-
1.发明申请公开(公告)号：US20100266660A1
公开(公告)日：2010-10-21
申请号：US12684480
申请日：2010-01-08
Applicant: William F. McKay , Scott D. Boden , Neil Beals
Inventor： William F. McKay , Scott D. Boden , Neil Beals
CPC classification number: A61B17/707 , A61B17/8085 , A61B2017/00004 , A61K38/1875 , A61L27/227 , A61L27/24 , A61L27/54 , A61L27/56 , A61L27/58 , A61L2300/252 , A61L2300/414 , A61L2430/02 , C07K14/51 , C07K14/78 , Y10S514/801
Abstract: Described are osteogenic implants that include a first implant material covered at least in part by a second implant material carrying an osteogenic protein such as a bone morphogenic protein. The first implant material can comprise a mineral and provide an inner scaffolding portion for supporting bone ingrowth, and the second implant material can comprise a collagen or other sponge carrier covering the first implant material and having a liquid osteogenic protein formulation imbibed therein. Related implant materials and methods of preparation and use constitute additional aspects of the invention.
Abstract translation: 描述的是成骨植入物，其包括至少部分地由承载成骨蛋白质例如骨形态发生蛋白质的第二种植体材料覆盖的第一种植体材料。 第一植入材料可以包括矿物并且提供用于支撑骨向内生长的内部支架部分，并且第二植入材料可以包括覆盖第一植入材料并且具有吸入其中的液体成骨蛋白质制剂的胶原蛋白或其它海绵载体。 相关植入材料及其制备和使用方法构成本发明的另外方面。
-
公开(公告)号：US20100112069A1
公开(公告)日：2010-05-06
申请号：US12634323
申请日：2009-12-09
Applicant: Neil Beals , Jeffrey L. Scifert , Scott D. Boden
Inventor： Neil Beals , Jeffrey L. Scifert , Scott D. Boden
CPC classification number: A61K9/0024 , A61K9/0085 , A61K38/177 , A61K38/1774 , A61K38/18 , A61K38/1825 , A61K38/1841 , A61K38/1858 , A61K38/1866 , A61K38/1875 , A61K38/19 , A61K38/30 , A61K47/42 , A61L27/24 , A61L27/54 , A61L27/56 , A61L2300/414
Abstract: A carrier matrix may be delivered to a target position within a patient in a minimally invasive manner by first cutting a collagen sponge sheet into a plurality of relatively small pieces. These pieces are sized so that, when wet, they are capable of flowing through a cannula and/or reduced-diameter syringe tip. The pieces are placed into a syringe and wetted, say with a morphogenic solution, and optionally mixed with a bulking material, which is similarly sized to fit through the cannula. The thoroughly mixed and wetted product forms a viscous aggregate which may then be injected into the patient at the target site.
Abstract translation: 通过首先将胶原海绵片切割成多个相对小的片，可以以微创方式将载体基质递送到患者体内的目标位置。 这些件的尺寸使得在潮湿时它们能够流过套管和/或减小直径的针头。 将片放置在注射器中并用形态发生溶液润湿，并且可选地与填充材料混合，膨胀材料的尺寸类似于穿过套管。 充分混合和润湿的产品形成粘性聚集体，然后可以在目标部位将其注入患者体内。
-
公开(公告)号：US20100266658A1
公开(公告)日：2010-10-21
申请号：US12684448
申请日：2010-01-08
Applicant: William F. McKay , Scott D. Boden , Neil Beals
Inventor： William F. McKay , Scott D. Boden , Neil Beals
CPC classification number: A61B17/707 , A61B17/8085 , A61B2017/00004 , A61K38/1875 , A61L27/227 , A61L27/24 , A61L27/54 , A61L27/56 , A61L27/58 , A61L2300/252 , A61L2300/414 , A61L2430/02 , C07K14/51 , C07K14/78 , Y10S514/801
Abstract: Described are osteogenic implants that include a first implant material covered at least in part by a second implant material carrying an osteogenic protein such as a bone morphogenic protein. The first implant material can comprise a mineral and provide an inner scaffolding portion for supporting bone ingrowth, and the second implant material can comprise a collagen or other sponge carrier covering the first implant material and having a liquid osteogenic protein formulation imbibed therein. Related implant materials and methods of preparation and use constitute additional aspects of the invention.
