APPLICATION OF SYNOVIUM-DERIVED MESENCHYMAL STEM CELLS (MSCS) FOR CARTILAGE OR MENISCUS REGENERATION
    1.
    发明申请
    APPLICATION OF SYNOVIUM-DERIVED MESENCHYMAL STEM CELLS (MSCS) FOR CARTILAGE OR MENISCUS REGENERATION 审中-公开
    使用衍生的MESENCHYMAL STEM细胞(MSCS)用于卡培或肉瘤再生

    公开(公告)号:US20100178274A1

    公开(公告)日:2010-07-15

    申请号:US12438298

    申请日:2007-08-22

    CPC classification number: C12N5/0655 A61K35/12 C12N5/0668 C12N2533/54

    Abstract: An object of the present invention is to provide a method for treating defects of articular cartilage or meniscus of a patient using in vivo chondrogenesis of synovium-derived MSCs. The present invention provides a method for treating a disease associated with defects of cartilage or meniscus. In the present invention, the method for treating a disease associated with defects of cartilage or meniscus comprises the following steps: culturing ex vivo autologous synovium-derived mesenchymal stem cells (MSCs); implanting the MSCs such that said cartilage defect site or meniscal defect site is covered by the MSCs; and regenerating cartilage tissue at the cartilage defect site or meniscal defect site in situ by differentiating the MSCs into cartilage cells.

    Abstract translation: 本发明的一个目的是提供一种使用滑膜衍生的MSC的体内软骨形成治疗患者的关节软骨或半月板的缺陷的方法。 本发明提供了治疗与软骨或半月板缺陷有关的疾病的方法。 在本发明中,用于治疗与软骨或半月板缺陷有关的疾病的方法包括以下步骤:培养离体自体滑膜间充质干细胞(MSC); 植入MSC,使得所述软骨缺损部位或半月板缺损部位被MSC覆盖; 并通过将MSC分化为软骨细胞,在软骨缺损部位或半月板缺损部位原位再生软骨组织。

    Method for treating tumors, infectious diseases, and autoimmune diseases with an activated HLA matching donor-originating lymphocyte
    2.
    发明申请
    Method for treating tumors, infectious diseases, and autoimmune diseases with an activated HLA matching donor-originating lymphocyte 审中-公开
    用激活的HLA匹配供体来源的淋巴细胞治疗肿瘤,感染性疾病和自身免疫性疾病的方法

    公开(公告)号:US20080014174A1

    公开(公告)日:2008-01-17

    申请号:US11834342

    申请日:2007-08-06

    CPC classification number: C12N5/0636 A61K2035/124 C12N2501/23 C12N2501/515

    Abstract: According to the present invention, HLA matching donor-originating activated lymphocytes highly effective in the treatment of patients with tumors, viral infections and autoimmune diseases are prepared by collecting cells contained in peripheral blood originating from an HLA matching donor or peripheral blood originating from an HLA matching donor achieving micro-chimerism and by stimulating and propagating the cells thus collected with, for instance, interleukin 2 and anti-CD3 antibodies or the like. The HLA matching donor-originating activated lymphocytes thus prepared can be administered to an HLA matching patient with a tumor, a viral infection or an autoimmune disease for therapeutic or preventive purposes.

    Abstract translation: 根据本发明,通过收集源自HLA匹配供体的外周血中含有的细胞,来源于HLA的外周血来源的HLA,可以通过收集高度有效治疗肿瘤,病毒感染和自身免疫疾病患者的HLA匹配供体来源的活化淋巴细胞 匹配供体实现微嵌合体,并通过刺激和繁殖用例如白细胞介素2和抗CD3抗体等收集的细胞。 如此制备的HLA匹配供体来源的活化淋巴细胞可以用于具有肿瘤,病毒感染或自身免疫疾病的HLA匹配患者用于治疗或预防目的。

    Color picture tube
    3.
    发明申请
    Color picture tube 失效
    彩色显像管

    公开(公告)号:US20060028115A1

    公开(公告)日:2006-02-09

    申请号:US11141380

    申请日:2005-05-31

    CPC classification number: H01J29/07

    Abstract: The radius of curvature of an outer surface of a panel useful portion is 10,000 mm or more. Assuming that a length of a perforated region of a shadow mask in an X-axis (major axis) direction is 2L, s is a variable satisfying 0

