公开(公告)号：US20240352058A1

公开(公告)日：2024-10-24

申请号：US18687411

申请日：2022-08-30

申请人： GUANGZHOU OCUSUN OPHTHALMIC BIOTECHNOLOGY CO., LTD. ,  OCUSUN OPHTHALMIC PHARMACEUTICAL (GUANGZHOU) CO., LTD.

发明人： Chuiliang Yu ,  Xiaolin Li ,  Yandong Wang ,  Xiaobing Lan ,  Fei Hao ,  Yingxue Su ,  Haiying He ,  Meirong Wu

IPC分类号： C07J9/00

CPC分类号： C07J9/00

摘要： A steroidal compound, a preparation method therefor and an application thereof. On one hand, provided are a compound represented by formula I, a preparation method therefor, and an application thereof in a method for separating and purifying lanosterol; on the other hand, provided is the method for separating and purifying lanosterol. The method is simple to operate, stable in process, high in productivity and low in cost, and the obtained lanosterol has high purity and can meet medical application thereof.

公开(公告)号：US20240315995A1

公开(公告)日：2024-09-26

申请号：US18577696

申请日：2022-07-08

申请人： GUANGZHOU OCUSUN OPHTHALMIC BIOTECHNOLOGY CO., LTD. ,  OCUSUN OPHTHALMIC PHARMACEUTICAL (GUANGZHOU) CO., LTD.

发明人： Chiyong Liang ,  Yandong Wang ,  Chuiliang Yu ,  Liang Li ,  Yaping Xue ,  Meirong Wu

IPC分类号： A61K31/192 ,  A61K47/14 ,  A61K47/18 ,  A61K47/36 ,  A61P27/02

CPC分类号： A61K31/192 ,  A61K47/14 ,  A61K47/183 ,  A61K47/186 ,  A61K47/36 ,  A61P27/02

摘要： The present invention relates to an application of loxoprofen sodium or a composition containing loxoprofen sodium in the preparation of a drug for preventing and/or treating the dry eye disease.

公开(公告)号：US20240315966A1

公开(公告)日：2024-09-26

申请号：US18577690

申请日：2022-07-08

申请人： GUANGZHOU OCUSUN OPHTHALMIC BIOTECHNOLOGY CO., LTD. ,  OCUSUN OPHTHALMIC PHARMACEUTICAL (GUANGZHOU) CO., LTD.

发明人： Shengan Zhou ,  Chuiliang Yu ,  Yandong Wang ,  Ximing Feng ,  Yaxiong Li ,  Meirong Wu

IPC分类号： A61K9/08 ,  A61K9/06 ,  A61K31/192 ,  A61K47/02 ,  A61K47/18 ,  A61K47/26 ,  A61K47/36 ,  A61P27/02

CPC分类号： A61K9/08 ,  A61K9/06 ,  A61K31/192 ,  A61K47/02 ,  A61K47/183 ,  A61K47/186 ,  A61K47/26 ,  A61K47/36 ,  A61P27/02

摘要： A composition containing loxoprofen sodium. The composition comprises loxoprofen sodium, sodium hyaluronate and polysorbate 80, wherein the molecular weight of sodium hyaluronate is 0.8×106−1.6×106. The composition has good stability and a long shelf life and is convenient to use.

公开(公告)号：US20230331696A1

公开(公告)日：2023-10-19

申请号：US18338355

申请日：2023-06-21

申请人： GUANGZHOU OCUSUN OPHTHALMIC BIOTECHNOLOGY CO., LTD. ,  OCUSUN OPHTHALMIC PHARMACEUTICAL (GUANGZHOU) CO., LTD.

发明人： Jian GE ,  Yandong WANG ,  Yizhi LIU ,  Lingyun WU ,  Xu YOU ,  Zheming XIAO ,  Shuhui CHEN

IPC分类号： C07D401/12

CPC分类号： C07D401/12 ,  C07B2200/11

摘要： Disclosed is a salt form of an isoquinolinone type compound as a ROCK protein kinase inhibitor and a preparation method therefor, and use of the salt form in the preparation of a medicament for treating glaucoma or ocular hypertension is further included.