-
公开(公告)号：US20120003315A1
公开(公告)日：2012-01-05
申请号：US13233100
申请日：2011-09-15
Applicant: Neil Beals , Jeffrey L. Scifert , Scott D. Boden
Inventor： Neil Beals , Jeffrey L. Scifert , Scott D. Boden
CPC classification number: A61K9/0024 , A61K9/0085 , A61K38/177 , A61K38/1774 , A61K38/18 , A61K38/1825 , A61K38/1841 , A61K38/1858 , A61K38/1866 , A61K38/1875 , A61K38/19 , A61K38/30 , A61K47/42 , A61L27/24 , A61L27/54 , A61L27/56 , A61L2300/414
Abstract: A carrier matrix may be delivered to a target position within a patient in a minimally invasive manner by first cutting a collagen sponge sheet into a plurality of relatively small pieces. These pieces are sized so that, when wet, they are capable of flowing through a cannula and/or reduced-diameter syringe tip. The pieces are placed into a syringe and wetted, say with a morphogenic solution, and optionally mixed with a bulking material, which is similarly sized to fit through the cannula. The thoroughly mixed and wetted product forms a viscous aggregate which may then be injected into the patient at the target site.
Abstract translation: 通过首先将胶原海绵片切割成多个相对小的片，可以以微创方式将载体基质递送到患者体内的目标位置。 这些件的尺寸使得在潮湿时它们能够流过套管和/或减小直径的针头。 将片放置在注射器中并用形态发生溶液润湿，并且可选地与填充材料混合，膨胀材料的尺寸类似于穿过套管。 充分混合和润湿的产品形成粘性聚集体，然后可以在目标部位将其注入患者体内。
-
Patent Agency Ranking
公开(公告)号：US20100086600A1
公开(公告)日：2010-04-08
申请号：US12635289
申请日：2009-12-10
Applicant: Neil Beals , Jeffrey L. Scifert , Scott D. Boden
Inventor： Neil Beals , Jeffrey L. Scifert , Scott D. Boden
CPC classification number: A61K9/0024 , A61K9/0085 , A61K38/177 , A61K38/1774 , A61K38/18 , A61K38/1825 , A61K38/1841 , A61K38/1858 , A61K38/1866 , A61K38/1875 , A61K38/19 , A61K38/30 , A61K47/42 , A61L27/24 , A61L27/54 , A61L27/56 , A61L2300/414
Abstract: A carrier matrix may be delivered to a target position within a patient in a minimally invasive manner by first cutting a collagen sponge sheet into a plurality of relatively small pieces. These pieces are sized so that, when wet, they are capable of flowing through a cannula and/or reduced-diameter syringe tip. The pieces are placed into a syringe and wetted, say with a morphogenic solution, and optionally mixed with a bulking material, which is similarly sized to fit through the cannula. The thoroughly mixed and wetted product forms a viscous aggregate which may then be injected into the patient at the target site.
-
6.发明申请Release of BMP, bioactive agents and/or cells via a pump into a carrier matrix 有权通过泵将BMP，生物活性剂和/或细胞释放到载体基质中公开(公告)号：US20080025987A1
公开(公告)日：2008-01-31
申请号：US11494237
申请日：2006-07-27
Applicant: Neil Beals , Jeffrey L. Scifert , Vanja M. King
Inventor： Neil Beals , Jeffrey L. Scifert , Vanja M. King
IPC: A61K39/395 , A61K38/18 , A61K9/22 , A61K31/56
CPC classification number: A61K9/0024 , A61K31/56 , A61K38/18 , A61K38/1825 , A61K38/1841 , A61K38/1858 , A61K38/1875 , A61K45/06 , Y10S514/801 , A61K2300/00
Abstract: A pump to deliver bone-growth factors to a carrier matrix within a patient. Pump can be internal or external. With external pumps, additional amounts of the same growth factor may be added, or the bioactive agent may be changed during the course of treatment. An external pump permits the use of cells to promote bone growth. The pump can have several reservoirs and the pump can itself be received in the carrier matrix with an outlet tube or other structure to defuse the growth factors into the carrier matrix. The pump protocol can be used for slow-to-heal fractures, such as closed fractures, and can be used for slow-to-heal patients.
Abstract translation: 用于将骨生长因子递送到患者体内的载体基质的泵。 泵可以是内部或外部。 使用外部泵，可以添加额外量的相同生长因子，或者可以在治疗过程中改变生物活性剂。 外部泵允许使用细胞来促进骨骼生长。 泵可以具有多个储存器，并且泵本身可以使用出口管或其它结构容纳在载体矩阵中，以将生长因子消除到载体矩阵中。 泵方案可用于慢愈合骨折，如闭合性骨折，可用于慢愈合患者。
-
公开(公告)号：US20110092953A1
公开(公告)日：2011-04-21
申请号：US12977310
申请日：2010-12-23
Applicant: Neil Beals , Jeffrey L. Scifert , Scott D. Boden
Inventor： Neil Beals , Jeffrey L. Scifert , Scott D. Boden
CPC classification number: A61K9/0024 , A61K9/0085 , A61K38/177 , A61K38/1774 , A61K38/18 , A61K38/1825 , A61K38/1841 , A61K38/1858 , A61K38/1866 , A61K38/1875 , A61K38/19 , A61K38/30 , A61K47/42 , A61L27/24 , A61L27/54 , A61L27/56 , A61L2300/414
Abstract: A carrier matrix may be delivered to a target position within a patient in a minimally invasive manner by first cutting a collagen sponge sheet into a plurality of relatively small pieces. These pieces are sized so that, when wet, they are capable of flowing through a cannula and/or reduced-diameter syringe tip. The pieces are placed into a syringe and wetted, say with a morphogenic solution, and optionally mixed with a bulking material, which is similarly sized to fit through the cannula. The thoroughly mixed and wetted product forms a viscous aggregate which may then be injected into the patient at the target site.