    Abstract translation: 面板有用部分的外表面的曲率半径为10,000mm以上。 假设荫罩的X轴(长轴)方向的穿孔区域的长度为2L,s为满足0 = 0.4, = s <= 0.8。 因此,可以提供具有令人满意的可视性的彩色显像管,并且具有由具有优异的可成形性和强度的荫罩引起的拱顶引起的色纯度的降低。

    Color cathode ray tube
    5.
    发明授权

    公开(公告)号:US06621206B2

    公开(公告)日:2003-09-16

    申请号:US09897050

    申请日:2001-07-03

    CPC classification number: H01J29/07 H01J2229/075 H01J2229/0788

    Abstract: A panel is provided with a substantially rectangular effective portion that has a substantially flat outer surface, and a phosphor screen is formed on the inner surface of the effective portion. A shadow mask that is opposed to the phosphor screen includes a substantially rectangular mask body formed having a large number of electron beam holes and a mask frame supporting the peripheral edge portion of the mask body. The interval between the electron beam holes in the direction of the major axis of the mask body increases from the center of the mask body toward the major axis end so that the rate of change of the interval has a maximum value in the region between the center of the mask body and the major axis end.

    Color cathode ray tube having particular arrangement of electron beam through hole arrays
    6.
    发明授权
    Color cathode ray tube having particular arrangement of electron beam through hole arrays 失效
    具有电子束通孔阵列的特定布置的彩色阴极射线管

    公开(公告)号:US06441545B1

    公开(公告)日:2002-08-27

    申请号:US09260014

    申请日:1999-03-02

    CPC classification number: H01J29/07 H01J2229/075

    Abstract: In a color cathode ray tube in which the external surface of an effective portion of a panel has a flat surface or a slight curvature, the shadow mask is set such that the layout distance between electron beam through hole array near the long side of an effective surface of the shadow mask is larger in the vicinity of the short axis than the layout distance at the center of the effective surface. Further, the layout distance becomes gradually smaller in direction away from the short axis, and thereafter, the layout distance changes to an increase. In the vicinity of the short side of the effective surface, the layout distance becomes equal to or larger than the layout distance near the short axis. Therefore, the curvature of the shadow mask and the electron beam through hole array are set in proper condition, and mislanding of beam landing due to deformation or oscillation of the shadow mask can be reduced. At the same time, howling of the phosphor screen can be minimized.

    Abstract translation: 在面板的有效部分的外表面具有平坦表面或略微曲率的彩色阴极射线管中,荫罩被设置为使得电子束通孔阵列在长边附近的布局距离有效 荫罩的表面在短轴附近比在有效表面中心的布局距离更大。 此外,布局距离在远离短轴的方向上逐渐变小,此后,布局距离变为增加。 在有效表面的短边附近,布局距离等于或大于短轴附近的布局距离。 因此,阴影掩模和电子束通孔阵列的曲率被设定在适当的条件下,并且可以减小由于荫罩的变形或振动引起的束着色的误着地。 同时,荧光屏的啸声可以最小化。

    Color cathode ray tube having reinforcing band arranged in a particular position relative to the position of stud pin
    7.
    发明授权
    Color cathode ray tube having reinforcing band arranged in a particular position relative to the position of stud pin 失效
    彩色阴极射线管,其具有相对于螺柱销的位置布置在特定位置的加强带

    公开(公告)号:US06342760B1

    公开(公告)日:2002-01-29

    申请号:US09268653

    申请日:1999-03-16

    CPC classification number: H01J29/87

    Abstract: A color cathode ray tube having a reinforcing band, which constricts the outer periphery of a skirt portion of a vacuum envelope, arranged so as to fulfill a relation, b≧2.0a, where a is the distance between first and second planes along a tube axis, the first plane intersecting an end edge of the skirt portion and extending perpendicular to the tube axis, the second plane containing the central axis of stud pins supporting a shadow mask and extending perpendicular to the tube axis, and b is the distance between the first plane and a third plane along the tube axis, the third plane intersecting a side edge of the reinforcing band facing a vacuum envelope funnel.

