公开(公告)号：US08778968B2

公开(公告)日：2014-07-15

申请号：US12504287

申请日：2009-07-16

申请人： Nnaemeka Ikechukwu Amobi ,  Ian Christopher Smith

发明人： Nnaemeka Ikechukwu Amobi ,  Ian Christopher Smith

IPC分类号： A01N43/00 ,  A61K31/445 ,  A01N43/64 ,  A61K31/41 ,  A01N31/14 ,  A61K31/075 ,  A01N33/18 ,  A01N33/24 ,  A61K31/04

摘要： A compound having formula I. R1, R2, R3 and R4 are independently H or lower alkyl. R5 is aryl, heteroaryl, cycloalkyl, heterocycloalkyl, aryloxy, heteroaryloxy, cycloalkyloxy, heterocycloalkyloxy, arylamino, heteroarylamino, cycloalkylamino, heterocycloalkyl amino, arylthio, heteroarylthio, cycloalkylthio, heterocycloalkylthio, or cyclic olefin, any of which may be substituted or non-substituted; or substituted alkyl, substituted alkyl oxy or substituted alkyl amino wherein the substituent is an aryl, a heteroaryl, a cycloalkyl, a heterocycloalkyl or a cyclic olefin, any of which may be substituted or non-substituted. X is C or N. n and p are independently whole numbers selected from 0, 1 and 2. (CH2)n and (CH2)p may be substituted or non-substituted. Ar1 and Ar2 are independently aryl or heteroaryl groups which may be substituted or non-substituted. Certain specific compounds are excluded.The compounds can be used in a medicament or a method for the reduction or prevention of the emission of sperm, or for the reduction or prevention of transmission of viral agents transmitted in seminal fluid.

公开(公告)号：US20100029624A1

公开(公告)日：2010-02-04

申请号：US12504287

申请日：2009-07-16

申请人： Nnaemeka Ikechukwu AMOBI ,  Ian Christopher SMITH

发明人： Nnaemeka Ikechukwu AMOBI ,  Ian Christopher SMITH

IPC分类号： A61K31/5415 ,  A61K31/473 ,  A61K31/472 ,  A61K31/47 ,  A61K31/445 ,  A61K31/4402 ,  A61K31/40 ,  A61K31/136 ,  A61P15/00

CPC分类号： C07C211/27 ,  C07C211/45 ,  C07C217/16 ,  C07C2603/26 ,  C07D207/09 ,  C07D209/08 ,  C07D211/12 ,  C07D211/14 ,  C07D211/26 ,  C07D215/06 ,  C07D215/12 ,  C07D217/10 ,  C07D221/04 ,  C07D279/26 ,  C07D279/28 ,  C07D295/03 ,  C07D401/06 ,  C07D417/06

摘要： A compound having formula I. R1, R2, R3 and R4 are independently H or lower alkyl. R5 is aryl, heteroaryl, cycloalkyl, heterocycloalkyl, aryloxy, heteroaryloxy, cycloalkyloxy, heterocycloalkyloxy, arylamino, heteroarylamino, cycloalkylamino, heterocycloalkyl amino, arylthio, heteroarylthio, cycloalkylthio, heterocycloalkylthio, or cyclic olefin, any of which may be substituted or non-substituted; or substituted alkyl, substituted alkyl oxy or substituted alkyl amino wherein the substituent is an aryl, a heteroaryl, a cycloalkyl, a heterocycloalkyl or a cyclic olefin, any of which may be substituted or non-substituted. X is C or N. n and p are independently whole numbers selected from 0, 1 and 2. (CH2)n and (CH2)p may be substituted or non-substituted. Ar1 and Ar2 are independently aryl or heteroaryl groups which may be substituted or non-substituted. Certain specific compounds are excluded.The compounds can be used in a medicament or a method for the reduction or prevention of the emission of sperm, or for the reduction or prevention of transmission of viral agents transmitted in seminal fluid.

摘要翻译： 具有式I的化合物.R 1，R 2，R 3和R 4独立地为H或低级烷基。 R5是芳基，杂芳基，环烷基，杂环烷基，芳氧基，杂芳氧基，环烷氧基，杂环烷氧基，芳基氨基，杂芳基氨基，环烷基氨基，杂环烷基氨基，芳硫基，杂芳硫基，环烷硫基，杂环烷硫基或环烯烃，其中任何一个可以是取代或未取代的; 或取代的烷基，取代的烷基氧基或取代的烷基氨基，其中取代基是芳基，杂芳基，环烷基，杂环烷基或环烯烃，其中任何一个可以被取代或未取代。 X是C或N.n，p独立地是选自0,1和2的整数。（CH 2）n和（CH 2）p可以是取代或未取代的。 Ar 1和Ar 2独立地为可被取代或未取代的芳基或杂芳基。 排除某些具体化合物。 这些化合物可以用于减少或预防精子发射的药物或方法，或用于减少或防止在精液中传播的病毒剂的传播。