公开(公告)号：US20240401004A1

公开(公告)日：2024-12-05

申请号：US18787024

申请日：2024-07-29

Applicant: OBSIDIAN THERAPEUTICS, INC.

Inventor： Vipin Suri ,  Dan Jun Li ,  Dexue Sun ,  Byron DeLaBarre ,  Vijaya Balakrishnan ,  Brian Dolinski ,  Mara Christine Inniss ,  Grace Y. Olinger

IPC: C12N9/06 ,  A61K39/00 ,  C07K14/54 ,  C07K14/705 ,  C07K14/715 ,  C12N15/85

Abstract: The present invention is related to compositions and methods for the regulated and controlled expression of proteins.

公开(公告)号：US20230092895A1

公开(公告)日：2023-03-23

申请号：US17753320

申请日：2019-08-30

Applicant: Obsidian Therapeutics, Inc.

Inventor： Vipin Suri ,  Michael Joseph Briskin ,  Brian Dolinski ,  Kutlu Goksu Elpek ,  Tucker Ezell ,  Scott Francis Heller ,  Mara Christine Inniss ,  Tariq A. Kassum ,  Nicole Kosmider ,  Abhishek Kulkarni ,  Meghan Langley ,  Dan Jun Li ,  Michelle Lynn Ols ,  Benjamin J. Primack ,  Celeste Richardson ,  Steven Mark Shamah ,  James Storer ,  Dexue Sun ,  Vijaya Balakrishnan ,  Andrew R.M. Bradbury ,  Michael Frank Erasmus ,  Fortunato Ferrara

IPC: C12N9/06 ,  C07K16/28 ,  C07K14/54 ,  C07K14/715 ,  C07K14/725 ,  A61K35/17

Abstract: The present invention provides biocircuit systems, effector modules and compositions for cancer immunotherapy. Methods for inducing anti-cancer immune responses in a subject are also provided.

公开(公告)号：US20230074330A1

公开(公告)日：2023-03-09

申请号：US17649592

申请日：2022-02-01

Applicant: Obsidian Therapeutics, Inc.

Inventor： Vipin Suri ,  Byron Delabarre ,  Michael N. Gladstone ,  Celeste Richardson ,  Brian Dolinski ,  Abhishek Kulkarni ,  Mara Christine Inniss ,  Dexue Sun ,  Dan Jun Li ,  Grace Y. Olinger ,  Scott Francis Heller

IPC: A61K38/46 ,  A61P35/00 ,  A61K31/4985 ,  A61K35/17 ,  A61K38/17 ,  A61K38/20 ,  A61K39/395 ,  C07K14/54 ,  C07K14/725 ,  C07K14/705 ,  C07K14/715 ,  C07K16/28 ,  C12N9/16

Abstract: The present invention relates to compositions and methods for the regulated and controlled expression of proteins. Methods for inducing anti-cancer immune responses in a subject are also provided.

公开(公告)号：US11058725B2

公开(公告)日：2021-07-13

申请号：US17017670

申请日：2020-09-10

Applicant: Obsidian Therapeutics, Inc.

Inventor： Kutlu Goksu Elpek ,  Dhruv Kam Sethi ,  Meghan C. Langley ,  Tucker Read Ezell ,  Dexue Sun ,  Jennifer Leah Gori ,  Geetha Hanna Mylvaganam ,  Michelle Ols ,  Michelle Fleury ,  Celeste Richardson ,  James A. Storer ,  Vipin Suri ,  Shyamsundar Subramanian ,  Colleen Foley ,  Molly Reed Perkins ,  Jeremy Hatem Tchaicha ,  Scott Francis Heller

IPC: A61K35/17 ,  C12N15/86 ,  C07K14/54 ,  A61K31/433 ,  C12N9/88 ,  C12N15/867 ,  C12N15/864 ,  C12N15/869 ,  C12N15/861

Abstract: The present disclosure provides drug responsive domains derived from human carbonic anhydrase 2 that can modulate protein stability for human interleukin 15 (IL15) payloads, as well as compositions and methods of use thereof.

公开(公告)号：US11666642B2

公开(公告)日：2023-06-06

申请号：US17649592

申请日：2022-02-01

Applicant: Obsidian Therapeutics, Inc.

Inventor： Vipin Suri ,  Byron Delabarre ,  Michael N. Gladstone ,  Celeste Richardson ,  Brian Dolinski ,  Abhishek Kulkarni ,  Mara Christine Inniss ,  Dexue Sun ,  Dan Jun Li ,  Grace Y. Olinger ,  Scott Francis Heller

IPC: A61K38/46 ,  A61P35/00 ,  A61K31/4985 ,  A61K35/17 ,  A61K38/17 ,  A61K38/20 ,  A61K39/395 ,  C07K14/54 ,  C07K14/725 ,  C07K14/705 ,  C07K14/715 ,  C07K16/28 ,  C12N9/16 ,  A61K39/00 ,  A61P37/04 ,  C07K19/00

CPC classification number: A61K38/465 ,  A61K31/4985 ,  A61K35/17 ,  A61K38/177 ,  A61K38/1774 ,  A61K38/1793 ,  A61K38/2086 ,  A61K39/3955 ,  A61P35/00 ,  C07K14/5443 ,  C07K14/7051 ,  C07K14/70517 ,  C07K14/70578 ,  C07K14/7155 ,  C07K16/2803 ,  C12N9/16 ,  C12Y301/04035 ,  A61K2039/505 ,  C07K2317/53 ,  C07K2317/622 ,  C07K2319/02 ,  C07K2319/03 ,  C07K2319/30 ,  C07K2319/33

Abstract: The present invention relates to compositions and methods for the regulated and controlled expression of proteins. Methods for inducing anti-cancer immune responses in a subject are also provided.

