ,  James A. STORER ,  Kutlu Goksu ELPEK

IPC: A61K35/28 ,  A61K31/4535 ,  A61K31/55 ,  C07K14/705 ,  C07K16/28 ,  C07K14/725 ,  C07K14/54 ,  C07K14/715 ,  A61P35/00

Abstract: The present disclosure is related to compositions and methods for the regulated and controlled expression of proteins.

公开(公告)号：US20240075064A1

公开(公告)日：2024-03-07

申请号：US18261761

申请日：2022-01-18

Applicant: OBSIDIAN THERAPEUTICS, INC.

Inventor： Kutlu Goksu Elpek ,  Celeste Richardson ,  Michelle Lois Fleury ,  James Alex Storer ,  Shyamsundar Subramanian ,  Mithun Khattar

IPC: A61K35/17 ,  A61K39/00 ,  A61P35/00 ,  C07K14/54 ,  C12N5/0783

CPC classification number: A61K35/17 ,  A61K39/4611 ,  A61K39/46444 ,  A61P35/00 ,  C07K14/5443 ,  C12N5/0636

Abstract: The present disclosure provides compositions and methods for expanding T cells or tumor infiltrating lymphocytes (TILs) in vitro. K562 feeder cells engineered to express a costimulatory molecule (e.g., 41BB ligand (41BBL)) and either interleukin 21 (IL21) or interleukin 7 (IL7) can be used in a rapid expansion protocol (REP) step to expand the T cells or TILs. Thus, provided herein is a culture comprising T-cells or TILs and modified K562 feeder cells. The T cells can be modified to express a chimeric antigen receptor (CAR) or a T cell receptor (TCR) or the TILs can be modified to express membrane-bound IL15 (mbIL15). The T cells or TILs can be expanded in vitro using aREP without the use of exogenous interleukin 2 (IL2), and the expanded cells can be used in adoptive cell therapy for treatment of cancer without concomitant use of an exogenous cytokine such as IL2.