Abstract translation: 通过首先将胶原海绵片切割成多个相对小的片，可以以微创方式将载体基质递送到患者体内的目标位置。 这些件的尺寸使得在潮湿时它们能够流过套管和/或减小直径的针头。 将片放置在注射器中并用形态发生溶液润湿，并且可选地与填充材料混合，膨胀材料的尺寸类似于穿过套管。 充分混合和润湿的产品形成粘性聚集体，然后可以在目标部位将其注入患者体内。
-
8.发明授权Release of BMP, bioactive agents and/or cells via a pump into a carrier matrix 有权通过泵将BMP，生物活性剂和/或细胞释放到载体基质中公开(公告)号：US07723291B2
公开(公告)日：2010-05-25
申请号：US11494237
申请日：2006-07-27
Applicant: Neil Beals , Jeffrey L. Scifert , Vanja M. King
Inventor： Neil Beals , Jeffrey L. Scifert , Vanja M. King
CPC classification number: A61K9/0024 , A61K31/56 , A61K38/18 , A61K38/1825 , A61K38/1841 , A61K38/1858 , A61K38/1875 , A61K45/06 , Y10S514/801 , A61K2300/00
Abstract: A pump to deliver bone-growth factors to a carrier matrix within a patient. Pump can be internal or external. With external pumps, additional amounts of the same growth factor may be added, or the bioactive agent may be changed during the course of treatment. An external pump permits the use of cells to promote bone growth. The pump can have several reservoirs and the pump can itself be received in the carrier matrix with an outlet tube or other structure to defuse the growth factors into the carrier matrix. The pump protocol can be used for slow-to-heal fractures, such as closed fractures, and can be used for slow-to-heal patients.
Abstract translation: 用于将骨生长因子递送到患者体内的载体基质的泵。 泵可以是内部或外部。 使用外部泵，可以添加额外量的相同生长因子，或者可以在治疗过程中改变生物活性剂。 外部泵允许使用细胞来促进骨骼生长。 泵可以具有多个储存器，并且泵本身可以使用出口管或其它结构容纳在载体矩阵中，以将生长因子消除到载体矩阵中。 泵方案可用于慢愈合骨折，如闭合性骨折，可用于慢愈合患者。
-
9.发明授权Osteogenic implants with combined implant materials, and materials and methods for same 有权具有组合种植体材料的成骨植入物，以及用于其的材料和方法公开(公告)号：US07722895B1
公开(公告)日：2010-05-25
申请号：US11361026
申请日：2006-02-23
Applicant: William F. McKay , Scott D. Boden , Neil Beals
Inventor： William F. McKay , Scott D. Boden , Neil Beals
IPC: A61F2/00 , A61F2/02 , A61F2/28 , A61K38/00 , A61K38/16 , A61K38/17 , A61K38/18 , C07K14/78 , C07K14/51
CPC classification number: A61B17/707 , A61B17/8085 , A61B2017/00004 , A61K38/1875 , A61L27/227 , A61L27/24 , A61L27/54 , A61L27/56 , A61L27/58 , A61L2300/252 , A61L2300/414 , A61L2430/02 , C07K14/51 , C07K14/78 , Y10S514/801
Abstract: Described are osteogenic implants that include a first implant material covered at least in part by a second implant material carrying an osteogenic protein such as a bone morphogenic protein. The first implant material can comprise a mineral and provide an inner scaffolding portion for supporting bone ingrowth, and the second implant material can comprise a collagen or other sponge carrier covering the first implant material and having a liquid osteogenic protein formulation imbibed therein. Related implant materials and methods of preparation and use constitute additional aspects of the invention.
Abstract translation: 描述的是成骨植入物，其包括至少部分地由承载成骨蛋白质例如骨形态发生蛋白质的第二种植体材料覆盖的第一种植体材料。 第一植入材料可以包括矿物并且提供用于支撑骨向内生长的内部支架部分，并且第二植入材料可以包括覆盖第一植入材料并且具有吸入其中的液体成骨蛋白质制剂的胶原蛋白或其它海绵载体。 相关植入材料及其制备和使用方法构成本发明的另外方面。
-
-
-
-
-
-
-
-
Search Results
9
records
(took 0.017 seconds)