公开(公告)号：US11629340B2

公开(公告)日：2023-04-18

申请号：US16558224

申请日：2019-09-02

Applicant: OBSIDIAN THERAPEUTICS, INC.

Inventor： Vipin Suri ,  Dan Jun Li ,  Dexue Sun ,  Byron Delabarre ,  Vijaya Balakrishnan ,  Brian Dolinski ,  Mara Christine Inniss ,  Grace Y. Olinger

IPC: C12N15/85 ,  C07K14/54 ,  A61K35/17 ,  C12N9/06 ,  C07K14/715 ,  C07K14/705

Abstract: The present invention is related to compositions and methods for the regulated and controlled expression of proteins.

公开(公告)号：US20190192691A1

公开(公告)日：2019-06-27

申请号：US16092829

申请日：2017-04-11

Applicant: Obsidian Therapeutics, Inc.

Inventor： Peter Barrett ,  Michael N. Gladstone ,  Tariq A. Kassum ,  Vipin Suri ,  Dan Jun Li ,  Dexue Sun ,  Brian Dolinski

IPC: A61K48/00 ,  A61K35/17 ,  A61P3/08 ,  C07K14/605 ,  C12N15/11 ,  C12N9/22 ,  C12N5/0789 ,  C07K14/195 ,  C07K14/54 ,  C12N9/00 ,  C07K16/28 ,  C07K14/705 ,  C07K14/725

CPC classification number: A61K48/0066 ,  A61K35/17 ,  A61K38/00 ,  A61P3/08 ,  C07K14/00 ,  C07K14/195 ,  C07K14/5428 ,  C07K14/5443 ,  C07K14/605 ,  C07K14/7051 ,  C07K14/70517 ,  C07K14/70578 ,  C07K16/2803 ,  C07K2317/622 ,  C07K2319/00 ,  C07K2319/03 ,  C07K2319/30 ,  C07K2319/31 ,  C07K2319/50 ,  C12N5/0647 ,  C12N9/22 ,  C12N9/93 ,  C12N15/11 ,  C12N2310/20 ,  C12N2501/125 ,  C12N2501/145 ,  C12N2501/22 ,  C12N2501/2303 ,  C12N2501/2316 ,  C12N2800/80 ,  C12Y603/04016

Abstract: The present invention provides regulatable biocircuit systems. Such systems provide modular and tunable protein expression systems in support of the discovery and development of therapeutic modalities.

公开(公告)号：US20240424136A1

公开(公告)日：2024-12-26

申请号：US18696810

申请日：2022-10-18

Applicant: OBSIDIAN THERAPEUTICS, INC.

Inventor： Dhruv Sethi ,  Sean Smith ,  Michelle Ols ,  Dexue Sun ,  Dan Jun Li ,  Jan ter Meulen ,  Michael Schebesta

IPC: A61K48/00 ,  A61K38/17 ,  A61K38/19 ,  A61K47/64 ,  C12N15/86

Abstract: Provided herein are engineered, regulatable polypeptides comprising a payload and a modulation hub with at least two drug responsive domains (DRD), wherein the modulation hub is operably linked to the payload and wherein the at least two DRDs are responsive to a ligand. Also provided are engineered monomers comprising an oligomerization domain and a payload, a DRD or both a payload and DRD, wherein the monomers are configured to assemble into oligomers by way of the oligomerization domain and the oligomers comprise at least one payload operably linked to a modulation hub. The abundance, availability and/or biological activity of the payload is regulated by interaction of the one or more DRDs and an effective amount of ligand.

公开(公告)号：US12104178B2

公开(公告)日：2024-10-01

申请号：US17646212

申请日：2021-12-28

Applicant: Obsidian Therapeutics, Inc.

Inventor： Vipin Suri ,  Dan Jun Li ,  Dexue Sun ,  Byron Delabarre ,  Vijaya Balakrishnan ,  Brian Dolinski ,  Mara Christine Inniss ,  Grace Y. Olinger

IPC: A61K35/17 ,  C07K14/54 ,  C07K14/705 ,  C07K14/715 ,  C12N9/06 ,  C12N15/85 ,  C12N15/86

CPC classification number: C12N9/003 ,  A61K35/17 ,  C07K14/5434 ,  C07K14/5443 ,  C07K14/70503 ,  C07K14/7155 ,  C12N15/85 ,  C12Y105/01003 ,  C07K2319/30 ,  C07K2319/33

Abstract: The present invention is related to compositions and methods for the regulated and controlled expression of proteins.

公开(公告)号：US11446398B2

公开(公告)日：2022-09-20

申请号：US16092829

申请日：2017-04-11

Applicant: Obsidian Therapeutics, Inc.

Inventor： Peter Barrett ,  Michael N. Gladstone ,  Tariq A. Kassum ,  Vipin Suri ,  Dan Jun Li ,  Dexue Sun ,  Brian Dolinski

IPC: A61K38/52 ,  C12N9/90 ,  A61K48/00 ,  C07K16/28 ,  C07K14/00 ,  A61P3/08 ,  A61K35/17 ,  C07K14/195 ,  C07K14/54 ,  C07K14/605 ,  C07K14/725 ,  C07K14/705 ,  C12N5/0789 ,  C12N9/22 ,  C12N9/00 ,  C12N15/11 ,  A61K38/00

Abstract: The present invention provides regulatable biocircuit systems. Such systems provide modular and tunable protein expression systems in support of the discovery and development of therapeutic modalities.