公开(公告)号：US4891312A

公开(公告)日：1990-01-02

申请号：US294031

申请日：1989-01-06

Applicant: Jon P. Schaumann ,  Jitka V. Olander ,  Nicholaos K. Harakas ,  Joseph Feder

Inventor： Jon P. Schaumann ,  Jitka V. Olander ,  Nicholaos K. Harakas ,  Joseph Feder

IPC: C07K16/30 ,  C07K16/40

CPC classification number: C07K16/40 ,  C07K16/3046 ,  Y10S436/815

Abstract: A monoclonal antibody is disclosed which is specific for human colon fibroblast-derived tissue plasminogen activator (t-PA), and which is useful for immunoaffinity chromatography purification of t-PA and determination of t-PA in a biological sample.

Abstract translation: 公开了对人结肠成纤维细胞衍生的组织纤溶酶原激活物（t-PA）特异的单克隆抗体，其可用于t-PA的免疫亲和层析纯化和生物样品中t-PA的测定。

公开(公告)号：US5132214A

公开(公告)日：1992-07-21

申请号：US849933

申请日：1986-04-09

Applicant: Joseph Feder ,  Nicholaos K. Harakas ,  Jon P. Schaumann ,  Daniel T. Connolly ,  Arthur J. Wittwer

Inventor： Joseph Feder ,  Nicholaos K. Harakas ,  Jon P. Schaumann ,  Daniel T. Connolly ,  Arthur J. Wittwer

IPC: C12N9/64 ,  A61K38/00 ,  C07K1/14 ,  C08B37/00 ,  C12N5/00 ,  C12N9/72 ,  C12R1/91

CPC classification number: C12N9/6459 ,  C08B37/00 ,  C12Y304/21069 ,  A61K38/00

Abstract: Plasminogen activators (PA) are obtained from cultured normal human colon cells which are adaptable to large scale production. A purified tissue PA (t-PA) is obtained from CCD-18Co normal human colon fibroblast cells which shows chemical differences from Bowes melanoma t-PA.

Abstract translation: 纤维蛋白溶酶原激活物（PA）是从适合大规模生产的培养的正常人结肠细胞获得的。 从CT-18Co正常人结肠成纤维细胞获得纯化的组织PA（t-PA），其显示与Bowes黑素瘤t-PA的化学差异。

公开(公告)号：US4833085A

公开(公告)日：1989-05-23

申请号：US896362

申请日：1986-08-13

Applicant: Jon P. Schaumann ,  Jitka V. Olander ,  Nicholaos K. Harakas ,  Joseph Feder

Inventor： Jon P. Schaumann ,  Jitka V. Olander ,  Nicholaos K. Harakas ,  Joseph Feder

IPC: G01N33/577 ,  A61K39/395 ,  C07K1/22 ,  C07K14/005 ,  C07K14/195 ,  C07K16/00 ,  C07K16/30 ,  C07K16/40 ,  C12N5/00 ,  C12N15/00 ,  C12N15/02 ,  C12P21/00 ,  C12P21/08 ,  C12R1/91 ,  G01N33/53 ,  G01N33/573

CPC classification number: C07K16/3046 ,  C07K16/40

Abstract: A monoclonal antibody is disclosed which is specific for human colon fibroblast-derived tissue plasminogen activator (t-PA), and which is useful for immunoaffinity chromatography purification of t-PA and determination of t-PA in a biological sample.

Abstract translation: 公开了对人结肠成纤维细胞衍生的组织纤溶酶原激活物（t-PA）特异的单克隆抗体，其可用于t-PA的免疫亲和层析纯化和生物样品中t-PA的测定。