    Abstract translation: 一种彩色阴极射线管,其具有限制真空外壳的裙部的外周的加强带,其布置成满足关系式b> = 2.0a,其中a是沿着第一和第二平面之间的距离 管轴,所述第一平面与所述裙部的端缘相交并且垂直于所述管轴线延伸,所述第二平面包含支撑荫罩并垂直于所述管轴线延伸的柱销的中心轴线,并且b是 第一平面和沿管轴的第三平面,第三平面与加强带的面向真空包络漏斗的侧边缘相交。

    Color cathode ray tube having a shadow mask with a plurality of strip shaped reinforcing beads
    8.
    发明授权
    Color cathode ray tube having a shadow mask with a plurality of strip shaped reinforcing beads 失效
    彩色阴极射线管,其具有带多个带状增强珠的荫罩

    公开(公告)号:US06294863B1

    公开(公告)日:2001-09-25

    申请号:US09210795

    申请日:1998-12-15

    CPC classification number: H01J29/07 H01J2229/0727

    Abstract: A color cathode ray tube is provided with a shadow mask having a mask body including a substantially rectangular effective surface in which a large number of electron beam passage apertures are formed. A plurality of reinforcing beads are formed on the effective surface, and project therefrom to have heights which varies in accordance with positions such that in at least a part of an area for provision of the reinforcing beads, the heights of the reinforcing beads satisfy the following relationship: dx1>dx2, dy1>dy2 where dx1 is the height measured at a first position which is apart from a longer axis of the effective surface and a distance x1 apart from a shorter axis thereof, dx2 is the height measured at a second position which is further apart from the longer axis than the first position and a distance x2 apart from the shorter axis, dy1 is the height measured at a third position which is located on the shorter axis and a distance y1 apart from the longer axis, dy2 is the height measured at a fourth position which is a distance apart from the shorter axis and a distance y2 apart from the longer axis, and the distances x1, x2, y1 and y2 satisfy the following relationship: x1=x2=y1=y2.

    Abstract translation: 一种彩色阴极射线管设置有荫罩,该荫罩具有掩模体,该荫罩主体包括大致矩形的有效表面,其中形成有大量的电子束通过孔。多个增强珠形成在有效表面上,并从其突出到 具有根据位置而变化的高度,使得在用于提供增强珠的区域的至少一部分中,增强珠的高度满足以下关系:其中dx1是在除了第一位置之外测量的高度 有效表面的长轴和距离其较短轴线的距离x1,dx2是在比第一位置更远离第二位置的距离和距离较短轴线的距离x2测量的高度,dy1 是位于较短轴上的第三位置测量的高度和距离长轴的距离y1,dy2是在第四位置测量的高度 距离较短轴距离的距离和远离长轴的距离y2,距离x1,x2,y1和y2满足以下关系:x1 = x2 = y1 = y2。

    Particle handling method by acoustic radiation force and apparatus
therefore
    9.
    发明授权
    Particle handling method by acoustic radiation force and apparatus therefore 失效
    因此,通过声辐射力和装置进行颗粒处理

    公开(公告)号:US5902489A

    公开(公告)日:1999-05-11

    申请号:US745656

    申请日:1996-11-08

    CPC classification number: B01J19/10 B01D21/283 B01D21/34 B01D43/00

    Abstract: A chamber for exerting an ultrasound beam on a sample solution containing particles to be concentrated, separated or arranged is provided with a view toward arbitrarily controlling the shape of a spatial distribution of potential energy created by the ultrasound beam and concentrating, separating or periodically arranging the particles. In contrast to the chamber, irradiation ultrasound sources for generating ultrasound beams are provided to create an ultrasonic intensity distribution for producing a position potential energy distribution used to exert a force forwarded in a predetermined direction or a force staying at a predetermined region to each particle. Thus, a specific spatial distribution of potential energy can be realized by ultrasound beams each having a specific intensity, a specific frequency and a specific phase or an ultrasound beam formed by superimposing these on one another. Further, at least one suction hole for recovering separated solvents or particles is defined in a wall surface of the tube, which is orthogonal to the flow of the sample solution.

    Abstract translation: 在包含要集中,分离或排列的颗粒的样品溶液上施加超声波束的腔室设置有任意控制由超声波束产生的势能空间分布的形状的集中,分离或周期性排列 粒子。 与腔室相反,提供用于产生超声波束的照射超声波源以产生用于产生用于施加沿预定方向传递的力的位置势能分布的超声波强度分布或者保持在每个粒子的预定区域的力。 因此,可以通过每个具有特定强度,特定频率和特定相位的超声波束或通过将它们彼此叠加而形成的超声波束来实现势能的特定空间分布。 此外,在管的壁表面中限定用于回收分离的溶剂或颗粒的至少一个吸孔,其与样品溶液的流动正交。

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